Archives of Virology最新文献_第2页

Biological characteristics and genome analysis of Citrobacter freundii phage K1M 弗氏柠檬酸杆菌噬菌体K1M的生物学特性及基因组分析

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-25 DOI: 10.1007/s00705-025-06291-9

Keming Xie, Chang Liu, Guangfeng Liu, Peng Zhu, Zheng Yang, Lihong Yuan, Jingzhe Jiang

引用次数: 0

A foot-and-mouth disease virus serotype O field strain from an outbreak in India has a three-codon deletion in the 3A coding region 来自印度暴发的口蹄疫病毒血清O型野毒株在3A编码区有三个密码子缺失

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-24 DOI: 10.1007/s00705-025-06286-6

Shyam Singh Dahiya, Saravanan Subramaniam, Sagar Sangam Rautaray, Manoranjan Rout, Jajati Keshari Mohapatra, Rabindra Prasad Singh

{"title":"A foot-and-mouth disease virus serotype O field strain from an outbreak in India has a three-codon deletion in the 3A coding region","authors":"Shyam Singh Dahiya, Saravanan Subramaniam, Sagar Sangam Rautaray, Manoranjan Rout, Jajati Keshari Mohapatra, Rabindra Prasad Singh","doi":"10.1007/s00705-025-06286-6","DOIUrl":"10.1007/s00705-025-06286-6","url":null,"abstract":"<div>In this study, we performed the first comprehensive analysis of the 3A region of foot-and-mouth disease virus (FMDV) serotype O isolates from India, covering a period of 60 years. Frequent substitutions were observed in the hypervariable C-terminal region, aligning with patterns seen in other serotypes. One isolate from an outbreak in 2021 displayed a unique three-codon deletion at positions 138-140, similar to deletions in serotype O viruses from Cambodia and Vietnam. While deletions in this region are tolerated, this change appears to have been a random event without long-term evolutionary benefit, as the strain did not persist in the field. Approximately 48% of the codons were found to be under purifying selection, while only four codons (132, 134, 143, and 146), all in the C-terminal half, showed signs of positive selection. Episodic selection further influenced positions 109, 125, 132, 134, 143, and 146, with transient bursts of positive selection amidst purifying pressure. This interplay likely drives adaptive evolution, enhancing viral fitness in the 3A region. The mean evolutionary rate of the 3A region of serotype O strains from 1962 to 2023 was estimated to be 2.594 × 10⁻3 substitutions/site/year, with a 95% highest posterior density interval of 1.759 × 10⁻3 to 3.419 × 10⁻3. This rate is comparable to estimates for the VP1 region of serotype O, aligning closely with rates for Indian (6.338 × 10⁻3 s/s/y), East African (2.7 × 10⁻3 s/s/y), and global (4.81 × 10⁻3 s/s/y) isolates.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refining the taxonomy of pithovirus-related giant DNA viruses within the order Pimascovirales 改进了皮炎病毒目中与皮炎病毒相关的巨型DNA病毒的分类

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-24 DOI: 10.1007/s00705-025-06297-3

Jean-Michel Claverie, Matthieu Legendre, Sofia Rigou, Chantal Abergel

{"title":"Refining the taxonomy of pithovirus-related giant DNA viruses within the order Pimascovirales","authors":"Jean-Michel Claverie, Matthieu Legendre, Sofia Rigou, Chantal Abergel","doi":"10.1007/s00705-025-06297-3","DOIUrl":"10.1007/s00705-025-06297-3","url":null,"abstract":"<div>The first member of the family Pithoviridae (Pithovirus sibericum) was isolated from ancient Siberian permafrost and characterized in 2014. Since then, many relatives have been isolated, characterized, and classified as members of the genera Alphapithovirus, Alphacedratvirus, and Alphaorpheovirus. In addition, one complete circular genome sequence was assembled from metagenomic data (hydrivirus). All of these viruses form distinctive giant elongated ovoid particles, up to 2 µm in length, but they differ significantly in the size of their genome, their nucleotide composition, and their gene content. Based on their shared ovoid virion shape, common replication strategy, and core gene similarity, we recently proposed to update their taxonomic status by classifying them in three distinct families (Pithoviridae, Orpheoviridae, and Hydriviridae) within a new suborder, the Ocovirineae, to separate them clearly from the other more distant families (Marseilleviridae, Ascoviridae, Iridoviridae) of the order Pimascovirales. This new taxonomy, validated by the last ICTV Ratification vote held in March 2025, extends the previous partition from three clades to four (to include hydrivirus) while keeping the genera Alphacedratvirus and Alphapithovirus in the same family, Pithoviridae (but split into two subfamilies), due to their much greater similarity to each other than to orpheovirus and hydrivirus.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143865522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discovery of a novel alphasatellite of the genus Clecrusatellite associated with a wide array of New World tomato-infecting begomoviruses 发现了一种与大量新世界感染番茄的begomovirus相关的新α星属

