Archives of Virology最新文献

{"title":"Pharmacological advances in HIV treatment: from ART to long-acting injectable therapies","authors":"Krzysztof Łupina,&nbsp;Klaudia Nowak,&nbsp;Dominika Lorek,&nbsp;Adrian Nowak,&nbsp;Anna Romac,&nbsp;Ewelina Głowacka,&nbsp;Jakub Janczura","doi":"10.1007/s00705-025-06381-8","DOIUrl":"10.1007/s00705-025-06381-8","url":null,"abstract":"<div><p>Human immunodeficiency virus (HIV) remains a global public health challenge, affecting millions worldwide despite significant advancements in antiretroviral therapy (ART). While ART has transformed HIV into a manageable chronic condition, long-term adherence, drug resistance, and access disparities continue to hinder treatment success. Recent research has focused on developing alternative therapeutic strategies, particularly long-acting injectable (LAI) therapies and immunotherapeutic approaches to improve adherence and potentially achieve viral remission. This review explores the evolution of pharmacological advancements in HIV treatment, highlighting the transition from daily oral ART to long-acting formulations such as cabotegravir, rilpivirine, and lenacapavir. LAI therapies reduce the burden of daily adherence, enhance treatment efficacy, and decrease stigma, particularly in vulnerable populations. Additionally, novel immunotherapeutic strategies such as broadly neutralizing antibodies, immune checkpoint inhibitors, and chimeric antigen receptor T cell therapy are being investigated for their potential to induce long-term viral suppression or cure. Despite these promising developments, several challenges remain, including resistance-associated mutations, accessibility issues, and long-term safety concerns. This review summarizes recent clinical trials, discusses the benefits and limitations of emerging HIV therapies, and outlines future research directions. The continued advancement of LAI therapies and immunotherapeutics holds great potential to improve treatment outcomes, expand global access to care, and move closer to a functional cure for HIV.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00705-025-06381-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144868866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two novel mitoviruses isolated from the filamentous fungus Gnomoniopsis sanguisorbae","authors":"Zhenmei Song,&nbsp;Juan Yang,&nbsp;Lina Zeng,&nbsp;Hongmei Liu,&nbsp;Lu Liang,&nbsp;Tingting Zhang","doi":"10.1007/s00705-025-06387-2","DOIUrl":"10.1007/s00705-025-06387-2","url":null,"abstract":"<div><p>In this study, we isolated two novel mitoviruses co-infecting the fungus <i>Gnomoniopsis sanguisorbae</i>, which were designated as “Gnomoniopsis sanguisorbae mitovirus L” (GsMV-L) and “Gnomoniopsis sanguisorbae mitovirus M” (GsMV-M). The complete genome lengths of GsMV-L and GsMV-M were determined to be 2,785 and 2,529 nucleotides, respectively, with a GC content of 44% and 35%, respectively. Both viruses possess a single open reading frame (ORF) that encodes an RNA-dependent RNA polymerase (RdRp) containing conserved catalytic motifs. BLASTp analysis revealed that the RdRps of GsMV-L and GsMV-M exhibited the highest amino acid sequence similarity to those of sunflower phomopsis-associated mitovirus 1 and Phomopsis viticola mitovirus 962_1, with 50.97% and 41.97% identity, respectively. Phylogenetic analysis based on RdRp sequences indicated that GsMV-L clustered with members of the genus <i>Triamitovirus</i>, while GsMV-M clustered with members of the genus <i>Unuamitovirus</i>, both of which are taxonomically classified within the family <i>Mitoviridae</i>. </p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144868867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phylogenomic analysis of bovine astrovirus expands the known repertoire of mamastrovirus genotypes in northern India","authors":"Raman Mehtani,&nbsp;Parveen Kumar,&nbsp;Sanjeevna K. Minhas,&nbsp;Ritu Panghal,&nbsp;Anshul Lather,&nbsp;Rajeev Kumar,&nbsp;Puneet Singh,&nbsp;Deepika Sheoran,&nbsp;Akhil K. Gupta,&nbsp;Rajesh Chhabra,&nbsp;Naresh Jindal","doi":"10.1007/s00705-025-06385-4","DOIUrl":"10.1007/s00705-025-06385-4","url":null,"abstract":"<div><p>Bovine astrovirus (BoAstV) belongs to the family <i>Astroviridae</i> and the genus <i>Mamastrovirus</i> (MAstV). Phylogenomic analysis based on partial sequences of the RNA-dependent RNA polymerase (RdRp) gene has allowed BoAstV isolates to be classified into the genotypes MAstV-13, 24, 28–30, and 33–35. However, information about the clinical significance and molecular characteristics of BoAstV from India is restricted to a single