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Annual review of physiology最新文献

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Intracellular Ion Control of WNK Signaling. 细胞内离子对WNK信号的调控。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031522-080651
Elizabeth J Goldsmith, Aylin R Rodan
{"title":"Intracellular Ion Control of WNK Signaling.","authors":"Elizabeth J Goldsmith,&nbsp;Aylin R Rodan","doi":"10.1146/annurev-physiol-031522-080651","DOIUrl":"https://doi.org/10.1146/annurev-physiol-031522-080651","url":null,"abstract":"<p><p>The with no lysine (K) (WNK) kinases are an evolutionarily ancient group of kinases with atypical placement of the catalytic lysine and diverse physiological roles. Recent studies have shown that WNKs are directly regulated by chloride, potassium, and osmotic pressure. Here, we review the discovery of WNKs as chloride-sensitive kinases and discuss physiological contexts in which chloride regulation of WNKs has been demonstrated. These include the kidney, pancreatic duct, neurons, and inflammatory cells. We discuss the interdependent relationship of osmotic pressure and intracellular chloride in cell volume regulation. We review the recent demonstration of potassium regulation of WNKs and speculate on possible physiological roles. Finally, structural and mechanistic aspects of intracellular ion and osmotic pressure regulation of WNKs are discussed.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9446895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Transformation of Our Understanding of Breathing Control by Molecular Tools. 我们对呼吸控制的分子工具的理解的转变。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-021522-094142
Kevin Yackle
{"title":"Transformation of Our Understanding of Breathing Control by Molecular Tools.","authors":"Kevin Yackle","doi":"10.1146/annurev-physiol-021522-094142","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021522-094142","url":null,"abstract":"<p><p>The rhythmicity of breath is vital for normal physiology. Even so, breathing is enriched with multifunctionality. External signals constantly change breathing, stopping it when under water or deepening it during exertion. Internal cues utilize breath to express emotions such as sighs of frustration and yawns of boredom. Breathing harmonizes with other actions that use our mouth and throat, including speech, chewing, and swallowing. In addition, our perception of breathing intensity can dictate how we feel, such as during the slow breathing of calming meditation and anxiety-inducing hyperventilation. Heartbeat originates from a peripheral pacemaker in the heart, but the automation of breathing arises from neural clusters within the brainstem, enabling interaction with other brain areas and thus multifunctionality. Here, we document how the recent transformation of cellular and molecular tools has contributed to our appreciation of the diversity of neuronal types in the breathing control circuit and how they confer the multifunctionality of breathing.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918693/pdf/nihms-1858700.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9818698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Iron and the Pathophysiology of Diabetes. 铁与糖尿病的病理生理学。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-09-22 DOI: 10.1146/annurev-physiol-022522-102832
Alexandria V Harrison, Felipe Ramos Lorenzo, Donald A McClain
{"title":"Iron and the Pathophysiology of Diabetes.","authors":"Alexandria V Harrison, Felipe Ramos Lorenzo, Donald A McClain","doi":"10.1146/annurev-physiol-022522-102832","DOIUrl":"10.1146/annurev-physiol-022522-102832","url":null,"abstract":"<p><p>High iron is a risk factor for type 2 diabetes mellitus (T2DM) and affects most of its cardinal features: decreased insulin secretion, insulin resistance, and increased hepatic gluconeogenesis. This is true across the normal range of tissue iron levels and in pathologic iron overload. Because of iron's central role in metabolic processes (e.g., fuel oxidation) and metabolic regulation (e.g., hypoxia sensing), iron levels participate in determining metabolic rates, gluconeogenesis, fuel choice, insulin action, and adipocyte phenotype. The risk of diabetes related to iron is evident in most or all tissues that determine diabetes phenotypes, with the adipocyte, beta cell, and liver playing central roles. Molecular mechanisms for these effects are diverse, although there may be integrative pathways at play. Elucidating these pathways has implications not only for diabetes prevention and treatment, but also for the pathogenesis of other diseases that are, like T2DM, associated with aging, nutrition, and iron.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10382175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flipping Off and On the Redox Switch in the Microcirculation. 打开和关闭微循环中的氧化还原开关
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031522-021457
Máté Katona, Mark T Gladwin, Adam C Straub
