Artificial Cells, Nanomedicine, and Biotechnology最新文献_第3页

Mechanism by which Qingre Lishi formula regulates Behçet's disease through gut microbiota-derived metabolites. 清热利湿方通过肠道微生物衍生代谢物调控behalet病的机制

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-03-17 DOI: 10.1080/21691401.2026.2640825

Yannan Xia, Shuhui Du, Ming Li, Mingze Wu, Chuanbing Huang

引用次数: 0

Coriandrum sativum improves prognosis in clear cell renal cell carcinoma by targeting NEK6 to modulate the immune microenvironment: a predictive study based on network pharmacology and multi-omics analysis. 芫荽通过靶向NEK6调节免疫微环境改善透明细胞肾细胞癌的预后：一项基于网络药理学和多组学分析的预测研究

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-01-22 DOI: 10.1080/21691401.2026.2618969

Jun Li, Yunfeng Zhang, Xing Wang, Penglin Zhang, Zuhuan Xu, Ruizhen Huang, Honglin Hu

{"title":"Coriandrum sativum improves prognosis in clear cell renal cell carcinoma by targeting NEK6 to modulate the immune microenvironment: a predictive study based on network pharmacology and multi-omics analysis.","authors":"Jun Li, Yunfeng Zhang, Xing Wang, Penglin Zhang, Zuhuan Xu, Ruizhen Huang, Honglin Hu","doi":"10.1080/21691401.2026.2618969","DOIUrl":"10.1080/21691401.2026.2618969","url":null,"abstract":"Coriandrum sativum L. (coriander) is a medicinal herb with diverse pharmacological properties, but its molecular mechanism in clear cell renal cell carcinoma (ccRCC) remains unclear. This study aimed to systematically investigate the underlying mechanisms of coriander in ccRCC by multi-omics analysis. Active compounds were screened using Traditional Chinese Medicine Systems Pharmacology (TCMSP) and predicted targets identified via SwissTargetPrediction (STP) and Similarity ensemble approach (SEA). Transcriptomic data from GSE53757 were analysed with WGCNA and intersected with coriander targets. Key genes were selected using LASSO, SVM, and random forest models. NEK6 was further analysed for clinical relevance, methylation, immune association, single-cell expression, molecular docking and molecular dynamics simulation. Fourteen coriander compounds were identified, yielding 22 potential ccRCC-related targets. NEK6 and PYGL were consistently selected by all machine learning algorithms. NEK6 was overexpressed in ccRCC and associated with better prognosis, promoter hypomethylation, and lower mutation rates. NEK6 expression correlated with immune infiltration, particularly macrophages, and was enriched in tumour and myeloid cells at the single-cell level. Molecular docking and molecular dynamics simulation revealed strong and stable binding of luteolin, quercetin, and chryseriol to NEK6. NEK6 may function as a prognostic and immune-regulatory biomarker in ccRCC. Coriander flavonoids could target NEK6 to modulate the immune microenvironment, providing new insight into plant-based therapeutic strategies for ccRCC.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"85-103"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The phytochemical analysis of Carissa macrocarpa, cytotoxic potential of fractions, and the molecular modulation on p53 expression in HT-29 and LS174T cell lines. 大Carissa macrocarpa的植物化学分析、部分的细胞毒性及对HT-29和LS174T细胞株p53表达的分子调控。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-05-11 DOI: 10.1080/21691401.2026.2668262

Salma S Alamri, Mohammad Y Alfaifi, Ali A Shati, Serag Eldin I Elbehairi, Dalia G El-Kolobby, Ahmed M Hussein, Fatma Alzahraa Mokhtar

