Biomarkers最新文献_第6页

Biomarker-guided drug development provides value for patients, payers and drug developers: lessons learned from 25 years in the biomarker industry 生物标志物指导下的药物开发为患者、支付方和药物开发商带来价值：生物标志物行业 25 年的经验教训

IF 2.6 4区医学

Biomarkers Pub Date : 2024-04-12 DOI: 10.1080/1354750x.2024.2342016

Alexander L. Reese-Petersen, Helene W. Breisnes, Daniel Gabor, Sarah R. Rønnow, Bruna Manoel, Mayuur Bajaj, Claus S. von Arenstorff, Elijah Aighobahi, Rune Vestermark, Morten A. Karsdal

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The role of Matrix Metalloproteinase-2 and Galectin-3 as predictive biomarkers for all-cause mortality in patients undergoing transfemoral transcatheter aortic valve implantation 基质金属蛋白酶-2和Galectin-3作为经口经导管主动脉瓣植入术患者全因死亡率预测生物标志物的作用

IF 2.6 4区医学

Biomarkers Pub Date : 2024-04-08 DOI: 10.1080/1354750x.2024.2341409

Kerstin Piayda, Julian Tim Heilemann, Stanislav Keranov, Luisa Schulz, Mani Arsalan, Christoph Liebetrau, Won-Keun Kim, Felix J. Hofmann, Pascal Bauer, Sandra Voss, Christian Troidl, Samuel T. Sossalla, Christian W. Hamm, Holger M. Nef, Oliver Dörr

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The Association Between Inflammatory Biomarkers and Low Back Disorder: A Systematic Review and Meta-analysis 炎症生物标志物与腰背痛之间的关系：系统回顾与元分析

IF 2.6 4区医学

Biomarkers Pub Date : 2024-04-05 DOI: 10.1080/1354750x.2024.2339285

Stone Sima, Xiaolong Chen, Ashish D. Diwan

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Upregulation of ESPL1 is associated with poor prognostic outcomes in endometrial cancer ESPL1的上调与子宫内膜癌的不良预后有关

IF 2.6 4区医学

Biomarkers Pub Date : 2024-04-03 DOI: 10.1080/1354750x.2024.2339288

Yuzhong Yang, Ying Sheng, Jinhua Zheng, Aiyu Ma, Shaohua Chen, Jing Lin, Xiaozhen Yang, Yuanna Liang, Yan Zhang, Xiang Zheng

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Exocyclic DNA adducts and oxidative stress parameters: useful tools for biomonitoring exposure to aldehydes in smokers 外环 DNA 加合物和氧化应激参数：对吸烟者接触醛类物质情况进行生物监测的有用工具

IF 2.6 4区医学

Biomarkers Pub Date : 2024-03-20 DOI: 10.1080/1354750x.2024.2333361

Héléna Alamil, Marie-Lise Colsoul, Natacha Heutte, Marie Van Der Schueren, Laurence Galanti, Mathilde Lechevrel

引用次数: 0

Interpreting quantitative RNA expression prognostic and predictive results generated from synchronous rather than solitary breast cancers 解读同步乳腺癌而非单发乳腺癌的定量 RNA 表达预后和预测结果

IF 2.6 4区医学

Biomarkers Pub Date : 2024-03-04 DOI: 10.1080/1354750x.2024.2324871

Steven Sorscher, Priya Gor

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Investigation of exosomal tetraspanin profile in sepsis patients as a promising diagnostic biomarker. 脓毒症患者外泌体Tetraspanin谱作为一种有前途的诊断生物标记物的研究

IF 2.6 4区医学

Biomarkers Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.1080/1354750X.2024.2319296

