Biomarkers最新文献

{"title":"Identification of <i>Mrm2</i> as a key regulator in mitochondrial dysfunction during radiation-induced intestinal injury.","authors":"Zhongwei Zhang, Jun Liu, Wei Xue, Haoran Zhang, Mimi Wang, Qing-Jie Liu","doi":"10.1080/1354750X.2026.2653892","DOIUrl":"10.1080/1354750X.2026.2653892","url":null,"abstract":"<p><strong>Background: </strong>Radiation-induced intestinal injury (RIII) is a serious complication of radiotherapy and is closely associated with mitochondrial dysfunction, but the underlying mechanism remains unclear.</p><p><strong>Methods: </strong>Mitochondria‑related differentially expressed genes (DEGs) were identified using online databases in an RIII model. Histopathological staining analysis was performed to evaluate injury severity. The expression of <i>Mrm2</i> was examined in vivo after irradiation.</p><p><strong>Results: </strong>The core functional modules of the identified DEGs included mitochondrial‑coding genes and apoptosis‑related genes. Histopathological analysis showed that RIII aggravated significantly in a dose‑ and time‑dependent manner. Notably, <i>Mrm2</i> was continuously upregulated after irradiation in vivo.</p><p><strong>Conclusion: </strong><i>Mrm2</i> may serve as a key regulatory factor mediating mitochondrial dysfunction in radiation‑induced intestinal injury.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"415-427"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic significance of serum phoenixin-14 and phoenixin-20 levels in patients with endometrial cancer.","authors":"Yeliz Çeçen Dönmez, Esra Keles, İsmail Bağlar, Fatih Şanlıkan, Sahra Sultan Kara, Öznur Dündar Akin, Hafize Uzun, Naile Fevziye Misirlioglu","doi":"10.1080/1354750X.2026.2715761","DOIUrl":"10.1080/1354750X.2026.2715761","url":null,"abstract":"<p><strong>Aim: </strong>This study aimed to evaluate the diagnostic utility and prognostic significance of serum phoenixin-14 (PNX-14) and phoenixin-20 (PNX-20) levels in patients with endometrial cancer (EC).</p><p><strong>Methods: </strong>A prospective case-control study was conducted, enrolling 52 patients with histologically confirmed EC and 45 healthy controls. Serum PNX-14 and PNX-20 concentrations were measured using enzyme-linked immunosorbent assay. Multivariable logistic regression and receiver operating characteristic (ROC) curve analyses were performed. Associations between phoenixin levels and clinicopathological parameters were evaluated.</p><p><strong>Results: </strong>Serum PNX-14 (80.70 ± 22.45 vs. 61.75 ± 18.73 pg/mL; <i>p</i> < 0.0001) and PNX-20 (888.2 ± 284.9 vs. 646.7 ± 243.8 pg/mL; <i>p</i> < 0.0001) levels were significantly elevated in the EC group. Elevated PNX-14 was significantly associated with distant metastasis (<i>p</i> = 0.0463) and disease recurrence (<i>p</i> = 0.0020). Multivariable logistic regression identified PNX-14 as an independent predictor for EC (OR: 1.07; 95%CI: 1.03-1.12; <i>p</i> = 0.001). The combined PNX-14/PNX-20 model yielded a superior area under the curve of 0.844.</p><p><strong>Conclusions: </strong>Serum PNX-14 and PNX-20 are significantly elevated in EC and demonstrate diagnostic potential. PNX-14 may serve as a prognostic biomarker for metastasis and recurrence.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"435-443"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage-dependent shifts in peritoneal cytokine profiles drive monocyte functional reprogramming in endometriosis.","authors":"Sofia Shifon, Tamara Tyrinova, Tatyana Veretelnikova, Aleksandra Maksimova, Ivan Rashchupkin, Natalia Pasman, Elena Chernykh","doi":"10.1080/1354750X.2026.2718915","DOIUrl":"10.1080/1354750X.2026.2718915","url":null,"abstract":"<p><strong>Introduction: </strong>Endometriosis is a chronic inflammatory disease in which monocytes/macrophages play a key pathogenetic role. The peritoneal fluid (PF) cytokine profile can modulate recruited monocyte functions, determining their contribution to disease progression.</p><p><strong>Aim: </strong>To investigate stage-specific changes in the PF cytokine profile and their impact on functional reprogramming of monocytes in endometriosis.</p><p><strong>Methods: </strong>The study included 26 patients with endometriosis (stages I-III) and 6 controls. PF cytokine concentrations were measured by multiplex analysis (Bio-Plex). The effect of PF on MerTK, CCR2, PD-1 and PD-L1 expression by healthy donor monocytes was assessed by flow cytometry.</p><p><strong>Results: </strong>PF composition changed dynamically with disease stage: At stage I, RANTES and IL-6 increased; at stage II, IL-12 decreased and IL-1ra increased; and at stage III, IFN-γ and IL-12 decreased. Stage I PF inhibited MerTK expression on monocytes, whereas stages II-III PF upregulated MerTK, PD-L1, PD-1 and CCR2. Pro-inflammatory cytokines negatively correlated with MerTK and PD-1 changes, while Th2 cytokines positively correlated with MerTK expression. Th2 cytokine levels were directly associated with serum CA-125 concentration.