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Annual review of physiology最新文献

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Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function. 代谢重组和通讯:肾近端小管功能的综合观点。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-27 DOI: 10.1146/annurev-physiol-042222-024724
Maria Chrysopoulou, Markus M Rinschen
{"title":"Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function.","authors":"Maria Chrysopoulou, Markus M Rinschen","doi":"10.1146/annurev-physiol-042222-024724","DOIUrl":"10.1146/annurev-physiol-042222-024724","url":null,"abstract":"<p><p>The kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic function through an integrative view of transport, metabolism, and function, and embed it in the context of metabolome-wide data-driven research. Function (filtration, transport, secretion, and reabsorption), metabolite transformation, and metabolite signaling determine kidney metabolic rewiring in disease. Energy metabolism and substrates for key metabolic pathways are orchestrated by metabolite sensors. Given the importance of renal function for the inner milieu, we also review metabolic communication routes with other organs. Exciting research opportunities exist to understand metabolic perturbation of kidney and proximal tubule function, for example, in hypertension-associated kidney disease. We argue that, based on the integrative view outlined here, kidney diseases without genetic cause should be approached scientifically as metabolic diseases.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"405-427"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial Dysfunction in Kidney Tubulopathies. 肾小管病变的线粒体功能障碍。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-27 DOI: 10.1146/annurev-physiol-042222-025000
Charlotte A Hoogstraten, Joost G Hoenderop, Jeroen H F de Baaij
{"title":"Mitochondrial Dysfunction in Kidney Tubulopathies.","authors":"Charlotte A Hoogstraten, Joost G Hoenderop, Jeroen H F de Baaij","doi":"10.1146/annurev-physiol-042222-025000","DOIUrl":"10.1146/annurev-physiol-042222-025000","url":null,"abstract":"<p><p>Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water and solute reabsorption processes along the nephron. Moreover, mitochondria contribute to cellular health by the regulation of autophagy, (oxidative) stress responses, and apoptosis. Mitochondrial abundance is particularly high in cortical segments, including proximal and distal convoluted tubules. Dysfunction of the mitochondria has been described for tubulopathies such as Fanconi, Gitelman, and Bartter-like syndromes and renal tubular acidosis. In addition, mitochondrial cytopathies often affect renal (tubular) tissues, such as in Kearns-Sayre and Leigh syndromes. Nevertheless, the mechanisms by which mitochondrial dysfunction results in renal tubular diseases are only scarcely being explored. This review provides an overview of mitochondrial dysfunction in the development and progression of kidney tubulopathies. Furthermore, it emphasizes the need for further mechanistic investigations to identify links between mitochondrial function and renal electrolyte reabsorption.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"379-403"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138443610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanosensing by Vascular Endothelium. 血管内皮的机制。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-10-20 DOI: 10.1146/annurev-physiol-042022-030946
Xin Rui Lim, Osama F Harraz
{"title":"Mechanosensing by Vascular Endothelium.","authors":"Xin Rui Lim, Osama F Harraz","doi":"10.1146/annurev-physiol-042022-030946","DOIUrl":"10.1146/annurev-physiol-042022-030946","url":null,"abstract":"<p><p>Mechanical forces influence different cell types in our bodies. Among the earliest forces experienced in mammals is blood movement in the vascular system. Blood flow starts at the embryonic stage and ceases when the heart stops. Blood flow exposes endothelial cells (ECs) that line all blood vessels to hemodynamic forces. ECs detect these mechanical forces (mechanosensing) through mechanosensors, thus triggering physiological responses such as changes in vascular diameter. In this review, we focus on endothelial mechanosensing and on how different ion channels, receptors, and membrane structures detect forces and mediate intricate mechanotransduction responses. We further highlight that these responses often reflect collaborative efforts involving several mechanosensors and mechanotransducers. We close with a consideration of current knowledge regarding the dysregulation of endothelial mechanosensing during disease. Because hemodynamic disruptions are hallmarks of cardiovascular disease, studying endothelial mechanosensing holds great promise for advancing our understanding of vascular physiology and pathophysiology.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"71-97"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10922104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era. 磷酸肌醇对TRP通道的调节：结构时代的功能综述。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-10-23 DOI: 10.1146/annurev-physiol-042022-013956
Tibor Rohacs
