Biomarkers最新文献_第3页

Evaluation of the protective effects of selenium against iron overload-induced toxicity in rats using a multiple-markers approach. 用多标记法评价硒对大鼠铁超载毒性的保护作用。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-03-01 Epub Date: 2026-02-09 DOI: 10.1080/1354750X.2025.2596015

Ateeqah Ghayth Alzwawy, Abdelhafidh Khazri, Ahmed Kouki, Manel Ben Ali, Mossadok Ben-Attia, Ezzeddine Mahmoudi, Mohsen Sakly, Badreddine Sellami

{"title":"Evaluation of the protective effects of selenium against iron overload-induced toxicity in rats using a multiple-markers approach.","authors":"Ateeqah Ghayth Alzwawy, Abdelhafidh Khazri, Ahmed Kouki, Manel Ben Ali, Mossadok Ben-Attia, Ezzeddine Mahmoudi, Mohsen Sakly, Badreddine Sellami","doi":"10.1080/1354750X.2025.2596015","DOIUrl":"10.1080/1354750X.2025.2596015","url":null,"abstract":"Background: Iron overload can promote the generation of reactive oxygen species (ROS), leading to oxidative stress and different human diseases. The trace element selenium has biological functions and can act as both an antioxidant and a prooxidant. This study aimed to evaluate the protective effects of selenium against iron overload-induced toxicity in rats. Adult Wistar rats were exposed to three increasing concentrations of iron (25, 50, and 100 mg/kg body weight [b.w.]), either alone or in combination with selenium (0.5 mg/kg b.w.).Methods: The biological interactions between these two compounds were investigated at the biochemical level in the liver, spleen, kidney, and pancreas.Results: Our results indicated that iron used alone induces oxidative stress. In all tissues studied and at all the administered doses, we observed changes in the levels of catalase (CAT), glutathione (GSH), glutathione-S-transferase (GST), malondialdehyde (MDA), and acetylcholinesterase (AChE). The responses were dose- and organ-dependent. Selenium administered at 0.5 mg/kg b.w. attenuate the adverse effects of the different iron dosages.Conclusion: These findings highlight the potential application of selenium in mitigating oxidative stress and organ toxicity associated with iron overload. Our research carries significant implications for the development of nutritional and therapeutic strategies aimed at managing disorders related to iron metabolism.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"67-79"},"PeriodicalIF":1.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and validation of gene markers for early detection and prognosis in colorectal cancer: a comprehensive RNA-seq based approach. 结直肠癌早期检测和预后基因标记的鉴定和验证：基于RNA-Seq的综合方法。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-26 DOI: 10.1080/1354750X.2026.2629484

Xiaolin Qian, Bin Qian, Shanshan Wang, Qiangsong Wu, Xiaoxue Li, Jing Zhu, Zhenmei Pu, Yi Hu, Deng Niu

{"title":"Identification and validation of gene markers for early detection and prognosis in colorectal cancer: a comprehensive RNA-seq based approach.","authors":"Xiaolin Qian, Bin Qian, Shanshan Wang, Qiangsong Wu, Xiaoxue Li, Jing Zhu, Zhenmei Pu, Yi Hu, Deng Niu","doi":"10.1080/1354750X.2026.2629484","DOIUrl":"10.1080/1354750X.2026.2629484","url":null,"abstract":"Background: Reliable molecular biomarkers are urgently needed for early diagnosis of colorectal cancer (CRC). This study aimed to identify and validate a robust diagnostic gene signature using integrated transcriptomic analysis.Methods: Eleven public gene expression datasets published between 2014 and 2024 were combined, including 329 CRC samples and 48 normal controls. Batch effects were corrected using the COMBAT algorithm. Differentially expressed genes (DEGs) were identified and subjected to Gene Ontology, KEGG, and REACTOME enrichment analyses. A protein-protein interaction network was constructed to screen hub genes. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis and a disease risk score (DRS), followed by external validation in independent cohorts.Results: A total of 1,101 DEGs were identified, including 544 upregulated and 557 downregulated genes. Functional enrichment analysis indicated that upregulated genes were mainly involved in extracellular matrix organization and inflammatory signaling, whereas downregulated genes were associated with transport and metal ion homeostasis. A ten-gene signature was established. The DRS demonstrated strong diagnostic performance in the pooled dataset (AUC = 0.96) and in external validation cohorts (AUC = 0.985). Stage-stratified analysis confirmed robust discrimination across all CRC stages, including early disease.Conclusions: This integrative analysis identified a stable ten-gene diagnostic signature with potential clinical utility for CRC detection.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-10"},"PeriodicalIF":1.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of circulating tumor DNA mutation panels to predict early recurrence and survival outcomes in early-stage breast cancer: a systematic review and meta-analysis. 循环肿瘤DNA突变面板预测早期乳腺癌早期复发和生存结果的预后价值：系统回顾和荟萃分析。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-26 DOI: 10.1080/1354750X.2026.2633567

