Archives of Virology最新文献_第4页

Undaria pinnatifida fucoidan extract inhibits activation of the NF-κB signaling pathway by herpes simplex virus type 1 and prevents amyloid-β peptide synthesis in retinal pigment epithelium cells 裙带菜岩藻多糖提取物抑制1型单纯疱疹病毒激活NF-κB信号通路，抑制视网膜色素上皮细胞淀粉样蛋白-β肽合成

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-01-06 DOI: 10.1007/s00705-024-06212-2

Macarena Giuliani, Camila Uboldi, Fernando Gaspar Dellatorre, Ezequiel Latour, Nora Marta Andrea Ponce, Carlos A. Stortz, Verónica Leticia Lassalle, Victoria Belen Ayala-Peña

{"title":"Undaria pinnatifida fucoidan extract inhibits activation of the NF-κB signaling pathway by herpes simplex virus type 1 and prevents amyloid-β peptide synthesis in retinal pigment epithelium cells","authors":"Macarena Giuliani, Camila Uboldi, Fernando Gaspar Dellatorre, Ezequiel Latour, Nora Marta Andrea Ponce, Carlos A. Stortz, Verónica Leticia Lassalle, Victoria Belen Ayala-Peña","doi":"10.1007/s00705-024-06212-2","DOIUrl":"10.1007/s00705-024-06212-2","url":null,"abstract":"<div>Neurodegenerative pathologies such as age-related macular degeneration currently have no cure or effective treatment. In this type of disease, the presence of amyloid-β peptides, oxidative stress, and inflammation trigger dysregulation of retinal pigment epithelial cells and progression toward the death of these cells, resulting in a loss of vision. The production of amyloid-β peptides, oxidative stress, and inflammation can be triggered in response to viral infections. Fucoidans are sulfated polysaccharides that are present in the cell walls of brown algae. There is a large body of literature reporting a wide range of biological properties of these compounds. In this study, we investigated whether Undaria pinnatifida fucoidan extract can prevent infection with herpes simplex virus type 1 and if the extract has antioxidant activity. We also evaluated whether, under viral infection conditions, the synthesis of amyloid-β peptide and NF-κB activation could be inhibited by the extract. The results showed for the first time that this extract can prevent viral infection in retinal pigment epithelial cells and that they can prevent the formation of amyloid-β peptide and the activation of the NF-κB pathway during viral infection. We also found that Undaria pinnatifida fucoidan extract has antioxidant activity and reduces the levels of reactive oxygen species. These data suggest that Undaria pinnatifida fucoidan extract might be effective for treating diseases triggered by viral infections, such as degenerative retinal diseases.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 2","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Molecular epidemiology and risk analysis for asymptomatic infection with feline enteric coronavirus in domestic and stray cats in Japan 更正：日本家猫和流浪猫无症状感染猫肠道冠状病毒的分子流行病学及风险分析

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-01-04 DOI: 10.1007/s00705-024-06174-5

Hitomi Kumano, Keisuke Nakagawa

引用次数: 0

Isolation and characterization of Iwanai Valley virus, a new tick-borne nairovirus from Ixodes ovatus ticks in Hokkaido, Japan 日本北海道卵形硬蜱新蜱传病毒岩井谷病毒的分离与鉴定

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-21 DOI: 10.1007/s00705-024-06195-0

Ryo Matsumura, Daisuke Kobayashi, Takeo Yamauchi, Eunsil Park, Ayano Nishino, Ken Maeda, Shinji Kasai, Kyo Itoyama, Haruhiko Isawa

{"title":"Isolation and characterization of Iwanai Valley virus, a new tick-borne nairovirus from Ixodes ovatus ticks in Hokkaido, Japan","authors":"Ryo Matsumura, Daisuke Kobayashi, Takeo Yamauchi, Eunsil Park, Ayano Nishino, Ken Maeda, Shinji Kasai, Kyo Itoyama, Haruhiko Isawa","doi":"10.1007/s00705-024-06195-0","DOIUrl":"10.1007/s00705-024-06195-0","url":null,"abstract":"<div>Most members of the genus Orthonairovirus, represented by Crimean-Congo hemorrhagic fever virus and Nairobi sheep disease virus, are tick-borne, and some have become a public health concern in recent years. Here, we report the isolation and genetic and biological characterization of a new orthonairovirus, designated as \"Iwanai Valley virus\" (IWVV), from Ixodes ovatus ticks in Hokkaido, Japan. The amino acid sequence of the viral nucleoprotein (NP) was found to be 34–45% identical to those of known orthonairoviruses. Phylogenetic analysis based on amino acid sequences of the viral NP revealed that IWVV is closely related to human-pathogenic tick-borne orthonairoviruses, including Songling virus, Tacheng tick virus 1, and Yezo virus, which were recently discovered in East Asia. BHK-21 (Syrian hamster kidney), Vero (African green monkey kidney), SW-13 (human adrenal adenocarcinoma), HuH-7 (human hepatocellular carcinoma), and ISE6 (Ixodes scapularis tick embryo) cells were found to be susceptible to IWVV infection. Notably, several human-derived cell lines supported efficient replication of the virus. Our findings provide new insights into the diversity, evolutionary dynamics, and geographical distribution of orthonairoviruses in East Asia.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular detection and evolutionary analysis of porcine epidemic diarrhea virus in Henan and Shaanxi provinces in China 河南省和陕西省猪流行性腹泻病毒的分子检测和进化分析。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-17 DOI: 10.1007/s00705-024-06201-5