{"title":"Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era.","authors":"Tibor Rohacs","doi":"10.1146/annurev-physiol-042022-013956","DOIUrl":"10.1146/annurev-physiol-042022-013956","url":null,"abstract":"<p><p>Transient receptor potential (TRP) ion channels have diverse activation mechanisms including physical stimuli, such as high or low temperatures, and a variety of intracellular signaling molecules. Regulation by phosphoinositides and their derivatives is their only known common regulatory feature. For most TRP channels, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P<sub>2</sub>] serves as a cofactor required for activity. Such dependence on PI(4,5)P<sub>2</sub> has been demonstrated for members of the TRPM subfamily and for the epithelial TRPV5 and TRPV6 channels. Intracellular TRPML channels show specific activation by PI(3,5)P<sub>2</sub>. Structural studies uncovered the PI(4,5)P<sub>2</sub> and PI(3,5)P<sub>2</sub> binding sites for these channels and shed light on the mechanism of channel opening. PI(4,5)P<sub>2</sub> regulation of TRPV1-4 as well as some TRPC channels is more complex, involving both positive and negative effects. This review discusses the functional roles of phosphoinositides in TRP channel regulation and molecular insights gained from recent cryo-electron microscopy structures.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"329-355"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structure, Function, and Regulation of the Junctophilin Family. 嗜Junctophilin家族的结构、功能和调控。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042022-014926
Duane D Hall, Hiroshi Takeshima, Long-Sheng Song
{"title":"Structure, Function, and Regulation of the Junctophilin Family.","authors":"Duane D Hall, Hiroshi Takeshima, Long-Sheng Song","doi":"10.1146/annurev-physiol-042022-014926","DOIUrl":"10.1146/annurev-physiol-042022-014926","url":null,"abstract":"<p><p>In both excitable and nonexcitable cells, diverse physiological processes are linked to different calcium microdomains within nanoscale junctions that form between the plasma membrane and endo-sarcoplasmic reticula. It is now appreciated that the junctophilin protein family is responsible for establishing, maintaining, and modulating the structure and function of these junctions. We review foundational findings from more than two decades of research that have uncovered how junctophilin-organized ultrastructural domains regulate evolutionarily conserved biological processes. We discuss what is known about the junctophilin family of proteins. Our goal is to summarize the current knowledge of junctophilin domain structure, function, and regulation and to highlight emerging avenues of research that help our understanding of the transcriptional, translational, and post-translational regulation of this gene family and its roles in health and during disease.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"123-147"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10922073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome. 剃刀边缘：急性炎症性肺损伤/急性呼吸窘迫综合征的血管反应。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-030731
David R Price, Joe G N Garcia
{"title":"A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome.","authors":"David R Price, Joe G N Garcia","doi":"10.1146/annurev-physiol-042222-030731","DOIUrl":"10.1146/annurev-physiol-042222-030731","url":null,"abstract":"<p><p>Historically considered a metabolically inert cellular layer separating the blood from the underlying tissue, the endothelium is now recognized as a highly dynamic, metabolically active tissue that is critical to organ homeostasis. Under homeostatic conditions, lung endothelial cells (ECs) in healthy subjects are quiescent, promoting vasodilation, platelet disaggregation, and anti-inflammatory mechanisms. In contrast, lung ECs are essential contributors to the pathobiology of acute respiratory distress syndrome (ARDS), as the quiescent endothelium is rapidly and radically altered upon exposure to environmental stressors, infectious pathogens, or endogenous danger signals into an effective and formidable regulator of innate and adaptive immunity. These dramatic perturbations, produced in a tsunami of inflammatory cascade activation, result in paracellular gap formation between lung ECs, sustained lung edema, and multi-organ dysfunction that drives ARDS mortality. The astonishing plasticity of the lung endothelium in negotiating this inflammatory environment and efforts to therapeutically target the aberrant ARDS endothelium are examined in further detail in this review.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"86 ","pages":"505-529"},"PeriodicalIF":15.7,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial Stiffness: From Basic Primers to Integrative Physiology. 动脉僵化：从基础入门到综合生理学》。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042022-031925
Véronique Regnault, Patrick Lacolley, Stéphane Laurent
{"title":"Arterial Stiffness: From Basic Primers to Integrative Physiology.","authors":"Véronique Regnault, Patrick Lacolley, Stéphane Laurent","doi":"10.1146/annurev-physiol-042022-031925","DOIUrl":"10.1146/annurev-physiol-042022-031925","url":null,"abstract":"<p><p>The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseases. Here, we provide new insight into the integrative physiology of arterial stiffening and its clinical consequence. We also comprehensively review progress made on pathways/molecules that appear today as important basic determinants of arterial stiffness, particularly those mediating the vascular smooth muscle cell (VSMC) contractility, plasticity and stiffness. We focus on membrane and nuclear mechanotransduction, clearance function of the vascular wall, phenotypic switching of VSMCs, immunoinflammatory stimuli and epigenetic mechanisms. Finally, we discuss the most important advances of the latest clinical studies that revisit the classical therapeutic concepts of arterial stiffness and lead to a patient-by-patient strategy according to cardiovascular risk exposure and underlying disease.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"86 ","pages":"99-121"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orchestration of the Adipose Tissue Immune Landscape by Adipocytes. 脂肪细胞协调脂肪组织的免疫格局