Mohsin Ali, Muhammad Imran, Jawad Hussain, Muhammad Zakria, Asma Ehsan Abbasi, Aneesa Sultan

{"title":"Prognostic value of circulating tumor DNA mutation panels to predict early recurrence and survival outcomes in early-stage breast cancer: a systematic review and meta-analysis.","authors":"Mohsin Ali, Muhammad Imran, Jawad Hussain, Muhammad Zakria, Asma Ehsan Abbasi, Aneesa Sultan","doi":"10.1080/1354750X.2026.2633567","DOIUrl":"10.1080/1354750X.2026.2633567","url":null,"abstract":"Background: Early-stage breast cancer (BC) shows heterogeneous recurrence risk. Circulating tumor DNA (ctDNA) is promising non-invasive biomarker for minimal residual disease and recurrence prediction, though prognostic performance varies by assay and context.Methods: Eligible studies on ctDNA-based recurrence and survival were identified through comprehensive searches, quality assessed, and analyzed using random-effects meta-analysis to estimate pooled hazard ratios for clinical outcomes. Heterogeneity (I2, τ2, Cochran's Q), subgroup (detection method or assay type), and sensitivity analyses were performed to examine the consistency and robustness of results.Results: For recurrence-free survival endpoints, the pooled HR was 3.28 [95% CI: 1.81; 5.93], indicating a high risk of recurrence-related events among ctDNA-positive patients, though substantial heterogeneity was observed (I2 = 93.3%). Pooled effect sized for overall survival (8.92 HR [0.45; 177.87], I2 = 74.7%) and recurrence/relapse (5.21 [0.98; 27.69], I2 = 84.4%) indicating substantial heterogeneity. Subgroup analysis showed lower heterogeneity with digital PCR and personalized ctDNA assays, and sensitivity testing confirmed result stability (2.47 [1.89; 3.23], I2 = 0%).Conclusion: CtDNA positivity, detected through mutation-based assays strongly associated with increased risk for early recurrence in early-stage BC. Digital PCR and personalized assays demonstrated superior consistency; however, prospective trials are needed to establish its clinical utility.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-19"},"PeriodicalIF":1.9,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146257198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease and Dementia in MCI: A Systematic Review and Robust Bayesian Meta-Analysis. 血浆NfL和GFAP对MCI患者转化为阿尔茨海默病和痴呆的预后价值：一项系统评价和稳健的贝叶斯荟萃分析

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-17 DOI: 10.1080/1354750X.2026.2633568

Çağrı Özkurt, Pelin Kelicen-Uğur

{"title":"Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease and Dementia in MCI: A Systematic Review and Robust Bayesian Meta-Analysis.","authors":"Çağrı Özkurt, Pelin Kelicen-Uğur","doi":"10.1080/1354750X.2026.2633568","DOIUrl":"https://doi.org/10.1080/1354750X.2026.2633568","url":null,"abstract":"Background: Accessible biomarkers to predict conversion to Alzheimer's disease and other dementias in Mild Cognitive Impairment (MCI) are urgently needed. Plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) are leading candidates, but their utility remains debated.Objective: We systematically reviewed the prognostic value of plasma NfL and GFAP in MCI using Robust Bayesian Meta-Analysis (RoBMA) to formally model and adjust for publication bias.Methods: We searched major databases through September 2025 for longitudinal cohort studies (Protocol: OSF 10.17605/OSF.IO/974ZD). RoBMA synthesized hazard ratios while adjusting for small-study effects. Risk of bias (QUIPS) and certainty (GRADE) were assessed.Results: We included 63 studies. For plasma GFAP (k = 3), Bayesian meta-analysis found moderate evidence for an association with dementia conversion (HR: 1.58, 95% CrI [1.00, 2.24]; Inclusion BF = 9.03). Conversely, for plasma NfL, the prognostic signal was driven by decisive publication bias (Bias BF > 4,000,000). After bias adjustment, the effect of NfL on conversion was null (HR: 1.00; Inclusion BF = 0.011). Evidence certainty was Low to Very Low.Conclusions: The prognostic value of plasma NfL for dementia conversion appears to be an artifact of publication bias. Plasma GFAP shows a promising but preliminary signal requiring high-quality validation.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-19"},"PeriodicalIF":1.9,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

