Archives of Virology最新文献_第3页

Effectiveness of inactivated COVID-19 vaccine against symptom severity in hospitalized COVID-19 patients infected with the Omicron variant

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-24 DOI: 10.1007/s00705-025-06275-9

Qing-Yan Ye, Zhi-Tian Jiang, Yun Jiang, Jing-Wen Cai, Zhen Zhou, Jie Song, Qian Wang, Qi-Qi Wu, Gang Zhao, Jia Chen, Qi-Hua Ling

{"title":"Effectiveness of inactivated COVID-19 vaccine against symptom severity in hospitalized COVID-19 patients infected with the Omicron variant","authors":"Qing-Yan Ye, Zhi-Tian Jiang, Yun Jiang, Jing-Wen Cai, Zhen Zhou, Jie Song, Qian Wang, Qi-Qi Wu, Gang Zhao, Jia Chen, Qi-Hua Ling","doi":"10.1007/s00705-025-06275-9","DOIUrl":"10.1007/s00705-025-06275-9","url":null,"abstract":"<div><p>In this study, we analysed the outcomes of 1165 symptomatic patients infected with the SARS-CoV-2 Omicron BA.2 variant and their response to Sinovac-CoronaVac vaccination. We assessed the effectiveness of vaccination against adverse outcomes (severe, critical, or fatal cases). Of these patients, 504 (43.3%) were men, the median age was 71 years, and 391 patients (66.4%) had received the Sinovac-CoronaVac COVID-19 vaccine (Sino Pharma, Beijing, China). The percentages of severe, critical, and fatal cases were 3.9%, 2.8%, and 3.7%, respectively, with significantly lower rates among vaccinated patients (2.8% vs. 14.2%; adjusted odds ratio [aOR], 0.306; 95% confidence interval [95% CI], 0.129–0.727). Age ≥ 70 years and a CRP level > 8 mg/L were independent predictors of an adverse outcome. Out of 630 patients aged ≥ 70 years, 107 (17.0%) were vaccinated. Seven vaccinated patients (6.5%) and 94 unvaccinated patients (18.0%) experienced adverse outcomes. Multivariate analysis indicated that vaccination (OR, 0.401; 95% CI 0.162–0.991) and CRP levels > 8 mg/L (OR, 3.262; 95% CI 1.754–6.067) were independently associated with adverse outcomes in patients aged ≥ 70 years. Inactivated vaccines were effective against symptomatic and severe COVID-19. Even in symptomatic Omicron infections, full vaccination with inactivated vaccines significantly reduced the number of adverse cases, especially in patients aged ≥ 70 years. Systemic inflammation (as measured by the CRP level) was independently correlated with adverse outcomes in patients infected with Omicron BA.2.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization of a novel gammascleroulivirus from the rice blast fungus Magnaporthe oryzae isolate ES155 来自稻瘟病真菌 Magnaporthe oryzae ES155 分离物的一种新型甘马氏硬核病毒的分子鉴定

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-23 DOI: 10.1007/s00705-025-06267-9

Cong Li, Yuxin Wu, Xinyi Li, Hongliu An, Shouguo Fang, Songbai Zhang, Qingchao Deng

引用次数: 0

The resurgence of monkeypox clade Ib: a global health emergency and concern

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-21 DOI: 10.1007/s00705-025-06270-0

Suresh Kumar, Gunasekaran Subramaniam, K. J. Senthil Kumar

引用次数: 0

Characterization of two novel mitoviruses co infecting a single strain of Fusarium pseudograminearum causing wheat crown rot

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-19 DOI: 10.1007/s00705-025-06242-4

