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Annual review of physiology最新文献

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Structure, Function, and Regulation of the Junctophilin Family. 嗜Junctophilin家族的结构、功能和调控。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042022-014926
Duane D Hall, Hiroshi Takeshima, Long-Sheng Song
{"title":"Structure, Function, and Regulation of the Junctophilin Family.","authors":"Duane D Hall, Hiroshi Takeshima, Long-Sheng Song","doi":"10.1146/annurev-physiol-042022-014926","DOIUrl":"10.1146/annurev-physiol-042022-014926","url":null,"abstract":"<p><p>In both excitable and nonexcitable cells, diverse physiological processes are linked to different calcium microdomains within nanoscale junctions that form between the plasma membrane and endo-sarcoplasmic reticula. It is now appreciated that the junctophilin protein family is responsible for establishing, maintaining, and modulating the structure and function of these junctions. We review foundational findings from more than two decades of research that have uncovered how junctophilin-organized ultrastructural domains regulate evolutionarily conserved biological processes. We discuss what is known about the junctophilin family of proteins. Our goal is to summarize the current knowledge of junctophilin domain structure, function, and regulation and to highlight emerging avenues of research that help our understanding of the transcriptional, translational, and post-translational regulation of this gene family and its roles in health and during disease.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10922073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era. 磷酸肌醇对TRP通道的调节：结构时代的功能综述。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-10-23 DOI: 10.1146/annurev-physiol-042022-013956
Tibor Rohacs
{"title":"Phosphoinositide Regulation of TRP Channels: A Functional Overview in the Structural Era.","authors":"Tibor Rohacs","doi":"10.1146/annurev-physiol-042022-013956","DOIUrl":"10.1146/annurev-physiol-042022-013956","url":null,"abstract":"<p><p>Transient receptor potential (TRP) ion channels have diverse activation mechanisms including physical stimuli, such as high or low temperatures, and a variety of intracellular signaling molecules. Regulation by phosphoinositides and their derivatives is their only known common regulatory feature. For most TRP channels, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P<sub>2</sub>] serves as a cofactor required for activity. Such dependence on PI(4,5)P<sub>2</sub> has been demonstrated for members of the TRPM subfamily and for the epithelial TRPV5 and TRPV6 channels. Intracellular TRPML channels show specific activation by PI(3,5)P<sub>2</sub>. Structural studies uncovered the PI(4,5)P<sub>2</sub> and PI(3,5)P<sub>2</sub> binding sites for these channels and shed light on the mechanism of channel opening. PI(4,5)P<sub>2</sub> regulation of TRPV1-4 as well as some TRPC channels is more complex, involving both positive and negative effects. This review discusses the functional roles of phosphoinositides in TRP channel regulation and molecular insights gained from recent cryo-electron microscopy structures.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49688439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arterial Stiffness: From Basic Primers to Integrative Physiology. 动脉僵化：从基础入门到综合生理学》。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042022-031925
Véronique Regnault, Patrick Lacolley, Stéphane Laurent
{"title":"Arterial Stiffness: From Basic Primers to Integrative Physiology.","authors":"Véronique Regnault, Patrick Lacolley, Stéphane Laurent","doi":"10.1146/annurev-physiol-042022-031925","DOIUrl":"10.1146/annurev-physiol-042022-031925","url":null,"abstract":"<p><p>The elastic properties of conductance arteries are one of the most important hemodynamic functions in the body, and data continue to emerge regarding the importance of their dysfunction in vascular aging and a range of cardiovascular diseases. Here, we provide new insight into the integrative physiology of arterial stiffening and its clinical consequence. We also comprehensively review progress made on pathways/molecules that appear today as important basic determinants of arterial stiffness, particularly those mediating the vascular smooth muscle cell (VSMC) contractility, plasticity and stiffness. We focus on membrane and nuclear mechanotransduction, clearance function of the vascular wall, phenotypic switching of VSMCs, immunoinflammatory stimuli and epigenetic mechanisms. Finally, we discuss the most important advances of the latest clinical studies that revisit the classical therapeutic concepts of arterial stiffness and lead to a patient-by-patient strategy according to cardiovascular risk exposure and underlying disease.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orchestration of the Adipose Tissue Immune Landscape by Adipocytes. 脂肪细胞协调脂肪组织的免疫格局
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-024353
David Bradley, Tuo Deng, Dharti Shantaram, Willa A Hsueh
