Cardiomyocyte Polyploidy and Implications for Heart Regeneration.

IF 15.7 1区医学 Q1 PHYSIOLOGY

Annual review of physiology Pub Date : 2020-02-10 DOI:10.1146/annurev-physiol-021119-034618

Peiheng Gan, Michaela Patterson, H. Sucov

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引用次数: 53

Abstract

In mammals, most cardiomyocytes (CMs) become polyploid (they have more than two complete sets of chromosomes). The purpose of this review is to evaluate assumptions about CM ploidy that are commonly discussed, even if not experimentally demonstrated, and to highlight key issues that are still to be resolved. Topics discussed here include (a) technical and conceptual difficulties in defining a polyploid CM, (b) the candidate role of reactive oxygen as a proximal trigger for the onset of polyploidy, (c) the relationship between polyploidization and other aspects of CM maturation, (d ) recent insights related to the regenerative role of the subpopulation of CMs that are not polyploid, and (e) speculations as to why CMs become polyploid at all. New approaches to experimentally manipulate CM ploidy may resolve some of these long-standing and fundamental questions. Expected final online publication date for the Annual Review of Physiology, Volume 82 is February 10, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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心肌细胞多倍体及其对心脏再生的意义。

在哺乳动物中，大多数心肌细胞(CMs)变成多倍体(它们有两套以上的完整染色体)。本综述的目的是评估关于CM倍性的普遍讨论的假设，即使没有实验证明，并强调仍有待解决的关键问题。这里讨论的主题包括(a)定义多倍体CM的技术和概念上的困难，(b)活性氧作为多倍体发病的近端触发因素的候选作用，(c)多倍体化与CM成熟的其他方面之间的关系，(d)最近与非多倍体CMs亚群再生作用相关的见解，以及(e)关于为什么CMs会变成多倍体的猜测。实验操作CM倍性的新方法可能解决这些长期存在的基本问题。《生理学年度评论》第82卷的最终在线出版日期预计为2020年2月10日。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of physiology 医学-生理学

CiteScore

35.60

自引率

0.00%

发文量

期刊介绍： Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.