</p><p><strong>Conclusion: </strong>Stage-specific shifts in the PF cytokine profile initiate the switching of monocytes from a pro-inflammatory to an immunosuppressive phenotype.</p><p><strong>Clinical significance: </strong>Endometriosis diagnosis remains challenging due to the limited sensitivity of CA-125, particularly in early-stage disease. This study demonstrates that stage-specific shifts in peritoneal fluid cytokine and chemokine profiles - including changes in RANTES, IL-6, IL-12, IFN-γ and IL-1ra - drive measurable reprogramming of monocyte surface markers (MerTK, PD-1, PD-L1 and CCR2). These exploratory findings suggest that profiling peritoneal fluid cytokines together with monocyte phenotypic markers may, in principle, provide additional information relevant to disease staging and to the future identification of immune biomarkers; however, the present cohort is small and single-centre, and these observations require validation in larger, independent cohorts before any diagnostic or clinical application can be proposed. Delineating the stage-dependent transition from a pro-inflammatory to an immunosuppressive monocyte phenotype may also help to inform future research into immunomodulatory approaches in endometriosis.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"444-457"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated molecular, epigenetic, microbial and liquid biopsy biomarkers in colorectal cancer: implications for prognosis and precision therapy.","authors":"Suvarna Bhokare, Anita Wagh, Prashant Jadhav, Jaymala A Kumawat, Madhuri Khandgaonkar, Monika Madibone, Sonali Kalam","doi":"10.1080/1354750X.2026.2715050","DOIUrl":"10.1080/1354750X.2026.2715050","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a biologically diverse malignancy driven by a complex interplay of genetic mutations, epigenetic changes, tumour microenvironmental factors and host-microbial interactions. Foundational molecular events including APC-associated Wnt/β-catenin dysregulation, TP53 inactivation, KRAS and BRAF mutations and aberrant PI3K/AKT signalling due to PIK3CA and PTEN alterations, contribute significantly to disease initiation, progression and therapeutic resistance. Microsatellite instability (MSI), arising from defective DNA mismatch repair, defines a distinct subset of CRC with characteristic biological and therapeutic behaviour.</p><p><strong>Objective: </strong>This review critically evaluates established and emerging molecular biomarkers for CRC, highlighting their mechanistic significance and translational relevance in the evolving precision oncology landscape.</p><p><strong>Methods: </strong>A comprehensive narrative evaluation of the literature was conducted, focusing on pathways regulating oncogenes, regulatory microRNAs, gut microbiota dysbiosis and liquid biopsy approaches, particularly circulating tumour cells (CTCs) and circulating free DNA (cfDNA).</p><p><strong>Results: </strong>Core molecular alterations remain central to CRC pathogenesis and influence treatment responsiveness. Increasing evidence also supports the role of microRNA dysregulation and microbiome imbalance in modulating tumour progression and immune escape. Liquid biopsy technologies offer minimally invasive, real-time assessment of tumour development.</p><p><strong>Discussion: </strong>An integrated understanding of molecular drivers and emerging biomarker platforms is essential for advancing personalized CRC management.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"458-473"},"PeriodicalIF":2.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of serum neuron-specific enolase and S100 calcium-binding protein B for sepsis-associated encephalopathy: a systematic review and meta-analysis.","authors":"Zhang Li, Shuyu Zhong, Minjing Chen, Huan Chen","doi":"10.1080/1354750X.2026.2722073","DOIUrl":"10.1080/1354750X.2026.2722073","url":null,"abstract":"<p><strong>Background: </strong>Sepsis-associated encephalopathy (SAE) is a frequent and serious complication of sepsis, but reliable diagnostic biomarkers remain limited.</p><p><strong>Objective: </strong>To evaluate the diagnostic value of serum neuron-specific enolase (NSE) and S100 calcium-binding protein B (S100B) in distinguishing SAE from sepsis without SAE.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in PubMed, Embase and Web of Science between inception and January 2026. Studies comparing serum NSE and/or S100B levels between patients with SAE and patients with sepsis without SAE were included.</p><p><strong>Results: </strong>Eight studies involving 722 participants (323 with SAE and 399 with sepsis but no SAE) were included. Both NSE and S100B levels were significantly elevated in the SAE group compared with the sepsis without SAE group. The pooled standardized mean difference (SMD) for NSE was 0.82 (95% confidence interval [CI]: 0.66-0.97, P < 0.001, I² = 0.0%), indicating a large effect size with minimal heterogeneity. The pooled SMD for S100B was 0.94 (95% CI: 0.77-1.11, P < 0.001, I² = 0.0%), also demonstrating a large effect size.