Biomarkers最新文献_第7页

Impact of switching from cigarette smoking to tobacco heating system use on biomarkers of potential harm in a randomized trial. 在一项随机试验中，从吸烟转向使用烟草加热系统对潜在危害生物标志物的影响。

IF 2 4区医学

Biomarkers Pub Date : 2024-07-01 Epub Date: 2024-06-07 DOI: 10.1080/1354750X.2024.2358318

S Michael Ansari, Paul S Hession, Morgane David, Nicolas Blanc, Guillaume de La Bourdonnaye, Sandrine Pouly, Christelle Haziza

{"title":"Impact of switching from cigarette smoking to tobacco heating system use on biomarkers of potential harm in a randomized trial.","authors":"S Michael Ansari, Paul S Hession, Morgane David, Nicolas Blanc, Guillaume de La Bourdonnaye, Sandrine Pouly, Christelle Haziza","doi":"10.1080/1354750X.2024.2358318","DOIUrl":"10.1080/1354750X.2024.2358318","url":null,"abstract":"Background: Smoking cessation reduces the risk of developing smoking-related diseases. Although smoking prevalence has declined, many continue smoking cigarettes. Switching completely to smoke-free alternatives like the Tobacco Heating System (THS) 2.2-a heated tobacco product for which there is evidence demonstrating significantly reduced formation and exposure to harmful chemicals compared to cigarettes-has the potential to reduce the harm caused by continuing to smoke cigarettes.Methods: We conducted a 6-month clinical study (NCT02396381) with a 6-month extension (NCT02649556), initially randomizing 984 adult smokers to continue smoking or switch to THS (non-mentholated), of which 672 continued into the extension study. Endpoints were evaluated at baseline and at 3, 6, and 12 months. We longitudinally assessed biomarkers of potential harm (BoPHs) known to be reversible upon smoking cessation as indicators of pathways involved in the pathogenesis of cardiovascular or respiratory diseases and carcinogenicity. The need to cough and safety profile were also assessed. Impact on eight key BoPHs was used as a proxy to evaluate harm reduction potential.Results: At 12 months, comparison of BoPH levels between the predominant THS use and cigarette smoking groups showed a positive effect in favor of switching, partially or in full, to THS.Conclusion: These results provide additional evidence of the harm reduction potential of THS for smokers who would otherwise continue smoking, but they need to be verified in long-term confirmatory studies.Clinical trial registration: Clinicaltrials.gov Identifier: NCT0264955. Date of registration: January 7, 2016 https://clinicaltrials.gov/ct2/show/NCT02649556.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"298-314"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic potential of protein serum biomarkers for distinguishing small and non-small cell lung cancer in patients with suspicious lung lesions. 蛋白血清生物标志物在区分肺部可疑病变患者的小细胞肺癌和非小细胞肺癌方面的诊断潜力。

IF 2 4区医学

Biomarkers Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.1080/1354750X.2024.2360038

Luz Fernanda Sua, Silvia J Serrano-Gomez, Marcela Nuñez, María A Amezquita-Dussan, Liliana Fernández-Trujillo

{"title":"Diagnostic potential of protein serum biomarkers for distinguishing small and non-small cell lung cancer in patients with suspicious lung lesions.","authors":"Luz Fernanda Sua, Silvia J Serrano-Gomez, Marcela Nuñez, María A Amezquita-Dussan, Liliana Fernández-Trujillo","doi":"10.1080/1354750X.2024.2360038","DOIUrl":"10.1080/1354750X.2024.2360038","url":null,"abstract":"Background: Biomarkers play a role in identifying, managing, and predicting cancer outcomes. In lung cancer, they are used at various time points. Doubts remain regarding their accuracy for differential diagnosis and histological subtyping. A diagnostic test study was conducted. It included malignant lesions and controls with benign lesions. Before lung biopsy, all patients had the following biomarkers measured in serum (Pro-GRP,NSE,CYFRA21-1,SCC-Ag,CEA).Methods: The predictive capacity of serum biomarkers was evaluated to discriminate between lung cancer and benign pathology. The accuracy was also assessed for distinguishing between SCLC and NSCLC and explored their ability to perform histological subtyping.Results: 93 patients were included, 60 with lung cancer, 33 with benign pathology. Pro-GRP and NSE were elevated in SCLC compared with NSCLC or nonmalignant disease. The most accurate for differentiating between malignant and benign pathology were CEA and CYFRA21-1. Pro-GRP had a poor predictive capacity for distinguishing NSCLC from SCLC. However, combined with CEA and CYFRA21-1, performance improved. For SCLC, the diagnostic capacity of Pro-GRP increased by combining with biomarkers, such as NSE/CYFRA21-1.Conclusions: Biomarkers lacked the sensitivity and specificity for independent differential diagnosis or histological subtyping. However, the observed patterns in biomarker levels associated with specific histological subtypes suggest potential utility in a multi-biomarker approach or in conjunction with other diagnostic tools. This insight could guide future research to improve diagnostic accuracy and personalized treatment strategies in lung cancer.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"315-323"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of cardiac biomarkers with long-term cardiovascular events in a community cohort. 社区队列中的心脏生物标志物与长期心血管事件的关系。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-06-01 Epub Date: 2024-04-26 DOI: 10.1080/1354750X.2024.2335245

