Annual review of physiology最新文献_第6页

Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond. 肾内外蛋白质转运和质量控制的机制。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031522-100639

Jillian L Shaw, Juan Lorenzo Pablo, Anna Greka

{"title":"Mechanisms of Protein Trafficking and Quality Control in the Kidney and Beyond.","authors":"Jillian L Shaw, Juan Lorenzo Pablo, Anna Greka","doi":"10.1146/annurev-physiol-031522-100639","DOIUrl":"https://doi.org/10.1146/annurev-physiol-031522-100639","url":null,"abstract":"Numerous trafficking and quality control pathways evolved to handle the diversity of proteins made by eukaryotic cells. However, at every step along the biosynthetic pathway, there is the potential for quality control system failure. This review focuses on the mechanisms of disrupted proteostasis. Inspired by diseases caused by misfolded proteins in the kidney (mucin 1 and uromodulin), we outline the general principles of protein biosynthesis, delineate the recognition and degradation pathways targeting misfolded proteins, and discuss the role of cargo receptors in protein trafficking and lipid homeostasis. We also discuss technical approaches including live-cell fluorescent microscopy, chemical screens to elucidate trafficking mechanisms, multiplexed single-cell CRISPR screening platforms to systematically delineate mechanisms of proteostasis, and the advancement of novel tools to degrade secretory and membrane-associated proteins. By focusing on components of trafficking that go awry, we highlight ongoing efforts to understand fundamental mechanisms of disrupted proteostasis and implications for the treatment of human proteinopathies.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"85 ","pages":"407-423"},"PeriodicalIF":18.2,"publicationDate":"2023-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10730659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular and Cellular Mechanisms of Salt Taste. 盐味的分子和细胞机制。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031522-075853

Akiyuki Taruno, Michael D Gordon

引用次数: 7

Neural Mechanisms That Make Perceptual Decisions Flexible. 使感知决策灵活的神经机制。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-11-07 DOI: 10.1146/annurev-physiol-031722-024731

Gouki Okazawa, Roozbeh Kiani

引用次数: 0

Polycystin Channel Complexes. 多囊卵巢蛋白通道复合物。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031522-084334

Orhi Esarte Palomero, Megan Larmore, Paul G DeCaen

引用次数: 0

Insulin Clearance in Health and Disease. 胰岛素清除在健康和疾病。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2023-02-10 DOI: 10.1146/annurev-physiol-031622-043133

Sonia M Najjar, Sonia Caprio, Amalia Gastaldelli

引用次数: 10

Paligenosis: Cellular Remodeling During Tissue Repair. 复生:组织修复过程中的细胞重塑。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-061121-035954

Jeffrey W Brown, Charles J Cho, Jason C Mills

{"title":"Paligenosis: Cellular Remodeling During Tissue Repair.","authors":"Jeffrey W Brown, Charles J Cho, Jason C Mills","doi":"10.1146/annurev-physiol-061121-035954","DOIUrl":"https://doi.org/10.1146/annurev-physiol-061121-035954","url":null,"abstract":"Complex multicellular organisms have evolved specific mechanisms to replenish cells in homeostasis and during repair. Here, we discuss how emerging technologies (e.g., single-cell RNA sequencing) challenge the concept that tissue renewal is fueled by unidirectional differentiation from a resident stem cell. We now understand that cell plasticity, i.e., cells adaptively changing differentiation state or identity, is a central tissue renewal mechanism. For example, mature cells can access an evolutionarily conserved program (paligenosis) to reenter the cell cycle and regenerate damaged tissue. Most tissues lack dedicated stem cells and rely on plasticity to regenerate lost cells. Plasticity benefits multicellular organisms, yet it also carries risks. For one, when long-lived cells undergo paligenotic, cyclical proliferation and redif-ferentiation, they can accumulate and propagate acquired mutations that activate oncogenes and increase the potential for developing cancer. Lastly, we propose a new framework for classifying patterns of cell proliferation in homeostasis and regeneration, with stem cells representing just one of the diverse methods that adult tissues employ.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"84 ","pages":"461-483"},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831470/pdf/nihms-1765649.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9238765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Vaping and Lung Inflammation and Injury. 电子烟与肺部炎症和损伤。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-061121-040014

