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Annual review of physiology最新文献

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A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome. 剃刀边缘：急性炎症性肺损伤/急性呼吸窘迫综合征的血管反应。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-030731
David R Price, Joe G N Garcia
{"title":"A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome.","authors":"David R Price, Joe G N Garcia","doi":"10.1146/annurev-physiol-042222-030731","DOIUrl":"10.1146/annurev-physiol-042222-030731","url":null,"abstract":"<p><p>Historically considered a metabolically inert cellular layer separating the blood from the underlying tissue, the endothelium is now recognized as a highly dynamic, metabolically active tissue that is critical to organ homeostasis. Under homeostatic conditions, lung endothelial cells (ECs) in healthy subjects are quiescent, promoting vasodilation, platelet disaggregation, and anti-inflammatory mechanisms. In contrast, lung ECs are essential contributors to the pathobiology of acute respiratory distress syndrome (ARDS), as the quiescent endothelium is rapidly and radically altered upon exposure to environmental stressors, infectious pathogens, or endogenous danger signals into an effective and formidable regulator of innate and adaptive immunity. These dramatic perturbations, produced in a tsunami of inflammatory cascade activation, result in paracellular gap formation between lung ECs, sustained lung edema, and multi-organ dysfunction that drives ARDS mortality. The astonishing plasticity of the lung endothelium in negotiating this inflammatory environment and efforts to therapeutically target the aberrant ARDS endothelium are examined in further detail in this review.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":15.7,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosome-Mediated Impact on Systemic Metabolism. 外泌体对全身代谢的影响
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-024535
Karina Cunha E Rocha, Wei Ying, Jerrold M Olefsky
{"title":"Exosome-Mediated Impact on Systemic Metabolism.","authors":"Karina Cunha E Rocha, Wei Ying, Jerrold M Olefsky","doi":"10.1146/annurev-physiol-042222-024535","DOIUrl":"10.1146/annurev-physiol-042222-024535","url":null,"abstract":"<p><p>Exosomes are small extracellular vesicles that carry lipids, proteins, and microRNAs (miRNAs). They are released by all cell types and can be found not only in circulation but in many biological fluids. Exosomes are essential for interorgan communication because they can transfer their contents from donor to recipient cells, modulating cellular functions. The miRNA content of exosomes is responsible for most of their biological effects, and changes in exosomal miRNA levels can contribute to the progression or regression of metabolic diseases. As exosomal miRNAs are selectively sorted and packaged into exosomes, they can be useful as biomarkers for diagnosing diseases. The field of exosomes and metabolism is expanding rapidly, and researchers are consistently making new discoveries in this area. As a result, exosomes have great potential for a next-generation drug delivery platform for metabolic diseases.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcendent Aspects of Proton Channels. 质子通道的超越方面。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042222-023242
Thomas E DeCoursey
{"title":"Transcendent Aspects of Proton Channels.","authors":"Thomas E DeCoursey","doi":"10.1146/annurev-physiol-042222-023242","DOIUrl":"10.1146/annurev-physiol-042222-023242","url":null,"abstract":"<p><p>A handful of biological proton-selective ion channels exist. Some open at positive or negative membrane potentials, others open at low or high pH, and some are light activated. This review focuses on common features that result from the unique properties of protons. Proton conduction through water or proteins differs qualitatively from that of all other ions. Extraordinary proton selectivity is needed to ensure that protons permeate and other ions do not. Proton selectivity arises from a proton pathway comprising a hydrogen-bonded chain that typically includes at least one titratable amino acid side chain. The enormously diverse functions of proton channels in disparate regions of the phylogenetic tree can be summarized by considering the chemical and electrical consequences of proton flux across membranes. This review discusses examples of cells in which proton efflux serves to increase pH<sub>i</sub>, decrease pH<sub>o</sub>, control the membrane potential, generate action potentials, or compensate transmembrane movement of electrical charge.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcellular Barriers to Glucose Delivery in the Body. 体内葡萄糖传递的跨细胞障碍。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042022-031657
Amira Klip, Katrien De Bock, Philip J Bilan, Erik A Richter
