Annual review of physiology最新文献_第9页

Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception. 通过感知的视角驱动生物体衰老的神经元机制。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2020-02-10 DOI: 10.1146/annurev-physiol-021119-034440

C. Gendron, T. Chakraborty, Brian Y. Chung, Zachary M. Harvanek, Kristina J Holme, Jacob C Johnson, Y. Lyu, Allyson S. Munneke, S. Pletcher

{"title":"Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception.","authors":"C. Gendron, T. Chakraborty, Brian Y. Chung, Zachary M. Harvanek, Kristina J Holme, Jacob C Johnson, Y. Lyu, Allyson S. Munneke, S. Pletcher","doi":"10.1146/annurev-physiol-021119-034440","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034440","url":null,"abstract":"Sensory neurons provide organisms with data about the world in which they live, for the purpose of successfully exploiting their environment. The consequences of sensory perception are not simply limited to decision-making behaviors; evidence suggests that sensory perception directly influences physiology and aging, a phenomenon that has been observed in animals across taxa. Therefore, understanding the neural mechanisms by which sensory input influences aging may uncover novel therapeutic targets for aging-related physiologies. In this review, we examine different perceptive experiences that have been most clearly linked to aging or age-related disease: food perception, social perception, time perception, and threat perception. For each, the sensory cues, receptors, and/or pathways that influence aging as well as the individual or groups of neurons involved, if known, are discussed. We conclude with general thoughts about the potential impact of this line of research on human health and aging. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034440","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46071068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Physiology of the Carotid Body: From Molecules to Disease. 颈动脉体生理学：从分子到疾病。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2020-02-10 DOI: 10.1146/annurev-physiol-020518-114427

P. Ortega-Sáenz, J. López-Barneo

{"title":"Physiology of the Carotid Body: From Molecules to Disease.","authors":"P. Ortega-Sáenz, J. López-Barneo","doi":"10.1146/annurev-physiol-020518-114427","DOIUrl":"https://doi.org/10.1146/annurev-physiol-020518-114427","url":null,"abstract":"The carotid body (CB) is an arterial chemoreceptor organ located in the carotid bifurcation and has a well-recognized role in cardiorespiratory regulation. The CB contains neurosecretory sensory cells (glomus cells), which release transmitters in response to hypoxia, hypercapnia, and acidemia to activate afferent sensory fibers terminating in the respiratory and autonomic brainstem centers. Knowledge of the physiology of the CB has progressed enormously in recent years. Herein we review advances concerning the organization and function of the cellular elements of the CB, with emphasis on the molecular mechanisms of acute oxygen sensing by glomus cells. We introduce the modern view of the CB as a multimodal integrated metabolic sensor and describe the properties of the CB stem cell niche, which support CB growth during acclimatization to chronic hypoxia. Finally, we discuss the increasing medical relevance of CB dysfunction and its potential impact on the mechanisms of disease. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-020518-114427","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49561479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

Intestinal Stem Cell Aging: Origins and Interventions. 肠道干细胞老化:起源和干预。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2020-02-10 DOI: 10.1146/annurev-physiol-021119-034359

H. Jasper

引用次数: 73

Contributions of Aging to Cerebral Small Vessel Disease. 衰老对脑血管疾病的影响。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2020-02-10 DOI: 10.1146/annurev-physiol-021119-034338

T. M. De Silva, F. Faraci

{"title":"Contributions of Aging to Cerebral Small Vessel Disease.","authors":"T. M. De Silva, F. Faraci","doi":"10.1146/annurev-physiol-021119-034338","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034338","url":null,"abstract":"Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related reductions in brain health. End-organ effects are diverse, resulting in both cognitive and noncognitive deficits. Underlying phenotypes and mechanisms are multifactorial, with no specific treatments at this time. Despite consequences that are already considerable, the impact of SVD is predicted to increase substantially with the growing aging population. In the face of this health challenge, the basic biology, pathogenesis, and determinants of SVD are poorly defined. This review summarizes recent progress and concepts in this area, highlighting key findings and some major unanswered questions. We focus on phenotypes and mechanisms that underlie microvascular aging, the greatest risk factor for cerebrovascular disease and its subsequent effects. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"1 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034338","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42219324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 42

Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms. 破骨细胞通过多种机制向成骨细胞系细胞提供耦合信号。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2020-02-10 DOI: 10.1146/annurev-physiol-021119-034425

