寨卡病毒编码蛋白的神经毒力。

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2025-06-07 DOI:10.1007/s00705-025-06338-x

Zi-Hui Ma, Li Xing

{"title":"寨卡病毒编码蛋白的神经毒力。","authors":"Zi-Hui Ma, Li Xing","doi":"10.1007/s00705-025-06338-x","DOIUrl":null,"url":null,"abstract":"Zika virus (ZIKV) is a neurophilic arthropod-borne virus (arbovirus) that causes severe neurological disease in humans. ZIKV encodes three structural proteins (capsid protein, C; precursor membrane protein, prM; and envelope protein, Env) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). These viral proteins not only participate in the replication of the virus but are also involved in immune evasion and virus-mediated neuropathogenicity. Thus, the functional interactions between viral proteins and cellular events are systemically reviewed here to provide insights to the mechanisms of virus-induced pathogenicity.","PeriodicalId":8359,"journal":{"name":"Archives of Virology","volume":"170 7","pages":"150"},"PeriodicalIF":2.5000,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neurovirulence of Zika virus-encoded proteins.\",\"authors\":\"Zi-Hui Ma, Li Xing\",\"doi\":\"10.1007/s00705-025-06338-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Zika virus (ZIKV) is a neurophilic arthropod-borne virus (arbovirus) that causes severe neurological disease in humans. ZIKV encodes three structural proteins (capsid protein, C; precursor membrane protein, prM; and envelope protein, Env) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). These viral proteins not only participate in the replication of the virus but are also involved in immune evasion and virus-mediated neuropathogenicity. Thus, the functional interactions between viral proteins and cellular events are systemically reviewed here to provide insights to the mechanisms of virus-induced pathogenicity.\",\"PeriodicalId\":8359,\"journal\":{\"name\":\"Archives of Virology\",\"volume\":\"170 7\",\"pages\":\"150\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-06-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Virology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s00705-025-06338-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VIROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Virology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00705-025-06338-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}

引用次数: 0

摘要

寨卡病毒（ZIKV）是一种亲神经节肢动物传播的病毒（虫媒病毒），可引起人类严重的神经系统疾病。ZIKV编码三种结构蛋白(衣壳蛋白C；前膜蛋白；包膜蛋白（Env）和7种非结构蛋白（NS1、NS2A、NS2B、NS3、NS4A、NS4B和NS5）。这些病毒蛋白不仅参与病毒的复制，还参与免疫逃避和病毒介导的神经致病性。因此，本文系统地回顾了病毒蛋白与细胞事件之间的功能相互作用，以提供对病毒诱导致病性机制的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Neurovirulence of Zika virus-encoded proteins.

Zika virus (ZIKV) is a neurophilic arthropod-borne virus (arbovirus) that causes severe neurological disease in humans. ZIKV encodes three structural proteins (capsid protein, C; precursor membrane protein, prM; and envelope protein, Env) and seven non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5). These viral proteins not only participate in the replication of the virus but are also involved in immune evasion and virus-mediated neuropathogenicity. Thus, the functional interactions between viral proteins and cellular events are systemically reviewed here to provide insights to the mechanisms of virus-induced pathogenicity.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.