生物传感器驱动的生物标志物分析:癌症诊断和治疗策略的开创性进展。

IF 2 4区 医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Gauri Nimhan, Mahavir Narwade, Kavita Gajbhiye
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引用次数: 0

摘要

通过早期癌症检测,成功治疗的可能性大大增加。遗憾的是,很多癌症直到发展到扩散到全身才被发现。这表明迫切需要临床诊断和更快更彻底的癌症检测技术。生物传感器有可能彻底改变我们检测和跟踪癌症的方式,为早期干预和更好的患者治疗提供有力的工具。通过将蛋白质、遗传物质或RNA等生物材料转化为电信号,这些设备被设计用于检测特定的生物分析物。这使得评估不同疗法在不同目标部位的效果成为可能。当诊断癌症时,这些分子标记——可以是蛋白质、多肽、异常高或低水平的基因标记或基因突变——经常被评估。它提供精确的癌细胞图像捕获,快速准确的癌细胞识别,血管生成和癌症扩散监测,以及评估化疗有效性的能力。本文将重点介绍用于多种癌症感知的生物传感器的发展,潜在癌症指标的当前变化,使用各种生物传感器进行癌症诊断以及相应的评估限制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biosensor driven biomarker analysis: pioneering advancements in cancer diagnosis and therapeutic strategies.

Introduction: Early cancer detection significantly improves treatment outcomes; however, many cancers remain undiagnosed until advanced stages. This highlights the urgent need for rapid and precise diagnostic tools. Biosensors offer a transformative approach in cancer diagnostics by enabling early detection and continuous monitoring through the identification of molecular biomarkers.

Methods: Biosensors function by converting biological elements-such as proteins, RNA, or genetic material-into measurable electrical signals. These devices are tailored to detect specific biomarkers, including proteins, peptides, gene mutations, or abnormal gene expression levels associated with various cancers.

Results: Biosensors provide high sensitivity and specificity in identifying cancer cells. They enable real-time monitoring of tumour progression, angiogenesis, and treatment responses. These tools also facilitate accurate imaging of cancer cells and help evaluate the effectiveness of targeted therapies such as chemotherapy.

Conclusion: The integration of biosensors into clinical practice could revolutionize cancer diagnostics by offering early, accurate, and minimally invasive detection methods. This review explores recent advances in biosensor development, the evolving landscape of cancer biomarkers, and the application of different biosensor technologies in cancer detection. Additionally, it addresses current limitations and challenges in clinical implementation, emphasizing the potential of biosensors to enhance patient outcomes through early intervention.

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来源期刊
Biomarkers
Biomarkers 医学-毒理学
CiteScore
5.00
自引率
3.80%
发文量
140
审稿时长
3 months
期刊介绍: The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.
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