Artificial Cells, Nanomedicine, and Biotechnology最新文献

{"title":"Antibacterial and antibiofilm evaluation of biogenic ternary CuO-AgO-MgO nanocomposite against clinical isolates of carbapenem-resistant <i>Klebsiella pneumoniae</i>.","authors":"Mohammed S Abdulrahman, Nasir A Ibrahim, Fathy M Elkady, Amr H Hashem, Faisal Alsenani, Nosiba S Basher, Faisal H Altemani, Abdel-Aty E Alfeky, Ayman Salama, Adnan Alharbi, Sulaiman A Alsalamah, Fahd A Nasr, Mohammed Aufy, Ebrahim Saied","doi":"10.1080/21691401.2026.2665582","DOIUrl":"https://doi.org/10.1080/21691401.2026.2665582","url":null,"abstract":"<p><p>Escalation of antimicrobial resistance amongst <i>Klebsiella pneumoniae</i> (<i>K. pneumoniae</i>) represents a remarkable worldwide health concern. This study reports the green biosynthesis of copper, silver and magnesium oxide trimetallic nanocomposites (CuO-AgO-MgO TNCs) using banana peel extract as a safe and sustainable reducing and stabilizing agent and emphasizes its inhibitory activity against carbapenem-resistant <i>K. pneumoniae</i> (CRKP) strains. The TNCs were characterized by ultraviolet-visible (UV-vis) spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, X-ray diffraction (XRD) analysis, transmission electron microscope (TEM), scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX) analysis, confirming their crystalline structure (average size 125 nm) and elemental composition (Cu, Ag, Mg, O). Cytotoxicity assessment using WI-38 normal cells showed minimal toxic effect with an IC₅₀ of 193.49 ± 2.85 µg/mL. Antibacterial activity was evaluated against genotypically diverse CRKP strains. Well diffusion assay (WDA) showed inhibition zones of 18-38 mm, while the broth microdilution assay provided minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values ranging from 8 to 1024 µg/mL and 128 to 2048 µg/mL, respectively. Time-kill assays indicated rapid bacterial growth reduction within 2 h, and antibiofilm assays showed 25-91% inhibition of biofilm formation. The image provided by SEM revealed pronounced morphological alterations in treated bacterial cells. Our findings exhibited biogenic CuO-AgO-MgO TNCs with potent antibacterial and antibiofilm activities against CRKP while showing negligible toxicity towards normal cells, highlighting their potential as a safe and effective alternative antimicrobial strategy.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"223-247"},"PeriodicalIF":4.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148238618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal cortex-extracellular vesicle RNAs coupling in alcohol use disorder: towards non-invasive biomarkers and targeted therapeutics.","authors":"Jie-Quan Wang, Qing-Rong Xia, Xuan Zhou, Chun-Yu Yan, Wen-Xiu Hong, Yi-Yun Deng, Feng Shan, Ya-Ru Liu, Jun Liang","doi":"10.1080/21691401.2026.2617703","DOIUrl":"10.1080/21691401.2026.2617703","url":null,"abstract":"<p><p>Alcohol use disorder (AUD) poses a substantial global health burden, with its molecular mechanism remaining elusive. This study integrated datasets (GSE253155, GSE180722, GSE182173 and GSE176122) and clinical specimens to identify non-invasive biomarkers and therapeutic candidates for AUD. Transcriptomic analysis of post-mortem prefrontal cortex identified 34 differentially expressed genes (DEGs), significantly enriched in TNF/IL-17 signalling, ribosome, cytokine-cytokine receptor interaction and endoplasmic reticulum protein processing. Among multiple machine learning algorithms, the support vector machine demonstrated superior classification performance, prioritizing <i>MDK</i>, <i>FAM225B</i> and <i>SERPINA3</i> as critical biomarkers. These were incorporated into a highly predictive diagnostic nomogram. Intersection with plasma extracellular vesicle (EV) RNAs showed that all three biomarkers were detectable and upregulated in AUD patients versus controls, which was confirmed by quantitative real-time PCR (qRT-PCR) in a clinical validation cohort. <i>SERPINA3</i> exhibited a particularly robust association with AUD, maintaining significance after adjustment for confounders and suggesting direct effects via mediation analysis. Cross-species validation confirmed a conserved dysregulation of murine Serpina3n. Computational drug repurposing identified loratadine, doxepin, citalopram and imipramine as promising therapeutic candidates targeting <i>SERPINA3</i>. Collectively, this work delineated PFC signature genes, proposed a EVs-supported brain-periphery molecular crosstalk, and provided translatable biomarkers and repurposable candidates for AUD precision medicine.