Xin Pan, Yuan Xie, Shuwei Yan, Xiaoting Zhang, Xinxin Liu, Youzhou Jiao, Fei Gao

{"title":"Characterization of two novel mitoviruses co infecting a single strain of Fusarium pseudograminearum causing wheat crown rot","authors":"Xin Pan, Yuan Xie, Shuwei Yan, Xiaoting Zhang, Xinxin Liu, Youzhou Jiao, Fei Gao","doi":"10.1007/s00705-025-06242-4","DOIUrl":"10.1007/s00705-025-06242-4","url":null,"abstract":"<div><p>Wheat crown rot (WCR), caused by <i>Fusarium pseudograminearum</i>, poses a threat to wheat production worldwide. Two mycoviruses, designated as \"Fusarium pseudograminearum mitovirus 2\" (FupgMV2) and \"Fusarium pseudograminearum mitovirus 3\" (FupgMV3), were identified in <i>F. pseudograminearum</i> strain YY514-10-2. The two viral genomes are 2,429 and 2,450 nucleotides long, each containing a single open reading frame (ORF) encoding a 724-amino-acid-long RNA-dependent RNA polymerase (RdRp), with 31.98% amino acid sequence identity to each other. BLASTp analysis revealed that the RdRp of FupgMV2 exhibits at least 88.84% amino acid sequence identity to that of Fusarium mitovirus 1, while the RdRp of FupgMV3 shows 80.19% amino acid sequence identity to that of Fusarium mitovirus 2. Phylogenetic analysis indicated that FupgMV2 and FupgMV3 both belong to the genus <i>Unuamitovirus</i> of the family <i>Mitoviridae</i>. This is the first report of two mitoviruses hosted by the same strain of the plant-pathogenic fungus <i>F. pseudograminearum</i>.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Humoral immune response characteristics of vulnerable populations against SARS-CoV-2 strains EG.5 and JN.1 after infection with strains BA.5 and XBB

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-18 DOI: 10.1007/s00705-025-06248-y

Huan Zhang, Shi Ouyang, Yunyun Qu, Zhuolin Li, Yushan Jiang, Tingting Peng, Guangyan Yang, Tao Chen, Baisheng Li, Chenguang Shen, Wei Zhao

{"title":"Humoral immune response characteristics of vulnerable populations against SARS-CoV-2 strains EG.5 and JN.1 after infection with strains BA.5 and XBB","authors":"Huan Zhang, Shi Ouyang, Yunyun Qu, Zhuolin Li, Yushan Jiang, Tingting Peng, Guangyan Yang, Tao Chen, Baisheng Li, Chenguang Shen, Wei Zhao","doi":"10.1007/s00705-025-06248-y","DOIUrl":"10.1007/s00705-025-06248-y","url":null,"abstract":"<div><p>In this study, we compared the humoral immune characteristics of children, elderly individuals, and pregnant women in Guangzhou, China, who had been infected with the SARS-CoV-2 strains BA.5 and XBB against the currently predominant strains EG.5 and JN.1. It was discovered that the neutralizing antibody titers in children, elderly individuals, and pregnant women against strains EG.5 and JN.1 were low in individuals who had been infected with strain BA.5, irrespective of their vaccination status. There was a significant positive correlation between the neutralization titers against JN.1 and EG.5 in both the acute and convalescent phases of BA.5 infection. For XBB-infected patients, the sera in the acute stage exhibited a low neutralizing titer against EG.5 and JN.1, whereas the convalescent sera demonstrated a significantly higher neutralizing titer against the two viruses, particularly in infected individuals who had been vaccinated. For XBB-infected patients, there was a strong positive correlation between the serum neutralizing antibody titers against EG.5 and JN.1 in both the acute and recovery phases. This finding provides crucial information for judging the epidemic trend of COVID-19 and the development of vaccines, especially for developing customized vaccines and immune strategies for different populations.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterization of a novel mycovirus from Curvularia lunata in China

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-17 DOI: 10.1007/s00705-025-06268-8

Bin Ke, Xiaohan Mo, Mengting Wu, Lin Wang, Ru Peng, Yuwen Lu, Jiejun Peng, Shaofei Rao, Guanwei Wu, Jianping Chen, Fei Yan, Hongying Zheng

{"title":"Molecular characterization of a novel mycovirus from Curvularia lunata in China","authors":"Bin Ke, Xiaohan Mo, Mengting Wu, Lin Wang, Ru Peng, Yuwen Lu, Jiejun Peng, Shaofei Rao, Guanwei Wu, Jianping Chen, Fei Yan, Hongying Zheng","doi":"10.1007/s00705-025-06268-8","DOIUrl":"10.1007/s00705-025-06268-8","url":null,"abstract":"<div><p>A novel mycovirus was identified in <i>Curvularia lunata</i> in China using high-throughput sequencing and RT-PCR, and the virus was named \"Curvularia lunata RNA virus 1\" (ClRV1). The genome of ClRV1 consists of 3,742 nucleotides and contains two open reading frames (ORFs). In a BLASTn search based on the complete genome sequence of ClRV1, this virus was found to have the most sequence similarity to Erysiphe necator associated umbra-like virus 4 (EnUlV4) (74% identity, 54% query coverage), and BLASTp searches showed that the ClRV1 HP and RdRp shared the highest amino acid sequence identity of 66.5% and 74.7%, respectively, with the corresponding proteins of EnUlV4. Phylogenetic analysis based on RdRp amino acid sequences indicated that ClRV1 grouped together with EnUlV4 and a number of other mycoviruses that have been variously named ‘ambiguiviruses’, ‘mycotombusviruses’, and ‘umbramycoviruses’, which appears to justify the creation of a new order within the phylum <i>Kitrinoviricota.</i> This is the first report of the complete genome sequence of the novel mycovirus ClRV1 infecting <i>Curvularia lunata</i>.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purification and serological detection of maize yellow mosaic virus

