Annual review of physiology最新文献_第3页

Specialized Pulmonary Vascular Cells in Development and Disease. 发育和疾病中的特化肺血管细胞

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105226

Arnav Sharma, Terren K Niethamer

引用次数: 0

Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction. 与人类疾病相关的 1,4,5-三磷酸肌醇受体突变：对受体功能和功能障碍的见解。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105627

Vikas Arige, David M MacLean, David I Yule

{"title":"Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction.","authors":"Vikas Arige, David M MacLean, David I Yule","doi":"10.1146/annurev-physiol-022724-105627","DOIUrl":"10.1146/annurev-physiol-022724-105627","url":null,"abstract":"Inositol 1,4,5-trisphosphate receptors (IP3Rs) are ubiquitous intracellular Ca2+ release channels. Their activation, subcellular localization, abundance, and regulation play major roles in defining the spatiotemporal characteristics of intracellular Ca2+ signals, which are in turn fundamental to the appropriate activation of effectors that control a myriad of cellular events. Over the past decade, ∼100 mutations in ITPRs associated with human diseases have been documented. Mutations have been detailed in all three IP3R subtypes and all functional domains of the protein, resulting in both gain and loss of receptor function. IP3R mutations are associated with a diverse array of pathology including spinocerebellar ataxia, peripheral neuropathy, immunopathy, anhidrosis, hyperparathyroidism, and squamous cell carcinoma. This review focuses on how studying the altered activity of these mutations provides information relating to IP3R structure and function, the physiology underpinned by specific IP3R subtypes, and the pathological consequences of dysregulated Ca2+ signaling in human disease.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"201-228"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics. 新陈代谢中的蛋白酪氨酸磷酸酶：治疗的新领域。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105540

Anton M Bennett, Tony Tiganis

引用次数: 0

Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training? 运动作为线粒体药物：运动处方如何影响线粒体对训练的适应？

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-104836

David J Bishop, Matthew J-C Lee, Martin Picard

{"title":"Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training?","authors":"David J Bishop, Matthew J-C Lee, Martin Picard","doi":"10.1146/annurev-physiol-022724-104836","DOIUrl":"10.1146/annurev-physiol-022724-104836","url":null,"abstract":"Mitochondria are multifaceted organelles with several life-sustaining functions beyond energy transformation, including cell signaling, calcium homeostasis, hormone synthesis, programmed cell death (apoptosis), and others. A defining aspect of these dynamic organelles is their remarkable plasticity, which allows them to sense, respond, and adapt to various stressors. In particular, it is well-established that the stress of exercise provides a powerful stimulus that can trigger transient or enduring changes to mitochondrial molecular features, activities, integrated functions, behaviors, and cell-dependent mitochondrial phenotypes. Evidence documenting the many beneficial mitochondrial adaptations to exercise has led to the notion of exercise as a mitochondrial medicine. However, as with other medicines, it is important to understand the optimal prescription (i.e., type, dose, frequency, duration). In this review, we build on a systematic biological framework that distinguishes between domains of mitochondrial biology to critically evaluate how different exercise prescription variables influence mitochondrial adaptations to training.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"107-129"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect. 心脏是一个智能泵：Frank-Starling定律的机械转导机制和Anrep效应。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-104846

Ye Chen-Izu, Tamas Banyasz, John A Shaw, Leighton T Izu

{"title":"The Heart Is a Smart Pump: Mechanotransduction Mechanisms of the Frank-Starling Law and the Anrep Effect.","authors":"Ye Chen-Izu, Tamas Banyasz, John A Shaw, Leighton T Izu","doi":"10.1146/annurev-physiol-022724-104846","DOIUrl":"10.1146/annurev-physiol-022724-104846","url":null,"abstract":"The Frank-Starling law and Anrep effect describe two intrinsic mechanisms that regulate contraction force in the heart. Based on recent advancements and the historical literature, we propose new perspectives and address several critical issues in this review. (a) The Frank-Starling mechanism and Anrep effect are dynamically linked and act synergistically. (b) An open question is how cardiomyocytes sense mechanical load and transduce to biochemical signals (called mechano-chemo-transduction or MCT) to regulate contraction in response to load changes. (c) One research focus is to identify various mechanosensors and decipher their downstream MCT pathways. (d) Innovative experimental techniques engage different mechanosensors that detect different local strain and stress in the cell architecture. (e) Closed-loop MCT feedback in the dynamic excitation-Ca2+ signaling-contraction system enables autoregulation of contraction in response to physiological load changes. (f) However, pathological overload such as volume and pressure overload lead to excessive MCT-Ca2+ gain, cardiac remodeling, and heart diseases.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"53-77"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142765757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Physiology of Enteric Glia. 肠胶质细胞的生理学。

IF 19.1 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105016

Jacques Gonzales, Brian D Gulbransen

引用次数: 0

Molecular Crowding: Physiologic Sensing and Control. 分子拥挤：生理传感与控制。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042222-025920