study from western Maharashtra, India. In this study, using RT-PCR detection of a portion of the RdRp gene, we investigated the presence of BoAstV in 134 rectal swabs samples from diarrheic and non-diarrheic calves less than three months of age from four states of North India (Rajasthan, Uttar Pradesh, Himachal Pradesh, and Haryana). Of these, 31 (23.1%) samples tested positive for BoAstV, with a higher rate of positivity in calves less than one month of age (30%, 21/70) than in calves between 1 and 3 months of age (15.6%, 10/64). Phylogenetic analysis based on partial RdRp gene sequences revealed the circulation of four different genotypes (MAstV 28, MAstV-33, MAstV-35, and MAstV-3) in Haryana. To the best of our knowledge, this is the first report of the presence of bovine astrovirus in cattle and buffalo calves in North India and of genotype MAstV-3 in calves.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of recent pre-booster studies on hepatitis B vaccine effectiveness across WHO regions with HBV prevalence above 1% in the general population up to 60 years of age: a systematic review","authors":"Tahereh Zadeh Mehrizi,&nbsp;Babak Eshrati,&nbsp;Hasan Ebrahimi Shahmabadi","doi":"10.1007/s00705-025-06382-7","DOIUrl":"10.1007/s00705-025-06382-7","url":null,"abstract":"<div>\u0000 \u0000 <p>Hepatitis B vaccination has substantially reduced the global burden of HBV infection. However, the long-term vaccine effectiveness (VE) and the need for booster doses are still uncertain, especially in some age groups living in meso- and hyperendemic regions. WHO has therefore emphasized the need for further studies to identify subgroups requiring booster doses to ensure sufficient levels of protection against HBV infection. Accordingly, in the present review, we evaluate VE and the need for booster doses among healthy urban populations aged up to 60 years in the WHO regions where the HBV prevalence exceeds 1%. This systematic review included studies reporting VE stratified by age that expressed estimates as odds ratios, risk ratios, or absolute risk. Of the 2,421 studies identified in PubMed, Web of Science, and Scopus, 11 met the inclusion criteria. There were significant age-related trends in VE. Among the 20- to 59-year-olds, especially the 20–39 age group, the effectiveness was the lowest in the Eastern Mediterranean Region, namely Tunisia and Iran. In China, the highest breakthrough infection rates were reported in the 18–29 age group, highlighting the significance of considering booster doses for enhanced protection in this population. The highest-risk ages in Vietnam were found to be 33.7, 53.8, and 24.9 years. In Africa, although the effectiveness was high among those who had received complete vaccine dosages, it declined among those aged 30–59 years with increasing age. Increased abnormal ALT rates with advancing age, a predictor of chronic HBV infection, also highlighted the need for additional booster immunizations in Taiwan and Gambia. The results indicate waning vaccine effectiveness, particularly in individuals 20–59 years old in meso- to hyper-endemic regions. These findings strongly support revisiting the vaccination schedules with consideration for targeted booster doses to maintain immunity for a longer period. This review also highlights the fact that the assessment of vaccine effectiveness and its side effects in various age and geographical groups is incomplete.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144853651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A feedback loop between DNA damage, genomic instability, and cytoplasmic DNA sensing contributes to cytokine production in COVID-19","authors":"Miguel A. Fernández-Rojas,&nbsp;Ana María Salazar,&nbsp;Patricia Ostrosky-Wegman,&nbsp;Ana Flisser,&nbsp;Fela Mendlovic","doi":"10.1007/s00705-025-06383-6","DOIUrl":"10.1007/s00705-025-06383-6","url":null,"abstract":"<div><p>Since the onset of the COVID-19 pandemic, several studies have investigated the inflammatory responses triggered by SARS-CoV-2 infection. In 2021, it was proposed that the cytokine storm observed in patients with severe COVID-19 may be initiated by sensing of cytoplasmic DNA released by micronuclei, which arises as a consequence of virus-induced genomic instability. Subsequent studies have described the presence of micronuclei and other genotoxic and cytotoxic markers in COVID-19 patients. However, the association between the development of a cytokine storm and cytoplasmic DNA sensing remains to be fully elucidated. In this review, we summarize current evidence on the dysregulated cytokine production in response to the detection of genetic material during SARS-CoV-2 infection. We focused mainly on the dysregulated production of cytokines induced by the activation of cytosolic DNA sensing pathways that promote inflammation. We emphasize the need to analyze the contribution of these signaling complexes to COVID-19 pathophysiology. DNA sensing amplifies the inflammatory response and plays a crucial role in the pathogenesis of severe disease manifestations observed in infected patients. Understanding this complex interplay can provide insights into potential therapeutic targets aimed at mitigating the hyper-inflammatory responses seen in severe COVID-19 cases.