Archives of Virology最新文献

Molecular insights into the mechanisms of occult hepatitis B virus infection 隐匿性乙型肝炎病毒感染机制的分子洞察

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-07 DOI: 10.1007/s00705-026-06639-9

Sina Mahdavi, Mohammad Ali Abyazi, Hadi Esmaeili Gouvarchin Ghaleh, Reza Golmohammadi, Ali Salimi Jeda

{"title":"Molecular insights into the mechanisms of occult hepatitis B virus infection","authors":"Sina Mahdavi, Mohammad Ali Abyazi, Hadi Esmaeili Gouvarchin Ghaleh, Reza Golmohammadi, Ali Salimi Jeda","doi":"10.1007/s00705-026-06639-9","DOIUrl":"10.1007/s00705-026-06639-9","url":null,"abstract":"<div><p>Occult hepatitis B virus Infection (OBI) is a form of hepatitis B virus (HBV) persistence that is not accompanied by the presence of circulating HBsAg. It is generally defined as the presence of replication-competent viral DNA, mostly covalently closed circular DNA (cccDNA), in hepatocytes. Although viral load is low and serum markers are typically undetectable, OBI has clinical significance due to its association with transmission, reactivation under immunosuppression, HCV replicative levels, and the progression of liver fibrosis, cirrhosis, and hepatocellular carcinoma. The presence of cccDNA, a stable episomal minichromosome sustained through epigenetic regulation and immune evasion mechanisms, forms the basis for viral evasion of immune clearance and diagnostic detection. The molecular drivers of OBI involve complex interactions among three key factors: viral genetic mutations (particularly in the S region), epigenetic modifications (including cytosine methylation and histone modifications), and host immune responses that are often weakened or exhausted. This review integrates current knowledge regarding these molecular pathways and their contributions to OBI’s persistence, reactivation, and associated diseases. A comprehensive understanding of these mechanisms is essential for improving diagnostic approaches, developing targeted therapies, and ultimately achieving the eradication of HBV in this resistant form of infection.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of two double-stranded RNA viruses on the virulence of the phytopathogenic fungus Fusarium oxysporum 两种双链RNA病毒对植物病原真菌尖孢镰刀菌毒力的影响

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-07 DOI: 10.1007/s00705-026-06616-2

Jing Wang, Yunxia Ni, Xintao Liu, Hui Zhao, Xingbei Zhao, Rui Qiu, Siyuan Feng, Xiaoyuan Tian, Shouye Song, Shujun Li, Hongyan Liu

{"title":"Effect of two double-stranded RNA viruses on the virulence of the phytopathogenic fungus Fusarium oxysporum","authors":"Jing Wang, Yunxia Ni, Xintao Liu, Hui Zhao, Xingbei Zhao, Rui Qiu, Siyuan Feng, Xiaoyuan Tian, Shouye Song, Shujun Li, Hongyan Liu","doi":"10.1007/s00705-026-06616-2","DOIUrl":"10.1007/s00705-026-06616-2","url":null,"abstract":"<div><p>Fusarium root rot, a persistent soil-borne disease, poses a serious threat to crop production, quality, and ultimately to food security. We identified two double-stranded RNA viruses co-infecting the phytopathogenic fungus <i>Fusarium oxysporum</i> strain 3 S-18: Fusarium oxysporum partitivirus 1 isolate 3 S-18 (FoPV1/3S18) and Fusarium oxysporum virus 1 (FoV1). The genome of FoPV1/3S18 consists of two segments. dsRNA1 is 1,761 nt in length with a large open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp) of 539 amino acids (aa). dsRNA2 is 1,556 nt in length with an ORF encoding a putative coat protein (CP) of 430 aa. Phylogenetic analysis based on both RdRp and CP amino sequences indicated that FoPV1/3S18 clusters with the members of the genus <i>Gammapartitivirus</i> within the family <i>Partitiviridae</i>. FoV1 was identified as a new monopartite dsRNA virus with 2,944 nt, containing two ORFs which encode a protein of 590 aa RdRp and 134 aa nucleocapsid protein, respectively. It belongs to the genus <i>Unirnavirus</i>, family <i>Amalgaviridae.</i> Furthermore, we demonstrated that both FoPV1/3S18 and FoV1 can be successfully transmitted via hyphal anastomosis to a virus-free strain. Co-infection with FoV1 and FoPV1/3S18 reduced conidial production but did not attenuate fungal virulence. However, infection with FoV1 alone not only reduced conidial production but also induced hypovirulence.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome sequence of Fraser’s dolphin morbillivirus isolated from a stranded Fraser’s dolphin (Lagenodelphis hosei) in Hawaiʻi 从夏威夷搁浅的弗雷泽海豚（lagendelphis hosei）中分离的弗雷泽海豚麻疹病毒的基因组序列