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-024353
David Bradley, Tuo Deng, Dharti Shantaram, Willa A Hsueh
{"title":"Orchestration of the Adipose Tissue Immune Landscape by Adipocytes.","authors":"David Bradley, Tuo Deng, Dharti Shantaram, Willa A Hsueh","doi":"10.1146/annurev-physiol-042222-024353","DOIUrl":"10.1146/annurev-physiol-042222-024353","url":null,"abstract":"<p><p>Obesity is epidemic and of great concern because of its comorbid and costly inflammatory-driven complications. Extensive investigations in mice have elucidated highly coordinated, well-balanced interactions between adipocytes and immune cells in adipose tissue that maintain normal systemic metabolism in the lean state, while in obesity, proinflammatory changes occur in nearly all adipose tissue immune cells. Many of these changes are instigated by adipocytes. However, less is known about obesity-induced adipose-tissue immune cell alterations in humans. Upon high-fat diet feeding, the adipocyte changes its well-known function as a metabolic cell to assume the role of an immune cell, orchestrating proinflammatory changes that escalate inflammation and progress during obesity. This transformation is particularly prominent in humans. In this review, we (<i>a</i>) highlight a leading and early role for adipocytes in promulgating inflammation, (<i>b</i>) discuss immune cell changes and the time course of these changes (comparing humans and mice when possible), and (<i>c</i>) note how reversing proinflammatory changes in most types of immune cells, including adipocytes, rescues adipose tissue from inflammation and obese mice from insulin resistance.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"86 ","pages":"199-223"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosome-Mediated Impact on Systemic Metabolism. 外泌体对全身代谢的影响
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-024535
Karina Cunha E Rocha, Wei Ying, Jerrold M Olefsky
{"title":"Exosome-Mediated Impact on Systemic Metabolism.","authors":"Karina Cunha E Rocha, Wei Ying, Jerrold M Olefsky","doi":"10.1146/annurev-physiol-042222-024535","DOIUrl":"10.1146/annurev-physiol-042222-024535","url":null,"abstract":"<p><p>Exosomes are small extracellular vesicles that carry lipids, proteins, and microRNAs (miRNAs). They are released by all cell types and can be found not only in circulation but in many biological fluids. Exosomes are essential for interorgan communication because they can transfer their contents from donor to recipient cells, modulating cellular functions. The miRNA content of exosomes is responsible for most of their biological effects, and changes in exosomal miRNA levels can contribute to the progression or regression of metabolic diseases. As exosomal miRNAs are selectively sorted and packaged into exosomes, they can be useful as biomarkers for diagnosing diseases. The field of exosomes and metabolism is expanding rapidly, and researchers are consistently making new discoveries in this area. As a result, exosomes have great potential for a next-generation drug delivery platform for metabolic diseases.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"86 ","pages":"225-253"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Psychedelics on Neuronal Physiology. 迷幻药对神经元生理的影响。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042022-020923
Cassandra J Hatzipantelis, David E Olson
{"title":"The Effects of Psychedelics on Neuronal Physiology.","authors":"Cassandra J Hatzipantelis, David E Olson","doi":"10.1146/annurev-physiol-042022-020923","DOIUrl":"10.1146/annurev-physiol-042022-020923","url":null,"abstract":"<p><p>Psychedelics are quite unique among drugs that impact the central nervous system, as a single administration of a psychedelic can both rapidly alter subjective experience in profound ways and produce sustained effects on circuits relevant to mood, fear, reward, and cognitive flexibility. These remarkable properties are a direct result of psychedelics interacting with several key neuroreceptors distributed across the brain. Stimulation of these receptors activates a variety of signaling cascades that ultimately culminate in changes in neuronal structure and function. Here, we describe the effects of psychedelics on neuronal physiology, highlighting their acute effects on serotonergic and glutamatergic neurotransmission as well as their long-lasting effects on structural and functional neuroplasticity in the cortex. We propose that the neurobiological changes leading to the acute and sustained effects of psychedelics might be distinct, which could provide opportunities for engineering compounds with optimized safety and efficacy profiles.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"27-47"},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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