Annual review of physiology最新文献_第10页

Aging and Lung Disease. 衰老与肺病。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-15 DOI: 10.1146/annurev-physiol-021119-034610

Soo Jung Cho, H. Stout-Delgado

引用次数: 124

The Acidic Tumor Microenvironment as a Driver of Cancer. 酸性肿瘤微环境是癌症的驱动因素。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-15 DOI: 10.1146/annurev-physiol-021119-034627

E. Boedtkjer, S. Pedersen

{"title":"The Acidic Tumor Microenvironment as a Driver of Cancer.","authors":"E. Boedtkjer, S. Pedersen","doi":"10.1146/annurev-physiol-021119-034627","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034627","url":null,"abstract":"Acidic metabolic waste products accumulate in the tumor microenvironment because of high metabolic activity and insufficient perfusion. In tumors, the acidity of the interstitial space and the relatively well-maintained intracellular pH influence cancer and stromal cell function, their mutual interplay, and their interactions with the extracellular matrix. Tumor pH is spatially and temporally heterogeneous, and the fitness advantage of cancer cells adapted to extracellular acidity is likely particularly evident when they encounter less acidic tumor regions, for instance, during invasion. Through complex effects on genetic stability, epigenetics, cellular metabolism, proliferation, and survival, the compartmentalized pH microenvironment favors cancer development. Cellular selection exacerbates the malignant phenotype, which is further enhanced by acid-induced cell motility, extracellular matrix degradation, attenuated immune responses, and modified cellular and intercellular signaling. In this review, we discuss how the acidity of the tumor microenvironment influences each stage in cancer development, from dysplasia to full-blown metastatic disease. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034627","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43560097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 412

IP3 Receptor Plasticity Underlying Diverse Functions. IP3受体在不同功能下的可塑性

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-15 DOI: 10.1146/annurev-physiol-021119-034433

K. Hamada, K. Mikoshiba

{"title":"IP3 Receptor Plasticity Underlying Diverse Functions.","authors":"K. Hamada, K. Mikoshiba","doi":"10.1146/annurev-physiol-021119-034433","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034433","url":null,"abstract":"In the body, extracellular stimuli produce inositol 1,4,5-trisphosphate (IP3), an intracellular chemical signal that binds to the IP3 receptor (IP3R) to release calcium ions (Ca2+) from the endoplasmic reticulum. In the past 40 years, the wide-ranging functions mediated by IP3R and its genetic defects causing a variety of disorders have been unveiled. Recent cryo-electron microscopy and X-ray crystallography have resolved IP3R structures and begun to integrate with concurrent functional studies, which can explicate IP3-dependent opening of Ca2+-conducting gates placed ∼90 Å away from IP3-binding sites and its regulation by Ca2+. This review highlights recent research progress on the IP3R structure and function. We also propose how protein plasticity within IP3R, which involves allosteric gating and assembly transformations accompanied by rapid and chronic structural changes, would enable it to regulate diverse functions at cellular microdomains in pathophysiological states. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"1 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034433","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"63972246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

APOL1 and Kidney Disease: From Genetics to Biology. APOL1与肾脏疾病:从遗传学到生物学。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-11 DOI: 10.1146/annurev-physiol-021119-034345

D. Friedman, M. Pollak

{"title":"APOL1 and Kidney Disease: From Genetics to Biology.","authors":"D. Friedman, M. Pollak","doi":"10.1146/annurev-physiol-021119-034345","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034345","url":null,"abstract":"Genetic variants in the APOL1 gene, found only in individuals of recent African ancestry, greatly increase risk of multiple types of kidney disease. These APOL1 kidney risk alleles are a rare example of genetic variants that are common but also have a powerful effect on disease susceptibility. These alleles rose to high frequency in sub-Saharan Africa because they conferred protection against pathogenic Trypanosomes that cause African sleeping sickness. We consider the genetic evidence supporting the association between APOL1 and kidney disease across the range of clinical phenotypes in the APOL1 nephropathy spectrum. We then explore the origins of the APOL1 risk variants and evolutionary struggle between humans and trypanosomes at both the molecular and population genetic level. Finally, we survey the rapidly growing literature investigating APOL1 biology as elucidated from experiments in cell-based systems, cell-free systems, mouse and lower organism models of disease, and through illuminating natural experiments in humans. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2019-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46453628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 90

Marrow Adipocytes: Origin, Structure, and Function. 骨髓脂肪细胞：起源、结构和功能。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-08 DOI: 10.1146/annurev-physiol-021119-034513

