Artificial Cells, Nanomedicine, and Biotechnology最新文献_第10页

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-31 DOI: 10.1080/21691401.2022.2060567

N. Asadi, N. Annabi, E. Mostafavi, Maryam Anzabi, Rovshan Khalilov, Siamak Saghfi, Masoud Mehrizadeh, A. Akbarzadeh

引用次数: 0

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-31 DOI: 10.1080/21691401.2022.2060561

Eommolbanin Ebrahimi, Amir Ahmad Khandaghi, F. Valipour, Soraia Babaie, Fatemeh Asghari, Soheila Motaali, E. Abbasi, A. Akbarzadeh, S. Davaran

引用次数: 0

Statement of Retraction 撤回声明

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-31 DOI: 10.1080/21691401.2022.2060559

Eommolbanin Ebrahimi, A. Akbarzadeh, E. Abbasi, Amir Ahmad Khandaghi, Farhad Abasalizadeh, S. Davaran

引用次数: 0

Statement of Retraction 撤回声明

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-31 DOI: 10.1080/21691401.2022.2054518

Linlin Wang, Xiaonan Zhao, Ye Wang

引用次数: 0

Statement of Retraction 撤回声明

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-31 DOI: 10.1080/21691401.2022.2054515

Sen Wei, Jinghao Liu, Xin Li, Xing Liu

引用次数: 0

Expression of Concern. 表达关心。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-01 DOI: 10.1080/21691401.2022.2103238

引用次数: 0

Effect of carbon monoxide administration using haemoglobin-vesicles on the hippocampal tissue. 用血红蛋白囊给药对海马组织的影响。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-01 DOI: 10.1080/21691401.2022.2027428

Chie Okuda, Hiromi Sakai

{"title":"Effect of carbon monoxide administration using haemoglobin-vesicles on the hippocampal tissue.","authors":"Chie Okuda, Hiromi Sakai","doi":"10.1080/21691401.2022.2027428","DOIUrl":"https://doi.org/10.1080/21691401.2022.2027428","url":null,"abstract":"Carbon monoxide (CO) is a toxic gas that causes neuropathy. However, CO is endogenously produced in small amounts showing various beneficial effects. We hypothesized that CO-bound haemoglobin-vesicle (HbV) administration would reduce cerebral ischaemia-reperfusion injury without causing neuropathy. Three experiments were conducted. First, rats were exposed to CO inhalation to create a CO-poisoning group, and they were sacrificed on 0, 7, 14, and 21 days after CO exposure. Histopathologically, hippocampal damage was prominent at 14 days. Second, the rats were administered with CO-HbV equivalent to 50 or 25% of circulating blood volume (CO-HbV50 or CO-HbV25 group). Rats were sacrificed 14 days after administration. Third, rats put into haemorrhagic shock by 50% of circulating blood withdrawal were resuscitated using saline, autologous blood, and CO-HbV. They were sacrificed 14 days after resuscitation. Hippocampal damage assessment clarified that almost no necrotic cells were observed in the CO-HbV50 group. Necrotic cells in the CO-HbV25 group were comparable to those found for the control group. In rats resuscitated from haemorrhagic shock, the hippocampal damage in the group using CO-HbV was the mildest. Administration of CO-HbV did not lead to marked hippocampal damage. Furthermore, CO-HbV was effective at preventing cerebral ischaemia-reperfusion injury after haemorrhagic shock.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":" ","pages":"1-9"},"PeriodicalIF":5.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39863122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Expression of Concern. 表达关心。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-01 DOI: 10.1080/21691401.2022.2103237

引用次数: 0

MicroRNA-219 loaded chitosan nanoparticles for treatment of glioblastoma. 载MicroRNA-219壳聚糖纳米颗粒治疗胶质母细胞瘤。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-01 DOI: 10.1080/21691401.2022.2092123

Rawan Alswailem, Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Bahauddeen M Alrfaei, Mohammad Badran, Qamraa Hamad Alqahtani, Hosam Gharib Abdelhady, Ibrahim Alsarra