Xiao Ma, Hongbo Cui, Yanfei Huang, Shijie Ma, Hongying Chen

{"title":"Molecular detection and evolutionary analysis of porcine epidemic diarrhea virus in Henan and Shaanxi provinces in China","authors":"Xiao Ma, Hongbo Cui, Yanfei Huang, Shijie Ma, Hongying Chen","doi":"10.1007/s00705-024-06201-5","DOIUrl":"10.1007/s00705-024-06201-5","url":null,"abstract":"<div>Porcine epidemic diarrhea (PED) caused by porcine epidemic diarrhea virus (PEDV) is a highly contagious and devastating enteric disease of pigs characterized by diarrhea, dehydration and 80-100% mortality in piglets, leading to substantial economic losses in the global swine industry. To investigate the prevalence of PEDV in Henan and Shaanxi provinces of China from 2022 to 2023, a total of 87 clinical samples (including intestinal tissues and faeces) were collected from diseased piglets during outbreaks of diarrhea on pig farms. Of the 87 samples, 32 (36.7%) tested positive for PEDV by RT-PCR, and the complete S gene from nine positive samples and the ORF3 gene from 11 positive samples, all from different farms, were subsequently sequenced. Phylogenetic analysis based on S gene sequences showed that most of the nine PEDV isolates sequenced belonged to the G2a clade and were most closely related to variant strains of PEDV. However, two strains from Shaanxi (CH-SX1-2023 and CH-SX2-2023) belonged to the G2b subtype, and one strain from Henan (CH-HNC2-2023) belonged to the S-INDEL branch. Amino acid sequence comparisons showed that there were several amino acid substitutions and deletions in the S and ORF3 proteins of the PEDV strains from Henan and Shaanxi compared to the CV777 vaccine strain. Some of these mutations occurred in neutralizing epitopes, particularly COE and might therefore be associated with the ineffective protection provided by existing vaccines. These results will provide insights for better understanding of the epidemiological situation of PEDV in Henan and Shaanxi provinces between 2022 and 2023, and this information also contributes to the development of new strategies for the prevention and control of variant PEDV strains.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Porvac® subunit vaccine induces neutralizing antibodies against all three main classical swine fever virus genotypes Porvac® 亚单位疫苗可诱导针对所有三种主要经典猪瘟病毒基因型的中和抗体

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-17 DOI: 10.1007/s00705-024-06198-x

Yusmel Sordo-Puga, Elaine Santana-Rodríguez, Danny Pérez-Pérez, Mary Karla Méndez-Orta, Talía Sardina-González, Milagros Vargas-Hernández, Carlos A. Duarte, María Pilar Rodríguez-Moltó, Mario P. Estrada, Aruna Ambagala, Marisela Suárez-Pedroso

引用次数: 0

Complete genome sequence of a novel iflavirus from wheat sawfly (Dolerus tritici) 来自小麦锯蝇（Dolerus tritici）的新型伊夫拉病毒的完整基因组序列

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-17 DOI: 10.1007/s00705-024-06206-0

Jiashu Guo, Wenwen Liu, Chen Chen, Zhongtian Xu, Frederic Francis, Xifeng Wang

{"title":"Complete genome sequence of a novel iflavirus from wheat sawfly (Dolerus tritici)","authors":"Jiashu Guo, Wenwen Liu, Chen Chen, Zhongtian Xu, Frederic Francis, Xifeng Wang","doi":"10.1007/s00705-024-06206-0","DOIUrl":"10.1007/s00705-024-06206-0","url":null,"abstract":"<div>Little is known about the insect viruses in wheat sawfly, Dolerus tritici, which is an important agricultural insect feeding on wheat leaves. Here, we used RNA sequencing to identify a novel single positive-strand RNA virus from the larvae of wheat sawfly collected in northern China and then determined its complete genome sequence by rapid amplification of cDNA ends. The complete genome is 9,594 nt in length, including a polyA tail at its 3′ terminus, and it is predicted to encode a 326.3-kDa polyprotein. Phylogenetic analysis based on deduced amino acid sequences of the polyprotein revealed that this RNA virus clustered in a clade with deformed wing virus of the genus Iflavirus, family Iflaviridae. The full genome of this RNA virus shows 42.0–50.0% sequence identity with other iflaviruses. Comparisons of amino acid sequences showed that the coat protein of this RNA virus is most similar to that of slow bee paralysis virus, with 33.6% identity, suggesting that this virus is a new member in the genus Iflavirus. Thus, we have tentatively designated it as “Dolerus tritici iflavirus 1” (DtIV1). To our knowledge, this is the first report of an insect virus in wheat sawfly.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142844980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of a novel hepacivirus in wild cavies (Cavia aperea aperea) 在野生豚鼠（Cavia aperea aperea）中检测到一种新型肝病毒