{"title":"The phytochemical analysis of Carissa macrocarpa, cytotoxic potential of fractions, and the molecular modulation on p53 expression in HT-29 and LS174T cell lines.","authors":"Salma S Alamri, Mohammad Y Alfaifi, Ali A Shati, Serag Eldin I Elbehairi, Dalia G El-Kolobby, Ahmed M Hussein, Fatma Alzahraa Mokhtar","doi":"10.1080/21691401.2026.2668262","DOIUrl":"10.1080/21691401.2026.2668262","url":null,"abstract":"Natural products remain an invaluable source of anticancer agents, with flavonoids and phenolic compounds being particularly recognized for their ability to modulate tumour suppressor pathways. Carissa macrocarpa (C. macrocarpa) is an edible plant rich in secondary metabolites. This study sought to identify the secondary metabolites of C. macrocarpa leaves using LC-MS/MS, evaluate their cytotoxic and pro-apoptotic effects in colorectal cancer cell lines (HT-29 and LS174T), and elucidate potential molecular interactions with p53 through in silico docking, thereby uncovering mechanistic insights into its anticancer activity. LC-MS/MS revealed abundant flavonoid glycosides, particularly derivatives of kaempferol, quercetin, and isorhamnetin. Biological assays demonstrated potent cytotoxicity of the extracts, with the total extract showing the strongest effect against LS174T cells (IC50 = 0.5 µg/mL). Extracts induced apoptosis, caused G1/S/G2 cell cycle arrest, and upregulated p53 expression. Docking confirmed strong binding affinities (-7.87 to -9.28 kcal/mol) for glycosylated flavonoids such as kaempferol-3-O-robinoside-7-O-rhamnoside, hesperidin, and isorhamnetin-3-O-rutinoside. Also, 100 ns molecular dynamics studies confirmed the stable binding of both kaempferol-3-O-robinoside-7-O-rhamnoside and hesperidin against the p53 pocket. In conclusion, this integrative study demonstrates that C. macrocarpa exerts anticancer effects in colorectal cancer cells by modulating p53 and provides a mechanistic rationale for its therapeutic potential.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"73-93"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147873268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first metal organic framework phthalocyanine integrated with ZnO using Amaranthus spinosus as an efficient therapeutic candidate for cancer therapy. 第一个金属有机框架酞菁结合氧化锌利用苋菜作为癌症治疗的有效候选药物。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-05-15 DOI: 10.1080/21691401.2026.2668978

Atena Naemi, Fereshteh Ezzati Ghadi

{"title":"The first metal organic framework phthalocyanine integrated with ZnO using Amaranthus spinosus as an efficient therapeutic candidate for cancer therapy.","authors":"Atena Naemi, Fereshteh Ezzati Ghadi","doi":"10.1080/21691401.2026.2668978","DOIUrl":"10.1080/21691401.2026.2668978","url":null,"abstract":"The first metal organic framework based on phthalocyanine was synthesized (MOF P). A green synthesis route was employed to fabricate zinc oxide (ZnO) nanoparticles using Amaranthus spinosus extract. The as-synthesized ZnO was subsequently integrated into MOF P, yielding a novel MOF P/ZnO nanocomposite. It was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), Fourier transform infra-red spectroscopy (FT-IR), Energy dispersive X-ray analysis (EDAX), elemental analysis, and Ultraviolet-visible (UV-Vis) spectroscopy. This study demonstrates a novel therapeutic platform based on phthalocyanine-integrated metal-organic frameworks (MOFs) and ZnO nanoparticles for targeted and efficient cancer therapy. MTT assay results demonstrated a dose-dependent reduction in cell viability following MOF P/ZnO treatment. Flow cytometry analysis of apoptosis revealed a marked increase in early and late apoptotic cells. Moreover, ROS levels were significantly elevated in treated cells.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"94-105"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro mineralization of borosilicate glasses and accompanying evolution of porous architecture. 硼硅酸盐玻璃的体外矿化及其伴随的多孔结构演化。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-06-26 DOI: 10.1080/21691401.2026.2694291

Mahesh Malpani, Saikat Chattopadhyay, R D K Misra, Kamakhya Prakash Misra

引用次数: 0

Recent advances of CRISPR-based gene editing technologies and delivery strategies. 基于crispr的基因编辑技术及其传递策略的最新进展。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-07-29 DOI: 10.1080/21691401.2026.2702869

Fanyu Xue, Zixuan Xin, Gaojie Wang, Jiayin Xing, Hengxin Han, Xiangxiang Zhao, Ningning Song

{"title":"Recent advances of CRISPR-based gene editing technologies and delivery strategies.","authors":"Fanyu Xue, Zixuan Xin, Gaojie Wang, Jiayin Xing, Hengxin Han, Xiangxiang Zhao, Ningning Song","doi":"10.1080/21691401.2026.2702869","DOIUrl":"10.1080/21691401.2026.2702869","url":null,"abstract":"CRISPR technology is a powerful tool for gene editing, in which the efficient delivery of living target cells allows it to show great clinical potential. At present, the commonly used in vivo delivery strategies mainly include biological methods (AAV, VLP, SEND) and chemical methods (LNP), which subtly deliver gene editors to living target cells safely and efficiently from different ways. However, existing delivery systems have different extents of limitations in terms of editing efficiency, immunogenicity, half-life, etc., so developing optimized delivery systems is the key to fully realizing the potential of CRISPR-Cas system for intracellular gene editing. In order to fully understand the advantages of different delivery strategies to maximize the ability to help CRISPR systems choose delivery methods, we conducted a systematic review. In this paper, we introduce the types, principles and characteristics of gene editing systems in order to understand their requirements for delivery tools. We focus on describing the type, principle, load, immunogenicity, specificity, toxicity, etc. of the delivery system, so as to fully analyse its advantages and disadvantages for the selection of different editing environments. This review aims to provide new insights to facilitate appropriate delivery systems or improve the efficacy of existing systems.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"415-431"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148598174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing bone tissue engineering: anisotropic performance of poly(lactic-co-glycolic acid) (PLGA) composites with nano-calcium sulphate (nCS) and fucoidan (fu). 推进骨组织工程：纳米硫酸钙（nCS）和岩藻聚糖（fu）聚乳酸-羟基乙酸（PLGA）复合材料的各向异性性能。