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"132-149"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the safety and efficacy of micronized encapsulated ferric pyrophosphate in patients with iron deficiency anaemia: a phase-IV open-label clinical study.","authors":"Belal Almajali, Giriraja Kv, Gowthamarajan Kuppusamy, Md Zeyaullah, Nayudu Teja, Veera Venkata Satyanarana Reddy Karri, Mohamed Rahamathulla, Muhammad Ali Abdullah Almoyad, Khursheed Muzammil, Mohammed Muqtader Ahmed, Ismail Pasha","doi":"10.1080/21691401.2026.2618967","DOIUrl":"https://doi.org/10.1080/21691401.2026.2618967","url":null,"abstract":"<p><p>An open-level, single-arm, phase-4 clinical trial was carried out to assess the safety and potential benefits of micronized coated ferric pyrophosphate (MEFP) in patients with iron deficiency anaemia (IDA). For 12 weeks, 60 patients between the ages of 18 and 60 with moderate IDA were randomly received MEFP by PO daily. The efficacy endpoints as haemoglobin levels, mean corpuscular haemoglobin (MCH), mean cell haemoglobin concentration (MCHC), packed cell volume (PCV), red blood cell count (RBC), serum ferritin and transferrin saturation (%) were measured. Adverse event reports and physical examinations were performed as a measure of safety assessment. The results revealed that haemoglobin, MCV, MCHC, serum ferritin, transferrin saturation (%), PCV and RBC increased significantly from baseline. Fewer occurrences were observed in a few patients, and their adverse events were minimal. There was no adverse effect on liver or renal functions. Few minor improvements were noticed at the completion of the study. In conclusion, MEFP appears to be effective in IDA and well tolerated, with a favourable safety profile. MEFP is an effective, safe therapeutic alternative in IDA subjects for increasing haemoglobin concentration and iron stores along with improvement of symptoms related to anaemia.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"150-158"},"PeriodicalIF":4.5,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The unmasking of two-faced portrait in sorafenib-resistant surroundings via systems pharmacology concept: a brightness or a silhouette.","authors":"Ki-Kwang Oh, Goo-Hyun Kwon, Jung-A Eom, Kyeong Jin Lee, Dong Joon Kim, Ki-Tae Suk","doi":"10.1080/21691401.2026.2655581","DOIUrl":"10.1080/21691401.2026.2655581","url":null,"abstract":"<p><p>This study aimed to identify novel key targets and mechanisms for repurposing strategies and mitigating sorafenib (SFB) resistance using the GEO transcriptomic dataset GSE94550 within a systems pharmacology framework. Potential counteracting molecules against SFB were retrieved from chemical repositories, followed by molecular docking tests (MDT), Kaplan-Meier survival analysis, and density functional theory (DFT) assessments to evaluate therapeutic potential. PPI networks were constructed using STRING and R to characterize the relationships between upregulated and downregulated genes. The most relevant signalling pathways associated with major targets were determined to elucidate the upstream regulatory mechanisms. Among the differentially expressed genes, APOB emerged as a pivotal regulator (log₂FC ≥ +2 or ≤ -2), modulating fifteen genes, including eleven upregulated and four downregulated nodes. At stricter thresholds (log₂FC ≥ +3 or ≤ -3 and ≥ +4 or ≤ -4), CD44 was identified as a key upregulated target. Its inhibition - particularly by verbacoside - was strongly associated with suppression of the ECM-receptor interaction pathway, suggesting a significant therapeutic axis. This study illuminates the molecular landscape of SFB-resistant environments through an integrative network approach and highlights verbacoside as a promising agent capable of attenuating SFB resistance, supporting its potential role in combination therapy.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"289-323"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer activity of fluoxetine Janus dendrimer against cancer cells.","authors":"Marcos Martínez-García, Isabel Hernández-Rioja, Israel Barajas-Mendoza, Alberto Espinosa-Hernández, Teresa Ramirez-Apan, Elena Martínez-Klimova","doi":"10.1080/21691401.2026.2672826","DOIUrl":"10.1080/21691401.2026.2672826","url":null,"abstract":"<p><p>Targeting the inflammation-related molecules with nonsteroidal anti-inflammatory drugs (NSAIDs) represents a promising approach for cancer prevention/therapy. We evaluated the <i>in vitro</i> anticancer effects of sulindac, ketoprofen, celecoxib and the antidepressant fluoxetine, both free and coupled with synthesized dendrons and dendrimers, on the proliferation and apoptosis of human MCF-7 (human mammary adenocarcinoma), SKLU-1 (human lung adenocarcinoma) and as a control the normal monkey kidney (COS-7) cell line. The antiproliferative activity and cytotoxicity of tested NSAIDs on MCF-7 and SKLU-1 cell lines were assessed by the sulforhodamine B (SRB) assay. The tested dendrons with NSAIDs showed activity against the tumour cell lines. Significant inhibition of the growth of cancer cells was observed for the Janus dendrimers with sulindac-celecoxib, which was selective against MCF-7; and Janus dendrimers with fluoxetine were highly cytotoxic. The fluoxetine-dendrimer could be a candidate for the development of new pharmacological strategies for the treatment and prevention of MCF-7 cancer.