White blood cell count as a prognostic and mechanistic mediator in acute diquat poisoning: a retrospective cohort study enabling risk stratification for resource-limited settings. 白细胞计数作为急性地奎特中毒的预后和机制中介：在资源有限的情况下进行风险分层的回顾性队列研究。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.1080/1354750X.2026.2614751

Ye Zhang, Xian Chen, Min Zhao, Xianglong Cai, Haike Du, Xiaoming Jiang, Yingmin Ma, Guoqiang Li, Haihong Li

{"title":"White blood cell count as a prognostic and mechanistic mediator in acute diquat poisoning: a retrospective cohort study enabling risk stratification for resource-limited settings.","authors":"Ye Zhang, Xian Chen, Min Zhao, Xianglong Cai, Haike Du, Xiaoming Jiang, Yingmin Ma, Guoqiang Li, Haihong Li","doi":"10.1080/1354750X.2026.2614751","DOIUrl":"10.1080/1354750X.2026.2614751","url":null,"abstract":"Background: Diquat poisoning is associated with high mortality, and accurate prognostication remains challenging in resource-limited settings. This retrospective cohort study evaluated white blood cell count (WBC) as both a prognostic biomarker and mechanistic mediator in acute diquat poisoning.Methods: This retrospective cohort included 134 patients with acute diquat poisoning (2016-2025). WBC was analysed continuously and categorically (median and ROC-derived cut-offs). Multivariable regression, subgroup, and mediation analyses were performed.Results: The high-WBC group (≥ 17.11 × 109/L) had significantly higher mortality (64.3% vs. 7.8%, p < 0.001). After adjustment, patients with WBC ≥ 17.235 × 109/L had a 3.43-fold higher mortality risk (95% CI: 1.37-8.60). Each 1 × 109/L WBC increase predicted a 6% mortality risk rise (adjusted OR = 1.06, 95% CI: 1.01-1.12). WBC mediated 15.5% (p = 0.02) of plasma diquat's total lethal effect. ROC analysis showed WBC had an AUC of 0.724 (95% CI: 63.5%-81.2%) at the optimal cut-off of 17.235 × 109/L, comparable to plasma diquat concentration's AUC of 0.817 (95% CI: 74.4%-88.9%).Conclusions: WBC serves as both a continuous predictor and triage tool at 17.235 × 109/L, providing a practical risk-stratification framework for settings lacking toxicological testing.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"51-59"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Creatine kinase and McMahon score as predictors for acute kidney injury, renal replacement therapy, and mortality associated with poisoning-induced rhabdomyolysis. 肌酸激酶和McMahon评分作为急性肾损伤、肾脏替代治疗和与中毒引起的横纹肌溶解相关的死亡率的预测因子。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-01 Epub Date: 2025-12-28 DOI: 10.1080/1354750X.2025.2596911

Nada A Kamel, Mohy El Masry, Sarah S Mohammed

{"title":"Creatine kinase and McMahon score as predictors for acute kidney injury, renal replacement therapy, and mortality associated with poisoning-induced rhabdomyolysis.","authors":"Nada A Kamel, Mohy El Masry, Sarah S Mohammed","doi":"10.1080/1354750X.2025.2596911","DOIUrl":"10.1080/1354750X.2025.2596911","url":null,"abstract":"Background: Poisoned patients presenting with rhabdomyolysis are at a higher risk of Acute Kidney Injury (AKI), and consequently, an increased risk of Renal Replacement Therapy (RRT) and mortality. We aimed to compare the prognostic significance of creatine kinase (CK) with the McMahon score for AKI, RRT, and mortality in acutely poisoned patients with rhabdomyolysis.Methods: This prospective study included 50 patients admitted to the Intensive Care Unit (ICU) with poisoning-induced rhabdomyolysis between the beginning of January 2023 and the end of September 2023.Results: The incidence of rhabdomyolysis was 6.6% in a total of 949 acutely poisoned patients. AKI and mortality rates were 34% and 6% respectively. Antipsychotics were the leading cause of rhabdomyolysis (52%), while substance abuse was the most common cause in the AKI group (58.9% of the AKI group). The initial CK and McMahon scores could predict AKI at the optimum cut-off values of CK > 982 and McMahon score > 6, with an AUC of 0.712 and 0.807, respectively.Conclusion: The variables independently associated with AKI development were age > 33 years, McMahon score ≥ 6, and WBC count > 18 (10³/µL). The McMahon score is superior to CK in predicting the need for hemodialysis and mortality.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-12"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145653379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNF186 as a prognostic biomarker and its correlation with immune cell infiltration in clear cell renal cell carcinoma. RNF186作为透明细胞肾细胞癌的预后生物标志物及其与免疫细胞浸润的相关性