N. Sims, T. Martin

{"title":"Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms.","authors":"N. Sims, T. Martin","doi":"10.1146/annurev-physiol-021119-034425","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034425","url":null,"abstract":"Bone remodeling is essential for the repair and replacement of damaged and old bone. The major principle underlying this process is that osteoclast-mediated resorption of a quantum of bone is followed by osteoblast precursor recruitment; these cells differentiate to matrix-producing osteoblasts, which form new bone to replace what was resorbed. Evidence from osteopetrotic syndromes indicate that osteoclasts not only resorb bone, but also provide signals to promote bone formation. Osteoclasts act upon osteoblast lineage cells throughout their differentiation by facilitating growth factor release from resorbed matrix, producing secreted proteins and microvesicles, and expressing membrane-bound factors. These multiple mechanisms mediate the coupling of bone formation to resorption in remodeling. Additional interactions of osteoclasts with osteoblast lineage cells, including interactions with canopy and reversal cells, are required to achieve coordination between bone formation and resorption during bone remodeling. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43634836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 125

Cardiomyocyte Polyploidy and Implications for Heart Regeneration. 心肌细胞多倍体及其对心脏再生的意义。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2020-02-10 DOI: 10.1146/annurev-physiol-021119-034618

Peiheng Gan, Michaela Patterson, H. Sucov

引用次数: 53

BMP Signaling in Development, Stem Cells, and Diseases of the Gastrointestinal Tract. BMP信号在胃肠道发育、干细胞和疾病中的作用。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2020-02-10 DOI: 10.1146/annurev-physiol-021119-034500

Yongchun Zhang, Jianwen Que

引用次数: 33

Regulation and Effects of FGF23 in Chronic Kidney Disease. FGF23在慢性肾脏疾病中的调节作用

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-19 DOI: 10.1146/annurev-physiol-021119-034650

J. Musgrove, M. Wolf

{"title":"Regulation and Effects of FGF23 in Chronic Kidney Disease.","authors":"J. Musgrove, M. Wolf","doi":"10.1146/annurev-physiol-021119-034650","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034650","url":null,"abstract":"Chronic kidney disease (CKD) is a global health epidemic that accelerates cardiovascular disease, increases risk of infection, and causes anemia and bone disease, among other complications that collectively increase risk of premature death. Alterations in calcium and phosphate homeostasis have long been considered nontraditional risk factors for many of the most morbid outcomes of CKD. The discovery of fibroblast growth factor 23 (FGF23), which revolutionized the diagnosis and treatment of rare hereditary disorders of FGF23 excess that cause hypophosphatemic rickets, has also driven major paradigm shifts in our understanding of the pathophysiology and downstream end-organ complications of disordered mineral metabolism in CKD. As research of FGF23 in CKD has rapidly advanced, major new questions about its regulation and effects continuously emerge. These are promoting exciting innovations in laboratory, patient-oriented, and epidemiological research and stimulating clinical trials of new therapies and repurposing of existing ones to target FGF23. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2019-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43250679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 70

Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior. 妊娠期暴露于常见的内分泌破坏性化学物质及其对神经发育和行为的影响。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-18 DOI: 10.1146/annurev-physiol-021119-034555

Dinushan Nesan, D. Kurrasch

{"title":"Gestational Exposure to Common Endocrine Disrupting Chemicals and Their Impact on Neurodevelopment and Behavior.","authors":"Dinushan Nesan, D. Kurrasch","doi":"10.1146/annurev-physiol-021119-034555","DOIUrl":"https://doi.org/10.1146/annurev-physiol-021119-034555","url":null,"abstract":"Endocrine disrupting chemicals are common in our environment and act on hormone systems and signaling pathways to alter physiological homeostasis. Gestational exposure can disrupt developmental programs, permanently altering tissues with impacts lasting into adulthood. The brain is a critical target for developmental endocrine disruption, resulting in altered neuroendocrine control of hormonal signaling, altered neurotransmitter control of nervous system function, and fundamental changes in behaviors such as learning, memory, and social interactions. Human cohort studies reveal correlations between maternal/fetal exposure to endocrine disruptors and incidence of neurodevelopmental disorders. Here, we summarize the major literature findings of endocrine disruption of neurodevelopment and concomitant changes in behavior by four major endocrine disruptor classes: bisphenol A, polychlorinated biphenyls, organophosphates, and polybrominated diphenyl ethers. We specifically review studies of gestational and/or lactational exposure to understand the effects of early life exposure to these compounds and summarize animal studies that help explain human correlative data. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":" ","pages":""},"PeriodicalIF":18.2,"publicationDate":"2019-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-physiol-021119-034555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49420539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Genetics of COPD. COPD的遗传学。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2019-11-15 DOI: 10.1146/ANNUREV-PHYSIOL-021317-121224

E. Silverman

引用次数: 67