{"title":"Orchestration of the Adipose Tissue Immune Landscape by Adipocytes.","authors":"David Bradley, Tuo Deng, Dharti Shantaram, Willa A Hsueh","doi":"10.1146/annurev-physiol-042222-024353","DOIUrl":"10.1146/annurev-physiol-042222-024353","url":null,"abstract":"<p><p>Obesity is epidemic and of great concern because of its comorbid and costly inflammatory-driven complications. Extensive investigations in mice have elucidated highly coordinated, well-balanced interactions between adipocytes and immune cells in adipose tissue that maintain normal systemic metabolism in the lean state, while in obesity, proinflammatory changes occur in nearly all adipose tissue immune cells. Many of these changes are instigated by adipocytes. However, less is known about obesity-induced adipose-tissue immune cell alterations in humans. Upon high-fat diet feeding, the adipocyte changes its well-known function as a metabolic cell to assume the role of an immune cell, orchestrating proinflammatory changes that escalate inflammation and progress during obesity. This transformation is particularly prominent in humans. In this review, we (<i>a</i>) highlight a leading and early role for adipocytes in promulgating inflammation, (<i>b</i>) discuss immune cell changes and the time course of these changes (comparing humans and mice when possible), and (<i>c</i>) note how reversing proinflammatory changes in most types of immune cells, including adipocytes, rescues adipose tissue from inflammation and obese mice from insulin resistance.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome. 剃刀边缘：急性炎症性肺损伤/急性呼吸窘迫综合征的血管反应。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-030731
David R Price, Joe G N Garcia
{"title":"A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome.","authors":"David R Price, Joe G N Garcia","doi":"10.1146/annurev-physiol-042222-030731","DOIUrl":"10.1146/annurev-physiol-042222-030731","url":null,"abstract":"<p><p>Historically considered a metabolically inert cellular layer separating the blood from the underlying tissue, the endothelium is now recognized as a highly dynamic, metabolically active tissue that is critical to organ homeostasis. Under homeostatic conditions, lung endothelial cells (ECs) in healthy subjects are quiescent, promoting vasodilation, platelet disaggregation, and anti-inflammatory mechanisms. In contrast, lung ECs are essential contributors to the pathobiology of acute respiratory distress syndrome (ARDS), as the quiescent endothelium is rapidly and radically altered upon exposure to environmental stressors, infectious pathogens, or endogenous danger signals into an effective and formidable regulator of innate and adaptive immunity. These dramatic perturbations, produced in a tsunami of inflammatory cascade activation, result in paracellular gap formation between lung ECs, sustained lung edema, and multi-organ dysfunction that drives ARDS mortality. The astonishing plasticity of the lung endothelium in negotiating this inflammatory environment and efforts to therapeutically target the aberrant ARDS endothelium are examined in further detail in this review.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":15.7,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11259086/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exosome-Mediated Impact on Systemic Metabolism. 外泌体对全身代谢的影响
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042222-024535
Karina Cunha E Rocha, Wei Ying, Jerrold M Olefsky
{"title":"Exosome-Mediated Impact on Systemic Metabolism.","authors":"Karina Cunha E Rocha, Wei Ying, Jerrold M Olefsky","doi":"10.1146/annurev-physiol-042222-024535","DOIUrl":"10.1146/annurev-physiol-042222-024535","url":null,"abstract":"<p><p>Exosomes are small extracellular vesicles that carry lipids, proteins, and microRNAs (miRNAs). They are released by all cell types and can be found not only in circulation but in many biological fluids. Exosomes are essential for interorgan communication because they can transfer their contents from donor to recipient cells, modulating cellular functions. The miRNA content of exosomes is responsible for most of their biological effects, and changes in exosomal miRNA levels can contribute to the progression or regression of metabolic diseases. As exosomal miRNAs are selectively sorted and packaged into exosomes, they can be useful as biomarkers for diagnosing diseases. The field of exosomes and metabolism is expanding rapidly, and researchers are consistently making new discoveries in this area. As a result, exosomes have great potential for a next-generation drug delivery platform for metabolic diseases.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcendent Aspects of Proton Channels. 质子通道的超越方面。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042222-023242
Thomas E DeCoursey
{"title":"Transcendent Aspects of Proton Channels.","authors":"Thomas E DeCoursey","doi":"10.1146/annurev-physiol-042222-023242","DOIUrl":"10.1146/annurev-physiol-042222-023242","url":null,"abstract":"<p><p>A handful of biological proton-selective ion channels exist. Some open at positive or negative membrane potentials, others open at low or high pH, and some are light activated. This review focuses on common features that result from the unique properties of protons. Proton conduction through water or proteins differs qualitatively from that of all other ions. Extraordinary proton selectivity is needed to ensure that protons permeate and other ions do not. Proton selectivity arises from a proton pathway comprising a hydrogen-bonded chain that typically includes at least one titratable amino acid side chain. The enormously diverse functions of proton channels in disparate regions of the phylogenetic tree can be summarized by considering the chemical and electrical consequences of proton flux across membranes. This review discusses examples of cells in which proton efflux serves to increase pH<sub>i</sub>, decrease pH<sub>o</sub>, control the membrane potential, generate action potentials, or compensate transmembrane movement of electrical charge.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10938948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcellular Barriers to Glucose Delivery in the Body. 体内葡萄糖传递的跨细胞障碍。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 DOI: 10.1146/annurev-physiol-042022-031657