IF 4.5 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-01-02 DOI: 10.1080/21691401.2025.2582447

Norshazliza Ab Ghani, Mohammed Rafiq Abdul Kadir, Sathiya Maran, Izdihar Kamal, Muhammad Khalis Abdul Karim, Mohd Hafiz Mohd Zaid, Hanumanth Rao Balaji Raghavendran, Muhammad Hanif Ramlee, Tunku Kamarul Zaman, Muhammad Imam Ammarullah

{"title":"Advancing bone tissue engineering: anisotropic performance of poly(lactic-co-glycolic acid) (PLGA) composites with nano-calcium sulphate (nCS) and fucoidan (fu).","authors":"Norshazliza Ab Ghani, Mohammed Rafiq Abdul Kadir, Sathiya Maran, Izdihar Kamal, Muhammad Khalis Abdul Karim, Mohd Hafiz Mohd Zaid, Hanumanth Rao Balaji Raghavendran, Muhammad Hanif Ramlee, Tunku Kamarul Zaman, Muhammad Imam Ammarullah","doi":"10.1080/21691401.2025.2582447","DOIUrl":"https://doi.org/10.1080/21691401.2025.2582447","url":null,"abstract":"This study investigates the anisotropic properties of three different poly(lactic-co-glycolic acid) (PLGA)-based materials: PLGA with nano-calcium sulphate (nCS), PLGA with fucoidan (fu) and PLGA with both nCS and fu. Using finite element analysis (FEA), the study explores their potential applications in bone tissue engineering. Anisotropy, or the directional dependency of mechanical properties, is critical in designing biomaterials for bone regeneration due to the complex, hierarchical structure of natural bone. The objective was to evaluate the mechanical behaviour of each composite material under simulated physiological conditions, focusing on their anisotropic responses to loading. The findings indicate that PLGA-nCS exhibited the highest degree of anisotropy, with enhanced stiffness and strength along preferred load-bearing directions, making it suitable for applications requiring higher mechanical stability. In contrast, PLGA-nCS-fu demonstrated moderate mechanical strength but displayed isotropic behaviour, ensuring consistent compressive performance across all directions. The study highlights the synergistic effects of incorporating nCS and fu into PLGA-based materials. fu, a natural sulphated polysaccharide derived from brown seaweed, significantly enhances the biological performance of these composites.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"53-73"},"PeriodicalIF":4.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preliminary genipin-crosslinked gelatin-asiaticoside injectable hydrogel for future biomaterials ink: physicochemical properties and cytocompatibility for wound repair. 用于未来生物材料的吉尼平交联明胶积雪草苷注射水凝胶的初步研究：伤口修复的物理化学性质和细胞相容性。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-02-18 DOI: 10.1080/21691401.2026.2627111

Raniya Razif, Andik Nisa Zahra Zainuddin, Nurul Ain Zawawi, Manira Maarof, Haslina Ahmad, Fatimah Mohd Nor, Mh Busra Fauzi

{"title":"Preliminary genipin-crosslinked gelatin-asiaticoside injectable hydrogel for future biomaterials ink: physicochemical properties and cytocompatibility for wound repair.","authors":"Raniya Razif, Andik Nisa Zahra Zainuddin, Nurul Ain Zawawi, Manira Maarof, Haslina Ahmad, Fatimah Mohd Nor, Mh Busra Fauzi","doi":"10.1080/21691401.2026.2627111","DOIUrl":"10.1080/21691401.2026.2627111","url":null,"abstract":"Chronic wounds remain a major healthcare concern due to delayed healing and high risk of infection. This study investigates the potential of genipin-crosslinked gelatin and asiaticoside (ASI) as innovative biomaterials ink for wound healing. Hydrogels were prepared using different concentrations of gelatin (9% w/v and 10% w/v) and asiaticoside at 0.05% w/v, with genipin employed as a natural crosslinker to improve mechanical strength. Their physicochemical characteristics, which includes swelling ratio, water vapour transmission rate (WVTR), contact angle, porosity, enzymatic degradation, and surface roughness were systematically evaluated, along with mechanical and cytotoxicity properties. Incorporation of asiaticoside enhanced hydrogel hydrophilicity, reduce porosity, and improved swelling behaviour, while preserving biodegradability and overall structural stability. The WVTR values remained within the optimal wound healing range (1500-2500 g/m2h). Furthermore, asiaticoside-loaded hydrogels demonstrated excellent cytocompatibility, supporting fibroblasts viability at lower concentrations including live/dead assay tests that were conducted. This study demonstrates that genipin-crosslinked gelatin-asiaticoside hydrogels are promising biomaterials ink for accelerated wound healing, with an initial characterization of an injectable formulation guiding their successful optimization to achieve the optimal injectability and printability for tissue engineering and three-dimenstional bioprinting (3D-bioprinting).","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"159-191"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network pharmacology analysis of integration of dietary plant-derived natural flavonoids and gut microbiota for the treatment of Polycystic Ovary syndrome (PCOS). 膳食植物源性天然黄酮类化合物与肠道菌群结合治疗多囊卵巢综合征的网络药理学分析。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-03-23 DOI: 10.1080/21691401.2026.2641374

