Biomarkers最新文献_第4页

Circulating KIM-1 as a prognostic biomarker and predictor of systemic treatment response in renal cell carcinoma: a systematic review and meta-analysis. 循环KIM-1作为肾细胞癌系统治疗反应的预后生物标志物和预测因子：一项系统综述和荟萃分析

IF 2.2 4区医学

Biomarkers Pub Date : 2026-06-01 Epub Date: 2026-05-04 DOI: 10.1080/1354750X.2026.2664868

Toni Febriyanto, Yosua Yerico Hutajulu, Noka Yogahutama, Wynne Wijaya, Ahmad Zulfan Hendri

{"title":"Circulating KIM-1 as a prognostic biomarker and predictor of systemic treatment response in renal cell carcinoma: a systematic review and meta-analysis.","authors":"Toni Febriyanto, Yosua Yerico Hutajulu, Noka Yogahutama, Wynne Wijaya, Ahmad Zulfan Hendri","doi":"10.1080/1354750X.2026.2664868","DOIUrl":"10.1080/1354750X.2026.2664868","url":null,"abstract":"Background: Renal cell carcinoma (RCC) exhibits heterogeneity and variable responses to systemic therapy. Kidney injury molecule-1 (KIM-1) has emerged as a biomarker in RCC, but its prognostic and treatment-response value has not been quantified. This review and meta-analysis evaluated whether baseline KIM-1 predicts survival in RCC and whether post-treatment changes in KIM-1 reflect systemic therapy response.Methods: A search of PubMed, Embase and the Cochrane Library was conducted through November 2025. Eligible studies measured serum or plasma KIM-1 in RCC and reported survival or treatment-response outcomes. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled.Results: Eight studies including 3002 patients met inclusion criteria. High baseline KIM-1 was associated with worse survival (HR 1.44, 95% CI 1.27-1.62) and disease-free survival (HR 1.72, 95% CI 1.45-2.04), with no heterogeneity (I2 = 0%). Declines in KIM-1 after systemic therapy were associated with improved progression-free survival (HR 0.55, 95% CI 0.32-0.94; I2 = 71.5%) and improved disease-free survival (HR 0.66, 95% CI 0.50-0.87).Conclusions: Elevated baseline circulating KIM-1 indicates higher RCC recurrence and mortality risk, while post-treatment declines may reflect therapeutic response. Preliminary evidence suggests KIM-1 prognostic and predictive value for RCC biomarker, though further validation is required due to lower certainty.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"339-349"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147810537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Depression and oxidative stress in pregnancy: a cross-sectional study of trimester-specific changes. 妊娠期抑郁和氧化应激：妊娠期特异性变化的横断面研究。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-06-01 Epub Date: 2026-06-02 DOI: 10.1080/1354750X.2026.2682423

Sule Sirin Berk, Kemal Hansu, Ergul Belge Kurutas, Oğuz Akman, Sema Baykara, Gürkan Cikim

{"title":"Depression and oxidative stress in pregnancy: a cross-sectional study of trimester-specific changes.","authors":"Sule Sirin Berk, Kemal Hansu, Ergul Belge Kurutas, Oğuz Akman, Sema Baykara, Gürkan Cikim","doi":"10.1080/1354750X.2026.2682423","DOIUrl":"10.1080/1354750X.2026.2682423","url":null,"abstract":"Background: The scientific community continues to debate the relationship between pregnancy depression and oxidative stress marker changes. The study tracked oxidative stress marker development in pregnant women with depression from the beginning to the end of their pregnancy.Method: Sixty-two pregnant women were included in the cross-sectional study. According to the Beck Depression Scale, the pregnant women were divided into depressed (n = 23, score ≥ 10) and control (n = 39, score < 10) groups. Catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) levels were measured in blood samples.Results: The Beck score was 17.83 ± 6.86 in pregnant women with depression and 4.51 ± 2.54 in the control group (p < 0.001). There was no difference between the groups in baseline CAT, SOD, and MDA levels (p > 0.05). MDA levels in pregnant women with depression increased significantly in the third trimester compared to the second trimester (from 4.02 ± 0.49 to 6.19 ± 0.52 nmol/mL, p < 0.01). A positive correlation was found between body mass index and MDA (r = 0.300, p < 0.05).Conclusion: The progression of pregnancy leads to increased lipid peroxidation in depressed women but depression itself does not impact oxidative stress markers. The extent of oxidative damage increases when mothers become obese during pregnancy.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"288-294"},"PeriodicalIF":2.2,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148100980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Stromal-Centered Single-Cell Landscape Identifies POSTN⁺ Fibroblasts as a High-Risk Stromal Subset in Hepatocellular Carcinoma. 以基质为中心的单细胞景观确定后n +成纤维细胞是肝细胞癌的高风险基质亚群。

