BMP信号在胃肠道发育、干细胞和疾病中的作用。

IF 15.7 1区医学 Q1 PHYSIOLOGY

Annual review of physiology Pub Date : 2020-02-10 DOI:10.1146/annurev-physiol-021119-034500

Yongchun Zhang, Jianwen Que

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引用次数: 33

摘要

骨形态发生蛋白(bone morphogenetic protein, BMP)通路对消化系统中多个器官的形态发生至关重要。异常BMP信号也与胃肠道和相关器官的疾病发生和进展有关。最近对动物模型、组织类器官和人类多能干细胞的研究极大地扩展了我们对bmp在胃肠道器官发育和稳态中所起作用的理解。很明显，BMP信号以组织特异性的方式调节涉及干细胞/祖细胞和炎症的GI功能和疾病进展。在这篇综述中，我们讨论了这些新的发现，重点是食道，胃和肠。

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BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract.

The bone morphogenetic protein (BMP) pathway is essential for the morphogenesis of multiple organs in the digestive system. Abnormal BMP signaling has also been associated with disease initiation and progression in the gastrointestinal (GI) tract and associated organs. Recent studies using animal models, tissue organoids, and human pluripotent stem cells have significantly expanded our understanding of the roles played by BMPs in the development and homeostasis of GI organs. It is clear that BMP signaling regulates GI function and disease progression that involve stem/progenitor cells and inflammation in a tissue-specific manner. In this review we discuss these new findings with a focus on the esophagus, stomach, and intestine.

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来源期刊

Annual review of physiology 医学-生理学

CiteScore

35.60

自引率

0.00%

发文量

期刊介绍： Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.