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-22 DOI: 10.1007/s00705-025-06293-7

Luciane de Nazaré A. dos Reis, Leonardo S. Boiteux, Maria Esther N. Fonseca, Rita de Cássia Pereira-Carvalho

{"title":"Discovery of a novel alphasatellite of the genus Clecrusatellite associated with a wide array of New World tomato-infecting begomoviruses","authors":"Luciane de Nazaré A. dos Reis, Leonardo S. Boiteux, Maria Esther N. Fonseca, Rita de Cássia Pereira-Carvalho","doi":"10.1007/s00705-025-06293-7","DOIUrl":"10.1007/s00705-025-06293-7","url":null,"abstract":"<div>A new alphasatellite was discovered via high-throughput sequencing in mixed infections with five distinct tomato-infecting begomoviruses in central Brazil, and the presence of this alphasatellite in tomato leaf samples was confirmed by PCR and Sanger sequencing. It has a circular genome of 1,321 nucleotides with typical features of alphasatellites belonging to the subfamily Geminialphasatellitinae, including a replication-associated hairpin sequence (TAGTATTAC) and an open reading frame encoding a replication-associated protein. Pairwise sequence comparisons and phylogenetic analysis indicated that this alphasatellite represents a new species, with 69–77% sequence identity to other members of the genus Clecrusatellite. Tomato golden vein virus (TGVV) was the only begomovirus present in all six positive samples. However, it was not possible to determine which of these viruses can function as a helper virus for the alphasatellite. The species name \"Clecrusatellite solanumbrasiliensis\" is proposed to classify this alphasatellite associated with endemic Brazilian begomoviruses. To our knowledge, this is the first report of a tomato-associated alphasatellite in the New World.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macroptilium yellow vein virus (Begomovirus macroptilivenae) associated with Macroptilium plants is geographically structured into divergent subpopulations 与巨麻属植物相关的巨麻黄脉病毒（巨麻begomvirus macroptilivenae）在地理上被划分为不同的亚群

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-22 DOI: 10.1007/s00705-025-06295-5

Aline Marques Melo, Ayane Fernanda Ferreira Quadros, João Paulo Herrera da Silva, Roberto Ramos-Sobrinho, Mayra Machado de Medeiros Ferro, Sarah Jacqueline Cavalcanti da Silva, Iraildes Pereira Assunção, Gaus Silvestre de Andrade Lima, F. Murilo Zerbini