IF 1.9 4区医学

Biomarkers Pub Date : 2026-05-22 DOI: 10.1080/1354750X.2026.2678877

Yalin Chen, Tingting Liu, Shichao Zhang, Dong Wu

{"title":"A Stromal-Centered Single-Cell Landscape Identifies POSTN+ Fibroblasts as a High-Risk Stromal Subset in Hepatocellular Carcinoma.","authors":"Yalin Chen, Tingting Liu, Shichao Zhang, Dong Wu","doi":"10.1080/1354750X.2026.2678877","DOIUrl":"https://doi.org/10.1080/1354750X.2026.2678877","url":null,"abstract":"Hepatocellular carcinoma (HCC) develops within a complex microenvironment in which cancer-associated fibroblasts (CAFs) are abundant, yet their heterogeneity and functional roles remain incompletely understood. Here, we integrated multi-site single-cell RNA sequencing of Normal liver, primary Tumor, portal vein tumor thrombus (PVTT), and metastatic Lymph node samples with bulk transcriptomic analysis, cell-cell communication inference, and functional assays to define stromal programs associated with HCC progression. We identified four transcriptionally distinct CAF subsets: SGCA+ mCAFs, POSTN+ mCAFs, TDO2+ CAFs, and CXCL14+ iCAFs, each showing site-specific distribution and distinct prognostic relevance. Among them, POSTN+ mCAFs were enriched for extracellular matrix organization and integrin signaling, and their signatures were consistently associated with poor overall survival across independent cohorts. Ligand-receptor analysis identified POSTN+ mCAFs as highly connected stromal hubs communicating with malignant and myeloid cells through ECM-integrin, collagen-SDC4, and chemokine pathways. Consistently, tumor-derived POSTN-high fibroblasts promoted hepatoma cell proliferation, migration, and invasion in vitro. Together, these findings identify POSTN+ mCAFs as a transcriptionally distinct and functionally pro-tumorigenic stromal subset in HCC, supporting POSTN-centered stromal programs as candidate markers of aggressive tumor microenvironments and a basis for future mechanistic investigation.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"1-17"},"PeriodicalIF":1.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of apigenin on immune responses and inflammatory biomarkers in sepsis: a comprehensive systematic review. 芹菜素对败血症免疫反应和炎症生物标志物的影响：一项全面的系统综述。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-05-01 Epub Date: 2026-04-02 DOI: 10.1080/1354750X.2026.2641063

Ghaleb Oriquat, Waleed K Abdulsahib, Sanan Thaer Abdal-Wahab, H Malathi, Biswaranjan Mohanty, J Bethanney Janney, Vimal Arora, Aashna Sinha, Zafar Aminov