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"106-119"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147986295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time RNA sensors for diabetes management: assessing the impact of endocrine disruptors on biosensing and point-of-care diagnostics.","authors":"Prit Ashara, Muktesh Chandra, Praveen Kumar Sharma, Irfan Nurhidayat, Mohd Asif Shah","doi":"10.1080/21691401.2026.2679936","DOIUrl":"10.1080/21691401.2026.2679936","url":null,"abstract":"<p><p>The advancements in the areas of real-time RNA biosensor technology and their application to more precise diabetes care have laid the groundwork for new and potentially efficient strategies for monitoring and management of the disease. At the same time, many researchers are now studying the influence of environmental factors, and more specifically, exposure to endocrine-disrupting chemicals (EDCs), that can impact not only the diabetes disease process itself, but also the reliability and consistency of biosensors to monitor these stressors. The current review summarizes recent advances in RNA sensor technology designed for diabetes care, evaluates the connection between it and point-of-care (POC) diagnostics, and purposefully analyzes the existing evidence on how such EDCs can affect biosensor accuracy, stability, and general clinical usefulness.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"206-222"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of genipin-crosslinked gelatin/PVA hydrogels and the chondroprotective influence of hydroxytyrosol: an In vitro study.","authors":"Wafa Ali Batarfi, Mohd Heikal Mohd Yunus, Adila A Hamid, Manira Maarof, Rizal Abdul Rani","doi":"10.1080/21691401.2026.2678704","DOIUrl":"https://doi.org/10.1080/21691401.2026.2678704","url":null,"abstract":"<p><p>Osteoarthritis (OA) presents a significant therapeutic challenge, necessitating innovative biomaterial strategies to reduce chronic inflammation and promote cartilage regeneration. This study developed a hybrid gelatine (GE)/polyvinyl alcohol (PVA) hydrogel crosslinked with genipin (GNP) to effectively deliver Hydroxytyrosol (HT). A 6% GE was incorporated with 3% and 5% PVA concentrations, followed by 0.1% (w/v) GNP. The physicochemical and biocompatibility properties were further evaluated. Physicochemical analysis identified the GPVA5%-GNP formulation as optimal, featuring an interconnected porous structure, optimal swelling ratio (640.43 ± 22.28%), improved hydrophilicity (44.50 ± 1.81°), controlled biodegradation, and enhanced compressive strength (96.88 ± 0.72%). Chemical tests confirmed thermal and structural stability, while biocompatibility assays showed over 95% cell viability. The therapeutic potential was evaluated using an IL-1β-induced inflammatory model in human chondrocytes. MTT assays revealed that HT at 12.5, 25, and 50 μM restored metabolic activity in a dose-dependent manner over 14 days, outperforming the 9 μM Glucosamine Sulphate positive control. The 50 μM HT dose yielded the best metabolic recovery, supported by Live/Dead imaging that showed increased viable cell density from Day 1 to Day 7. Overall, the GPVA5%-GNP hydrogel loaded with 50 μM HT offers a robust protective environment that reduces catabolic stress and promotes cell proliferation, making it a promising localized therapy for cartilage regeneration in OA.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"248-275"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A functional polymorphism in <i>ADAMTS7</i> 3'-UTR abrogates miR-654-5p-mediated <i>ADAMTS7</i> expression suppression and increases the incidence, short-term outcome, and recurrence of large artery atherosclerotic stroke among southern Chinese population.","authors":"Linfa Chen, Shan Wei, Zishan Li, Yutian Zhang, Jiahao Li, Jinjin Yan, Chun Xiao, You Li","doi":"10.1080/21691401.2026.2670966","DOIUrl":"10.1080/21691401.2026.2670966","url":null,"abstract":"<p><strong>Background: </strong>A Disintegrin and Metalloproteinase with Thrombospondin motifs 7 (ADAMTS7) plays a critical role in atherosclerosis by degrading the extracellular matrix and modulating smooth muscle cell (SMC) proliferation, migration, and phenotypic transformation. This study investigated the association between the <i>ADAMTS7</i> single-nucleotide polymorphism (SNP) rs1045130 and large artery atherosclerotic (LAA) stroke.</p><p><strong>Materials and methods: </strong>Genotyping analyses were conducted on two independent case-control cohorts comprising 1,027 LAA patients and 1,043 age-matched controls, followed by the quantification of ADAMTS7 expression and its downstream molecular effects.