Robert A Churchill, Benjamin R Gochanour, Christopher G Scott, Vlad C Vasile, Richard J Rodeheffer, Jeffrey W Meeusen, Allan S Jaffe

{"title":"Association of cardiac biomarkers with long-term cardiovascular events in a community cohort.","authors":"Robert A Churchill, Benjamin R Gochanour, Christopher G Scott, Vlad C Vasile, Richard J Rodeheffer, Jeffrey W Meeusen, Allan S Jaffe","doi":"10.1080/1354750X.2024.2335245","DOIUrl":"10.1080/1354750X.2024.2335245","url":null,"abstract":"Materials and methods: The study assessed major adverse cardiac events (MACE) (myocardial infarction, coronary artery bypass graft, percutaneous intervention, stroke, and death. Cox proportional hazards models assessed apolipoprotein AI (ApoA1), apolipoprotein B (ApoB), ceramide score, cystatin C, galectin-3 (Gal3), LDL-C, Non-HDL-C, total cholesterol (TC), N-terminal B-type natriuretic peptide (NT proBNP), high-sensitivity cardiac troponin (HscTnI) and soluble interleukin 1 receptor-like 1. In adjusted models, Ceramide score was defined by from N-palmitoyl-sphingosine [Cer(16:0)], N-stearoyl-sphingosine [Cer(18:0)], N-nervonoyl-sphingosine [Cer(24:1)] and N-lignoceroyl-sphingosine [Cer(24:0)]. Multi-biomarker models were compared with C-statistics and Integrated Discrimination Index (IDI).Results: A total of 1131 patients were included. Adjusted NT proBNP per 1 SD resulted in a 31% increased risk of MACE/death (HR = 1.31) and a 31% increased risk for stroke/MI (HR = 1.31). Adjusted Ceramide per 1 SD showed a 13% increased risk of MACE/death (HR = 1.13) and a 29% increased risk for stroke/MI (HR = 1.29). These markers added to clinical factors for both MACE/death (p = 0.003) and stroke/MI (p = 0.034). HscTnI was not a predictor of outcomes when added to the models.Discussion: Ceramide score and NT proBNP improve the prediction of MACE and stroke/MI in a community primary prevention cohort.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"161-170"},"PeriodicalIF":2.6,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-tissue FRMD6 expression predicts better outcomes among colorectal cancer patients. 组织中 FRMD6 的高表达预示着结直肠癌患者会有更好的预后。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-05-01 Epub Date: 2024-02-29 DOI: 10.1080/1354750X.2024.2321916

Arthur von Koskull, Jaana Hagström, Caj Haglund, Tuomas Kaprio, Camilla Böckelman

{"title":"High-tissue FRMD6 expression predicts better outcomes among colorectal cancer patients.","authors":"Arthur von Koskull, Jaana Hagström, Caj Haglund, Tuomas Kaprio, Camilla Böckelman","doi":"10.1080/1354750X.2024.2321916","DOIUrl":"10.1080/1354750X.2024.2321916","url":null,"abstract":"Introduction: Colorectal cancer (CRC) is the second most common cause of cancer-related deaths. The hippo pathway works as a regulator of organ growth and is often a target for mutations in cancer. Ferm domain containing protein 6 (FRMD6) is an activator of the hippo pathway. This study aimed to explore the role of FRMD6 in CRC and to determine how well it works as a prognostic factor among CRC patients.Methods: The tumor expression of FRMD6 was evaluated using immunohistochemistry in 538 colorectal patients operated on at Helsinki University Hospital. We assessed FRMD6 expression with clinicopathological parameters and the impact of FRMD6 expression on survival.Results: Patients with a high FRMD6 expression exhibited a better prognosis (univariable hazard ratio [HR] 0.58, 95% confidence interval [CI] 0.41-0.81), with a 5-year disease-specific survival (DSS) of 66.3%. By contrast, patients with a low FRMD6 expression had a 5-year DSS of 52.8%. A high FRMD6 expression level served as an independent predictor for better survival in the Cox multivariable survival analysis (HR 0.53, 95% CI 0.33-0.86).Discussion: To our knowledge, this is the first study to show that a high FRMD6 expression is an independent marker for a better prognosis in CRC and could help determine the prognosis for CRC patients.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"127-133"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139929899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ile105Val polymorphism in the GSTP1 gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis. GSTP1 基因中的 Ile105Val 多态性与急性髓性白血病的易感性相关：最新的系统综述和荟萃分析。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.1080/1354750X.2024.2326538