{"title":"The effects of apigenin on immune responses and inflammatory biomarkers in sepsis: a comprehensive systematic review.","authors":"Ghaleb Oriquat, Waleed K Abdulsahib, Sanan Thaer Abdal-Wahab, H Malathi, Biswaranjan Mohanty, J Bethanney Janney, Vimal Arora, Aashna Sinha, Zafar Aminov","doi":"10.1080/1354750X.2026.2641063","DOIUrl":"10.1080/1354750X.2026.2641063","url":null,"abstract":"Background: Apigenin, a flavonoid predominantly found in citrus fruits, particularly grapefruit, has attracted significant attention in ethnopharmacology for its diverse therapeutic properties.Method: This systematic review focuses on the potential therapeutic impact of Apigenin on sepsis complications. Google Scholar, Scopus, Web of Science, PubMed and Embase databases were searched for relevant keywords up to August 2025.Results: A total of 421 articles were screened in the databases. Finally, only 30 studies remain. Evidence from in vivo and in vitro studies indicates that Apigenin modulates key signalling pathways, such as Rho-associated coiled-coil containing protein kinase (ROCK)/Ras homolog family member A (RhoA)/Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB), Peroxisome Proliferator-activated receptor gamma (PPARγ)/microRNA-21 (miR-21) and Kelch-like eCH-associated protein 1 (KEAP1)/Nuclear factor erythroid 2-related factor 2 (Nrf2), to alleviate sepsis-induced damage in organs such as the lungs, intestines, heart and kidneys. Additionally, Apigenin promotes macrophage polarization towards the M2 macrophage phenotype (M2) phenotype and reduces proinflammatory cytokines (Interleukin-6 (IL-6), Tumour necrosis factor alpha (TNF-α), Interleukin-1 beta (IL-1β).Conclusion: Despite its promising effects, further clinical trials are needed to confirm its efficacy and safety in septic patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"234-246"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short- and long-term metabolic exposure data as predicators of coronary microvascular dysfunction in a positron emission tomography myocardial perfusion imaging (PET-MPI) cohort with near concurrent angiography. 短期和长期代谢暴露数据作为冠脉微血管功能障碍的预测因子在正电子发射断层扫描心肌灌注成像（PET-MPI）队列与近并发血管造影。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-05-01 Epub Date: 2026-03-23 DOI: 10.1080/1354750X.2026.2639408

Joseph Van Galen, Sarah J Ratcliffe, Jamieson Bourque

{"title":"Short- and long-term metabolic exposure data as predicators of coronary microvascular dysfunction in a positron emission tomography myocardial perfusion imaging (PET-MPI) cohort with near concurrent angiography.","authors":"Joseph Van Galen, Sarah J Ratcliffe, Jamieson Bourque","doi":"10.1080/1354750X.2026.2639408","DOIUrl":"10.1080/1354750X.2026.2639408","url":null,"abstract":"Background: Coronary microvascular disease (CMD) is defined by impaired myocardial stress flow reactivity and is associated with worse cardiovascular outcomes. Studying CMD is complicated by the overlap of its risk factors and patient-important cardiovascular sequelae with those of epicardial atherosclerotic disease. Published studies have not yet used longitudinal data to investigate the time dependencies of dynamic processes like obesity in their effects on microvascular health.Methods and results: In a mixed-sex cohort of 85 patients for whom epicardial obstruction was angiographically excluded, a multivariate model was developed to measure strengths of association between repeated-measurement metabolic data and microvascular stress flow reactivity as assessed by position emission tomography myocardial perfusion imaging (PET-MPI). Body mass index (BMI) and the diagnosis of insulin-dependent diabetes mellitus (DM) were associated with CMD on clinically meaningful scales when analysing all metabolic data collected in the year prior to stress PET-MPI (β [95% CI]: -0.019 [-0.033, -0.0051], p = 0.0072; -0.33 [-0.65, -0.0026], p = 0.048). Parallel modelling using single-time-point metabolomics data generated comparable results, suggesting that simplified assessments may be used as valid surrogates for repeated-measurement data in this setting.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"229-233"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Removal: Expression levels of miR-146a-5p, miR-155-5p, and the pro-inflammatory cytokine IL-8 in pregnant women with anti-phospholipid syndrome. miR-146a-5p、miR-155-5p及促炎细胞因子IL-8在抗磷脂综合征孕妇中的表达水平

IF 2.2 4区医学

Biomarkers Pub Date : 2026-05-01 Epub Date: 2026-04-09 DOI: 10.1080/1354750X.2026.2636140

Mai M Shaker

引用次数: 0

Identification and validation of AFAP1L1 as an immune-related prognostic biomarker in clear cell renal cell carcinoma. AFAP1L1在透明细胞肾细胞癌中作为免疫相关预后生物标志物的鉴定和验证

IF 2.2 4区医学

Biomarkers Pub Date : 2026-05-01 Epub Date: 2026-03-23 DOI: 10.1080/1354750X.2026.2630072

Qiaoping Yan, Binbin Zhang, Yunhan Yu, Yuewen Si, Yuan Zhang, Zijian Ye, Qingming Zhang, Wenling Wu, Xuegang Luo, Biao Xie

