Genetic characterization of rat hepatitis E virus (Rocahepevirus ratti) in urban brown rats (Rattus norvegicus) in Helsinki, Finland

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2025-09-29 DOI:10.1007/s00705-025-06412-4

Mert Erdin, Eda Altan, Nina Suomalainen, Hussein Alburkat, Tuomas Aivelo, Tarja Sironen, Teemu Smura

引用次数: 0

Abstract

We report complete and partial genome sequences of rat hepatitis E virus (RHEV, Rocahepevirus ratti), from archived brown rats captured in Helsinki, Finland. Phylogenetic analysis confirmed the presence of the pathogenic RHEV genotype C1 in the Helsinki region. Finnish strains clustered together with strains from South Korea and Spain. However, the polytomous topology of phylogenetic trees and the large genetic distances between spatially distinct strains suggest that RHEV has remained inadequately sampled on a global scale. Further surveillance of rocahepeviruses is needed to assess their threat to public health and to understand their diversity and evolutionary patterns.

查看原文本刊更多论文

芬兰赫尔辛基城市褐鼠（Rattus norvegicus）中大鼠戊型肝炎病毒（rocahepervirus ratti）的遗传特征

我们报告了从芬兰赫尔辛基捕获的存档褐鼠中获得的大鼠戊型肝炎病毒（RHEV，鼠罗卡hepevirus ratti）的全基因组和部分基因组序列。系统发育分析证实在赫尔辛基地区存在致病性RHEV基因C1型。芬兰的菌株与韩国和西班牙的菌株聚集在一起。然而，系统发育树的多组拓扑结构和空间不同菌株之间的大遗传距离表明，RHEV在全球范围内的采样仍然不足。需要进一步监测罗卡佩病毒，以评估其对公共卫生的威胁，并了解其多样性和进化模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.