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-16 DOI: 10.1007/s00705-024-06199-w

Gabriela Espíndola Birlem, Alexandre Sita, Juliana Schons Gularte, Deivid de Souza da Silva, Meriane Demoliner, Paula Rodrigues de Almeida, Juliane Deise Fleck, Fernando Rosado Spilki, Severino Silvano dos Santos Higino, Sergio Santos de Azevedo, Matheus Nunes Weber

{"title":"Detection of a novel hepacivirus in wild cavies (Cavia aperea aperea)","authors":"Gabriela Espíndola Birlem, Alexandre Sita, Juliana Schons Gularte, Deivid de Souza da Silva, Meriane Demoliner, Paula Rodrigues de Almeida, Juliane Deise Fleck, Fernando Rosado Spilki, Severino Silvano dos Santos Higino, Sergio Santos de Azevedo, Matheus Nunes Weber","doi":"10.1007/s00705-024-06199-w","DOIUrl":"10.1007/s00705-024-06199-w","url":null,"abstract":"<div>Hepacivirus is a genus of RNA viruses within the family Flaviviridae of which hepatitis C virus (HCV) is the prototype. Several hepaciviruses have been identified in mammals, including rodents of multiple families. Each rodent hepacivirus described so far has been found only in members of a single rodent species. Here, we report the discovery and characterization of a putative new genotype of an unclassified rodent hepacivirus in a wild cavy (Cavia aperea aperea) that was reported previously in Proechimys semispinosus. This virus was detected in one out of 14 (7.14%) wild cavy sera tested by RT-PCR. The complete genome sequence was obtained by high-throughput sequencing using an Illumina MiSeq platform. This is the first report of a hepacivirus in a member of the family Caviidae. Our findings show that members of different rodent species and even families can be infected by hepaciviruses of the same species. The identification and characterization of novel hepaciviruses might lead to the discovery of reservoirs of viruses that are genetically related to human pathogens, and this can help to elucidate the evolutionary origins of HCV and other hepaciviruses.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An isolate of human blood-associated partitivirus naturally infects the phytopathogenic fungus Bipolaris maydis 分离的人血液相关的部分病毒自然感染植物病原真菌双北极星。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-13 DOI: 10.1007/s00705-024-06204-2

Kun Zhang, Ge Mu, Weilan Wu, Peng Wang, Jun Shang, Changquan Li, Qingchao Deng, Shouguo Fang, Haoran Wang, Songbai Zhang

引用次数: 0

Characterization of the complete genome of a novel allexivirus infecting Sauropus androgynus in China 中国一种新型雌雄同体索罗猴（Sauropus androgynus）等位病毒全基因组的鉴定

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-13 DOI: 10.1007/s00705-024-06202-4

Li-Juan Zhu, Lan-Yi Su, Xing Chen, Shifang Pan, Fagang Xia, Yan-Hong Han, Zhongtian Xu, Qian Xu

引用次数: 0

2024 taxonomic update for the families Naryaviridae, Nenyaviridae, and Vilyaviridae Naryaviridae， neneyaviridae和Vilyaviridae的分类更新。

IF 2.5 4区医学

Archives of Virology Pub Date : 2024-12-13 DOI: 10.1007/s00705-024-06186-1

Arvind Varsani, Andrew Hopkins, Michael C Lund, Mart Krupovic

{"title":"2024 taxonomic update for the families Naryaviridae, Nenyaviridae, and Vilyaviridae","authors":"Arvind Varsani, Andrew Hopkins, Michael C Lund, Mart Krupovic","doi":"10.1007/s00705-024-06186-1","DOIUrl":"10.1007/s00705-024-06186-1","url":null,"abstract":"<div>The families Naryaviridae (order Rivendellvirales), Nenyaviridae (order Rohanvirales), and Vilyaviridae (order Cirlivirales), all within the class Arfiviricetes of the phylum Cressdnaviricota, include single-stranded DNA viruses associated with protozoan parasites of the genera Entamoeba and Giardia as well as viruses found in various environmental samples, also likely infecting protozoans. Here, we provide a taxonomic update for these three families, which were recently expanded with multiple new members. In particular, we established seven new genera and nine new species in the family Naryaviridae, one new genus with one new species in the family Nenyaviridae, and three new genera and nine new species in the family Vilyaviridae. We also summarize the genomic properties and protein characteristics, including conserved motifs of the rolling-circle replication initiation proteins, of the viruses in the three families. Notably, the high GC content of vilyavirids (51–61%) and considerably lower GC content of naryavirids and nenyavirids (33–44%) appear to represent an adaptation to their hosts, Giardia and Entamoeba species, respectively.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0