发布求助
文献互助 智能选刊 最新文献

Annual review of physiology最新文献

筛选
英文 中文
Insulin Clearance in Health and Disease. 胰岛素清除在健康和疾病。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031622-043133
Sonia M Najjar, Sonia Caprio, Amalia Gastaldelli
{"title":"Insulin Clearance in Health and Disease.","authors":"Sonia M Najjar,&nbsp;Sonia Caprio,&nbsp;Amalia Gastaldelli","doi":"10.1146/annurev-physiol-031622-043133","DOIUrl":"https://doi.org/10.1146/annurev-physiol-031622-043133","url":null,"abstract":"<p><p>Insulin action is impaired in type 2 diabetes. The functions of the hormone are an integrated product of insulin secretion from pancreatic β-cells and insulin clearance by receptor-mediated endocytosis and degradation, mostly in liver (hepatocytes) and, to a lower extent, in extrahepatic peripheral tissues. Substantial evidence indicates that genetic or acquired abnormalities of insulin secretion or action predispose to type 2 diabetes. In recent years, along with the discovery of the molecular foundation of receptor-mediated insulin clearance, such as through the membrane glycoprotein CEACAM1, a consensus has begun to emerge that reduction of insulin clearance contributes to the disease process. In this review, we consider the evidence suggesting a pathogenic role for reduced insulin clearance in insulin resistance, obesity, hepatic steatosis, and type 2 diabetes.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9305312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Polycystin Channel Complexes. 多囊卵巢蛋白通道复合物。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031522-084334
Orhi Esarte Palomero, Megan Larmore, Paul G DeCaen
{"title":"Polycystin Channel Complexes.","authors":"Orhi Esarte Palomero, Megan Larmore, Paul G DeCaen","doi":"10.1146/annurev-physiol-031522-084334","DOIUrl":"10.1146/annurev-physiol-031522-084334","url":null,"abstract":"<p><p>Polycystin subunits can form hetero- and homotetrameric ion channels in the membranes of various compartments of the cell. Homotetrameric polycystin channels are voltage- and calcium-modulated, whereas heterotetrameric versions are proposed to be ligand- or autoproteolytically regulated. Their importance is underscored by variants associated with autosomal dominant polycystic kidney disease and by vital roles in fertilization and embryonic development. The diversity in polycystin assembly and subcellular distribution allows for a multitude of sensory functions by this class of channels. In this review, we highlight their recent structural and functional characterization, which has provided a molecular blueprint to investigate the conformational changes required for channel opening in response to unique stimuli. We consider each polycystin channel type individually, discussing how they contribute to sensory cell biology, as well as their impact on the physiology of various tissues.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10029091/pdf/nihms-1882989.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9208372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paligenosis: Cellular Remodeling During Tissue Repair. 复生:组织修复过程中的细胞重塑。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-061121-035954
Jeffrey W Brown, Charles J Cho, Jason C Mills
{"title":"Paligenosis: Cellular Remodeling During Tissue Repair.","authors":"Jeffrey W Brown,&nbsp;Charles J Cho,&nbsp;Jason C Mills","doi":"10.1146/annurev-physiol-061121-035954","DOIUrl":"https://doi.org/10.1146/annurev-physiol-061121-035954","url":null,"abstract":"<p><p>Complex multicellular organisms have evolved specific mechanisms to replenish cells in homeostasis and during repair. Here, we discuss how emerging technologies (e.g., single-cell RNA sequencing) challenge the concept that tissue renewal is fueled by unidirectional differentiation from a resident stem cell. We now understand that cell plasticity, i.e., cells adaptively changing differentiation state or identity, is a central tissue renewal mechanism. For example, mature cells can access an evolutionarily conserved program (paligenosis) to reenter the cell cycle and regenerate damaged tissue. Most tissues lack dedicated stem cells and rely on plasticity to regenerate lost cells. Plasticity benefits multicellular organisms, yet it also carries risks. For one, when long-lived cells undergo paligenotic, cyclical proliferation and redif-ferentiation, they can accumulate and propagate acquired mutations that activate oncogenes and increase the potential for developing cancer. Lastly, we propose a new framework for classifying patterns of cell proliferation in homeostasis and regeneration, with stem cells representing just one of the diverse methods that adult tissues employ.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831470/pdf/nihms-1765649.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9238765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Vaping and Lung Inflammation and Injury. 电子烟与肺部炎症和损伤。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-061121-040014
Jin-Ah Park, Laura E Crotty Alexander, David C Christiani