{"title":"Macroptilium yellow vein virus (Begomovirus macroptilivenae) associated with Macroptilium plants is geographically structured into divergent subpopulations","authors":"Aline Marques Melo, Ayane Fernanda Ferreira Quadros, João Paulo Herrera da Silva, Roberto Ramos-Sobrinho, Mayra Machado de Medeiros Ferro, Sarah Jacqueline Cavalcanti da Silva, Iraildes Pereira Assunção, Gaus Silvestre de Andrade Lima, F. Murilo Zerbini","doi":"10.1007/s00705-025-06295-5","DOIUrl":"10.1007/s00705-025-06295-5","url":null,"abstract":"<div>The genus Begomovirus (family Geminiviridae) includes plant viruses that have a negative impact on the production of several economically important crops worldwide. Begomoviruses infect a wide range of non-cultivated plants, which may serve as alternative hosts or inoculum sources for epidemics in crops. In this study, we evaluated the genetic variability and population structure of Macroptilium yellow vein virus (MacYVV; Begomovirus macroptilivenae), associated with non-cultivated Macroptilium spp. in the state of Alagoas (AL), northeastern Brazil. Complete DNA-A sequences (n = 29) were obtained from symptomatic plants collected in different municipalities of AL during 2019 and 2020. Pairwise sequence comparisons indicated a low degree of genetic variability, with 93.9–100% identity to 18 previously characterized sequences. To better understand the population structuring of MacYVV in AL, the complete DNA-A data set (n = 47) was analyzed. Although the DAPC and STRUCTURE approaches yielded slightly divergent numbers of putative MacYVV subpopulations, the results are consistent with the phylogenetic relationships among MacYVV isolates, where five well-supported subgroups correlated with geographic location were observed. The low variability of the MacYVV population could be related to the small number of recombination events detected and be reflective of a long-term virus-host relationship in which the virus is very well adapted to the host.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulation of non-polio enteroviruses in the Ural Federal District and Western Siberia in 2023: the return of an old foe? 2023年乌拉尔联邦区和西伯利亚西部非脊髓灰质炎肠道病毒的流行：老敌人的回归？

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-22 DOI: 10.1007/s00705-025-06284-8

Tarek M. Itani, Vladislav I. Chalapa, Vasilii N. Slautin, Bolat S. Imangaliev, Maria S. Kungurtseva, Anastasia K. Patrusheva, Aleksandr G. Sergeev, Aleksandr V. Semenov

{"title":"Circulation of non-polio enteroviruses in the Ural Federal District and Western Siberia in 2023: the return of an old foe?","authors":"Tarek M. Itani, Vladislav I. Chalapa, Vasilii N. Slautin, Bolat S. Imangaliev, Maria S. Kungurtseva, Anastasia K. Patrusheva, Aleksandr G. Sergeev, Aleksandr V. Semenov","doi":"10.1007/s00705-025-06284-8","DOIUrl":"10.1007/s00705-025-06284-8","url":null,"abstract":"<div>Human non-polio enteroviruses (NPEVs) cause a wide range of illnesses such as hand, foot, and mouth disease (HFMD), herpangina, and aseptic meningitis. In this study, we investigated the incidence of NPEV infections in the Ural Federal District and Western Siberia, Russia, from 2019 to 2023 in patients with various NPEV-associated diseases, identified the main circulating genotypes in 2023, and analyzed their epidemiological characteristics. A total of 384 samples that tested positive by polymerase chain reaction (PCR) for NPEVs were genotyped by semi-nested PCR specific for the VP1 gene. A total of 20 genotypes were identified among the patients in this study, with enterovirus A accounting for 57.2% of all typed samples, enterovirus B accounting for 41%, and enterovirus C accounting for 1.8%. Coxsackievirus A6 (CVA6) was the most common genotype in HFMD cases. Echovirus 30 (E30) was predominant in aseptic meningitis patients, and coxsackievirus A2 was primarily associated with herpangina. Phylogenetic analysis showed that most of the CVA6 strains identified in this study displayed a close genetic relationship to strains that circulated in China, while E30 genotypes circulating in the studied region belonged to subgenotype V. Laboratory-based monitoring and epidemiological surveillance for genetic changes and evolutionary studies are necessary for improving prevention and clinical care.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct amplification and sequencing of enterovirus genomes from clinical and wastewater samples reveals uncommon virus types in Cameroon 从临床和废水样本中直接扩增和测序肠道病毒基因组揭示了喀麦隆不常见的病毒类型

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-22 DOI: 10.1007/s00705-025-06296-4

Abdou Fatawou Modiyinji, Marie-Line Joffret, Serge Alain Sadeuh-Mba, Mohand Ait Ahmed, Nick J. Knowles, Richard Njouom, Marie-Claire Endegue-Zanga, Maël Bessaud

