发布求助
文献互助 智能选刊 最新文献

Annual review of physiology最新文献

筛选
英文 中文
Preterm Brain Injury: Mechanisms and Challenges. 早产儿脑损伤：机制与挑战。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-104754
Michael J Beacom, Alistair J Gunn, Laura Bennet
{"title":"Preterm Brain Injury: Mechanisms and Challenges.","authors":"Michael J Beacom, Alistair J Gunn, Laura Bennet","doi":"10.1146/annurev-physiol-022724-104754","DOIUrl":"10.1146/annurev-physiol-022724-104754","url":null,"abstract":"<p><p>Preterm fetuses and newborns have a high risk of neural injury and impaired neural maturation, leading to neurodevelopmental disability. Developing effective treatments is rather challenging, as preterm brain injury may occur at any time during pregnancy and postnatally, and many cases involve multiple pathogenic factors. This review examines research on how the preterm fetus responds to hypoxia-ischemia and how brain injury evolves after hypoxia-ischemia, offering windows of opportunity for treatment and insights into the mechanisms of injury during key phases. We highlight research showing that preterm fetuses can survive hypoxia-ischemia and continue development in utero with evolving brain injury. Early detection of fetal brain injury would provide an opportunity for treatments to reduce adverse neurodevelopmental outcomes, including cerebral palsy. However, this requires that we can detect injury using noninvasive methods. We discuss how circadian changes in fetal heart rate variability may offer utility as a biomarker for detecting injury and phases of injury.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"79-106"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
At the Crossroads of Health and Disease: Consequences of Fat in the Liver.
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 DOI: 10.1146/annurev-physiol-022724-105515
Matthew Dukewich, Liyun Yuan, Norah A Terrault
{"title":"At the Crossroads of Health and Disease: Consequences of Fat in the Liver.","authors":"Matthew Dukewich, Liyun Yuan, Norah A Terrault","doi":"10.1146/annurev-physiol-022724-105515","DOIUrl":"https://doi.org/10.1146/annurev-physiol-022724-105515","url":null,"abstract":"<p><p>The liver plays a central role in regulating lipid and glucose metabolism, particularly in transitioning between energy storage and provision in fed and fasting states. Loss of metabolic flexibility, characterized by the impaired capacity to shift between different energy substrates, sets the stage for accumulation of hepatic triglyceride as lipid droplets and further metabolic perturbations. Cross talk between the liver and other organs, including adipose tissue, pancreas, and muscle, is relevant in this transition. In addition to the metabolic consequences of steatosis, there are significant liver risks related to triggered inflammatory and fibrotic processes. Steatotic liver diseases affect an estimated one in three adults globally and contribute to substantial morbidity and mortality. This review focuses on the liver's role in lipid metabolism, defining metabolic health and unhealth, the pathogenic underpinnings that lead to steatohepatitis and hepatic fibrosis, and the clinical features and therapies for the most common forms of steatotic liver diseases.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"87 1","pages":"325-352"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chloride-Dependent Cation Transport via SLC12 Carriers at Atomic Resolution.
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 DOI: 10.1146/annurev-physiol-022624-020130
Eric Delpire
{"title":"Chloride-Dependent Cation Transport via <i>SLC12</i> Carriers at Atomic Resolution.","authors":"Eric Delpire","doi":"10.1146/annurev-physiol-022624-020130","DOIUrl":"https://doi.org/10.1146/annurev-physiol-022624-020130","url":null,"abstract":"<p><p>The <i>SLC12</i> family of genes encodes electroneutral Cl--dependent cation transporters (i.e., Na-Cl, K-Cl, Na-K-2Cl cotransporters), which play significant roles in maintaining cell and body homeostasis. Recent resolution of their structures at the atomic level provides a new understanding how these transporters operate in health and disease and how they are targeted for therapeutic intervention. Overall, the SLC12 transporter cryo-EM structures confirm some key features established by traditional biochemical and molecular methods, such as the presence of 12 transmembrane domains and the formation of a functional dimer. Study of these structures also uncovers previously unknown features, such as the presence of strategic salt bridges that explain why transporters are stabilized in specific conformations. The cryo-EM structures show similarities with other transport protein structures, especially regarding the position of the cations. The structures also pose challenging questions regarding the number of ions bound and the strict electroneutrality that is conventional understanding.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"87 1","pages":"397-419"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proresolving Lipid Mediators in the Respiratory System. 呼吸系统中的前溶脂介质
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-020924-033209
Charles N Serhan, Bruce D Levy