{"title":"Vaping and Lung Inflammation and Injury.","authors":"Jin-Ah Park,&nbsp;Laura E Crotty Alexander,&nbsp;David C Christiani","doi":"10.1146/annurev-physiol-061121-040014","DOIUrl":"https://doi.org/10.1146/annurev-physiol-061121-040014","url":null,"abstract":"<p><p>The use of electronic (e)-cigarettes was initially considered a beneficial solution to conventional cigarette smoking cessation. However, paradoxically, e-cigarette use is rapidly growing among nonsmokers, including youth and young adults. In 2019, this rapid growth resulted in an epidemic of hospitalizations and deaths of e-cigarette users (vapers) due to acute lung injury; this novel disease was termed e-cigarette or vaping use-associated lung injury (EVALI). Pathophysiologic mechanisms of EVALI likely involve cytotoxicity and neutrophilic inflammation caused by inhaled chemicals, but further details remain unknown. The undiscovered mechanisms of EVALI are a barrier to identifying biomarkers and developing therapeutics. Furthermore, adverse effects of e-cigarette use have been linked to chronic lung diseases and systemic effects on multiple organs. In this comprehensive review, we discuss the diverse spectrum of vaping exposures, epidemiological and clinical reports, and experimental findings to provide a better understanding of EVALI and the adverse health effects of chronic e-cigarette exposure.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228557/pdf/nihms-1788026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Cardiac Transverse Tubules in Physiology and Heart Failure. 心脏横小管生理学和心力衰竭。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-061121-040148
Katharine M Dibb, William E Louch, Andrew W Trafford
{"title":"Cardiac Transverse Tubules in Physiology and Heart Failure.","authors":"Katharine M Dibb,&nbsp;William E Louch,&nbsp;Andrew W Trafford","doi":"10.1146/annurev-physiol-061121-040148","DOIUrl":"https://doi.org/10.1146/annurev-physiol-061121-040148","url":null,"abstract":"<p><p>In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma but also a network of membrane invaginations called transverse (t-) tubules. These structures carry the action potential deep into the cell interior, allowing efficient triggering of Ca<sup>2+</sup> release and initiation of contraction. Once thought to serve as rather static enablers of excitation-contraction coupling, recent work has provided a newfound appreciation of the plasticity of the t-tubule network's structure and function. Indeed, t-tubules are now understood to support dynamic regulation of the heartbeat across a range of timescales, during all stages of life, in both health and disease. This review article aims to summarize these concepts, with consideration given to emerging t-tubule regulators and their targeting in future therapies.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10300726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Mechanisms Underlying Calcium Nephrolithiasis. 钙性肾结石的机制。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-26 DOI: 10.1146/annurev-physiol-052521-121822
R T Alexander, D G Fuster, H Dimke
{"title":"Mechanisms Underlying Calcium Nephrolithiasis.","authors":"R T Alexander,&nbsp;D G Fuster,&nbsp;H Dimke","doi":"10.1146/annurev-physiol-052521-121822","DOIUrl":"https://doi.org/10.1146/annurev-physiol-052521-121822","url":null,"abstract":"<p><p>Nephrolithiasis is a worldwide problem with increasing prevalence, enormous costs, and significant morbidity. Calcium-containing kidney stones are by far the most common kidney stones encountered in clinical practice, and thus, hypercalciuria is the greatest risk factor for kidney stone formation. Hypercalciuria can result from enhanced intestinal absorption, increased bone resorption, or altered renal tubular transport. Kidney stone formation is complex and driven by high concentrations of calcium-oxalate or calcium-phosphate in the urine. After discussing the mechanism mediating renal calcium salt precipitation, we review recent discoveries in renal tubular calcium transport from the proximal tubule, thick ascending limb, and distal convolution. Furthermore, we address how calcium is absorbed from the intestine and mobilized from bone. The effect of acidosis on bone calcium resorption and urinary calcium excretion is also considered. Although recent discoveries provide insight into these processes, much remains to be understood in order to provide improved therapies for hypercalciuria and prevent kidney stone formation.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39558539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Sepsis-Induced Immunosuppression. Sepsis-Induced免疫抑制。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-27 DOI: 10.1146/annurev-physiol-061121-040214
Lisa K Torres, Peter Pickkers, Tom van der Poll
{"title":"Sepsis-Induced Immunosuppression.","authors":"Lisa K Torres,&nbsp;Peter Pickkers,&nbsp;Tom van der Poll","doi":"10.1146/annurev-physiol-061121-040214","DOIUrl":"https://doi.org/10.1146/annurev-physiol-061121-040214","url":null,"abstract":"<p><p>Sepsis is expected to have a substantial impact on public health and cost as its prevalence increases. Factors contributing to increased prevalence include a progressively aging population, advances in the use of immunomodulatory agents to treat a rising number of diseases, and immune-suppressing therapies in organ transplant recipients and cancer patients. It is now recognized that sepsis is associated with profound and sustained immunosuppression, which has been implicated as a predisposing factor in the increased susceptibility of patients to secondary infections and mortality. In this review, we discuss mechanisms of sepsis-induced immunosuppression and biomarkers that identify a state of impaired immunity. We also highlight immune-enhancing strategies that have been evaluated in patients with sepsis, as well as therapeutics under current investigation. Finally, we describe future challenges and the need for a new treatment paradigm, integrating predictive enrichment with patient factors that may guide the future selection of tailored immunotherapy.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39562755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 57
Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms. 酒精相关组织损伤：病理生理机制的最新观点。
IF 15.7 1区 医学
Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-060821-014008
Liz Simon, Flavia M Souza-Smith, Patricia E Molina
{"title":"Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms.","authors":"Liz Simon, Flavia M Souza-Smith, Patricia E Molina","doi":"10.1146/annurev-physiol-060821-014008","DOIUrl":"10.1146/annurev-physiol-060821-014008","url":null,"abstract":"<p><p>At-risk alcohol use is a major contributor to the global health care burden and leads to preventable deaths and diseases including alcohol addiction, alcoholic liver disease, cardiovascular disease, diabetes, traumatic injuries, gastrointestinal diseases, cancers, and fetal alcohol syndrome. Excessive and frequent alcohol consumption has increasingly been linked to alcohol-associated tissue injury and pathophysiology, which have significant adverse effects on multiple organ systems. Extensive research in animal and in vitro models has elucidated the salient mechanisms involved in alcohol-induced tissue and organ injury. In some cases, these pathophysiological mechanisms are shared across organ systems. The major alcohol- and alcohol metabolite-mediated mechanisms include oxidative stress, inflammation and immunometabolic dysregulation, gut leak and dysbiosis, cell death, extracellular matrix remodeling, endoplasmic reticulum stress, mitochondrial dysfunction, and epigenomic modifications. These mechanisms are complex and interrelated, and determining the interplay among them will make it possible to identify how they synergistically or additively interact to cause alcohol-mediated multiorgan injury. In this article, we review the current understanding of pathophysiological mechanisms involved in alcohol-induced tissue injury.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":15.7,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10613279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling. 心肌细胞微管：控制力学、运输和重塑。
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-06 DOI: 10.1146/annurev-physiol-062421-040656
Keita Uchida, Emily A Scarborough, Benjamin L Prosser
{"title":"Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.","authors":"Keita Uchida, Emily A Scarborough, Benjamin L Prosser","doi":"10.1146/annurev-physiol-062421-040656","DOIUrl":"10.1146/annurev-physiol-062421-040656","url":null,"abstract":"<p><p>Microtubules are essential cytoskeletal elements found in all eukaryotic cells. The structure and composition of microtubules regulate their function, and the dynamic remodeling of the network by posttranslational modifications and microtubule-associated proteins generates diverse populations of microtubules adapted for various contexts. In the cardiomyocyte, the microtubules must accommodate the unique challenges faced by a highly contractile, rigidly structured, and long-lasting cell. Through their canonical trafficking role and positioning of mRNA, proteins, and organelles, microtubules regulate essential cardiomyocyte functions such as electrical activity, calcium handling, protein translation, and growth. In a more specialized role, posttranslationally modified microtubules form load-bearing structures that regulate myocyte mechanics and mechanotransduction. Modified microtubules proliferate in cardiovascular diseases, creating stabilized resistive elements that impede cardiomyocyte contractility and contribute to contractile dysfunction. In this review, we highlight the most exciting new concepts emerging from recent studies into canonical and noncanonical roles of cardiomyocyte microtubules.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097619/pdf/nihms-1800999.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9482095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling. 通过大脑雌激素信号在整个生命周期运行女性电网
IF 18.2 1区 医学
Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-11-15 DOI: 10.1146/annurev-physiol-061121-035914
Holly A Ingraham, Candice B Herber, William C Krause
{"title":"Running the Female Power Grid Across Lifespan Through Brain Estrogen Signaling.","authors":"Holly A Ingraham, Candice B Herber, William C Krause","doi":"10.1146/annurev-physiol-061121-035914","DOIUrl":"10.1146/annurev-physiol-061121-035914","url":null,"abstract":"<p><p>The role of central estrogen in cognitive, metabolic, and reproductive health has long fascinated the lay public and scientists alike. In the last two decades, insight into estrogen signaling in the brain and its impact on female physiology is beginning to catch up with the vast information already established for its actions on peripheral tissues. Using newer methods to manipulate estrogen signaling in hormone-sensitive brain regions, neuroscientists are now identifying the molecular pathways and neuronal subtypes required for controlling sex-dependent energy allocation. However, the immense cellular complexity of these hormone-sensitive brain regions makes it clear that more research is needed to fully appreciate how estrogen modulates neural circuits to regulate physiological and behavioral end points. Such insight is essential for understanding how natural or drug-induced hormone fluctuations across lifespan affect women's health.</p>","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831472/pdf/nihms-1771780.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10682557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信