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-01 Epub Date: 2026-01-12 DOI: 10.1080/1354750X.2025.2608599

Peng Wu, Xiaolu Zhang, Jia Zou, Wenya An, Wenchuan Fan, Ting'an Chen, Zaijun Zhang, Dongmei Chen

{"title":"RNF186 as a prognostic biomarker and its correlation with immune cell infiltration in clear cell renal cell carcinoma.","authors":"Peng Wu, Xiaolu Zhang, Jia Zou, Wenya An, Wenchuan Fan, Ting'an Chen, Zaijun Zhang, Dongmei Chen","doi":"10.1080/1354750X.2025.2608599","DOIUrl":"10.1080/1354750X.2025.2608599","url":null,"abstract":"Background: Ring finger 186 (RNF186) is implicated in cancer development, but its role in clear cell renal cell carcinoma (ccRCC) remains unclear.Methods: RNF186 expression was analyzed using TCGA, GEO, and clinical samples. Its diagnostic and prognostic significance, protein interactions, functional pathways, immune microenvironment associations, and drug sensitivity were evaluated. Single-cell analysis and molecular docking were also performed.Results: RNF186 was significantly upregulated in ccRCC and negatively correlated with advanced tumor stage. High RNF186 expression indicated better prognosis and showed diagnostic value. It participated in key biological processes and immune modulation, with predominant enrichment in malignant cells. Elevated RNF186 expression was linked to enhanced sensitivity to targeted therapies like sunitinib, which exhibited a favorable predicted binding energy.Conclusion: RNF186 serves as a potential biomarker for prognosis prediction, tumor microenvironment characterization, and personalized targeted therapy in ccRCC.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"13-28"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cigarette smoke-induced apoptosis via regulation of the miR-122/PTEN/AKT axis in NR8383 cells and rat model of COPD. 香烟烟雾通过调控miR-122/PTEN/AKT轴在NR8383细胞和COPD大鼠模型中诱导凋亡

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-01 Epub Date: 2026-01-14 DOI: 10.1080/1354750X.2025.2612554

Yang Jiang, Xiaosheng Jin

{"title":"Cigarette smoke-induced apoptosis via regulation of the miR-122/PTEN/AKT axis in NR8383 cells and rat model of COPD.","authors":"Yang Jiang, Xiaosheng Jin","doi":"10.1080/1354750X.2025.2612554","DOIUrl":"10.1080/1354750X.2025.2612554","url":null,"abstract":"Background: PM2.5-induced COPD lacks effective therapies due to unclear pathogenesis. This study explores the role of miR-122 and PTEN in PM2.5-related COPD.Methods: Using a combination of in vitro and in vivo assays, including cigarette smoke extract (CSE)-induced NR8383 cells and a rat smoke model, combined with MTT, qPCR, flow cytometry, WB, HE staining, Masson staining, HIC, and TUNEL assays, we investigated the role of microRNA-122 (miR-122) and phosphatase and tensin homolog (PTEN) in the molecular mechanisms underlying PM2.5-induced COPD.Results: Our findings demonstrate that CSE-induced the down-regulated expression of miR-122 leads to the activation of PTEN, which in turn regulates the AKT signaling pathway in NR8383 cells. This modulation results in decreased expression of B-cell lymphoma 2 (BCL2), promoting cell apoptosis. Besides, the result from a rat model of COPD exposed to smoke also confirms this molecular axis which ultimately exacerbating COPD. Specifically, compared with the control, there is significant pulmonary structural damage in model rats exposed to PM2.5, including enlarged alveolar intervals, increased alveolar cavity size, pulmonary fibrosis, and evidence of alveolar destruction with concomitant parabronchial inflammation.Conclusion: Our research reveals novel insights of PM2.5-induced COPD and proposes the miR-122/PTEN pathway as a potential therapeutic target.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"40-50"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145896027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of c-MYC in gastric cancer prognosis: a Kaplan-Meier-derived patient data meta-analysis. c-MYC在胃癌预后中的作用：kaplan - meier衍生患者数据荟萃分析