{"title":"Proresolving Lipid Mediators in the Respiratory System.","authors":"Charles N Serhan, Bruce D Levy","doi":"10.1146/annurev-physiol-020924-033209","DOIUrl":"10.1146/annurev-physiol-020924-033209","url":null,"abstract":"<p><p>Lung inflammation, infection, and injury can lead to critical illness and death. The current means to pharmacologically treat excessive uncontrolled lung inflammation needs improvement because many treatments are or will become immunosuppressive. The inflammatory response evolved to protect the host from microbes, injury, and environmental insults. This response brings phagocytes from the bloodstream to the tissue site to phagocytize and neutralize bacterial invaders and enables airway antimicrobial functions. This physiologic response is ideally self-limited with initiation and resolution phases. Polyunsaturated essential fatty acids are precursors to potent molecules that govern both phases. In the initiation phase, arachidonic acid is converted to prostaglandins and leukotrienes that activate leukocytes to transmigrate from postcapillary venules. The omega-3 fatty acids (e.g., DHA and EPA) are precursors to resolvins, protectins, and maresins, which are families of chemically distinct mediators with potent functions in resolution of acute and chronic inflammation in the respiratory system.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"491-512"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11810588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142279718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial Transcriptomics of the Respiratory System. 呼吸系统的空间转录组学。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105144
Stathis Megas, Anna Wilbrey-Clark, Aidan Maartens, Sarah A Teichmann, Kerstin B Meyer
{"title":"Spatial Transcriptomics of the Respiratory System.","authors":"Stathis Megas, Anna Wilbrey-Clark, Aidan Maartens, Sarah A Teichmann, Kerstin B Meyer","doi":"10.1146/annurev-physiol-022724-105144","DOIUrl":"10.1146/annurev-physiol-022724-105144","url":null,"abstract":"<p><p>Over the last decade, single-cell genomics has revealed remarkable heterogeneity and plasticity of cell types in the lungs and airways. The challenge now is to understand how these cell types interact in three-dimensional space to perform lung functions, facilitating airflow and gas exchange while simultaneously providing barrier function to avoid infection. An explosion in novel spatially resolved gene expression technologies, coupled with computational tools that harness machine learning and deep learning, now promise to address this challenge. Here, we review the most commonly used spatial analysis workflows, highlighting their advantages and limitations, and outline recent developments in machine learning and artificial intelligence that will augment how we interpret spatial data. Together these technologies have the potential to transform our understanding of the respiratory system in health and disease, and we showcase studies in lung development, COVID-19, lung cancer, and fibrosis where spatially resolved transcriptomics is already providing novel insights.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"447-470"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Specialized Pulmonary Vascular Cells in Development and Disease. 发育和疾病中的特化肺血管细胞
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105226
Arnav Sharma, Terren K Niethamer
{"title":"Specialized Pulmonary Vascular Cells in Development and Disease.","authors":"Arnav Sharma, Terren K Niethamer","doi":"10.1146/annurev-physiol-022724-105226","DOIUrl":"10.1146/annurev-physiol-022724-105226","url":null,"abstract":"<p><p>Endothelial cells (ECs) develop organ-specific gene expression and function in response to signals from the surrounding tissue. In turn, ECs can affect organ development and morphogenesis and promote or hinder disease response. In the lung, ECs play an essential role in gas exchange with the external environment, requiring both a close physical connection and a strong axis of communication with alveolar epithelial cells. A complete picture of the composition of the pulmonary endothelium is therefore critical for a full understanding of development, maintenance, and repair of the gas exchange interface. Defining the factors that control lung-specific EC specification, establish EC heterogeneity within the lung, and promote the differing contributions of EC subtypes to development, health, and disease will facilitate the development of much-needed regenerative therapies. This includes targeting therapeutics directly to ECs, developing pluripotent or primary cell-derived ECs to replace damaged or diseased vasculature, and vascularizing engineered tissues for transplant.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"229-255"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction. 与人类疾病相关的 1,4,5-三磷酸肌醇受体突变：对受体功能和功能障碍的见解。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105627
Vikas Arige, David M MacLean, David I Yule
{"title":"Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease: Insights into Receptor Function and Dysfunction.","authors":"Vikas Arige, David M MacLean, David I Yule","doi":"10.1146/annurev-physiol-022724-105627","DOIUrl":"10.1146/annurev-physiol-022724-105627","url":null,"abstract":"<p><p>Inositol 1,4,5-trisphosphate receptors (IP<sub>3</sub>Rs) are ubiquitous intracellular Ca2+ release channels. Their activation, subcellular localization, abundance, and regulation play major roles in defining the spatiotemporal characteristics of intracellular Ca2+ signals, which are in turn fundamental to the appropriate activation of effectors that control a myriad of cellular events. Over the past decade, ∼100 mutations in <i>ITPR</i>s associated with human diseases have been documented. Mutations have been detailed in all three IP<sub>3</sub>R subtypes and all functional domains of the protein, resulting in both gain and loss of receptor function. IP<sub>3</sub>R mutations are associated with a diverse array of pathology including spinocerebellar ataxia, peripheral neuropathy, immunopathy, anhidrosis, hyperparathyroidism, and squamous cell carcinoma. This review focuses on how studying the altered activity of these mutations provides information relating to IP<sub>3</sub>R structure and function, the physiology underpinned by specific IP<sub>3</sub>R subtypes, and the pathological consequences of dysregulated Ca2+ signaling in human disease.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"201-228"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training? 运动作为线粒体药物：运动处方如何影响线粒体对训练的适应？