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-07 DOI: 10.1007/s00705-026-06629-x

Nelmarie Landrau-Giovannetti, Thomas B. Waltzek, John A. Lednicky, Kristi West

引用次数: 0

Complete genome and phylogenetic characterization of a novel papillomavirus from Cuniculus paca in the Brazilian Amazon 巴西亚马逊地区一种新型冠状虫乳头瘤病毒的全基因组和系统发育特征

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-07 DOI: 10.1007/s00705-026-06636-y

Cleyton Silva de Araújo, Laura Gabrielly Alves Henrique, Hanna Gabriela da Silva Oliveira, Jhonatan Henrique Lima da Rocha, Junio Damasceno de Souza¹, Agnes de Souza Lima, Vania Maria França Ribeiro, Francisco Carlos da Silva, David Driemeier, Cláudio Wageck Canal, John Munday, Felipe Masiero Salvarani, Flavio Roberto Chaves da Silva, Cíntia Daudt

{"title":"Complete genome and phylogenetic characterization of a novel papillomavirus from Cuniculus paca in the Brazilian Amazon","authors":"Cleyton Silva de Araújo, Laura Gabrielly Alves Henrique, Hanna Gabriela da Silva Oliveira, Jhonatan Henrique Lima da Rocha, Junio Damasceno de Souza¹, Agnes de Souza Lima, Vania Maria França Ribeiro, Francisco Carlos da Silva, David Driemeier, Cláudio Wageck Canal, John Munday, Felipe Masiero Salvarani, Flavio Roberto Chaves da Silva, Cíntia Daudt","doi":"10.1007/s00705-026-06636-y","DOIUrl":"10.1007/s00705-026-06636-y","url":null,"abstract":"<div><p>Wild rodents remain underrepresented in papillomavirus genomics, limiting current understanding of host range, tissue tropism, and evolutionary diversity. Here, we report the first papillomavirus identified in the spotted lowland paca, <i>Cuniculus paca</i>, from the Brazilian Amazon, provisionally designated <i>Cuniculus paca</i> papillomavirus 1 (CpPV1). Histopathological examination supported the diagnosis of a virally induced squamous papilloma. Broad-range L1 PCR (FAP59/64), rolling-circle amplification, and Illumina MiSeq sequencing enabled recovery of a complete circular genome of 8,803 bp containing the canonical early (E6, E7, E1, and E2) and late (L2 and L1) open reading frames, together with a typical long control region. Pairwise comparison of the complete L1 gene showed 63.10% nucleotide identity to <i>Erethizon dorsatum</i> papillomavirus 2 (EdPV2), well below the threshold used for papillomavirus type demarcation. Maximum-likelihood phylogenetic analysis recovered CpPV1 as a distinct lineage sister to EdPV2 within a broader, non-monophyletic rodent papillomavirus assemblage. This finding expands the known diversity of <i>Papillomaviridae</i> in Neotropical rodents and provides new insight into papillomavirus evolution in an under-sampled host group.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s00705-026-06636-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of efficient geminivirus-derived LIR-elements for exogenous protein expression 用于外源蛋白表达的高效双病毒衍生lir元件的鉴定

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-07 DOI: 10.1007/s00705-026-06635-z