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00705-025-06383-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144810722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of canine distemper virus (CDV) infection and expression of its receptors nectin-4 and SLAM in uterine samples of dogs: can CDV cause persistent uterine infection?","authors":"Hakan Aydin,&nbsp;Serkan Yildirim,&nbsp;Mehmet Ozkan Timurkan,&nbsp;Gizem Eser","doi":"10.1007/s00705-025-06376-5","DOIUrl":"10.1007/s00705-025-06376-5","url":null,"abstract":"<div><p>Canine distemper virus (CDV) causes highly contagious, systemic, and fatal infections of domestic carnivores worldwide. The high genetic and antigenic variability of the CDV H protein and the specificity of its interaction with signaling lymphocyte activation molecule (SLAM) and nectin-4 play a crucial role in determining the host specificity and tropism of the virus. It remains to be definitely established whether CDV may be localised in the urogenital tract or cause abortions in pregnant dogs. In this study, we investigated SLAM- and nectin-4-associated CDV infection of uterine tissue and adaptation of CDV to uterine tissue of dogs. For this purpose, 100 canine uterus samples were included in the study. CDV was detected by PCR in dogs without clinical signs, and molecular characterization of the virus was performed by bioinformatic analysis and comparison of partial amino acid sequences of the CDV H protein. In these uterine tissues infected with CDV, cellular SLAM and nectin-4 expression using histopathological, immunohistochemical, and immunofluorescence techniques. Sequence analysis showed that CDV strains belonging to the Asia-1 lineage are circulating in dogs in Türkiye and are responsible for uterine infections. Pathological analysis revealed increased SLAM and nectin-4 expression in CDV-infected uterine tissues compared to healthy uterine tissues. CDV was detected in 13 out of 100 uterine specimens tested, and increased expression of SLAM and nectin-4 was demonstrated for the first time in infected uterine tissues. Molecular and pathological analysis indicated that CDV may play a role in receptor-associated uterine infections. The data from this study will provide a basis for more extensive future research.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five novel RNA viruses of the invasive big-headed ant (Pheidole megacephala)","authors":"Charly T. Hartle,&nbsp;Chih-Chi Lee,&nbsp;Hung-Wei Hsu,&nbsp;Chun-Yi Lin,&nbsp;Kuan-Ling Liu,&nbsp;Joey Yin-Xin Chang,&nbsp;John A. Lawrence,&nbsp;Jia-Wei Tay,&nbsp;Chin-Cheng Scotty Yang","doi":"10.1007/s00705-025-06375-6","DOIUrl":"10.1007/s00705-025-06375-6","url":null,"abstract":"<div><p>The African big-headed ant, <i>Pheidole megacephala</i>, is one of the most destructive invasive ant species, posing a significant threat to native biodiversity and ecosystem function, particularly in island ecosystems. Despite recent efforts to characterize pathogens in other major invasive ants, <i>P</i>. <i>megacephala</i> has received comparatively little attention. In this study, we characterized five novel RNA viruses actively replicating in <i>P</i>. <i>megacephala</i>, which we have named Pheidole megacephala virus 1–5 (PmV1-5), and examined viral diversity and prevalence in two invasive populations in Taiwan and Hawaii. This ant possesses a unique trait of true morphological worker dimorphism (major and minor), allowing us to test whether virus prevalence differs between the major and minor worker castes. Our findings indicate that all five novel viruses were present in both populations, but viral prevalence was higher in Hawaii than in Taiwan, potentially due to differences in supercolony structure. Multiple-virus infections were common, with coinfection by PmV1 and PmV5 being the most frequent. Notably, we found no significant difference in infection patterns between major and minor workers, suggesting that virus distribution is stable within colonies and that sampling different castes does not introduce bias in pathogen detection. This study represents the first characterization of viral pathogens in <i>P</i>. <i>megacephala</i> and may contribute to the development of microbial control strategies against this globally invasive ant.