Arohan R Subramanya, Cary R Boyd-Shiwarski

{"title":"Molecular Crowding: Physiologic Sensing and Control.","authors":"Arohan R Subramanya, Cary R Boyd-Shiwarski","doi":"10.1146/annurev-physiol-042222-025920","DOIUrl":"10.1146/annurev-physiol-042222-025920","url":null,"abstract":"The cytoplasm is densely packed with molecules that contribute to its nonideal behavior. Cytosolic crowding influences chemical reaction rates, intracellular water mobility, and macromolecular complex formation. Overcrowding is potentially catastrophic; to counteract this problem, cells have evolved acute and chronic homeostatic mechanisms that optimize cellular crowdedness. Here, we provide a physiology-focused overview of molecular crowding, highlighting contemporary advances in our understanding of its sensing and control. Long hypothesized as a form of crowding-induced microcompartmentation, phase separation allows cells to detect and respond to intracellular crowding through the action of biomolecular condensates, as indicated by recent studies. Growing evidence indicates that crowding is closely tied to cell size and fluid volume, homeostatic responses to physical compression and desiccation, tissue architecture, circadian rhythm, aging, transepithelial transport, and total body electrolyte and water balance. Thus, molecular crowding is a fundamental physiologic parameter that impacts diverse functions extending from molecule to organism.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"429-452"},"PeriodicalIF":15.7,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11472293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health. 肠绒毛细胞：形态、功能和对人类健康的意义。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-10-20 DOI: 10.1146/annurev-physiol-042022-030310

Jennifer B Silverman, Paige N Vega, Matthew J Tyska, Ken S Lau

{"title":"Intestinal Tuft Cells: Morphology, Function, and Implications for Human Health.","authors":"Jennifer B Silverman, Paige N Vega, Matthew J Tyska, Ken S Lau","doi":"10.1146/annurev-physiol-042022-030310","DOIUrl":"10.1146/annurev-physiol-042022-030310","url":null,"abstract":"Tuft cells are a rare and morphologically distinct chemosensory cell type found throughout many organs, including the gastrointestinal tract. These cells were identified by their unique morphologies distinguished by large apical protrusions. Ultrastructural data have begun to describe the molecular underpinnings of their cytoskeletal features, and tuft cell-enriched cytoskeletal proteins have been identified, although the connection of tuft cell morphology to tuft cell functionality has not yet been established. Furthermore, tuft cells display variations in function and identity between and within tissues, leading to the delineation of distinct tuft cell populations. As a chemosensory cell type, they display receptors that are responsive to ligands specific for their environment. While many studies have demonstrated the tuft cell response to protists and helminths in the intestine, recent research has highlighted other roles of tuft cells as well as implicated tuft cells in other disease processes including inflammation, cancer, and viral infections. Here, we review the literature on the cytoskeletal structure of tuft cells. Additionally, we focus on new research discussing tuft cell lineage, ligand-receptor interactions, tuft cell tropism, and the role of tuft cells in intestinal disease. Finally, we discuss the implication of tuft cell-targeted therapies in human health and how the morphology of tuft cells may contribute to their functionality.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"479-504"},"PeriodicalIF":15.7,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11193883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49673724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation. 心血管疾病中的脂肪组织：从基础科学到临床翻译。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-06-11 DOI: 10.1146/annurev-physiol-042222-021346

Murray D Polkinghorne, Henry W West, Charalambos Antoniades

{"title":"Adipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation.","authors":"Murray D Polkinghorne, Henry W West, Charalambos Antoniades","doi":"10.1146/annurev-physiol-042222-021346","DOIUrl":"10.1146/annurev-physiol-042222-021346","url":null,"abstract":"The perception of adipose tissue as a metabolically quiescent tissue, primarily responsible for lipid storage and energy balance (with some endocrine, thermogenic, and insulation functions), has changed. It is now accepted that adipose tissue is a crucial regulator of metabolic health, maintaining bidirectional communication with other organs including the cardiovascular system. Additionally, adipose tissue depots are functionally and morphologically heterogeneous, acting not only as sources of bioactive molecules that regulate the physiological functioning of the vasculature and myocardium but also as biosensors of the paracrine and endocrine signals arising from these tissues. In this way, adipose tissue undergoes phenotypic switching in response to vascular and/or myocardial signals (proinflammatory, profibrotic, prolipolytic), a process that novel imaging technologies are able to visualize and quantify with implications for clinical prognosis. Furthermore, a range of therapeutic modalities have emerged targeting adipose tissue metabolism and altering its secretome, potentially benefiting those at risk of cardiovascular disease.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"175-198"},"PeriodicalIF":15.7,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Mineralocorticoid Receptor in the Vasculature: Friend or Foe? 血管中的矿皮质激素受体：朋友还是敌人？

IF 18.2 1区医学

Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-10-03 DOI: 10.1146/annurev-physiol-042022-015223

Jaime Ibarrola, Iris Z Jaffe

引用次数: 0