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-01 Epub Date: 2026-01-22 DOI: 10.1080/1354750X.2025.2611007

Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Larissa Emi Tanimoto, Andressa Girelli Cardoso, Mario Hiroyuki Hirata, Rommel Mario Rodríguez Burbano

{"title":"The role of c-MYC in gastric cancer prognosis: a Kaplan-Meier-derived patient data meta-analysis.","authors":"Francisco Cezar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Larissa Emi Tanimoto, Andressa Girelli Cardoso, Mario Hiroyuki Hirata, Rommel Mario Rodríguez Burbano","doi":"10.1080/1354750X.2025.2611007","DOIUrl":"10.1080/1354750X.2025.2611007","url":null,"abstract":"Background: Gastric cancer (GC) is the fifth leading cause of cancer-related death worldwide, with a median overall survival of approximately 12 months. The proto-oncogene c-MYC is among the most frequently activated oncogenes, implicated in roughly 20% of all malignancies.Methods: PubMed, Embase, and Web of Science were systematically searched for studies evaluating the association between c-MYC expression and (1) disease-specific survival (DSS) and (2) overall survival (OS). Hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a fixed-effects model. A two-sided p ≤ 0.05 was considered statistically significant.Results: Across 15 studies encompassing 2,372 gastric cancer patients (802 c-MYC-positive; 410 male), male gender was strongly associated with c-MYC positivity (OR 8.83; 95% CI 5.74-13.56; p < 0.00001), as were deeper invasion (T3-T4 vs T1-T2: OR 0.38; 95% CI 0.24-0.60; p < 0.00001) and advanced stage (III-IV vs I-II: OR 2.69; 95% CI 1.71-4.23; p < 0.00001). Patients with c-MYC-negative tumors exhibited a markedly higher DSS compared to those with c-MYC-positive tumors (HR 3.73; 95% CI, 2.22-6.26; p < 0.0001).Conclusion: Our findings identify c-MYC as a significant prognostic biomarker for disease-specific survival in gastric cancer.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"29-39"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aquaporin-9 and endometriomas: pathophysiological insights from a case-control study. 水通道蛋白-9和子宫内膜瘤：一项病例对照研究的病理生理学见解。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-02-01 Epub Date: 2026-01-21 DOI: 10.1080/1354750X.2026.2615799

Emine Kirsan Ileri, Anil Erturk, Nazlı Yenigul, Gulten Ozgen, Burcu Dincgez, Nergis Kender Erturk

{"title":"Aquaporin-9 and endometriomas: pathophysiological insights from a case-control study.","authors":"Emine Kirsan Ileri, Anil Erturk, Nazlı Yenigul, Gulten Ozgen, Burcu Dincgez, Nergis Kender Erturk","doi":"10.1080/1354750X.2026.2615799","DOIUrl":"10.1080/1354750X.2026.2615799","url":null,"abstract":"Introduction: Endometriosis is an estrogen-dependent condition characterized by ectopic implantation of endometrial tissue; molecular mechanisms underlying lesion persistence remain incompletely understood. Aquaporins (AQPs), transmembrane water channels involved in migration and proliferation, have been implicated in endometriosis pathophysiology, although data on AQP9 are limited.Methods: This prospective case-control study evaluated AQP9 concentrations in serum, peritoneal fluid, and cervicovaginal secretions of women with endometriomas compared with healthy surgical controls. Twenty-seven women with unilateral endometrioma and 30 undergoing bilateral tubal ligation were included. AQP9 levels were measured using ELISA, and analyses included correlation, receiver operating characteristic (ROC) curve analysis, and logistic regression adjusted for age, body mass index (BMI), gravida and parity.Results: Peritoneal fluid AQP9 concentrations were significantly higher in women with endometriomas than in controls (275 [58-669] vs. 171.5 [6.6-507] ng/mL, p = 0.023), whereas serum and cervicovaginal AQP9 levels showed no differences. ROC analysis demonstrated high sensitivity (92.6%) but limited specificity (43.3%). Logistic regression confirmed that peritoneal AQP9 > 128 ng/mL was independently associated with endometrioma (OR 4.40, 95%CI 1.66-29.28, p = 0.025). Serum AQP9 was inversely correlated with endometrioma size (p = 0.008).Conclusion: Peritoneal AQP9 elevation reflects alterations in the local peritoneal microenvironment, supporting its potential role in the pathophysiology of endometriosis.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"60-65"},"PeriodicalIF":1.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0