Evaluating Cell-Free Circulatory Mitochondrial DNA as a Comprehensive Biomarker for Stress: Meta-Analysis of Psychological and Physiological Stress Responses.

IF 2 4区医学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biomarkers Pub Date : 2025-06-21 DOI:10.1080/1354750X.2025.2522888

Arpan Chattopadhyay, Harshita Tak, Hemanth Naick B

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引用次数: 0

Abstract

Background: Mitochondria play a crucial role in cellular processes such as energy metabolism, reactive oxygen species (ROS) generation, and apoptosis. Mitochondrial dysfunction induced by stress has been implicated in various health conditions. Circulating cell-free mitochondrial DNA (CFC-MT-DNA) has emerged as a potential biomarker reflecting mitochondrial damage under stress.

Methods: To evaluate the association between CFC-MT-DNA levels and human stress through a systematic review and meta-analysis of case-control studies. A comprehensive literature search was conducted across PubMed, Web of Science, and ScienceDirect databases up to September 2023. Eight eligible studies assessing CFC-MT-DNA levels in stressed versus control individuals were included. Data were analysed using RevMan 5.4 software.

Results: The meta-analysis revealed significantly elevated CFC-MT-DNA levels in individuals experiencing stress (P = 0.03), particularly in psychological stress-related conditions such as bipolar disorder and major depressive disorder. However, no significant increase was observed in physiological stress conditions, including diabetes and sports training. High heterogeneity (I² = 96%) was observed across studies.

Conclusion: CFC-MT-DNA shows promise as a non-invasive biomarker for psychological stress. Further longitudinal and mechanistic studies are needed to clarify its role across different types of stress and its potential clinical utility.

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评估无细胞循环线粒体DNA作为应激的综合生物标志物：心理和生理应激反应的荟萃分析。

背景：线粒体在能量代谢、活性氧（ROS）生成和细胞凋亡等细胞过程中起着至关重要的作用。由压力引起的线粒体功能障碍与各种健康状况有关。循环无细胞线粒体DNA （CFC-MT-DNA）已成为反映线粒体在应激下损伤的潜在生物标志物。方法：通过对病例对照研究的系统回顾和荟萃分析，评估CFC-MT-DNA水平与人类应激之间的关系。到2023年9月，在PubMed、Web of Science和ScienceDirect数据库中进行了全面的文献检索。8项符合条件的研究评估了应激个体与对照个体的CFC-MT-DNA水平。采用RevMan 5.4软件对数据进行分析。结果：荟萃分析显示，在经历压力的个体中，CFC-MT-DNA水平显著升高（P = 0.03），特别是在心理压力相关的情况下，如双相情感障碍和重度抑郁症。然而，在生理应激条件下，包括糖尿病和运动训练，没有观察到显著的增加。各研究均观察到高异质性（I2 = 96%）。结论：CFC-MT-DNA有望成为一种无创的心理应激生物标志物。需要进一步的纵向和机制研究来阐明其在不同类型应激中的作用及其潜在的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomarkers 医学-毒理学

CiteScore

5.00

自引率

3.80%

发文量

140

审稿时长

3 months

期刊介绍： The journal Biomarkers brings together all aspects of the rapidly growing field of biomarker research, encompassing their various uses and applications in one essential source. Biomarkers provides a vital forum for the exchange of ideas and concepts in all areas of biomarker research. High quality papers in four main areas are accepted and manuscripts describing novel biomarkers and their subsequent validation are especially encouraged: • Biomarkers of disease • Biomarkers of exposure • Biomarkers of response • Biomarkers of susceptibility Manuscripts can describe biomarkers measured in humans or other animals in vivo or in vitro. Biomarkers will consider publishing negative data from studies of biomarkers of susceptibility in human populations.