{"title":"Identification and validation of AFAP1L1 as an immune-related prognostic biomarker in clear cell renal cell carcinoma.","authors":"Qiaoping Yan, Binbin Zhang, Yunhan Yu, Yuewen Si, Yuan Zhang, Zijian Ye, Qingming Zhang, Wenling Wu, Xuegang Luo, Biao Xie","doi":"10.1080/1354750X.2026.2630072","DOIUrl":"10.1080/1354750X.2026.2630072","url":null,"abstract":"Background: Clear cell renal cell carcinoma (ccRCC) accounts for over 75% of all renal cancer and contributes significantly to cancer-associated mortality. This study aims to identify a new ccRCC biomarker.Methods: Univariate and multivariate Cox regression models were performed for prognostic analysis. Differentially expressed genes (DEGs) were identified based on high and low expression AFAP1L1 groups. Functional enrichment analysis was conducted on the DEGs. Immunoassays were conducted on immune checkpoints, immune cells, and other components. Single-cell expression of AFAP1L1, along with associated pseudo-temporal trajectory analyses, was evaluated. The Connectivity Map was employed to identify potentially small-molecules. AFAP1L1 mRNA expression was measured via quantitative real-time PCR (qRT-PCR) experiment.Results: AFAP1L1 was significantly upregulated in training cohort and qRT-PCR, and lower expression level was correlated with shorter overall survival, which was also confirmed in E-MTAB-1980 and CPTAC validation cohorts. The upregulated DEGs were primarily involved in signaling pathways, nephron development, and transporter activity. AFAP1L1 was positively related with neutrophils and macrophages. AFAP1L1 exhibited a relatively higher expression level in endothelial cells at the single-cell level. Five potential therapeutic agents targeting ccRCC were identified.Conclusions: AFAP1L1 may impact the ccRCC development and progression, acting as an immune-related prognostic marker for ccRCC.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"186-201"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic significance of the combination of serum CCL20 and Oncostatin M for early-stage endometrial cancer. 血清CCL20与癌抑素M联合检测对早期子宫内膜癌的诊断意义。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-05-01 Epub Date: 2026-04-16 DOI: 10.1080/1354750X.2026.2628040

Yuhua Wei, Xiaojuan Lv, Huan Tang, Yeliang Sun, Li Chen, Liping Han, Xiaohong Zhu

{"title":"Diagnostic significance of the combination of serum CCL20 and Oncostatin M for early-stage endometrial cancer.","authors":"Yuhua Wei, Xiaojuan Lv, Huan Tang, Yeliang Sun, Li Chen, Liping Han, Xiaohong Zhu","doi":"10.1080/1354750X.2026.2628040","DOIUrl":"10.1080/1354750X.2026.2628040","url":null,"abstract":"Aim: Our study aimed to preliminarily investigate the role of combined detection of serum CCL20 and Oncostatin M in the diagnosis of early-stage endometrial cancer (EC).Methods: A retrospective study was conducted on 109 patients with early-stage EC. Serum CCL20 and Oncostatin M levels were determined, and their correlations with sex hormone indicators (TTE and DHEAS) in EC patients were analyzed. Influencing factors for EC and the early diagnostic value of each indicator were analyzed.Results: Serum CCL20 and Oncostatin M were high in EC patients and positively correlated with TTE and DHEAS. Elevated CCL20 and Oncostatin M were independent risk factors for EC. The diagnostic efficacy of serum CCL20 + Oncostatin M in combination was better than that of serum CCL20, Oncostatin M, CA125, and HE4 alone. The diagnostic test combining serum CCL20 and Oncostatin M in endometrioid carcinoma demonstrated an AUC of 0.855, with a sensitivity of 68.00% and a specificity of 92.86%, comparable to that in the whole early-stage endometrial carcinoma group (AUC = 0.867).Conclusion: Combined detection of serum CCL20 and Oncostatin M may offer a promising adjunctive approach for the diagnosis of early-stage EC, with their levels correlated to sex hormones and clinicopathological characteristics.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"164-175"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146130961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and validation of gene markers for early detection and prognosis in colorectal cancer: a comprehensive RNA-seq based approach. 结直肠癌早期检测和预后基因标记的鉴定和验证：基于RNA-Seq的综合方法。

IF 2.2 4区医学

Biomarkers Pub Date : 2026-05-01 Epub Date: 2026-02-26 DOI: 10.1080/1354750X.2026.2629484

Xiaolin Qian, Bin Qian, Shanshan Wang, Qiangsong Wu, Xiaoxue Li, Jing Zhu, Zhenmei Pu, Yi Hu, Deng Niu