Roushka Bhagwan Valjee, Irene Mackraj, Roshila Moodley, Usri H Ibrahim

{"title":"Investigation of exosomal tetraspanin profile in sepsis patients as a promising diagnostic biomarker.","authors":"Roushka Bhagwan Valjee, Irene Mackraj, Roshila Moodley, Usri H Ibrahim","doi":"10.1080/1354750X.2024.2319296","DOIUrl":"10.1080/1354750X.2024.2319296","url":null,"abstract":"Introduction: Sepsis, a leading cause of mortality globally, has a complex and multifaceted pathophysiology which still requires elucidation. Therefore, this study aimed to analyze and quantify the number of exosomes in sepsis patients from a South African cohort using the ExoView (NanoView Biosciences, Boston, MA) platform.Methods: Blood samples were collected from black South African patients attending the local Intensive Care Unit (ICU) hospital. Exosomes were isolated and characterize via TEM and CD63 ELISA kits. ExoView was used to determine particle count, particle size distribution and colocalization of different tetraspanin markers.Results: Exosomal levels in sepsis patients were significantly higher compared to the control group (p < 0.05). Sepsis exosomes showed a homogenous size distribution ranging from 55 to 70 nm. Tetraspanin colocalization analysis revealed that sepsis exosomes have significantly higher CD63/CD9, CD63/CD81 and CD63/CD9/CD81 colocalization percentages than the control group.Conclusion: This unique tetraspanin colocalization pattern of sepsis exosomes could serve as a potential sepsis biomarker. Further investigations are required to identify sepsis exosomal cargo signatures for further understanding of sepsis pathophysiology in order to develop effective diagnostics and treatments.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"78-89"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139728853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating tRNA-derived fragments are decreased in patients with rheumatoid arthritis and increased in patients with psoriatic arthritis. 类风湿性关节炎患者体内循环 tRNA 衍生片段减少，而银屑病关节炎患者体内循环 tRNA 衍生片段增加。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.1080/1354750X.2024.2319297

Marina Dunaeva, Jan Blom, Rogier Thurlings, Margot van Weijsten, Fons A J van de Loo, Ger J M Pruijn

{"title":"Circulating tRNA-derived fragments are decreased in patients with rheumatoid arthritis and increased in patients with psoriatic arthritis.","authors":"Marina Dunaeva, Jan Blom, Rogier Thurlings, Margot van Weijsten, Fons A J van de Loo, Ger J M Pruijn","doi":"10.1080/1354750X.2024.2319297","DOIUrl":"10.1080/1354750X.2024.2319297","url":null,"abstract":"Introduction: tRNA-derived fragments (tRFs) play an important role in immune responses. To clarify the role of tRFs in autoimmunity we studied circulating tRF-levels in patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), and in a murine model for arthritis.Material and methods: Circulating tRF-levels were quantified by miR-Q RT-qPCR. tRNA processing and modification enzyme expression was analysed by RT-qPCR and public transcriptomics data.Results: Significant reduction (up to 3-fold on average) of tRF-levels derived from tRNA-Gly-GCC,CCC, tRNA-Glu-CTC and tRNA-Val-CAC,AAC was observed in RA patients, whereas tRNA-Glu-CTC and tRNA-Val-CAC,AAC tRFs were found at significantly higher levels (up to 3-fold on average) in PsA patients, compared to healthy controls. Also in arthritic IL1Ra-KO mice reduced levels of tRNA-Glu-CTC fragments were seen. The expression of NSUN2, a methyltransferase catalysing tRNA methylation, was increased in RA-peripheral blood mononuclear cells (PBMCs) compared to PsA, but this is not consistently supported by public transcriptomics data.Discussion: The observed changes of specific tRF-levels may be involved in the immune responses in RA and PsA and may be applicable as new biomarkers.Conclusion: Circulating tRF-levels are decreased in RA and increased in PsA and this may, at least in part, be mediated by methylation changes.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"90-99"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma. 蛋白激酶 C delta 可提高肝细胞癌的诊断性能。

IF 2.6 4区医学

Biomarkers Pub Date : 2024-03-01 Epub Date: 2024-02-15 DOI: 10.1080/1354750X.2024.2312990

