Artificial Cells, Nanomedicine, and Biotechnology最新文献_第10页

Expression of Concern 表达关注

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-04-26 DOI: 10.1080/21691401.2022.2054523

引用次数: 0

Antibacterial activity of nano zinc oxide green-synthesised from Gardenia thailandica triveng. Leaves against Pseudomonas aeruginosa clinical isolates: in vitro and in vivo study 以泰国栀子为原料合成的纳米氧化锌绿的抑菌活性。叶片抗铜绿假单胞菌临床分离株:体外和体内研究

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-04-01 DOI: 10.1080/21691401.2022.2056191

B. Alotaibi, W. Negm, E. Elekhnawy, T. El-Masry, M. E. Elharty, A. Saleh, D. Abdelkader, F. A. Mokhtar

{"title":"Antibacterial activity of nano zinc oxide green-synthesised from Gardenia thailandica triveng. Leaves against Pseudomonas aeruginosa clinical isolates: in vitro and in vivo study","authors":"B. Alotaibi, W. Negm, E. Elekhnawy, T. El-Masry, M. E. Elharty, A. Saleh, D. Abdelkader, F. A. Mokhtar","doi":"10.1080/21691401.2022.2056191","DOIUrl":"https://doi.org/10.1080/21691401.2022.2056191","url":null,"abstract":"Abstract The increasing emergence of bacterial resistance is a challenge for the research community, thus novel antibacterial agents should be developed. Metal nanoparticles are promising antibacterial agents and could solve the problem of antibiotic resistance. Herein, we used Gardenia thailandica methanol extract (GTME) to biogenically synthesise zinc oxide nanoparticles (ZnO-NPs). The characterisation of ZnO-NPs was performed by UV spectroscopy, FTIR, scanning and transmission electron microscopes, dynamic light scattering, and X-ray diffraction. The antibacterial activity of ZnO-NPs was studied both in vitro and in vivo against Pseudomonas aeruginosa clinical isolates. Its minimum inhibitory concentration values ranged from 2 to 64 µg/mL, and it significantly decreased the membrane integrity and resulted in a significant increase in the inner and outer membrane permeability. Also, the ZnO-NPs treated cells possessed a distorted and deformed shape when examined by scanning electron microscope. The in vivo study (biochemical parameters and histological investigation) was conducted and it revealed a protective effect of ZnO-NPs against the deleterious influences of P. aeruginosa bacteria on lung, liver, and kidney tissues. LC-ESI-MS/MS revealed a phytochemical tentative identification of 57 compounds for the first time. We propose that GTME is a useful source for ZnO-NPs which has a promising antibacterial activity. Graphical Abstract","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"118 1","pages":"96 - 106"},"PeriodicalIF":5.8,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89345081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Effective detection of ZnO in nicotine using butterfly wing scales 利用蝴蝶翅鳞有效检测尼古丁中的氧化锌

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-04-01 DOI: 10.1080/21691401.2022.2056609

Thanachai Changcharoen, Thidsanu Apiphatnaphakul, Wasupon Watjanavarreerat, K. Locharoenrat

{"title":"Effective detection of ZnO in nicotine using butterfly wing scales","authors":"Thanachai Changcharoen, Thidsanu Apiphatnaphakul, Wasupon Watjanavarreerat, K. Locharoenrat","doi":"10.1080/21691401.2022.2056609","DOIUrl":"https://doi.org/10.1080/21691401.2022.2056609","url":null,"abstract":"Abstract This study aimed to elucidate the optical functions of naturally butterfly wing scales via precise control of morphology as an effective photonic sensor and confirm the content of metal oxide nanoparticles in surrounding nicotine. Metal oxide nanoparticles mixed with nicotine were deposited on the wing scales through the spin-coating method and hence investigated using optical microscopy and spectroscopy. Experimental results demonstrated that absorption intensities of ZnO and TiO2 mixed with nicotine on Danaus genutia were remarkably enhanced. Due to the relatively high concentration of zinc found in e-cigarette aerosol, the intensity of ZnO/nicotine modelled as aerosol adsorption on Danaus genutia, further held a certain linear relationship with the concentration of ZnO. The limit of detection of ZnO was as low as 1 nM. The working mechanism of our sensor was explained through the molecular adsorption after H-bond formation of ZnO/nicotine molecules as high-index materials on the wing scales of Danaus genutia without aggregation. This photonic sensor is an alternative to the present-day methods for the rapid test of ZnO content, which is very simple without complicated instrumentation. Furthermore, our method might become a starting point for the advancement of portable instruments for onsite ZnO detection.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"60 1","pages":"87 - 95"},"PeriodicalIF":5.8,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82961087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of tenofovir disoproxil fumarate loaded silver nanoparticle on testicular morphology in experimental type-2 diabetic rats 富马酸替诺福韦二氧吡酯纳米银对实验性2型糖尿病大鼠睾丸形态的影响