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-104836
David J Bishop, Matthew J-C Lee, Martin Picard
{"title":"Exercise as Mitochondrial Medicine: How Does the Exercise Prescription Affect Mitochondrial Adaptations to Training?","authors":"David J Bishop, Matthew J-C Lee, Martin Picard","doi":"10.1146/annurev-physiol-022724-104836","DOIUrl":"10.1146/annurev-physiol-022724-104836","url":null,"abstract":"<p><p>Mitochondria are multifaceted organelles with several life-sustaining functions beyond energy transformation, including cell signaling, calcium homeostasis, hormone synthesis, programmed cell death (apoptosis), and others. A defining aspect of these dynamic organelles is their remarkable plasticity, which allows them to sense, respond, and adapt to various stressors. In particular, it is well-established that the stress of exercise provides a powerful stimulus that can trigger transient or enduring changes to mitochondrial molecular features, activities, integrated functions, behaviors, and cell-dependent mitochondrial phenotypes. Evidence documenting the many beneficial mitochondrial adaptations to exercise has led to the notion of exercise as a mitochondrial medicine. However, as with other medicines, it is important to understand the optimal prescription (i.e., type, dose, frequency, duration). In this review, we build on a systematic biological framework that distinguishes between domains of mitochondrial biology to critically evaluate how different exercise prescription variables influence mitochondrial adaptations to training.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"107-129"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics. 新陈代谢中的蛋白酪氨酸磷酸酶：治疗的新领域。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105540
Anton M Bennett, Tony Tiganis
{"title":"Protein Tyrosine Phosphatases in Metabolism: A New Frontier for Therapeutics.","authors":"Anton M Bennett, Tony Tiganis","doi":"10.1146/annurev-physiol-022724-105540","DOIUrl":"10.1146/annurev-physiol-022724-105540","url":null,"abstract":"<p><p>The increased prevalence of chronic metabolic disorders, including obesity and type 2 diabetes and their associated comorbidities, are among the world's greatest health and economic challenges. Metabolic homeostasis involves a complex interplay between hormones that act on different tissues to elicit changes in the storage and utilization of energy. Such processes are mediated by tyrosine phosphorylation-dependent signaling, which is coordinated by the opposing actions of protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Perturbations in the functions of PTPs can be instrumental in the pathophysiology of metabolic diseases. The goal of this review is to highlight key advances in our understanding of how PTPs control body weight and glucose metabolism, as well as their contributions to obesity and type 2 diabetes. The emerging appreciation of the integrated functions of PTPs in metabolism, coupled with significant advances in pharmaceutical strategies aimed at targeting this class of enzymes, marks the advent of a new frontier in combating metabolic disorders.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"301-324"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Physiology of Enteric Glia. 肠胶质细胞的生理学。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1146/annurev-physiol-022724-105016
Jacques Gonzales, Brian D Gulbransen
{"title":"The Physiology of Enteric Glia.","authors":"Jacques Gonzales, Brian D Gulbransen","doi":"10.1146/annurev-physiol-022724-105016","DOIUrl":"10.1146/annurev-physiol-022724-105016","url":null,"abstract":"<p><p>Enteric glia are the partners of neurons in the enteric nervous system throughout the gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining intestinal homeostasis through interactions with neurons, immune cells, and the intestinal epithelium. Glial influences optimize physiological gut processes such as intestinal motility and epithelial barrier integrity through actions that regulate the microenvironment of the enteric nervous system, the activity of enteric neurons, intestinal epithelial functions, and immune response. Changes to glial phenotype in disease switch glial functions and contribute to intestinal inflammation, dysmotility, pain, neuroplasticity, and tumorigenesis. This review summarizes current concepts regarding the physiological roles of enteric glial cells and their potential contributions to gut disease. The discussion is focused on recent evidence that suggests important glial contributions to gastrointestinal health and pathophysiology.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":"353-380"},"PeriodicalIF":15.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信