New Approaches to Target Inflammation in Heart Failure: Harnessing Insights from Studies of Immune Cell Diversity.

IF 15.7 1区医学 Q1 PHYSIOLOGY

Annual review of physiology Pub Date : 2020-02-10 DOI:10.1146/annurev-physiol-021119-034412

A. J. Rhee, K. Lavine

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引用次数: 22

Abstract

Despite mounting evidence implicating inflammation in cardiovascular diseases, attempts at clinical translation have shown mixed results. Recent preclinical studies have reenergized this field and provided new insights into how to favorably modulate cardiac macrophage function in the context of acute myocardial injury and chronic disease. In this review, we discuss the origins and roles of cardiac macrophage populations in the steady-state and diseased heart, focusing on the human heart and mouse models of ischemia, hypertensive heart disease, and aortic stenosis. Specific attention is given to delineating the roles of tissue-resident and recruited monocyte-derived macrophage subsets. We also highlight emerging concepts of monocyte plasticity and heterogeneity among monocyte-derived macrophages, describe possible mechanisms by which infiltrating monocytes acquire unique macrophage fates, and discuss the putative impact of these populations on cardiac remodeling. Finally, we discuss strategies to target inflammatory macrophage populations. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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针对心力衰竭炎症的新方法：利用免疫细胞多样性研究的见解。

尽管越来越多的证据表明炎症与心血管疾病有关，但临床翻译的尝试显示出喜忧参半的结果。最近的临床前研究重新激发了这一领域的活力，并为如何在急性心肌损伤和慢性疾病的背景下有利地调节心脏巨噬细胞功能提供了新的见解。在这篇综述中，我们讨论了心脏巨噬细胞群体在稳态和患病心脏中的起源和作用，重点是缺血、高血压心脏病和主动脉狭窄的人类心脏和小鼠模型。特别注意描述组织驻留和募集的单核细胞衍生的巨噬细胞亚群的作用。我们还强调了单核细胞来源的巨噬细胞中单核细胞可塑性和异质性的新概念，描述了浸润性单核细胞获得独特巨噬细胞命运的可能机制，并讨论了这些群体对心脏重塑的假定影响。最后，我们讨论了针对炎症巨噬细胞群体的策略。《生理学年度评论》第82卷预计最终在线出版日期为2020年2月10日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of physiology 医学-生理学

CiteScore

35.60

自引率

0.00%

发文量

期刊介绍： Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.

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