Yingying Wang, Weikuo Huang, Na Xiao, Yuman Zhang, Rongxiang Fang

{"title":"Identification of efficient geminivirus-derived LIR-elements for exogenous protein expression","authors":"Yingying Wang, Weikuo Huang, Na Xiao, Yuman Zhang, Rongxiang Fang","doi":"10.1007/s00705-026-06635-z","DOIUrl":"10.1007/s00705-026-06635-z","url":null,"abstract":"<div><p>Viral vectors have emerged as powerful platforms for producing medical and metabolite products. To explore how diverse regulatory components can enhance gene expression, and leveraging the abundant diversity of long intergenic regions (LIRs) in geminiviruses, we systematically screened the bidirectional promoter activities of 209 LIR fragments from 8 genera within the <i>Geminiviridae</i> family. This screening was performed using a dual-reporter vector (GFP/Firefly luciferase) via transient expression in <i>Nicotiana benthamiana</i>, leading to the identification of four highly active LIR elements (LIR-2, 37, 51, and 62) derived from three distinct genera. Corresponding geminivirus expression vectors were then constructed based on these LIRs. Among them, the GM2, GM37, and GM62 vectors significantly enhanced GFP/GUS expression levels, showing 1.27 ± 0.20- to 1.82 ± 0.17-fold and 1.16 ± 0.10- to 1.64 ± 0.33-fold increases at 3 dpi, respectively, compared to the cauliflower mosaic virus 35S promoter in the pCAMBIA1300 plant vector. Furthermore, these vectors successfully expressed the medically relevant protein human papillomavirus 16 L1 (HPV16 L1), which is typically difficult to express using the pCAMBIA1300 vector. The GM2 vector exhibited the highest expression level, reaching 1.70 ± 0.38 times that of GM37, underscoring its potential as a superior expression platform. Collectively, the LIR elements identified in this study enrich the toolbox for developing virus-based expression vectors in plants, and are particularly suitable for applications in plant bioreactors requiring simultaneous expression of multiple target molecules.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147829160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A V2-SKP1 interface in soybean stay-green associated virus: evidence from evolutionary and structural analyses 大豆枯绿相关病毒的V2-SKP1界面：来自进化和结构分析的证据

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-03 DOI: 10.1007/s00705-026-06622-4

Saqib Ali

{"title":"A V2-SKP1 interface in soybean stay-green associated virus: evidence from evolutionary and structural analyses","authors":"Saqib Ali","doi":"10.1007/s00705-026-06622-4","DOIUrl":"10.1007/s00705-026-06622-4","url":null,"abstract":"<div><p>Soybean stay-green associated virus (SoSGV) is an emerging begomovirus associated with severe disease in soybean crops in East Asia. This study investigated its evolutionary relationships, population structure, recombination history, adaptive signal, and candidate host-interaction features using integrated phylogenetic, population genetic, natural selection, and structural modeling analyses of 54 complete genome sequences. Maximum-likelihood and Bayesian phylogenetic analyses recovered SoSGV as a distinct monophyletic lineage, with strong support in the maximum-likelihood analysis (96% bootstrap support). Population genetic analysis revealed high haplotype diversity (Hd = 0.962), moderate nucleotide diversity (π = 0.022), and a negative Tajima’s D value (D = − 1.49, <i>p</i> < 0.05), a pattern consistent with recent demographic expansion but not, by itself, proof of emergence timing. Recombination screening identified two robust coat protein-associated events (best <i>p</i> = 1.95 × 10⁻⁷ and 1.91 × 10⁻¹⁴), and sliding-window similarity analysis independently supported the resulting mosaic structure. Natural selection analyses detected adaptive signal in the V2 gene; MEME identified episodic selection at residues 35 and 36 (<i>p</i> < 0.1), while complementary methods supported additional method-dependent signals. ColabFold predicted a moderate-confidence V2 structure (mean pLDDT = 73.36). Protein docking identified a plausible V2-SKP1-related interface comprising 39 contacting residues, while a short 10 ns molecular dynamics simulation indicated preliminary structural compatibility rather than biological validation. These findings support the hypothesis that recombination contributed to SoSGV diversification and that V2 may interact with SKP1-related host proteins.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete genome sequence of a lytic phage, vB_KaeP_KM5, infecting multidrug-resistant Klebsiella aerogenes 感染多药耐药产气克雷伯菌的噬菌体vB_KaeP_KM5的全基因组序列

