Annual review of physiology最新文献

Leptin: 30 Years Later. 瘦素：30年后。

IF 19.1 1区医学

Annual review of physiology Pub Date : 2025-10-03 DOI: 10.1146/annurev-physiol-042324-100259

Rexford S Ahima, Jeffrey S Flier

引用次数: 0

Myeloid Cell Reprogramming and Immune Suppression. 骨髓细胞重编程与免疫抑制。

IF 19.1 1区医学

Annual review of physiology Pub Date : 2025-10-03 DOI: 10.1146/annurev-physiol-050824-111031

Amit Grover, Evgenii N Tcyganov, Dmitry I Gabrilovich

{"title":"Myeloid Cell Reprogramming and Immune Suppression.","authors":"Amit Grover, Evgenii N Tcyganov, Dmitry I Gabrilovich","doi":"10.1146/annurev-physiol-050824-111031","DOIUrl":"https://doi.org/10.1146/annurev-physiol-050824-111031","url":null,"abstract":"Plasticity of myeloid cells, characterized by their ability to undergo reprogramming in response to environmental cues, is a fundamental feature enabling their versatile functions during immune responses. Macrophages and neutrophils, the primary myeloid cell types, exhibit distinct polarization states. Classical polarization states of macrophages and neutrophils are associated with antimicrobial activity, inflammation promotion, and tissue remodeling. Pathological polarization, observed in chronic inflammation, cancer, and other conditions, is marked by enhanced immune-suppressive activity, aberrant enzymatic activity, and atypical cytokine production, diverging from their classical functions. This review delves into the most up-to-date characterization of those polarization states, the transcriptional and epigenetic factors, and the metabolic pathways governing myeloid cell reprogramming, highlighting the influence of cytokines and tissue-specific conditions, such as hypoxia in tumors, on this process. Understanding the mechanisms underlying the pathological polarization of myeloid cells offers a promising avenue to modulate their activity for targeted therapeutic interventions.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":19.1,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Developmental Origins of Asthma and COPD. 哮喘和慢性阻塞性肺病的发展起源。

IF 19.1 1区医学

Annual review of physiology Pub Date : 2025-09-18 DOI: 10.1146/annurev-physiol-042924-084007

Francesca Polverino, Don D Sin

{"title":"The Developmental Origins of Asthma and COPD.","authors":"Francesca Polverino, Don D Sin","doi":"10.1146/annurev-physiol-042924-084007","DOIUrl":"https://doi.org/10.1146/annurev-physiol-042924-084007","url":null,"abstract":"Approximately two-thirds of cases of chronic obstructive pulmonary disease (COPD) and adult asthma are in part driven by impaired lung development related to early-life events. Many children who suffer insults to their lungs during the first few years of life experience abnormal lung development, growth, and/or maturation, leading to impaired lung function, which may persist throughout their lifespan. This abnormal lung trajectory may be exacerbated by lung dysanapsis, genetic and epigenetic alterations, oxidative stress and/or inflammation in the airways related to environmental factors including exposure to active or secondhand smoke, air pollution, poor nutrition and social deprivation, and repeated childhood respiratory tract infections. Children with asthma may transition to COPD in adulthood if their asthma is poorly controlled or in the presence of other risk factors such as smoking. As many of these factors are modifiable, prompt diagnosis and implementation of preventive measures should be considered as early as possible in children at risk for abnormal lung development. This review provides an update on the interplay between genetic, environmental, and socioeconomic factors, their cumulative impact on lung development, and its implication for the risk and burden of asthma and COPD in the global population.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":19.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Managing Glucose Homeostasis Through the Gut Microbiome. 通过肠道微生物群管理葡萄糖稳态。

IF 19.1 1区医学

Annual review of physiology Pub Date : 2025-09-17 DOI: 10.1146/annurev-physiol-051524-094728

Savanna N Weninger, Andrew Manley, Frank A Duca

引用次数: 0

Novel Advances in Our Understanding of Sex-Dependent Control of Blood Pressure. 性别依赖性血压控制的新进展。

IF 19.1 1区医学

Annual review of physiology Pub Date : 2025-09-02 DOI: 10.1146/annurev-physiol-050724-022450