{"title":"Flipping Off and On the Redox Switch in the Microcirculation.","authors":"Máté Katona, Mark T Gladwin, Adam C Straub","doi":"10.1146/annurev-physiol-031522-021457","DOIUrl":"10.1146/annurev-physiol-031522-021457","url":null,"abstract":"<p><p>Resistance arteries and arterioles evolved as specialized blood vessels serving two important functions: (<i>a</i>) regulating peripheral vascular resistance and blood pressure and (<i>b</i>) matching oxygen and nutrient delivery to metabolic demands of organs. These functions require control of vessel lumen cross-sectional area (vascular tone) via coordinated vascular cell responses governed by precise spatial-temporal communication between intracellular signaling pathways. Herein, we provide a contemporary overview of the significant roles that redox switches play in calcium signaling for orchestrated endothelial, smooth muscle, and red blood cell control of arterial vascular tone. Three interrelated themes are the focus: (<i>a</i>) smooth muscle to endothelial communication for vasoconstriction, (<i>b</i>) endothelial to smooth muscle cell cross talk for vasodilation, and (<i>c</i>) oxygen and red blood cell interregulation of vascular tone and blood flow. We intend for this thematic framework to highlight gaps in our current knowledge and potentially spark interest for cross-disciplinary studies moving forward.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11046419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10730658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells. 内质网-浆膜连接是可兴奋细胞中去极化诱导 Ca2+ 信号传导的场所
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-10-06 DOI: 10.1146/annurev-physiol-032122-104610
Rose E Dixon, James S Trimmer
{"title":"Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced Ca<sup>2+</sup> Signaling in Excitable Cells.","authors":"Rose E Dixon, James S Trimmer","doi":"10.1146/annurev-physiol-032122-104610","DOIUrl":"10.1146/annurev-physiol-032122-104610","url":null,"abstract":"<p><p>Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM), or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles in organizing diverse forms of Ca<sup>2+</sup> signaling as triggered by membrane depolarization. ER-PM junctions underlie crucial physiological processes such as excitation-contraction coupling, smooth muscle contraction and relaxation, and various forms of activity-dependent signaling and plasticity in neurons. In many cases the structure and molecular composition of ER-PM junctions in excitable cells comprise important regulatory feedback loops linking depolarization-induced Ca<sup>2+</sup> signaling at these sites to the regulation of membrane potential. Here, we describe recent findings on physiological roles and molecular composition of native ER-PM junctions in excitable cells. We focus on recent studies that provide new insights into canonical forms of depolarization-induced Ca<sup>2+</sup> signaling occurring at junctional triads and dyads of striated muscle, as well as the diversity of ER-PM junctions in these cells and in smooth muscle and neurons.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10729605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infectious and Inflammatory Pathways to Cough. 咳嗽的感染和炎症途径
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-09-28 DOI: 10.1146/annurev-physiol-031422-092315
Kubra F Naqvi, Stuart B Mazzone, Michael U Shiloh
{"title":"Infectious and Inflammatory Pathways to Cough.","authors":"Kubra F Naqvi, Stuart B Mazzone, Michael U Shiloh","doi":"10.1146/annurev-physiol-031422-092315","DOIUrl":"10.1146/annurev-physiol-031422-092315","url":null,"abstract":"<p><p>Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathogens to facilitate disease transmission. Microbial components or infection-induced inflammatory mediators can directly interact with sensory nerve receptors to induce a cough response. Analysis of cough-generated aerosols and transmission studies have further demonstrated how infectious disease is spread through coughing. This review summarizes the neurophysiology of cough, cough induction by respiratory pathogens and inflammation, and cough-mediated disease transmission.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9918720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10746886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial to Mesenchymal Transition in Health and Disease. 健康与疾病中的内皮细胞向间充质细胞转化。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-032222-080806
Yang Xu, Jason C Kovacic