{"title":"Identification and validation of gene markers for early detection and prognosis in colorectal cancer: a comprehensive RNA-seq based approach.","authors":"Xiaolin Qian, Bin Qian, Shanshan Wang, Qiangsong Wu, Xiaoxue Li, Jing Zhu, Zhenmei Pu, Yi Hu, Deng Niu","doi":"10.1080/1354750X.2026.2629484","DOIUrl":"10.1080/1354750X.2026.2629484","url":null,"abstract":"Background: Reliable molecular biomarkers are urgently needed for early diagnosis of colorectal cancer (CRC). This study aimed to identify and validate a robust diagnostic gene signature using integrated transcriptomic analysis.Methods: Eleven public gene expression datasets published between 2014 and 2024 were combined, including 329 CRC samples and 48 normal controls. Batch effects were corrected using the COMBAT algorithm. Differentially expressed genes (DEGs) were identified and subjected to Gene Ontology, KEGG, and REACTOME enrichment analyses. A protein-protein interaction network was constructed to screen hub genes. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis and a disease risk score (DRS), followed by external validation in independent cohorts.Results: A total of 1,101 DEGs were identified, including 544 upregulated and 557 downregulated genes. Functional enrichment analysis indicated that upregulated genes were mainly involved in extracellular matrix organization and inflammatory signaling, whereas downregulated genes were associated with transport and metal ion homeostasis. A ten-gene signature was established. The DRS demonstrated strong diagnostic performance in the pooled dataset (AUC = 0.96) and in external validation cohorts (AUC = 0.985). Stage-stratified analysis confirmed robust discrimination across all CRC stages, including early disease.Conclusions: This integrative analysis identified a stable ten-gene diagnostic signature with potential clinical utility for CRC detection.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"176-185"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral ischemia-reperfusion induced cardiac injury in rats: involvement of oxidative stress, apoptosis, TLR4, nF-κB and HSP70: the rescue effect of losartan. 脑缺血再灌注大鼠心脏损伤：氧化应激、细胞凋亡、TLR4、NF-κB、HSP70的参与：氯沙坦的拯救作用

IF 2.2 4区医学

Biomarkers Pub Date : 2026-05-01 Epub Date: 2026-03-04 DOI: 10.1080/1354750X.2026.2634890

Yasaman Shakouri, Hamid Soraya, Roya Naderi

{"title":"Cerebral ischemia-reperfusion induced cardiac injury in rats: involvement of oxidative stress, apoptosis, TLR4, nF-κB and HSP70: the rescue effect of losartan.","authors":"Yasaman Shakouri, Hamid Soraya, Roya Naderi","doi":"10.1080/1354750X.2026.2634890","DOIUrl":"10.1080/1354750X.2026.2634890","url":null,"abstract":"Background: This study aimed to explore the effect of cerebral ischemia reperfusion and losartan on oxidative stress, inflammation, apoptosis and its molecular mediators in the rat heart.Methods: The groups were as follows (n = 6): 1) sham 2) ischemia-reperfusion (IR, 20 min ischemia, 24 hours reperfusion), 3) ischemia-reperfusion +losartan (IR+LOS, 3 mg/kg, ip, 1 hour before ischemia).Results: In IR animals' heart Malondialdehyde (MDA) and Total oxidative status (TOS) increased while Total antioxidant capacity (TAC) and Superoxide dismutase (SOD) concentration decreased compared to the sham rats. Cerebral IR increased apoptotic index evidenced by increased cytochrome c and c-caspase3/p-caspase3 ratio, as well as elevated Toll-like receptor4 (TLR4), Nuclear factor kappa B (NF-κB) and Heat Shock Protein70 (HSP70) in the heart tissue. These alterations could be mitigated by losartan. TLR4 is positively correlated with NF-κB, r = 0.61; MDA, r = 0.64; TOS, r = 0.59 (p < 0.01), cytochrome c, r = 0.83; c-caspase3/p-caspase3, r = 0.72 (p < 0.001) and negatively correlated with SOD, r = -0.73 and TAC, r = -0.83 (p < 0.001).Conclusion: In all, cerebral IR increased cardiac oxidative stress and apoptosis which positively correlates with TLR4/NF-κB pathway. Additionally, losartan can be considered as a potential target for preventing cardiac injury following stroke.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"221-228"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0