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-03-27 DOI: 10.1080/21691401.2022.2042009

S. O. Olojede, S. Lawal, A. Dare, E. C. Naidu, C. Rennie, O. Azu

{"title":"Evaluation of tenofovir disoproxil fumarate loaded silver nanoparticle on testicular morphology in experimental type-2 diabetic rats","authors":"S. O. Olojede, S. Lawal, A. Dare, E. C. Naidu, C. Rennie, O. Azu","doi":"10.1080/21691401.2022.2042009","DOIUrl":"https://doi.org/10.1080/21691401.2022.2042009","url":null,"abstract":"Abstract Reproductive derangement and metabolic disorders in human immunodeficiency virus (HIV) infected persons require a nanoparticle delivery system to convey antiretroviral drugs to the anatomical sanctuary such as testis. This study investigated the effects of tenofovir disoproxil fumarate (TDF) loaded silver nanoparticles (AgNPs) on the testicular oxidative stress, inflammatory cytokines and histology in male diabetic rats. Thirty-six Sprague-Dawley rats weighing 230 ± 20 g were randomly divided into diabetic and non-diabetic groups (n = 18). Diabetes was induced using the fructose-streptozotocin (Frt-STZ) rat model. Both groups were further divided into three (n = 6) and administered distilled water, TDF, or TDF-AgNP. Results obtained with the TDF-AgNP administration showed a significant increase (p < .05) in the reduced glutathione and catalase levels. Tumour necrosis factor-alpha and interleukin 6 were reduced in diabetic rats administered TDF-AgNP. More so, administration of TDF-AgNP to diabetic rats improved testicular histoarchitecture in diabetic rats. In addition, diabetic rats administered TDF-AgNP showed a significant reduction (p < .05) in blood glucose levels. TDF-AgNP to diabetic rats enhanced testicular antioxidant enzyme, reduced testicular inflammation, and alleviated structural derangements in the testis. Thus, the application of AgNP to deliver TDF may alleviate testicular toxicity and subsequently cater for neglected reproductive dysfunction during the management of HIV infection.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"34 1","pages":"71 - 80"},"PeriodicalIF":5.8,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85432975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prevention of peritoneal adhesions formation by core-shell electrospun ibuprofen-loaded PEG/silk fibrous membrane 核壳静电纺布洛芬聚乙二醇/丝纤维膜预防腹膜粘连的形成

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-03-17 DOI: 10.1080/21691401.2021.1883043