{"title":"Direct amplification and sequencing of enterovirus genomes from clinical and wastewater samples reveals uncommon virus types in Cameroon","authors":"Abdou Fatawou Modiyinji, Marie-Line Joffret, Serge Alain Sadeuh-Mba, Mohand Ait Ahmed, Nick J. Knowles, Richard Njouom, Marie-Claire Endegue-Zanga, Maël Bessaud","doi":"10.1007/s00705-025-06296-4","DOIUrl":"10.1007/s00705-025-06296-4","url":null,"abstract":"<div>Knowledge about the genetic diversity of enteroviruses in sub-Saharan Africa remains biased by the fact that it has mainly been described through the characterization of specimens isolated in cell cultures. The aim of this study was to characterize enteroviruses that circulate among humans in Cameroon by focusing more specifically on respiratory enteroviruses and on enteroviruses that are non-cultivable or non-cytopathogenic in standard cell lines. For this purpose, RNA was extracted from nasopharyngeal swabs, stool suspensions, and sewage concentrates collected in Cameroon from January 2018 to December 2019, and the RNA extracts were subjected to molecular screening to detect enterovirus genomes, which were subsequently sequenced using Illumina technology. Overall, 81 strains of 32 virus types were identified. Most of the strains (61.7%) belonged to the species Enterovirus coxsackiepol, followed by members of the species Enterovirus betacoxsackie (21%), Enterovirus alphacoxsackie (14.8%), and Enterovirus deconjuncti (2.5%). Almost all of the strains were found in sewage concentrates (79%) and stool suspensions (18.5%). Only two EV-D68 strains were identified in nasopharyngeal swabs. Interestingly, several virus types that have rarely been reported were detected, including non-cultivable/non-cytopathogenic EV-C strains, among which was a new virus type assigned as EV-C119. These results highlight the fact that virus isolation and unbiased cell-culture-free approaches complement each other to provide a more complete view of the enterovirus landscape in humans.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and genome analysis of the novel virulent Burkholderia phage Bm1, which is active against pan-drug-resistant Burkholderia multivorans 对泛耐药多沃氏伯克氏菌具有活性的新型致病性伯克氏菌噬菌体Bm1的鉴定和基因组分析

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-16 DOI: 10.1007/s00705-025-06282-w

Evgenii Rubalskii, Ludwig Sedlacek, Jan Hegermann, Leonard Knegendorf, Christina Salmoukas, Carsten Mueller, Nicolaus Schwerk, Dirk Schlüter, Arjang Ruhparwar, Christian Kuehn, Stefan Ruemke

{"title":"Characterization and genome analysis of the novel virulent Burkholderia phage Bm1, which is active against pan-drug-resistant Burkholderia multivorans","authors":"Evgenii Rubalskii, Ludwig Sedlacek, Jan Hegermann, Leonard Knegendorf, Christina Salmoukas, Carsten Mueller, Nicolaus Schwerk, Dirk Schlüter, Arjang Ruhparwar, Christian Kuehn, Stefan Ruemke","doi":"10.1007/s00705-025-06282-w","DOIUrl":"10.1007/s00705-025-06282-w","url":null,"abstract":"<div>The escalating challenges of antibiotic resistance in bacterial pathogens have necessitated the exploration of alternative therapeutic strategies. Among these, bacteriophage therapy has regained attention as a promising approach to combat multidrug-resistant bacteria. Bacteriophages are viruses that infect and lyse specific bacterial strains, making them attractive candidates for targeted antimicrobial treatment. Burkholderia multivorans, a Gram-negative bacterium, is known to cause opportunistic infections, particularly in individuals with a compromised immune system or with cystic fibrosis. The prevalence of antibiotic-resistant Burkholderia strains has raised concerns about treatment options. In this study, we characterized the Burkholderia phage Bm1, a virulent bacteriophage isolated from an environmental source. Electron microscopy revealed that Bm1 phage particles have myovirus morphology, with an icosahedral head of 72 nm in diameter and a contractile tail of 100 nm in length and 18 nm in width. The genome of phage Bm1 consists of a double-stranded DNA of 67,539 bp with a terminal repeat region at each end. Comparative analysis indicated that the closest relative of phage Bm1 is Burkholderia phage BCSR129, with a calculated VIRIDIC identity of 57.7%. The apparent absence of an integrase gene suggests that the Burkholderia phage Bm1 has a strictly lytic life cycle.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00705-025-06282-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete genome sequence of a new polerovirus identified in Ageratum conyzoides 在 Ageratum conyzoides 中发现的一种新的脊髓灰质炎病毒的完整基因组序列