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-03 DOI: 10.1007/s00705-026-06633-1

Xundie Li, Xinyi Zheng, Meijia Huang, Hongjuan Zhang, Hanyu Liu, Shaoxuan Li, Xiaoyan Zhu, Bin Shan

引用次数: 0

Biological characterization of an avian leukosis virus subgroup J isolate from yunnan indigenous black-bone chickens and generation of its full-length infectious clone 云南地方乌骨鸡禽白血病病毒J亚群分离物的生物学特性及其全长感染性克隆的建立

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-05-03 DOI: 10.1007/s00705-026-06632-2

Hongya Yan, Guojun Wang, Rong Zhao, Ke Li, Zhengju Yuan, Wengui Li, Aiguo Xin

{"title":"Biological characterization of an avian leukosis virus subgroup J isolate from yunnan indigenous black-bone chickens and generation of its full-length infectious clone","authors":"Hongya Yan, Guojun Wang, Rong Zhao, Ke Li, Zhengju Yuan, Wengui Li, Aiguo Xin","doi":"10.1007/s00705-026-06632-2","DOIUrl":"10.1007/s00705-026-06632-2","url":null,"abstract":"<div><p>Avian leukosis virus subgroup J (ALV-J) remains a major threat to poultry health and production, particularly in indigenous chicken populations in China. In this study, a highly pathogenic ALV-J field strain, YN2021, was first isolated from indigenous black-bone chickens in Yunnan Province, China, and its biological characteristics and pathogenicity were systematically evaluated in specific-pathogen-free (SPF) chickens. Infected chickens exhibited significant growth retardation, delayed sexual maturation, and increased mortality, accompanied by pathological lesions consistent with ALV-J. To further assess reproductive performance, egg production and egg weight were recorded. YN2021-infected hens showed a reduction in total egg production (70 vs. 92 eggs; ~23.9% decrease) and a significantly lower mean egg weight (35.2 ± 0.2 g vs. 43.7 ± 0.3 g; <i>P</i> < 0.001) compared to controls. To facilitate mechanistic studies and future control strategies, a full-length infectious clone of YN2021 was constructed using a reverse genetics approach, and a synonymous molecular marker was introduced for viral identification. The rescued recombinant virus exhibited replication kinetics, p27 antigen expression, and biological characteristics in DF-1 cells comparable to those of the parental strain, and the molecular marker remained genetically stable during serial passages. Collectively, these results demonstrate that the ALV-J YN2021 strain exhibits high pathogenicity and negatively affects growth and reproductive performance in chickens. The infectious clone established in this study provides a reliable experimental platform for investigating ALV-J pathogenesis and supports the development of effective control strategies to mitigate production losses in poultry.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147807603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence and molecular characterization of a resistance-breaking tomato spotted wilt virus isolate on bell pepper plants harboring the Tsw resistance gene in Japan 在日本携带Tsw抗性基因的甜椒植株上获得一株抗番茄斑点枯萎病毒分离株的出现及分子特性。

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-04-29 DOI: 10.1007/s00705-026-06608-2