</p><p><strong>Conclusions: </strong>Serum NSE and S100B are significantly elevated in SAE and may help identify SAE early in patients with sepsis.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-9"},"PeriodicalIF":2.2,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the prognosis of patients with sepsis or septic shock based on plasma proenkephalin levels: a meta-analysis.","authors":"Shize Yang, Zuxin Zhou, Yongpeng Xie, Xuefeng Chen","doi":"10.1080/1354750X.2026.2697747","DOIUrl":"10.1080/1354750X.2026.2697747","url":null,"abstract":"<p><strong>Background: </strong>Sepsis can induce multiple organ dysfunction, and its complications, such as acute kidney injury, are associated with poor prognoses. Serum pro-enkephalin (pro-ENK), as a stable biomarker, holds potential value for risk stratification and prognostic assessment in sepsis. This review aimed to investigate its value through a meta-analysis.</p><p><strong>Methods: </strong>Databases (PubMed, Embase, Cochrane Library, Web of Science) were searched from database establishment to June 16, 2025, and literature was screened according to the established PICOS principles. Cohort studies that examined the relationship between pro-ENK levels and poor prognosis were included. Data were extracted, and study quality was appraised via the NOS (Newcastle-Ottawa Scale) assessment tool. This meta-analysis was conducted using Stata 15.0.</p><p><strong>Results: </strong>9 studies were included, with sample sizes ranging from 40 to 956 participants per study. In sepsis or shock patients, pro-ENK levels were higher in the AKI group (SMD: 1.82, 95% CI: 1.26-2.39); pro-ENK levels were higher in the non-survivor group among patients with sepsis or shock (SMD: 0.85, 95% CI: 0.60-1.10). AKI occurrence was associated with penKid levels (OR: 2.50, 95% CI: 2.02-2.99).</p><p><strong>Conclusion: </strong>Current evidence identifies pro-ENK as an auxiliary biomarker for sepsis-related AKI and its prognosis and provides valuable insights for further clinical research.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"406-414"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of murine C-terminal alpha-1-antitrypsin peptides in experimental sepsis and their comparison with human sepsis peptide biomarkers.","authors":"Franziska Scherr, Na Liu, Ikebana Konwar, Michael Kiehntopf, Adrian T Press, Friedemann R Börner","doi":"10.1080/1354750X.2026.2682420","DOIUrl":"10.1080/1354750X.2026.2682420","url":null,"abstract":"<p><strong>Context: </strong>The levels of alpha-1-antitrypsin (AAT) peptides could be used as prognostic biomarkers in critically ill patients, and peptide treatment has therapeutic efficiency in experimental sepsis. However, the regulation of AAT peptides in <i>M. musculus</i> is unknown, although they may be prerequisites for peptide-based therapies. This study aims to quantify murine AAT peptides and investigate their regulation during experimental sepsis.</p><p><strong>Methods: </strong>LC-MS/MS was used to quantify six AAT peptides from two murine AAT isoforms in plasma of septic mice.</p><p><strong>Results: </strong>Peptide mC36-2 is the most abundant and significantly regulated murine AAT peptide, with approximately 20-fold higher level than in critically ill patients. In contrast, the upregulation of peptide C42 in septic patients is absent in mice; thus, it may represent a specific marker of human disease. Nevertheless, the increase and kinetics of mC36 during experimental sepsis reflect our observations in patients.</p><p><strong>Conclusions: </strong>In summary, the conserved upregulation of AAT peptides reflects important pathophysiological mechanisms of severe infections; thus, peptide levels can be used as predictive biomarkers in experimental and clinical sepsis. Although species-specific differences exist and need to be considered, quantification of AAT peptides might help to characterize individual immune responses and build the foundation for novel therapeutic approaches in pre-clinical and clinical research.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"372-380"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial injury predicts mortality in elderly carbon monoxide poisoning: development and internal validation of a simple prognostic model.","authors":"Yong Ai Ling, Changsheng Ye, Xianwei Xiong, Huihua Huang, Weiguang Wang","doi":"10.1080/1354750X.2026.2681013","DOIUrl":"10.1080/1354750X.2026.2681013","url":null,"abstract":"<p><strong>Background: </strong>Myocardial injury is a serious complication of acute carbon monoxide poisoning in elderly patients, we aimed to evaluate its association with short-term mortality and to develop a simplified prognostic model with internal validation.</p><p><strong>Methods: </strong>This retrospective cohort study with 90-day follow-up included consecutive patients aged ≥ 65 years with acute carbon monoxide poisoning (2019-2024). Myocardial injury was defined as cardiac troponin I ≥ 0.05 ng/mL. Analyses included non-parametric tests, survival analysis, and ROC curves.