Raphael Enrique Tiongco, Neil David Cayanan, Miljun Catacata, Michael John Dominguez

{"title":"Ile105Val polymorphism in the GSTP1 gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis.","authors":"Raphael Enrique Tiongco, Neil David Cayanan, Miljun Catacata, Michael John Dominguez","doi":"10.1080/1354750X.2024.2326538","DOIUrl":"10.1080/1354750X.2024.2326538","url":null,"abstract":"Background and objective: Several genetic variations are associated with acute myeloid leukemia (AML) susceptibility, including the GSTP1 Ile105Val polymorphism. Even with the existing meta-analysis conducted on the topic, no consensus has been reached since none of the studies available performed in-depth data analysis. Hence, we performed an updated systematic review and meta-analysis in this paper to obtain more precise estimates.Materials and methods: We searched various databases and calculated the odds ratio (OR) and 95% confidence interval (CI) to examine whether the GSTP1 Ile105Val polymorphism is associated with AML susceptibility. Further statistical analysis was also done to obtain more accurate and reliable findings.Results: A total of 15 studies are included in the systematic review, but only 9 were included in the meta-analysis due to the studies deviating from the Hardy-Weinberg equilibrium. The analysis showed significantly increased susceptibility to AML in the allelic, co-dominant, and recessive models. Furthermore, subgroup analysis noted increased AML susceptibility in the non-Asian population. Comparing the proportions of the genotypes and alleles showed a significantly higher proportion of the Val/Val genotype and Val allele in the non-Asian cohort.Conclusion: The GSTP1 Ile105Val polymorphism is significantly associated with AML susceptibility, especially among non-Asians. Further investigation should be performed to strengthen the current results.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"134-142"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140012132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Date (Phoenix dactylifera L. Mill) fruit enhances sexual performance via modulation of oxido-inflammatory mediators and purinergic signaling in hypertensive male rats. 椰枣（Phoenix dactylifera L. Mill）果实通过调节高血压雄性大鼠体内的氧化-炎症介质和嘌呤能信号转导来提高性能力。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-05-01 Epub Date: 2024-03-21 DOI: 10.1080/1354750X.2024.2331502

Adeniyi A Adebayo, Ayokunle O Ademosun, Ganiyu Oboh

{"title":"Date (Phoenix dactylifera L. Mill) fruit enhances sexual performance via modulation of oxido-inflammatory mediators and purinergic signaling in hypertensive male rats.","authors":"Adeniyi A Adebayo, Ayokunle O Ademosun, Ganiyu Oboh","doi":"10.1080/1354750X.2024.2331502","DOIUrl":"10.1080/1354750X.2024.2331502","url":null,"abstract":"Introduction: The present study aimed at investigating the effect of dietary supplementation of Phoenix dactylifera, an important component of aphrodisiac supplements, on sexual performance, oxido-inflammatory mediators and purinergic signaling system in hypertensive rats.Material and methods: Hypertension was induced via oral administration of 40 mg/kg L-NAME. Thereafter, the sexual performance of the experimental animals was determined and the hypertensive rats with impaired sexual activities were placed on P. dactylifera-supplemented diet for 21 days, and the effects of the treatment on the overall sexual behavior, antioxidant status, oxido-inflammatory biomarkers, and enzyme activity of the purinergic system were assessed.Results: Hypertensive rats showed a significant (p < 0.05) decrease in sexual performance, elevated level of oxido-inflammatory mediators, and altered purinergic enzymes activity when compared with the control. However, sub-chronic feeding with P. dactylifera-supplemented diet improved sexual performance, significantly lowered oxido-inflammatory biomarkers, and enhanced the activity of purinergic enzymes in hypertensive rats.Conclusion: Findings presented in this study suggest that dietary inclusion of P. dactylifera could be useful in managing erectile dysfunction (ED) commonly observed in subjects with hypertension. Findings highlighted in this study thus provide the scientific basis supporting the folkloric use of P. dactylifera as a key ingredient in aphrodisiac supplements.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"143-153"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140130663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the diagnostic potential of IL-1β, IL-10, and IL-36γ in gingival crevicular fluid in patients with different periodontal conditions. 研究不同牙周病患者牙龈蠕动液中 IL-1β、IL-10 和 IL-36γ 的诊断潜力