Momoko Matsuyama, Motonori Takagi, Yasuhiro Tomitaka

{"title":"Emergence and molecular characterization of a resistance-breaking tomato spotted wilt virus isolate on bell pepper plants harboring the Tsw resistance gene in Japan","authors":"Momoko Matsuyama, Motonori Takagi, Yasuhiro Tomitaka","doi":"10.1007/s00705-026-06608-2","DOIUrl":"10.1007/s00705-026-06608-2","url":null,"abstract":"<div><p>Tomato spotted wilt virus (TSWV) is distributed all over Japan and globally, seriously damaging infected plants. A resistance-conferring gene, <i>Tsw</i>, that controls the yellow spotted wilt disease in bell pepper (<i>Capsicum annuum</i>) plants caused by TSWV infection in Japan, is now commercially available. In this study, we isolated for the first time in Japan, a resistance-breaking isolate, TSWV-JRB, from bell pepper plants harboring <i>Tsw</i>. The virus overcame the resistance conferred by <i>Tsw</i> in its heterozygous and homozygous configurations. The host range or virulence of TSWV-JRB and one of the non-resistance breaking isolates from Japan did not differ, except in the plants harboring <i>Tsw</i>. The TSWV-JRB acquisition rates and transmission rates of the thrip pests <i>Frankliniella occidentalis</i> and <i>F</i>. <i>intonsa</i> were 93% 38%, and 78% and 38%, respectively<i>.</i> A phylogenetic analysis of the <i>N</i> gene sequences indicated a distant relationship between TSWV-JRB and other Japanese isolates but a close association with Asian and European isolates. A comparison of the amino acid sequences encoded by these resistance-breaking and non-resistance-breaking <i>NS</i>s suggested that a residue 74 (S→P) is a putative resistance breaking-associated substitution. This is the first study to report <i>Tsw</i>-induced resistance breaking by TSWV in Japan. These results indicated the presence of a novel substitution in TSWV that might contribute to <i>Tsw</i>-resistance breaking.</p></div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The first complete genome sequence of a highly pathogenic fowl adenovirus serotype 4 isolate from an infected chicken in Pakistan reveals the absence of a natural large genomic deletion 从巴基斯坦一只受感染的鸡中分离出的高致病性禽腺病毒血清型4的第一个完整基因组序列显示不存在天然的大基因组缺失。

IF 2.5 4区医学

Archives of Virology Pub Date : 2026-04-29 DOI: 10.1007/s00705-026-06630-4

Salman Ahmad, Syeda Fakhra Waheed, Itra Ayoub, Ayesha Siddiqua, Soban Tufail, Sofia Irfan, Raheem Ullah, Muhammad Salahuddin Shah, Mazhar Iqbal, Moazur Rahman, Aamir Shehzad

{"title":"The first complete genome sequence of a highly pathogenic fowl adenovirus serotype 4 isolate from an infected chicken in Pakistan reveals the absence of a natural large genomic deletion","authors":"Salman Ahmad, Syeda Fakhra Waheed, Itra Ayoub, Ayesha Siddiqua, Soban Tufail, Sofia Irfan, Raheem Ullah, Muhammad Salahuddin Shah, Mazhar Iqbal, Moazur Rahman, Aamir Shehzad","doi":"10.1007/s00705-026-06630-4","DOIUrl":"10.1007/s00705-026-06630-4","url":null,"abstract":"<div>\u0000 \u0000 <p>Here, we present the complete genome sequence of a highly pathogenic fowl adenovirus serotype 4 (FAdV-4) isolate (PK-1-SBL2021), collected in 2021, from an infected chicken in Pakistan. Analysis of the genome sequence revealed that PK-1-SBL2021 is closely related to highly pathogenic FAdV-4 isolates from neighboring countries (China and Iran). However, the genome is devoid of a large (1966 bp) deletion commonly found in highly pathogenic FAdV-4 isolates from neighboring countries (China and Iran). Other features of the genome, such as distinct amino acid substitutions in specific proteins encoded by the genome and repeat sequences, are similar to those found in highly pathogenic FAdV-4 isolates. To the best of our knowledge, PK-1-SBL2021 represents the first highly pathogenic FAdV-4 isolate identified in the region that lacks a 1966 bp deletion in its genome. Our sequence analysis reveals that the deletion is also lacking in the genomes of multiple pathogenic FAdV-4 isolates from Pakistan, suggesting that the genomic deletion is dispensable for increased virulence of FAdV-4.</p>\u0000 </div>","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"171 5","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147760141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0