Jin-Ah Park, Laura E Crotty Alexander, David C Christiani

{"title":"Vaping and Lung Inflammation and Injury.","authors":"Jin-Ah Park, Laura E Crotty Alexander, David C Christiani","doi":"10.1146/annurev-physiol-061121-040014","DOIUrl":"https://doi.org/10.1146/annurev-physiol-061121-040014","url":null,"abstract":"The use of electronic (e)-cigarettes was initially considered a beneficial solution to conventional cigarette smoking cessation. However, paradoxically, e-cigarette use is rapidly growing among nonsmokers, including youth and young adults. In 2019, this rapid growth resulted in an epidemic of hospitalizations and deaths of e-cigarette users (vapers) due to acute lung injury; this novel disease was termed e-cigarette or vaping use-associated lung injury (EVALI). Pathophysiologic mechanisms of EVALI likely involve cytotoxicity and neutrophilic inflammation caused by inhaled chemicals, but further details remain unknown. The undiscovered mechanisms of EVALI are a barrier to identifying biomarkers and developing therapeutics. Furthermore, adverse effects of e-cigarette use have been linked to chronic lung diseases and systemic effects on multiple organs. In this comprehensive review, we discuss the diverse spectrum of vaping exposures, epidemiological and clinical reports, and experimental findings to provide a better understanding of EVALI and the adverse health effects of chronic e-cigarette exposure.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"84 ","pages":"611-629"},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228557/pdf/nihms-1788026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9534252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Cardiac Transverse Tubules in Physiology and Heart Failure. 心脏横小管生理学和心力衰竭。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-061121-040148

Katharine M Dibb, William E Louch, Andrew W Trafford

引用次数: 13

Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms. 酒精相关组织损伤：病理生理机制的最新观点。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-060821-014008

Liz Simon, Flavia M Souza-Smith, Patricia E Molina

{"title":"Alcohol-Associated Tissue Injury: Current Views on Pathophysiological Mechanisms.","authors":"Liz Simon, Flavia M Souza-Smith, Patricia E Molina","doi":"10.1146/annurev-physiol-060821-014008","DOIUrl":"10.1146/annurev-physiol-060821-014008","url":null,"abstract":"At-risk alcohol use is a major contributor to the global health care burden and leads to preventable deaths and diseases including alcohol addiction, alcoholic liver disease, cardiovascular disease, diabetes, traumatic injuries, gastrointestinal diseases, cancers, and fetal alcohol syndrome. Excessive and frequent alcohol consumption has increasingly been linked to alcohol-associated tissue injury and pathophysiology, which have significant adverse effects on multiple organ systems. Extensive research in animal and in vitro models has elucidated the salient mechanisms involved in alcohol-induced tissue and organ injury. In some cases, these pathophysiological mechanisms are shared across organ systems. The major alcohol- and alcohol metabolite-mediated mechanisms include oxidative stress, inflammation and immunometabolic dysregulation, gut leak and dysbiosis, cell death, extracellular matrix remodeling, endoplasmic reticulum stress, mitochondrial dysfunction, and epigenomic modifications. These mechanisms are complex and interrelated, and determining the interplay among them will make it possible to identify how they synergistically or additively interact to cause alcohol-mediated multiorgan injury. In this article, we review the current understanding of pathophysiological mechanisms involved in alcohol-induced tissue injury.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"84 ","pages":"87-112"},"PeriodicalIF":15.7,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11268381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10613279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling. 心肌细胞微管：控制力学、运输和重塑。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-06 DOI: 10.1146/annurev-physiol-062421-040656

Keita Uchida, Emily A Scarborough, Benjamin L Prosser

{"title":"Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.","authors":"Keita Uchida, Emily A Scarborough, Benjamin L Prosser","doi":"10.1146/annurev-physiol-062421-040656","DOIUrl":"10.1146/annurev-physiol-062421-040656","url":null,"abstract":"Microtubules are essential cytoskeletal elements found in all eukaryotic cells. The structure and composition of microtubules regulate their function, and the dynamic remodeling of the network by posttranslational modifications and microtubule-associated proteins generates diverse populations of microtubules adapted for various contexts. In the cardiomyocyte, the microtubules must accommodate the unique challenges faced by a highly contractile, rigidly structured, and long-lasting cell. Through their canonical trafficking role and positioning of mRNA, proteins, and organelles, microtubules regulate essential cardiomyocyte functions such as electrical activity, calcium handling, protein translation, and growth. In a more specialized role, posttranslationally modified microtubules form load-bearing structures that regulate myocyte mechanics and mechanotransduction. Modified microtubules proliferate in cardiovascular diseases, creating stabilized resistive elements that impede cardiomyocyte contractility and contribute to contractile dysfunction. In this review, we highlight the most exciting new concepts emerging from recent studies into canonical and noncanonical roles of cardiomyocyte microtubules.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":"84 ","pages":"257-283"},"PeriodicalIF":15.7,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097619/pdf/nihms-1800999.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9482095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0