肾小管病变的线粒体功能障碍。

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-27 DOI:10.1146/annurev-physiol-042222-025000
Charlotte A Hoogstraten, Joost G Hoenderop, Jeroen H F de Baaij
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引用次数: 0

摘要

线粒体在肾脏的生理和病理中起着关键作用。它们产生ATP,为需要能量的水和沿肾元的溶质重吸收过程提供燃料。此外,线粒体通过调节自噬、(氧化)应激反应和细胞凋亡来促进细胞健康。在皮质节段,包括近曲小管和远曲小管,线粒体丰度特别高。线粒体功能障碍已被描述为小管病变,如Fanconi, Gitelman和bartter样综合征和肾小管酸中毒。此外,线粒体细胞病变常影响肾(小管)组织,如卡恩斯-塞尔综合征和利综合征。然而,线粒体功能障碍导致肾小管疾病的机制几乎没有被探索。本文综述了线粒体功能障碍在肾小管病变发生和发展中的作用。此外,它强调需要进一步的机制研究,以确定线粒体功能和肾电解质重吸收之间的联系。《生理学年度评论》第86卷的最终在线出版日期预计为2024年2月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitochondrial Dysfunction in Kidney Tubulopathies.

Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel energy-demanding water and solute reabsorption processes along the nephron. Moreover, mitochondria contribute to cellular health by the regulation of autophagy, (oxidative) stress responses, and apoptosis. Mitochondrial abundance is particularly high in cortical segments, including proximal and distal convoluted tubules. Dysfunction of the mitochondria has been described for tubulopathies such as Fanconi, Gitelman, and Bartter-like syndromes and renal tubular acidosis. In addition, mitochondrial cytopathies often affect renal (tubular) tissues, such as in Kearns-Sayre and Leigh syndromes. Nevertheless, the mechanisms by which mitochondrial dysfunction results in renal tubular diseases are only scarcely being explored. This review provides an overview of mitochondrial dysfunction in the development and progression of kidney tubulopathies. Furthermore, it emphasizes the need for further mechanistic investigations to identify links between mitochondrial function and renal electrolyte reabsorption.

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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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