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-14 DOI: 10.1007/s00705-025-06249-x

Jennifer R. Wilson, Kristen J. Willie, Nitika Khatri

{"title":"Purification and serological detection of maize yellow mosaic virus","authors":"Jennifer R. Wilson, Kristen J. Willie, Nitika Khatri","doi":"10.1007/s00705-025-06249-x","DOIUrl":"10.1007/s00705-025-06249-x","url":null,"abstract":"<div><p>Maize yellow mosaic virus (MaYMV) is an emerging polerovirus that was first reported in maize in China in 2013 but has since been reported in Africa and the Americas. Due to its novelty, no antibodies or serological diagnostics for the virus existed prior to the current study. In this study, we developed the first purification method for maize yellow mosaic virus with the goal of generating an antibody and subsequently developing diagnostic tests. Yields of 0.634–1.275 milligrams of virus per kilogram of maize tissue were obtained, which is comparable to the yields obtained for other grass-infecting poleroviruses. Under an electron microscope, purified virus particles appear icosahedral in shape and roughly 30 nm in diameter. A polyclonal antibody was generated against the gradient-purified virus preparation and cross-adsorbed to uninfected maize tissue. The antibody is effective for detection of MaYMV via enzyme-linked immunosorbent assay (ELISA) and western blot. The ELISA could detect virus in quantities as low as 0.395 µg and in 1:32 dilutions of infected plant extract, and the antibody showed little to no cross-reactivity with five closely related viruses. After protein gel electrophoresis and antibody detection, protein bands corresponding in size to two viral structural proteins could be seen: the coat protein of roughly 21 kDa and the readthrough protein, around 72 kDa. Finally, virus particles purified using this protocol were found to be transmissible by the primary aphid vector, <i>Rhopalosiphum maidis</i>, and to cause systemic, symptomatic infection of maize plants, indicating that the vector transmissibility and infectivity of the virus particles were preserved during purification.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of a betaendornavirus isolated from the edible fungus Morchella sextelata

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-14 DOI: 10.1007/s00705-025-06264-y

Ruiling Lyu, Junlin Chen, Qing Tang, Du Hai, Tun Wu, Huagang Xiao, Jiatao Xie, Yang Xiao

引用次数: 0

Im Memoriam Marc H. V. van Regenmortel (1934-2024)

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-14 DOI: 10.1007/s00705-025-06260-2

Dion du Plessis

引用次数: 0

The final cut: how giant viruses of protists are released from their hosts’ cells

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-03-13 DOI: 10.1007/s00705-025-06261-1

Isabella Luiza Martins de Aquino, Bruna Luiza Azevedo, Nidia Esther Colquehuanca Arias, Matheus Felipe dos Reis Rodrigues, Jônatas Santos Abrahão

{"title":"The final cut: how giant viruses of protists are released from their hosts’ cells","authors":"Isabella Luiza Martins de Aquino, Bruna Luiza Azevedo, Nidia Esther Colquehuanca Arias, Matheus Felipe dos Reis Rodrigues, Jônatas Santos Abrahão","doi":"10.1007/s00705-025-06261-1","DOIUrl":"10.1007/s00705-025-06261-1","url":null,"abstract":"<div><p>Viruses are the most abundant biological entities on Earth, with an estimated 10<sup>31</sup> viruses in the biosphere. These particles serve as the crucial link between viral replication cycles in different host cells, employing a variety of release mechanisms, such as cell lysis, exocytosis, and budding. Among the diverse viral groups, giant viruses have garnered significant scientific interest due to their complex particles and genomes. Giant viruses may infect amoebae and other unicellular protists, exhibiting remarkable variation in size, shape, and symmetry. They belong to the realm <i>Varidnaviria</i>, kingdom <i>Bamfordvirae</i>, and phylum <i>Nucleocytoviricota</i>. This review examines the diverse viral release strategies employed by giant viruses, highlighting the mechanisms they use to exit host cells. These include the induction of cell lysis, vesicle formation, and exocytosis, which vary not only between different species but also within individual viral groups. The diversity of release mechanisms reflects the complex evolutionary adaptations of giant viruses, providing information about their biology and life cycles.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0