F. D. de Paula, C. Rosen

{"title":"Marrow Adipocytes: Origin, Structure, and Function.","authors":"F. D. de Paula, C. Rosen","doi":"10.1146/annurev-physiol-021119-034513","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034513","url":null,"abstract":"The skeleton harbors an array of lineage cells that have an essential role in whole body homeostasis. Adipocytes start the colonization of marrow space early in postnatal life, expanding progressively and influencing other components of the bone marrow through paracrine signaling. In this unique, closed, and hypoxic environment close to the endosteal surface and adjacent to the microvascular space the marrow adipocyte can store or provide energy, secrete adipokines, and target neighboring bone cells. Adipocyte progenitors can also migrate from the bone marrow to populate white adipose tissue, a process that accelerates during weight gain. The marrow adipocyte also has an endocrine role in whole body homeostasis through its varied secretome that targets distant adipose depots, skeletal muscle, and the nervous system. Further insights into the biology of this unique and versatile cell will undoubtedly lead to novel therapeutic approaches to metabolic and age-related disorders such as osteoporosis and diabetes mellitus. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45165590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Cell Death in the Lung: The Apoptosis-Necroptosis Axis. 肺部的细胞死亡：细胞凋亡-新陈代谢轴。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-02-10 Epub Date: 2018-11-28 DOI: 10.1146/annurev-physiol-020518-114320

Maor Sauler, Isabel S Bazan, Patty J Lee

引用次数: 0

Regulation of BK Channels by Beta and Gamma Subunits. β和γ亚基对BK通道的调控。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-02-10 DOI: 10.1146/annurev-physiol-022516-034038

Vivian Gonzalez-Perez, Christopher J Lingle

引用次数: 72

Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair. 伤口相关细胞和介质在胃肠道粘膜伤口修复中的作用。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-02-10 Epub Date: 2018-10-24 DOI: 10.1146/annurev-physiol-020518-114504

Miguel Quirós, Asma Nusrat

{"title":"Contribution of Wound-Associated Cells and Mediators in Orchestrating Gastrointestinal Mucosal Wound Repair.","authors":"Miguel Quirós, Asma Nusrat","doi":"10.1146/annurev-physiol-020518-114504","DOIUrl":"10.1146/annurev-physiol-020518-114504","url":null,"abstract":"The gastrointestinal mucosa, structurally formed by the epithelium and lamina propria, serves as a selective barrier that separates luminal contents from the underlying tissues. Gastrointestinal mucosal wound repair is orchestrated by a series of spatial and temporal events that involve the epithelium, recruited immune cells, resident stromal cells, and the microbiota present in the wound bed. Upon injury, repair of the gastrointestinal barrier is mediated by collective migration, proliferation, and subsequent differentiation of epithelial cells. Epithelial repair is intimately regulated by a number of wound-associated cells that include immune cells and stromal cells in addition to mediators released by luminal microbiota. The highly regulated interaction of these cell types is perturbed in chronic inflammatory diseases that are associated with impaired wound healing. An improved understanding of prorepair mechanisms in the gastrointestinal mucosa will aid in the development of novel therapeutics that promote mucosal healing and reestablish the critical epithelial barrier function.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"81 ","pages":"189-209"},"PeriodicalIF":18.2,"publicationDate":"2019-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-020518-114504","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36602343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges. 肿瘤血管功能正常化:进展、机遇和挑战。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-02-10 DOI: 10.1146/annurev-physiol-020518-114700

John D Martin, Giorgio Seano, Rakesh K Jain

{"title":"Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges.","authors":"John D Martin, Giorgio Seano, Rakesh K Jain","doi":"10.1146/annurev-physiol-020518-114700","DOIUrl":"https://doi.org/10.1146/annurev-physiol-020518-114700","url":null,"abstract":"Abnormal blood and lymphatic vessels create a hostile tumor microenvironment characterized by hypoxia, low pH, and elevated interstitial fluid pressure. These abnormalities fuel tumor progression, immunosuppression, and treatment resistance. In 2001, we proposed a novel hypothesis that the judicious use of antiangiogenesis agents-originally developed to starve tumors-could transiently normalize tumor vessels and improve the outcome of anticancer drugs administered during the window of normalization. In addition to providing preclinical and clinical evidence in support of this hypothesis, we also revealed the underlying molecular mechanisms. In parallel, we demonstrated that desmoplasia could also impair vascular function by compressing vessels, and that normalizing the extracellular matrix could improve vascular function and treatment outcome in both preclinical and clinical settings. Here, we summarize the progress made in understanding and applying the normalization concept to cancer and outline opportunities and challenges ahead to improve patient outcomes using various normalizing strategies.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"81 ","pages":"505-534"},"PeriodicalIF":18.2,"publicationDate":"2019-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-020518-114700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36950944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 266

ATP-Gated P2X Receptor Channels: Molecular Insights into Functional Roles. atp门控P2X受体通道:功能角色的分子洞察。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-02-10 Epub Date: 2018-10-24 DOI: 10.1146/annurev-physiol-020518-114259

Ralf Schmid, Richard J Evans

引用次数: 39