IF 2.6 4区医学

Biomarkers Pub Date : 2024-05-01 Epub Date: 2024-03-11 DOI: 10.1080/1354750X.2024.2318256

Mihtikar Gürsel, Tuba Bayat, Niyazi Dündar, Ayşegül Yabacı Tak, Burcu Karaduman

{"title":"Investigating the diagnostic potential of IL-1β, IL-10, and IL-36γ in gingival crevicular fluid in patients with different periodontal conditions.","authors":"Mihtikar Gürsel, Tuba Bayat, Niyazi Dündar, Ayşegül Yabacı Tak, Burcu Karaduman","doi":"10.1080/1354750X.2024.2318256","DOIUrl":"10.1080/1354750X.2024.2318256","url":null,"abstract":"Background: The study aimed to analyze cytokine levels, including interleukin (IL)-1β, IL-10, and IL-36γ, to investigate the link between pro- and anti-inflammatory responses in periodontal conditions and assess their potential as diagnostic biomarkers for distinguishing between different types of periodontal conditions.Methods: 80 systemically healthy non-smokers (25 periodontally healthy, 25 with gingivitis, 30 with periodontitis) were included. Clinical periodontal parameters were recorded, and gingival crevicular fluid (GCF) samples were obtained. Receiver operating characteristic (ROC) curve analysis was applied to determine the diagnostic value of cytokines.Results: IL-36γ had the highest sensitivity for diagnosing periodontitis, although its specificity for identifying those without periodontitis was relatively low. The combination of IL-1β and IL-36γ was the most effective in differentiating periodontitis from periodontal health. IL-10 was found to be an acceptable discriminator for distinguishing gingivitis from healthy conditions. However, its sensitivity and specificity for identifying gingivitis were lower. The combination of the three cytokines showed the highest ability to distinguish between periodontitis and gingivitis.Conclusion: The levels of IL-1β, IL-10, and IL-36γ in GCF may provide insights into periodontal health and disease status. Further studies are needed to validate these results and explore the potential of these cytokines in periodontal disease management.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"118-126"},"PeriodicalIF":2.6,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BCAT1, IKZF1 and SEPT9: methylated DNA biomarkers for detection of pan-gastrointestinal adenocarcinomas BCAT1、IKZF1 和 SEPT9：用于检测泛胃肠道腺癌的甲基化 DNA 生物标记物

IF 2.6 4区医学

Biomarkers Pub Date : 2024-04-22 DOI: 10.1080/1354750x.2024.2340663

Geraldine Laven-Law, Ganessan Kichenadasse, Graeme P. Young, Erin L. Symonds, Jean M. Winter

引用次数: 0

A prognostic risk model based on lactate metabolism and transport-related lncRNAs for gastric adenocarcinoma 基于乳酸代谢和转运相关 lncRNA 的胃腺癌预后风险模型

IF 2.6 4区医学

Biomarkers Pub Date : 2024-04-17 DOI: 10.1080/1354750x.2024.2341411

Zhenyuan Qian, Fang Wu, Guoqing Feng, Wenfa Lin, Xufan Cai, Jianzhang Wu, Kun Ke, Zaiyuan Ye, Guoxi Xu

引用次数: 0

Biomarker-guided drug development provides value for patients, payers and drug developers: lessons learned from 25 years in the biomarker industry 生物标志物指导下的药物开发为患者、支付方和药物开发商带来价值：生物标志物行业 25 年的经验教训

IF 2.6 4区医学

Biomarkers Pub Date : 2024-04-12 DOI: 10.1080/1354750x.2024.2342016

Alexander L. Reese-Petersen, Helene W. Breisnes, Daniel Gabor, Sarah R. Rønnow, Bruna Manoel, Mayuur Bajaj, Claus S. von Arenstorff, Elijah Aighobahi, Rune Vestermark, Morten A. Karsdal

引用次数: 0