{"title":"Transcellular Barriers to Glucose Delivery in the Body.","authors":"Amira Klip, Katrien De Bock, Philip J Bilan, Erik A Richter","doi":"10.1146/annurev-physiol-042022-031657","DOIUrl":"10.1146/annurev-physiol-042022-031657","url":null,"abstract":"<p><p>Glucose is the universal fuel of most mammalian cells, and it is largely replenished through dietary intake. Glucose availability to tissues is paramount for the maintenance of homeostatic energetics and, hence, supply should match demand by the consuming organs. In its journey through the body, glucose encounters cellular barriers for transit at the levels of the absorbing intestinal epithelial wall, the renal epithelium mediating glucose reabsorption, and the tight capillary endothelia (especially in the brain). Glucose transiting through these cellular barriers must escape degradation to ensure optimal glucose delivery to the bloodstream or tissues. The liver, which stores glycogen and generates glucose de novo, must similarly be able to release it intact to the circulation. We present the most up-to-date knowledge on glucose handling by the gut, liver, brain endothelium, and kidney, and discuss underlying molecular mechanisms and open questions. Diseases associated with defects in glucose delivery and homeostasis are also briefly addressed. We propose that the universal problem of sparing glucose from catabolism in favor of translocation across the barriers posed by epithelia and endothelia is resolved through common mechanisms involving glucose transfer to the endoplasmic reticulum, from where glucose exits the cells via unconventional cellular mechanisms.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Psychedelics on Neuronal Physiology. 迷幻药对神经元生理的影响。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042022-020923
Cassandra J Hatzipantelis, David E Olson
{"title":"The Effects of Psychedelics on Neuronal Physiology.","authors":"Cassandra J Hatzipantelis, David E Olson","doi":"10.1146/annurev-physiol-042022-020923","DOIUrl":"10.1146/annurev-physiol-042022-020923","url":null,"abstract":"<p><p>Psychedelics are quite unique among drugs that impact the central nervous system, as a single administration of a psychedelic can both rapidly alter subjective experience in profound ways and produce sustained effects on circuits relevant to mood, fear, reward, and cognitive flexibility. These remarkable properties are a direct result of psychedelics interacting with several key neuroreceptors distributed across the brain. Stimulation of these receptors activates a variety of signaling cascades that ultimately culminate in changes in neuronal structure and function. Here, we describe the effects of psychedelics on neuronal physiology, highlighting their acute effects on serotonergic and glutamatergic neurotransmission as well as their long-lasting effects on structural and functional neuroplasticity in the cortex. We propose that the neurobiological changes leading to the acute and sustained effects of psychedelics might be distinct, which could provide opportunities for engineering compounds with optimized safety and efficacy profiles.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy. 平衡行动:从过去吸取教训，建立面向未来的阿片类药物战略。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-29 DOI: 10.1146/annurev-physiol-042022-015914
Sarah Warren Gooding, Jennifer L Whistler
{"title":"A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy.","authors":"Sarah Warren Gooding, Jennifer L Whistler","doi":"10.1146/annurev-physiol-042022-015914","DOIUrl":"10.1146/annurev-physiol-042022-015914","url":null,"abstract":"<p><p>The harmful side effects of opioid drugs such as respiratory depression, tolerance, dependence, and abuse potential have limited the therapeutic utility of opioids for their entire clinical history. However, no previous attempt to develop effective pain drugs that substantially ameliorate these effects has succeeded, and the current opioid epidemic affirms that they are a greater hindrance to the field of pain management than ever. Recent attempts at new opioid development have sought to reduce these side effects by minimizing engagement of the regulatory protein arrestin-3 at the mu-opioid receptor, but there is significant controversy around this approach. Here, we discuss the ongoing effort to develop safer opioids and its relevant historical context. We propose a new model that reconciles results previously assumed to be in direct conflict to explain how different signaling profiles at the mu-opioid receptor contribute to opioid tolerance and dependence. Our goal is for this framework to inform the search for a new generation of lower liability opioid analgesics.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Coding Logic of Interoception 截取的编码逻辑
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-12-07 DOI: 10.1146/annurev-physiol-042222-023455
Ruiqi Wang, Rui B. Chang