{"title":"Endothelial to Mesenchymal Transition in Health and Disease.","authors":"Yang Xu,&nbsp;Jason C Kovacic","doi":"10.1146/annurev-physiol-032222-080806","DOIUrl":"https://doi.org/10.1146/annurev-physiol-032222-080806","url":null,"abstract":"<p><p>The endothelium is one of the largest organ systems in the body, and data continue to emerge regarding the importance of endothelial cell (EC) dysfunction in vascular aging and a range of cardiovascular diseases (CVDs). Over the last two decades and as a process intimately related to EC dysfunction, an increasing number of studies have also implicated endothelial to mesenchymal transition (EndMT) as a potentially disease-causal pathobiologic process that is involved in a multitude of differing CVDs. However, EndMT is also involved in physiologic processes (e.g., cardiac development), and transient EndMT may contribute to vascular regeneration in certain contexts. Given that EndMT involves a major alteration in the EC-specific molecular program, and that it potentially contributes to CVD pathobiology, the clinical translation opportunities are significant, but further molecular and translational research is needed to see these opportunities realized.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9290358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Myostatin: A Skeletal Muscle Chalone. 肌肉生长抑制素:一种骨骼肌抑制剂。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-012422-112116
Se-Jin Lee
{"title":"Myostatin: A Skeletal Muscle Chalone.","authors":"Se-Jin Lee","doi":"10.1146/annurev-physiol-012422-112116","DOIUrl":"https://doi.org/10.1146/annurev-physiol-012422-112116","url":null,"abstract":"<p><p>Myostatin (GDF-8) was discovered 25 years ago as a new transforming growth factor-β family member that acts as a master regulator of skeletal muscle mass. Myostatin is made by skeletal myofibers, circulates in the blood, and acts back on myofibers to limit growth. Myostatin appears to have all of the salient properties of a chalone, which is a term proposed over a half century ago to describe hypothetical circulating, tissue-specific growth inhibitors that control tissue size. The elucidation of the molecular, cellular, and physiological mechanisms underlying myostatin activity suggests that myostatin functions as a negative feedback regulator of muscle mass and raises the question as to whether this type of chalone mechanism is unique to skeletal muscle or whether it also operates in other tissues.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10163667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9417133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Metabolic Recruitment in Brain Tissue. 脑组织中的代谢补充。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-021422-091035
L F Barros, I Ruminot, T Sotelo-Hitschfeld, R Lerchundi, I Fernández-Moncada
{"title":"Metabolic Recruitment in Brain Tissue.","authors":"L F Barros,&nbsp;I Ruminot,&nbsp;T Sotelo-Hitschfeld,&nbsp;R Lerchundi,&nbsp;I Fernández-Moncada","doi":"10.1146/annurev-physiol-021422-091035","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021422-091035","url":null,"abstract":"<p><p>Information processing imposes urgent metabolic demands on neurons, which have negligible energy stores and restricted access to fuel. Here, we discuss metabolic recruitment, the tissue-level phenomenon whereby active neurons harvest resources from their surroundings. The primary event is the neuronal release of K<sup>+</sup> that mirrors workload. Astrocytes sense K<sup>+</sup> in exquisite fashion thanks to their unique coexpression of NBCe1 and α2β2 Na<sup>+</sup>/K<sup>+</sup> ATPase, and within seconds switch to Crabtree metabolism, involving GLUT1, aerobic glycolysis, transient suppression of mitochondrial respiration, and lactate export. The lactate surge serves as a secondary recruiter by inhibiting glucose consumption in distant cells. Additional recruiters are glutamate, nitric oxide, and ammonium, which signal over different spatiotemporal domains. The net outcome of these events is that more glucose, lactate, and oxygen are made available. Metabolic recruitment works alongside neurovascular coupling and various averaging strategies to support the inordinate dynamic range of individual neurons.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10796748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Lung Cell Atlases in Health and Disease. 健康与疾病中的肺细胞图谱。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-032922-082826
Taylor S Adams, Arnaud Marlier, Naftali Kaminski
{"title":"Lung Cell Atlases in Health and Disease.","authors":"Taylor S Adams,&nbsp;Arnaud Marlier,&nbsp;Naftali Kaminski","doi":"10.1146/annurev-physiol-032922-082826","DOIUrl":"https://doi.org/10.1146/annurev-physiol-032922-082826","url":null,"abstract":"<p><p>The human lung cellular portfolio, traditionally characterized by cellular morphology and individual markers, is highly diverse, with over 40 cell types and a complex branching structure highly adapted for agile airflow and gas exchange. While constant during adulthood, lung cellular content changes in response to exposure, injury, and infection. Some changes are temporary, but others are persistent, leading to structural changes and progressive lung disease. The recent advance of single-cell profiling technologies allows an unprecedented level of detail and scale to cellular measurements, leading to the rise of comprehensive cell atlas styles of reporting. In this review, we chronical the rise of cell atlases and explore their contributions to human lung biology in health and disease.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9305327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
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