Serum free light chains among twin siblings: is the kappa/lambda ratio genetically determined?

IF 2 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomarkers Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI:10.1080/1354750X.2024.2319308

Alan H B Wu, Chia-Ching Wang

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引用次数: 0

Abstract

Background: Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed that free light chains have a low within and high between-individual variation. We determined if this variation were genetically linked.

Methods: We obtained a single serum sample from 16 pairs of identical twins, 8 neonate twins, and 19 presumed directly-related siblings children, measured Κ and λ light chains and computed the Κ/λ ratio.

Results: As expected, Κ/λ results from each twin neonate were near identical (reflecting maternal/placental transfer). For older children and adult twins, the Κ/λ ratio form a cluster of results that were a subset of the reference range. There was one outlier, a female with a high, different from her twin sister. She likely had a monoclonal gammopathy (no followup was possible). Excluding this pair, results from neonate twins (14.4% ±10.3%) and non-neonate twins (18.0 ± 15.3%) were not significantly different. Results between non-twin siblings were more scattered (53.2%±53.4%) and different from neonate and non-neonate twin adult and children.

Conclusion: We suggest that the Κ/λ free light chains may be genetically linked.

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双胞胎兄弟姐妹的血清游离轻链：kappa/lambda 比率是由基因决定的吗？

背景：血清 kappa、lambda 和 K/λ 轻链浓度用于筛查、诊断和监测多发性骨髓瘤和其他浆细胞疾病患者。对健康受试者进行的生物变异研究表明，游离轻链的个体内变异较小，个体间变异较大。我们确定这种变异是否与遗传有关：方法：我们从 16 对同卵双胞胎、新生双胞胎和 19 个假定有直接血缘关系的兄弟姐妹中采集了一份血清样本，测量了 Κ 和 λ 轻链，并计算了 Κ/λ 比值：不出所料，每对双胞胎新生儿的Κ/λ结果几乎相同（反映了母体/胎盘转移）。对于年龄较大的儿童和成年双胞胎，Κ/λ比值形成了一组结果，这些结果是参考范围的一个子集。有一个异常值，即一名女性的Κ/λ比值偏高，与她的双胞胎姐妹不同。她可能患有单克隆丙种球蛋白病（无法进行随访）。除去这对双胞胎，新生儿（14.4% ± 10.3%）和非新生儿双胞胎（18.0 ± 15.3%）的结果没有显著差异。非双胞胎兄弟姐妹之间的结果更为分散（53.1%±53.4%），且与新生儿、非新生儿成人和儿童的结果不同：我们认为，Κ/λ游离轻链可能与遗传有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.