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-16 DOI: 10.1007/s00705-025-06288-4

Fumei Zhao, Yilin Zhang, Jie Li, Yuting Tian, Yongjiang Wang, Desheng Zhang, Qi Qiao, Zhenchen Zhang

{"title":"Complete genome sequence of a new polerovirus identified in Ageratum conyzoides","authors":"Fumei Zhao, Yilin Zhang, Jie Li, Yuting Tian, Yongjiang Wang, Desheng Zhang, Qi Qiao, Zhenchen Zhang","doi":"10.1007/s00705-025-06288-4","DOIUrl":"10.1007/s00705-025-06288-4","url":null,"abstract":"<div>A new polerovirus, designated as \"ageratum virus 3\" (AgV3), was detected in an Ageratum conyzoides plant in China. The complete genome sequence of AgV3 was determined using high-throughput sequencing, rapid amplification of cDNA ends, and Sanger sequencing of RT-PCR fragments. The organization of its single-stranded RNA genome of 5,652 nucleotides is typical of members of the genus Polerovirus in the family Solemoviridae, with seven putative open reading frames (ORFs 0–5 and ORF3a). The AgV3 genome shares the highest nucleotide sequence identity (65.7%) with that of cucurbit aphid-borne yellows virus (genus Polerovirus). Sequence comparisons of the gene products of AgV3 to those of its closest relatives revealed that all of them, with the exception of the ORF3a protein, had amino acid sequence identity values that were below the threshold for demarcation for species within the genus Polerovirus established by the International Committee of Taxonomy of Viruses (ICTV), suggesting that AgV3 is a new member of the genus Polerovirus. Phylogenetic analysis based on P1-P2 and coat protein amino acid sequences also indicated that AgV3 is a novel polerovirus.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal molecular epidemiology of human adenovirus in pediatric respiratory infections: a 12-year study in Korea (2008–2019) 韩国儿童呼吸道感染中人腺病毒的纵向分子流行病学研究（2008-2019）

IF 2.5 4区医学

Archives of Virology Pub Date : 2025-04-16 DOI: 10.1007/s00705-025-06279-5

Bin Ahn, Ki Wook Yun, Hoan Jong Lee, Sun Jung Kim, Seong Yeon Lee, Eun Hwa Choi

{"title":"Longitudinal molecular epidemiology of human adenovirus in pediatric respiratory infections: a 12-year study in Korea (2008–2019)","authors":"Bin Ahn, Ki Wook Yun, Hoan Jong Lee, Sun Jung Kim, Seong Yeon Lee, Eun Hwa Choi","doi":"10.1007/s00705-025-06279-5","DOIUrl":"10.1007/s00705-025-06279-5","url":null,"abstract":"<div>Human adenovirus (HAdV) is a leading cause of respiratory infections, with clinical manifestations and disease severity varying by type. In this study, we analyzed HAdV types in South Korea over a 12-year period before the COVID-19 pandemic. From January 2008 to December 2019, HAdV isolates were prospectively collected from children with suspected respiratory infections at a single tertiary center. HAdV typing was performed through sequence analysis of hexon gene hypervariable regions (HVRs) 1–6. Among 350 HAdV isolates, members of four species (A, B, C, and E) and 10 types (1–6, 31, 34, 35, and 55) were identified. Overall, HAdV-3 was most prevalent (49.4%), followed by HAdV-2 (19.1%), HAdV-1 (14.6%), and HAdV-4 (6.6%). HAdV-3 caused four recurrent outbreaks at intervals of 3 to 4 years without significant genetic changes in the hexon HVRs. HAdV species C (types 1, 2, 5, and 6) was detected endemically throughout the study period. Notably, HAdV-55, which was associated with fatal cases in military recruits in South Korea during 2017–2018, appeared in pediatric cases. HAdV epidemiology studies are important for providing clinical data on circulating HAdVs in children, and there is a need for ongoing surveillance and research.</div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0