</p><p><strong>Results: </strong>Among 258 patients, 70 had myocardial injury. These patients were older and had higher rates of renal dysfunction, hospitalization, and severe neurological impairment, along with worse biochemical profiles (lower pH and base excess, reduced PaCO₂, higher lactate). The 90-day mortality was significantly higher in the injury group (24.3% vs. 2.1%, <i>P</i> < 0.001). Myocardial injury was the strongest independent predictor of death (adjusted OR 8.16, 95% CI: 2.49-26.78), followed by neurological impairment and age. A model combining these three predictors showed good discriminative ability (AUC 0.879, 95% CI: 0.793-0.964).</p><p><strong>Conclusion: </strong>Myocardial injury is a key prognostic factor in elderly patients with carbon monoxide poisoning. A model incorporating myocardial injury, neurological status, and age may support risk stratification, pending external validation.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"363-371"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148026452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential time-sensitive biomarkers for the detection of acute mesenteric ischaemia: a systematic review of animal data.","authors":"Alastair Forbes, Kaspar F Bachmann, Karri Kase, Ele Kiisk, Kaja-Triin Laisaar, Vladislav Mihnovits, Marko Murruste, Merli Koitmäe, Joel Starkopf, Kadri Tamme, Anna-Liisa Voomets, Annika Reintam Blaser","doi":"10.1080/1354750X.2026.2681936","DOIUrl":"10.1080/1354750X.2026.2681936","url":null,"abstract":"<p><strong>Background: </strong>Acute mesenteric ischemia (AMI) is difficult to recognize and is often diagnosed late. Currently there are no established biomarkers that can assist in diagnosis or management. The present study was a systematic review of animal data, intended to identify potentially time-sensitive biomarkers for human AMI.</p><p><strong>Methods: </strong>A systematic literature search was conducted using PubMed, Web of Science, and Scopus up to 10/02/25. Studies assessing potential biomarkers of AMI in mammalian models, with timed responses from the onset of experimental ischemia were selected. Data quality was assessed using CAMARADES, and PRISMA guidelines were followed.</p><p><strong>Results: </strong>Searches identified 2175 publications from which 342 were selected for full text review, and 61 papers describing 103 experiments on 53 potential biomarkers were analyzed. The models were very heterogeneous and a meaningful meta-analysis was not possible for any biomarker. However, a pragmatic list of biomarkers of potential value in AMI that could warrant investigation in humans has been formulated. Those proposed are D-lactate, intestinal fatty acid-binding protein, ischaemia-modified albumin, and signal peptide-CUB-EGF domain-containing protein 1.</p><p><strong>Conclusions: </strong>No single biomarker has provided unambiguous evidence to promote its use in clinical practice, but several may deserve further evaluation in future human studies.</p><p><strong>Systematic review registration: </strong>PROSPERO CRD42023400888 (reference 400888).</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"381-396"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148293349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic model for colorectal cancer based on folic acid metabolism-related genes reveals immune landscape.","authors":"Lu Bai, Bo Liu","doi":"10.1080/1354750X.2026.2674791","DOIUrl":"10.1080/1354750X.2026.2674791","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a common malignant tumor with high invasiveness and mortality. Folic acid metabolism-related genes (FAMGs) are critical for DNA synthesis and repair, but their roles in CRC initiation and progression remain unclear.</p><p><strong>Methods: </strong>TCGA-COAD/READ datasets served as the training set, and GSE38832 as the validation set. CRC was molecularly subtyped via FAMGs expression. Prognostic genes were identified through LASSO regression, and univariate/multivariate Cox analyses, with a prognostic model constructed. Immune infiltration was assessed using CIBERSORT, ssGSEA, and ESTIMATE, and molecular mechanisms explored via GSEA, GO, and KEGG.</p><p><strong>Results: </strong>Three CRC subgroups with distinct biological functions and immune heterogeneity were identified. Six FAMGs highly expressed in CRC were used to build a prognostic model. High-risk groups showed lower immune cell infiltration, and upregulated DEGs between risk groups were enriched in the Wnt signaling pathway.</p><p><strong>Conclusion: </strong>This study explores FAMGs' roles in CRC's tumor microenvironment and molecular mechanisms, providing new insights for CRC's pathological research and treatment strategies.</p>","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"351-362"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147959691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}