S. Nadri, A. Rahmani, S. H. Hosseini, M. Habibizadeh, M. Araghi, Hossein Mostafavi

{"title":"Prevention of peritoneal adhesions formation by core-shell electrospun ibuprofen-loaded PEG/silk fibrous membrane","authors":"S. Nadri, A. Rahmani, S. H. Hosseini, M. Habibizadeh, M. Araghi, Hossein Mostafavi","doi":"10.1080/21691401.2021.1883043","DOIUrl":"https://doi.org/10.1080/21691401.2021.1883043","url":null,"abstract":"Abstract Adhesion bands are pathological fibrous tissues that create in the middle of tissues and organs, often reasons of intestinal obstruction, and female infertility. Here, we explored the anti-adhesive and inflammatory capacities of PEG/silk and Ibuprofen-loaded PEG/Silk core-shell nanofibrous membranes, respectively. The ibuprofen-loaded Silk Fibroin-Poly ethylene Glycol (SF-PEG) core-shell membrane was fabricated by electrospinning and considered in terms of morphology, surface wettability, drug release, and degradation. To reveal the membrane capability for adhesion bands inhibition, the membrane was stitched among the abdominal partition and peritoneum and then evaluated using two scoring adhesion systems. According to results, the fibrous membrane hindered cell proliferation, and the scoring systems and pathology showed that in a rat model, Ibuprofen-loaded PEG/Silk core-shell membrane caused a lightening in post-operative adhesion bands and the low-grade inflammatory reaction in animal models. Collectively, we fabricated new ibuprofen-loaded PEG/SF membranes with anti-adhesion and anti-inflammation properties. Moreover, this core-shell electrospun fibrous membrane has not even now been used to prevent peritendinous adhesion generation.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"68 1","pages":"40 - 48"},"PeriodicalIF":5.8,"publicationDate":"2022-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80337941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund’s adjuvant induced arthritis rats 水凝胶载体中萘普生-磺胺吡啶反式杂化复合物:完全弗氏佐剂诱导的关节炎大鼠的抗炎反应

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-03-09 DOI: 10.1080/21691401.2022.2047712

Sajeev Kumar Babasahib, Roaddy Well Born, N. M. Raghavendra

{"title":"Trans ethosomal hybrid composites of naproxen-sulfapyridine in hydrogel carrier: anti-inflammatory response in complete Freund’s adjuvant induced arthritis rats","authors":"Sajeev Kumar Babasahib, Roaddy Well Born, N. M. Raghavendra","doi":"10.1080/21691401.2022.2047712","DOIUrl":"https://doi.org/10.1080/21691401.2022.2047712","url":null,"abstract":"Abstract Current treatment for Rheumatoid arthritis (RA) utilizes Disease-modifying antirheumatic drugs, non-steroidal anti-inflammatory drugs or its combination, to decrease joint inflammation. In the present study, naproxen (NAP) and sulfapyridine (SULF) ethosomes were prepared by a thin-film hydration technique using PL90G and cholesterol, later crosslinked with carbopol®934. The ethosomes and ethosomal hydrogel were evaluated for rheological properties, physico-chemical analysis, in vitro and in vivo study. The results show, NAP and SULF ethosomes exhibited an average vesicle size between 251.1 ± 1.80–343.5 ± 3.23 nm and 269.0 ± 1.17–358.8 ± 1.22 nm, respectively, with good stability (zeta potential > 30 mV) and polydispersity index. Differential scanning calorimeter and Fourier transform infrared studies reveal no significant changes in the drug properties of ethosomes. Transmission electron microscopy analysis discloses spherical shape vesicles below 200 nm. The entrapment efficiency of NAP and SULF ethosomes was above 66%, and NAP-SULF ethosomes-hydrogel (EH) exhibited a sustained release effect (>8 h). In vivo studies on NAP-SULF EH shows significant inhibition of inflammation (84.63%), with less paw volume (0.1935 ± 0.08 ml) on induced arthritis Albino Wistar rats, (p < .01). NAP-SULF EH was stable at 25 °C ± 0.5 for 3-months. To conclude, a hybrid composite of NAP-SULF in hydrogel carrier prevents inflammation effectively, and could be novel for trans delivery of drugs in RA. Graphical Abstract","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"29 1","pages":"59 - 70"},"PeriodicalIF":5.8,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84293662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Statement of Retraction. 撤回声明。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2021-12-01 DOI: 10.1080/21691401.2021.1899427

引用次数: 0

Expression of Concern. 表达关心。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2021-12-01 DOI: 10.1080/21691401.2021.1899377

引用次数: 0

Expression of Concern. 表达关心。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2021-12-01 DOI: 10.1080/21691401.2021.1899383

引用次数: 0

Expression of Concern. 表达关心。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2021-12-01 DOI: 10.1080/21691401.2021.1899387

引用次数: 0