Hong Chen, Hongying Kuang, Yang Zhang, Qionghua Chen, Dongxia Yang

{"title":"Network pharmacology analysis of integration of dietary plant-derived natural flavonoids and gut microbiota for the treatment of Polycystic Ovary syndrome (PCOS).","authors":"Hong Chen, Hongying Kuang, Yang Zhang, Qionghua Chen, Dongxia Yang","doi":"10.1080/21691401.2026.2641374","DOIUrl":"10.1080/21691401.2026.2641374","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder manifested by hyperandrogenism, ovulatory dysfunction, and systemic metabolic dysregulation. While the 'gut-diet' axis offers potential therapeutic avenues, the synergistic molecular mechanisms integrating dietary flavonoids and gut microbiota remain elusive. This study employed a comprehensive network pharmacology approach, coupled with molecular docking validation, to decode the tripartite interaction network of 'Dietary Flavonoids-Gut Microbiota-Host Targets.' Our analysis identified Luteolin and Quercetin as critical bioactive mediators that interact with specific gut microbial taxa. Topological network analysis revealed that these compounds exert the effects by targeting pivotal nodes-AKT Serine/Threonine Kinase 1 (AKT1), Epidermal Growth Factor Receptor (EGFR), and Insulin Receptor (INSR). Functional enrichment analysis further demonstrated that these targets converge on the Mitogen-Activated Protein Kinase (MAPK) signalling pathway. Conclusively, this study establishes a systematic theoretical framework for the integrated management of PCOS. Future research should prioritize experimental validation and clinical translation of the findings to develop personalized precision medicines targeting the gut-metabolic axis.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"209-231"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147497447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A scheme to tackle the dilemma from hepatoma cells under doxorubicin-resistant surroundings: a brightness or a silhouette. 一种解决肝癌细胞在阿霉素耐药环境下的困境的方案：亮度或轮廓。

IF 5.6 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-07-21 DOI: 10.1080/21691401.2026.2694920

Ki-Kwang Oh, Goo-Hyun Kwon, Jung-A Eom, Kyeong Jin Lee, Dong Joon Kim, Ki-Tae Suk

{"title":"A scheme to tackle the dilemma from hepatoma cells under doxorubicin-resistant surroundings: a brightness or a silhouette.","authors":"Ki-Kwang Oh, Goo-Hyun Kwon, Jung-A Eom, Kyeong Jin Lee, Dong Joon Kim, Ki-Tae Suk","doi":"10.1080/21691401.2026.2694920","DOIUrl":"https://doi.org/10.1080/21691401.2026.2694920","url":null,"abstract":"Background: The aim of this study was to investigate key target(s), mechanism(s) from hepatoma cells in harsh doxorubicin-resistant conditions (DRCs) from GSE125180 datasets in GEO (Gene Expression Omnibus).Methods: The identified components can be denoted as a brightness (therapeutic mark) or darkness (resistant mark) in DRCs. The protein-protein interaction (PPI) networks were assembled to identify the relationships between upregulated and downregulated genes via STRING, and R program.Results: In the |log2 FC| > 1, and |log2 FC| > 2 subgroups, the uppermost target was a non-receptor tyrosine kinase (SRC) downregulated in DRCs, indicating that the dampened SRC is a therapeutic mark by doxorubicin (DOX). In contrast, in the |log2 FC| > 3 subgroup, the most significant target was Cluster of Differentiation 93 (CD93) upregulated in DRCs, suggesting that the overexpressed CD93 is a resistant mark in DRCs. Metoclopramide (MET) @ CD93 + DOX conformer is a highlighted capture to illuminate as combination therapy to overcome DRCs because MET is an inhibitor against CD93 as well as a non-competitive inhibitor on (MET @ CD93 + DOX) conformer.Conclusions: These findings provide a mechanistic rationale for repurposing MET as an adjuvant agent to enhance therapeutic efficacy and overcome drug resistance in combination treatment strategies.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"374-388"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0