Amira Klip, Katrien De Bock, Philip J Bilan, Erik A Richter
{"title":"Transcellular Barriers to Glucose Delivery in the Body.","authors":"Amira Klip, Katrien De Bock, Philip J Bilan, Erik A Richter","doi":"10.1146/annurev-physiol-042022-031657","DOIUrl":"10.1146/annurev-physiol-042022-031657","url":null,"abstract":"<p><p>Glucose is the universal fuel of most mammalian cells, and it is largely replenished through dietary intake. Glucose availability to tissues is paramount for the maintenance of homeostatic energetics and, hence, supply should match demand by the consuming organs. In its journey through the body, glucose encounters cellular barriers for transit at the levels of the absorbing intestinal epithelial wall, the renal epithelium mediating glucose reabsorption, and the tight capillary endothelia (especially in the brain). Glucose transiting through these cellular barriers must escape degradation to ensure optimal glucose delivery to the bloodstream or tissues. The liver, which stores glycogen and generates glucose de novo, must similarly be able to release it intact to the circulation. We present the most up-to-date knowledge on glucose handling by the gut, liver, brain endothelium, and kidney, and discuss underlying molecular mechanisms and open questions. Diseases associated with defects in glucose delivery and homeostasis are also briefly addressed. We propose that the universal problem of sparing glucose from catabolism in favor of translocation across the barriers posed by epithelia and endothelia is resolved through common mechanisms involving glucose transfer to the endoplasmic reticulum, from where glucose exits the cells via unconventional cellular mechanisms.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy. 平衡行动:从过去吸取教训，建立面向未来的阿片类药物战略。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-29 DOI: 10.1146/annurev-physiol-042022-015914
Sarah Warren Gooding, Jennifer L Whistler
{"title":"A Balancing Act: Learning from the Past to Build a Future-Focused Opioid Strategy.","authors":"Sarah Warren Gooding, Jennifer L Whistler","doi":"10.1146/annurev-physiol-042022-015914","DOIUrl":"10.1146/annurev-physiol-042022-015914","url":null,"abstract":"<p><p>The harmful side effects of opioid drugs such as respiratory depression, tolerance, dependence, and abuse potential have limited the therapeutic utility of opioids for their entire clinical history. However, no previous attempt to develop effective pain drugs that substantially ameliorate these effects has succeeded, and the current opioid epidemic affirms that they are a greater hindrance to the field of pain management than ever. Recent attempts at new opioid development have sought to reduce these side effects by minimizing engagement of the regulatory protein arrestin-3 at the mu-opioid receptor, but there is significant controversy around this approach. Here, we discuss the ongoing effort to develop safer opioids and its relevant historical context. We propose a new model that reconciles results previously assumed to be in direct conflict to explain how different signaling profiles at the mu-opioid receptor contribute to opioid tolerance and dependence. Our goal is for this framework to inform the search for a new generation of lower liability opioid analgesics.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138457418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effects of Psychedelics on Neuronal Physiology. 迷幻药对神经元生理的影响。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI: 10.1146/annurev-physiol-042022-020923
Cassandra J Hatzipantelis, David E Olson
{"title":"The Effects of Psychedelics on Neuronal Physiology.","authors":"Cassandra J Hatzipantelis, David E Olson","doi":"10.1146/annurev-physiol-042022-020923","DOIUrl":"10.1146/annurev-physiol-042022-020923","url":null,"abstract":"<p><p>Psychedelics are quite unique among drugs that impact the central nervous system, as a single administration of a psychedelic can both rapidly alter subjective experience in profound ways and produce sustained effects on circuits relevant to mood, fear, reward, and cognitive flexibility. These remarkable properties are a direct result of psychedelics interacting with several key neuroreceptors distributed across the brain. Stimulation of these receptors activates a variety of signaling cascades that ultimately culminate in changes in neuronal structure and function. Here, we describe the effects of psychedelics on neuronal physiology, highlighting their acute effects on serotonergic and glutamatergic neurotransmission as well as their long-lasting effects on structural and functional neuroplasticity in the cortex. We propose that the neurobiological changes leading to the acute and sustained effects of psychedelics might be distinct, which could provide opportunities for engineering compounds with optimized safety and efficacy profiles.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71477422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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