{"title":"MicroRNA-219 loaded chitosan nanoparticles for treatment of glioblastoma.","authors":"Rawan Alswailem, Fulwah Yahya Alqahtani, Fadilah Sfouq Aleanizy, Bahauddeen M Alrfaei, Mohammad Badran, Qamraa Hamad Alqahtani, Hosam Gharib Abdelhady, Ibrahim Alsarra","doi":"10.1080/21691401.2022.2092123","DOIUrl":"https://doi.org/10.1080/21691401.2022.2092123","url":null,"abstract":"Recent evidence has implicated microRNA-219 (miR-219) in regulation of gene contributed in glioblastoma (GBM) pathogenesis. This study aimed to prepare miR-219 in chitosan (CS) nanoparticles (NPs), characterize and investigate their efficacy on human GBM cell line (U87 MG). NPs were prepared using ionic gelation method. The influence of process parameters on physicochemical characteristics of NPs was investigated. Apoptotic effect of miR-219 was examined on U87 MG cells. Formulated NPs showed particle size of 109 ± 2.18 nm, with poly dispersity index equal to 0.2 ± 0.05, and zeta potential of +20.5 ± 0.7 mV. Entrapment efficiency of miR-219 in loaded NP has reached 95%. The in vitro release study demonstrated sustained release pattern of miR-219 from CS-NPs. Gel retardation assay has confirmed the integrity of miR-219 after production process. The fabricated NPs reduced the survival of U87 MG cells to 78% after 24 h of post-transfection, and into 67.5% after 48 h. However, fibroblasts were not affected by the NPs, revealing their specificity for GBM cells. Given the tumour suppressing function of miR-219, and advantage of CS-NPs for gene delivery to the central nervous system, the presented NPs have a great potential for treatment of GBM.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":" ","pages":"198-207"},"PeriodicalIF":5.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40405679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Anticandidal activity of green synthesised silver nanoparticles and extract loaded chitosan nanoparticles of Euphorbia prostata. 绿色合成前列腺大大麻纳米银及壳聚糖纳米提取物的抗药活性研究。

IF 5.8 3区生物学

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2022-12-01 DOI: 10.1080/21691401.2022.2088546

Jean P Dzoyem, Roland T Tchuenguem, Jamshed Iqbal, Muhammad Arfat Yameen, Abdul Mannan, Irum Shahzadi, Tariq Ismail, Nighat Fatima, Ghulam Murtaza

{"title":"Anticandidal activity of green synthesised silver nanoparticles and extract loaded chitosan nanoparticles of Euphorbia prostata.","authors":"Jean P Dzoyem, Roland T Tchuenguem, Jamshed Iqbal, Muhammad Arfat Yameen, Abdul Mannan, Irum Shahzadi, Tariq Ismail, Nighat Fatima, Ghulam Murtaza","doi":"10.1080/21691401.2022.2088546","DOIUrl":"https://doi.org/10.1080/21691401.2022.2088546","url":null,"abstract":"This study aimed to synthesize the silver nanoparticles (SNPs) and loaded chitosan nanoparticles (LCNPs) using Euphorbia prostata based on their anticandidal activity. Antioxidant capacity and the total phenolic and total flavonoid content of plant samples and synthesized nanoparticles (NPs) were also evaluated. SNPs and LCNPs were prepared, respectively using chemical reduction of silver salt solution and ionotropic gelation method. The anticandidal activity was assessed by broth micro-dilution method and the antioxidant activity was determined using free-radical scavenging assays. The synthesized NPs after the optimization process were found to be spherical with sizes ranging from 12 to 100 nm. Spectroscopic analysis of NPs showed the appearance of peaks in prescribed wavelength ranging between 402 and 493 nm. The synthesized NPs showed potent anticandidal activity compared to the free extract. The SNPs formulations NpEPM 7.5 and NpEPMR 7.5, showed significantly low MIC values ranging between 2 and 128 µg/mL. In the case of LCNPs, NpEPM (4:1) and NpEPME (4:1) also showed lower MIC values ranging from 32 to 256 µg/mL. The plant samples as well as NPs showed antioxidant potential. In addition, plant extracts and NPs possess the potent biological potential and can be further investigated through in vivo experiments.","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":" ","pages":"188-197"},"PeriodicalIF":5.8,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0