</p><p><strong>Results: </strong>ADAMTS7 was highly expressed in endothelial cells, SMCs, and macrophage-derived foam cells of vulnerable human aortic plaques. Furthermore, individuals carrying the rs1045130 A allele or GA/AA genotype had a significantly higher susceptibility to LAA stroke, poorer short-term outcomes, and an increased risk of one-month recurrence. Mechanistically, the G > A mutation disrupts the <i>ADAMTS7</i>-miR-654-5p interaction, leading to elevated <i>ADAMTS7</i> expression and subsequent promotion of foamed vascular SMCs (VSMCs) proliferation and migration.</p><p><strong>Conclusions: </strong>The rs1045130 G > A variant is associated with increased LAA stroke incidence and worse prognosis. The mutation promotes the proliferation and migration of foamed VSMCs by disrupting the miR-654-5p/<i>ADAMTS7</i> axis, potentially accounting for the higher disease risk and poorer prognosis observed in affected individuals.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"137-151"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism by which Qingre Lishi formula regulates Behçet's disease through gut microbiota-derived metabolites.","authors":"Yannan Xia, Shuhui Du, Ming Li, Mingze Wu, Chuanbing Huang","doi":"10.1080/21691401.2026.2640825","DOIUrl":"10.1080/21691401.2026.2640825","url":null,"abstract":"<p><p>This research employs an integrated approach combining network pharmacology and molecular docking to assess the therapeutic potential of a Heat-Clearing and Dampness-Eliminating Formula alongside gut microbiota (GM) metabolites in the management of Behçet's disease (BD). Active constituents of the formula and GM-derived metabolites were sourced from specialized databases including TCMSP, SwissTargetPrediction, PubChem, and gutMGene. Disease-associated targets for BD and metabolite-related targets were compiled using publicly available datasets. Through protein-protein interaction (PPI) network construction and KEGG enrichment analysis, pivotal targets and major signalling pathways implicated in BD pathology were identified. Molecular docking simulations further assessed the binding interactions between active metabolites and target proteins, corroborating the predictions derived from network pharmacology. Further experimental validation using <i>in vitro</i> and <i>in vivo</i> models is warranted to substantiate these computational insights.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"245-263"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147472403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coriandrum sativum improves prognosis in clear cell renal cell carcinoma by targeting NEK6 to modulate the immune microenvironment: a predictive study based on network pharmacology and multi-omics analysis.","authors":"Jun Li, Yunfeng Zhang, Xing Wang, Penglin Zhang, Zuhuan Xu, Ruizhen Huang, Honglin Hu","doi":"10.1080/21691401.2026.2618969","DOIUrl":"10.1080/21691401.2026.2618969","url":null,"abstract":"<p><p><i>Coriandrum sativum</i> L. (coriander) is a medicinal herb with diverse pharmacological properties, but its molecular mechanism in clear cell renal cell carcinoma (ccRCC) remains unclear. This study aimed to systematically investigate the underlying mechanisms of coriander in ccRCC by multi-omics analysis. Active compounds were screened using Traditional Chinese Medicine Systems Pharmacology (TCMSP) and predicted targets identified <i>via</i> SwissTargetPrediction (STP) and Similarity ensemble approach (SEA). Transcriptomic data from GSE53757 were analysed with WGCNA and intersected with coriander targets. Key genes were selected using LASSO, SVM, and random forest models. NEK6 was further analysed for clinical relevance, methylation, immune association, single-cell expression, molecular docking and molecular dynamics simulation. Fourteen coriander compounds were identified, yielding 22 potential ccRCC-related targets. NEK6 and PYGL were consistently selected by all machine learning algorithms. NEK6 was overexpressed in ccRCC and associated with better prognosis, promoter hypomethylation, and lower mutation rates. NEK6 expression correlated with immune infiltration, particularly macrophages, and was enriched in tumour and myeloid cells at the single-cell level. Molecular docking and molecular dynamics simulation revealed strong and stable binding of luteolin, quercetin, and chryseriol to NEK6. NEK6 may function as a prognostic and immune-regulatory biomarker in ccRCC. Coriander flavonoids could target NEK6 to modulate the immune microenvironment, providing new insight into plant-based therapeutic strategies for ccRCC.</p>","PeriodicalId":8736,"journal":{"name":"Artificial Cells, Nanomedicine, and Biotechnology","volume":"54 1","pages":"85-103"},"PeriodicalIF":5.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146017349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}