Rachel Q Muir, Jiaojiao Xu, Alexandra D Medcalf, Jennifer L Pluznick

引用次数: 0

Sex, Gender, and COPD. 性、性别与慢性阻塞性肺病。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-042022-014322

Dawn L DeMeo

引用次数: 0

Sex Differences in Electrophysiology and Calcium Handling in Atrial Health and Fibrillation. 心房健康和心房颤动中电生理学和钙处理的性别差异。

IF 19.1 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-104938

Charlotte E R Smith, Haibo Ni, Eleonora Grandi

引用次数: 0

The Calcium Homeostasis of Human Red Blood Cells in Health and Disease: Interactions of PIEZO1, the Plasma Membrane Calcium Pump, and Gardos Channels. 人类红细胞在健康和疾病中的钙稳态：PIEZO1、质膜钙泵和加多斯通道的相互作用

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105119

Virgilio L Lew

引用次数: 0

Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease. 缺血性心脏病心功能电异质性的机制及其影响

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-042022-020541

Hector Martinez-Navarro, Xin Zhou, Blanca Rodriguez

{"title":"Mechanisms and Implications of Electrical Heterogeneity in Cardiac Function in Ischemic Heart Disease.","authors":"Hector Martinez-Navarro, Xin Zhou, Blanca Rodriguez","doi":"10.1146/annurev-physiol-042022-020541","DOIUrl":"10.1146/annurev-physiol-042022-020541","url":null,"abstract":"A healthy heart shows intrinsic electrical heterogeneities that play a significant role in cardiac activation and repolarization. However, cardiac diseases may perturb the baseline electrical properties of the healthy cardiac tissue, leading to increased arrhythmic risk and compromised cardiac functions. Moreover, biological variability among patients produces a wide range of clinical symptoms, which complicates the treatment and diagnosis of cardiac diseases. Ischemic heart disease is usually caused by a partial or complete blockage of a coronary artery. The onset of the disease begins with myocardial ischemia, which can develop into myocardial infarction if it persists for an extended period. The progressive regional tissue remodeling leads to increased electrical heterogeneities, with adverse consequences on arrhythmic risk, cardiac mechanics, and mortality. This review aims to summarize the key role of electrical heterogeneities in the heart on cardiac function and diseases. Ischemic heart disease has been chosen as an example to show how adverse electrical remodeling at different stages may lead to variable manifestations in patients. For this, we have reviewed the dynamic electrophysiological and structural remodeling from the onset of acute myocardial ischemia and reperfusion to acute and chronic stages post-myocardial infarction. The arrhythmic mechanisms, patient phenotypes, risk stratification at different stages, and patient management strategies are also discussed. Finally, we provide a brief review on how computational approaches incorporate human electrophysiological heterogeneity to facilitate basic and translational research.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"25-51"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity. 基于胰岛素的肥胖症治疗方法的机制原理。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105443

Ricardo J Samms, Christine M Kusminski

{"title":"A Mechanistic Rationale for Incretin-Based Therapeutics in the Management of Obesity.","authors":"Ricardo J Samms, Christine M Kusminski","doi":"10.1146/annurev-physiol-022724-105443","DOIUrl":"10.1146/annurev-physiol-022724-105443","url":null,"abstract":"Driven by increased caloric intake relative to expenditure, obesity is a major health concern placing economic and operational strain on healthcare and social care worldwide. Pharmacologically, one of the most effective avenues for the management of excess adiposity is the suppression of appetite. However, owing to the body's natural physiological defense to weight loss and tolerability issues that typically accompany anorectic agents, leveraging this approach to induce sustained weight loss is often easier said than done. As such, to address these challenges, researchers have coupled a thorough understanding of the gut-brain axis with advancements in peptide engineering to design therapeutics mimicking the actions of endocrine hormones to promote a negative energy balance. Indeed, multireceptor agonists targeting the GLP-1, GIP, and glucagon receptors produce meaningful weight loss in people with obesity. Herein, we provide a rationale for how activation of the GIP receptor in the brain and the glucagon receptor in the liver and adipose tissue functions to synergize with GLP-1 receptor agonism to curb the drive to feed and ignite the combustion of excess calories for providing next-generation weight loss.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"279-299"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0