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12328527/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characterization of a novel chrysovirus isolated from the phytopathogenic fungus Fusarium commune","authors":"Wen Xin Huang,&nbsp;Li E Yang,&nbsp;Yan Bin Huang,&nbsp;Tao Sha Xu,&nbsp;Jie Zhong,&nbsp;Ya Rong Wang,&nbsp;Yan Song Xiao","doi":"10.1007/s00705-025-06363-w","DOIUrl":"10.1007/s00705-025-06363-w","url":null,"abstract":"<div><p>In this study, a novel double-stranded RNA (dsRNA) mycovirus was isolated from the phytopathogenic fungus <i>Fusarium commune</i>, the causal agent of tobacco root rot, and designated \"Fusarium commune chrysovirus 1\" (FcCV1). The complete genome of FcCV1 consists of five dsRNA fragments with lengths of 3670 bp, 3242 bp, 2866 bp, 2829 bp, and 1258 bp, designated as dsRNA1 to dsRNA5 according to their size. Each of these five dsRNA segments contains a single open reading frame (ORF), designated ORF1 to ORF5, with strictly conserved termini in their 5′ and 3′ untranslated regions. Notably, ORF1 encodes a potential RNA-dependent RNA polymerase (RdRp) comprising 1151 amino acids (aa), which exhibits the highest sequence identity (56.14%) with the RdRp of Tolypocladium cylindrosporum virus 2 (TcV2). ORF2, ORF3, and ORF5 encode hypothetical proteins of unknown function, displaying amino acid sequence similarity to proteins encoded by different dsRNAs of chrysoviruses. ORF4 encodes a predicted coat protein (CP). Phylogenetic analysis based on RdRp sequences placed FcCV1 within the genus <i>Betachrysovirus</i> of the family <i>Chrysoviridae</i>. This is the first report of a novel chrysovirus infecting <i>F. commune</i>.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 9","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and genetic evolution of Muscovy duck parvovirus in Guangdong province","authors":"Hao Liu,&nbsp;Yao Qin,&nbsp;Yuan-yuan Hu,&nbsp;Ling Zhang,&nbsp;Xin-yu Zhang,&nbsp;Jieyu Xie,&nbsp;Shu-ting Chen,&nbsp;Jia-fan Liu,&nbsp;Lixia Li","doi":"10.1007/s00705-025-06371-w","DOIUrl":"10.1007/s00705-025-06371-w","url":null,"abstract":"<div><p>In this study, we analyzed 137 liver samples collected from deceased Muscovy ducks in Guangdong, China, between 2020 and 2023. The Muscovy duck parvovirus (MDPV) strain GD2407 was isolated from these samples, and its genome sequence was determined. The genome of MDVP strain GD2407 is 5067 nt in length, encoding both non-structural and structural proteins, and its genome sequence is 99.9% identical to that of strain GDZJ1901. Recombination analysis suggested that strain GD2407 originated from a recombination event between MDPV and goose parvovirus (GPV). Phylogenetic analysis showed that strain GD2407 is genetically closely related to strain GDZJ1901 but distinct from strain GD201911, which was prevalent before 2020. These findings suggest that the circulation of MDPV in this region may contribute to illness and mortality in ducks. </p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and characterisation of Klebsiella pneumoniae bacteriophages vB_Kpn_Lilla1 and vB_Kpn_Lilla2","authors":"Timothy Martin,&nbsp;Liana Theodoridis,&nbsp;Emma Stent,&nbsp;Julia Lilla,&nbsp;Steve Petrovski","doi":"10.1007/s00705-025-06374-7","DOIUrl":"10.1007/s00705-025-06374-7","url":null,"abstract":"<div><p><i>Klebsiella pneumoniae</i> is an opportunistic pathogen that is commonly associated with pulmonary infections. It is of particular concern due to its increasing resistance to antibiotics, particularly carbapenem. Alternative treatments for these bacterial infections are required, and phage application is an attractive option. In this study, we isolated two novel <i>Klebsiella pneumonia</i> bacteriophages from wastewater, vB_Kpn_Lilla1 and vB_Kpn_Lilla2, both of which have lytic activity against <i>Klebsiella oxytoca</i> and <i>Klebsiella michiganensis</i>. Genome sequencing and phylogenetic analysis revealed that both phages belong to the family <i>Straboviridae</i>, with vB_Kpn_Lilla1 belonging to the genus <i>Jiaodavirus</i> and vB_Kpn_Lilla2 belonging to the genus <i>Slopekvirus</i>. Growth kinetics showed an effective reduction of <i>K. pneumoniae</i> populations when infected with either phage.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}