Chika Nakagawa, Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Kuniko Katagiri, Naoko Tago, Hiroshi Kamioka, Kaoru Ueda, Koichiro Haruki, Kenei Furukawa, Masanori Nakano, Yuichi Torisu, Toru Ikegami, Kiyotsugu Yoshida, Masayuki Saruta

{"title":"Protein kinase C delta enhances the diagnostic performance of hepatocellular carcinoma.","authors":"Chika Nakagawa, Tsunekazu Oikawa, Kohji Yamada, Akihito Tsubota, Chisato Saeki, Kuniko Katagiri, Naoko Tago, Hiroshi Kamioka, Kaoru Ueda, Koichiro Haruki, Kenei Furukawa, Masanori Nakano, Yuichi Torisu, Toru Ikegami, Kiyotsugu Yoshida, Masayuki Saruta","doi":"10.1080/1354750X.2024.2312990","DOIUrl":"10.1080/1354750X.2024.2312990","url":null,"abstract":"Background: The conventional markers for hepatocellular carcinoma (HCC), α-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), have several limitations; both have low sensitivity in patients with early-stage HCC; low sensitivity for AFP with HCC after eliminating hepatitis C virus (HCV); low specificity for DCP in patients with non-viral HCC, which is increasing worldwide; low specificity for AFP in patients with liver injury; and low specificity for DCP in patients treated with warfarin. To overcome these issues, the identification of novel biomarkers is an unmet need.Objective: This study aimed to assess the usefulness of serum protein kinase C delta (PKCδ) for detecting these HCCs.Methods: PKCδ levels were measured using a sandwich enzyme-linked immunosorbent assay in 363 chronic liver disease (CLD) patients with and without HCC.Results: In both viral and non-viral CLD, PKCδ can detect HCCs with high sensitivity and specificity, particularly in the very early stages. Notably, the value and sensitivity of PKCδ were not modified by HCV elimination status. Liver injury and warfarin administration, which are known to cause false-positive results for conventional markers, did not modify PKCδ levels.Conclusions: PKCδ is an enhanced biomarker for the diagnosis of HCC that compensates for the drawbacks of conventional markers.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"55-67"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum free light chains among twin siblings: is the kappa/lambda ratio genetically determined? 双胞胎兄弟姐妹的血清游离轻链：kappa/lambda 比率是由基因决定的吗？

IF 2.6 4区医学

Biomarkers Pub Date : 2024-03-01 Epub Date: 2024-02-27 DOI: 10.1080/1354750X.2024.2319308

Alan H B Wu, Chia-Ching Wang

{"title":"Serum free light chains among twin siblings: is the kappa/lambda ratio genetically determined?","authors":"Alan H B Wu, Chia-Ching Wang","doi":"10.1080/1354750X.2024.2319308","DOIUrl":"10.1080/1354750X.2024.2319308","url":null,"abstract":"Background: Serum kappa, lambda, the K/λ light chain concentrations are used for screening, diagnosis, and monitoring of patients with multiple myeloma and other plasma cell disorders. Biological variation studies conducted on healthy subjects showed that free light chains have a low within and high between-individual variation. We determined if this variation were genetically linked.Methods: We obtained a single serum sample from 16 pairs of identical twins, 8 neonate twins, and 19 presumed directly-related siblings children, measured Κ and λ light chains and computed the Κ/λ ratio.Results: As expected, Κ/λ results from each twin neonate were near identical (reflecting maternal/placental transfer). For older children and adult twins, the Κ/λ ratio form a cluster of results that were a subset of the reference range. There was one outlier, a female with a high, different from her twin sister. She likely had a monoclonal gammopathy (no followup was possible). Excluding this pair, results from neonate twins (14.4% ±10.3%) and non-neonate twins (18.0 ± 15.3%) were not significantly different. Results between non-twin siblings were more scattered (53.2%±53.4%) and different from neonate and non-neonate twin adult and children.Conclusion: We suggest that the Κ/λ free light chains may be genetically linked.","PeriodicalId":8921,"journal":{"name":"Biomarkers","volume":" ","pages":"100-104"},"PeriodicalIF":2.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139728854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0