{"title":"The Coding Logic of Interoception","authors":"Ruiqi Wang, Rui B. Chang","doi":"10.1146/annurev-physiol-042222-023455","DOIUrl":"https://doi.org/10.1146/annurev-physiol-042222-023455","url":null,"abstract":"Interoception, the ability to precisely and timely sense internal body signals, is critical for life. The interoceptive system monitors a large variety of mechanical, chemical, hormonal, and pathological cues using specialized organ cells, organ innervating neurons, and brain sensory neurons. It is important for maintaining body homeostasis, providing motivational drives, and regulating autonomic, cognitive, and behavioral functions. However, compared to external sensory systems, our knowledge about how diverse body signals are coded at a system level is quite limited. In this review, we focus on the unique features of interoceptive signals and the organization of the interoceptive system, with the goal of better understanding the coding logic of interoception.Expected final online publication date for the Annual Review of Physiology, Volume 86 is February 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138556278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Physiology of TRPV Channels: Controversies and Future Challenges. TRPV通道的分子生理学:争议和未来的挑战。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-030222-012349
Tamara Rosenbaum, León D Islas
{"title":"Molecular Physiology of TRPV Channels: Controversies and Future Challenges.","authors":"Tamara Rosenbaum,&nbsp;León D Islas","doi":"10.1146/annurev-physiol-030222-012349","DOIUrl":"https://doi.org/10.1146/annurev-physiol-030222-012349","url":null,"abstract":"<p><p>The ability to detect stimuli from the environment plays a pivotal role in our survival. The molecules that allow the detection of such signals include ion channels, which are proteins expressed in different cells and organs. Among these ion channels, the transient receptor potential (TRP) family responds to the presence of diverse chemicals, temperature, and osmotic changes, among others. This family of ion channels includes the TRPV or vanilloid subfamily whose members serve several physiological functions. Although these proteins have been studied intensively for the last two decades, owing to their structural and functional complexities, a number of controversies regarding their function still remain. Here, we discuss some salient features of their regulation in light of these controversies and outline some of the efforts pushing the field forward.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10738143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
The Role of the Gut Microbiota in the Relationship Between Diet and Human Health. 肠道菌群在饮食与人体健康关系中的作用。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031522-092054
Bryce K Perler, Elliot S Friedman, Gary D Wu
{"title":"The Role of the Gut Microbiota in the Relationship Between Diet and Human Health.","authors":"Bryce K Perler,&nbsp;Elliot S Friedman,&nbsp;Gary D Wu","doi":"10.1146/annurev-physiol-031522-092054","DOIUrl":"https://doi.org/10.1146/annurev-physiol-031522-092054","url":null,"abstract":"<p><p>The interplay between diet, the gut microbiome, and host health is complex. Diets associated with health have many similarities: high fiber, unsaturated fatty acids, and polyphenols while being low in saturated fats, sodium, and refined carbohydrates. Over the past several decades, dietary patterns have changed significantly in Westernized nations with the increased consumption of calorically dense ultraprocessed foods low in fiber and high in saturated fats, salt, and refined carbohydrates, leading to numerous negative health consequences including obesity, metabolic syndrome, and cardiovascular disease. The gut microbiota is an environmental factor that interacts with diet and may also have an impact on health outcomes, many of which involve metabolites produced by the microbiota from dietary components that can impact the host. This review focuses on our current understanding of the complex relationship between diet, the gut microbiota, and host health, with examples of how diet can support health, increase an individual's risk for disease, and be used as a therapy for specific diseases.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10797392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver. 哺乳动物肝脏细胞平衡与再生的多面性
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-10-21 DOI: 10.1146/annurev-physiol-032822-094134
Stacey S Huppert, Robert E Schwartz
{"title":"Multiple Facets of Cellular Homeostasis and Regeneration of the Mammalian Liver.","authors":"Stacey S Huppert, Robert E Schwartz","doi":"10.1146/annurev-physiol-032822-094134","DOIUrl":"10.1146/annurev-physiol-032822-094134","url":null,"abstract":"<p><p>Liver regeneration occurs in response to diverse injuries and is capable of functionally reestablishing the lost parenchyma. This phenomenon has been known since antiquity, encapsulated in the Greek myth where Prometheus was to be punished by Zeus for sharing the gift of fire with humanity by having an eagle eat his liver daily, only to have the liver regrow back, thus ensuring eternal suffering and punishment. Today, this process is actively leveraged clinically during living donor liver transplantation whereby up to a two-thirds hepatectomy (resection or removal of part of the liver) on a donor is used for transplant to a recipient. The donor liver rapidly regenerates to recover the lost parenchymal mass to form a functional tissue. This astonishing regenerative process and unique capacity of the liver are examined in further detail in this review.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":15.7,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10060557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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