Annual review of physiology最新文献_第6页

Physiological Functions of CRAC Channels. CRAC通道的生理功能。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-12 DOI: 10.1146/annurev-physiol-052521-013426

Scott M Emrich, Ryan E Yoast, Mohamed Trebak

引用次数: 37

Roles of Mineralocorticoid Receptors in Cardiovascular and Cardiorenal Diseases. 矿化皮质激素受体在心血管和心肾疾病中的作用。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-060821-013950

Jonatan Barrera-Chimal, Benjamin Bonnard, Frederic Jaisser

{"title":"Roles of Mineralocorticoid Receptors in Cardiovascular and Cardiorenal Diseases.","authors":"Jonatan Barrera-Chimal, Benjamin Bonnard, Frederic Jaisser","doi":"10.1146/annurev-physiol-060821-013950","DOIUrl":"https://doi.org/10.1146/annurev-physiol-060821-013950","url":null,"abstract":"Mineralocorticoid receptor (MR) activation in the heart and vessels leads to pathological effects, such as excessive extracellular matrix accumulation, oxidative stress, and sustained inflammation. In these organs, the MR is expressed in cardiomyocytes, fibroblasts, endothelial cells, smooth muscle cells, and inflammatory cells. We review the accumulating experimental and clinical evidence that pharmacological MR antagonism has a positive impact on a battery of cardiac and vascular pathological states, including heart failure, myocardial infarction, arrhythmic diseases, atherosclerosis, vascular stiffness, and cardiac and vascular injury linked to metabolic comorbidities and chronic kidney disease. Moreover, we present perspectives on optimization of the use of MR antagonists in patients more likely to respond to such therapy and review the evidence suggesting that novel nonsteroidal MR antagonists offer an improved safety profile while retaining their cardiovascular protective effects. Finally, we highlight future therapeutic applications of MR antagonists in cardiovascular injury.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39611413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Mitochondria and Inflammatory Bowel Diseases: Toward a Stratified Therapeutic Intervention. 线粒体和炎症性肠病:迈向分层治疗干预。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-06 DOI: 10.1146/annurev-physiol-060821-083306

Gwo-Tzer Ho, Arianne L Theiss

引用次数: 27

Pericyte Control of Blood Flow Across Microvascular Zones in the Central Nervous System. 周细胞对中枢神经系统微血管区血流的控制。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-061121-040127

David A Hartmann, Vanessa Coelho-Santos, Andy Y Shih

{"title":"Pericyte Control of Blood Flow Across Microvascular Zones in the Central Nervous System.","authors":"David A Hartmann, Vanessa Coelho-Santos, Andy Y Shih","doi":"10.1146/annurev-physiol-061121-040127","DOIUrl":"https://doi.org/10.1146/annurev-physiol-061121-040127","url":null,"abstract":"The vast majority of the brain's vascular length is composed of capillaries, where our understanding of blood flow control remains incomplete. This review synthesizes current knowledge on the control of blood flow across microvascular zones by addressing issues with nomenclature and drawing on new developments from in vivo optical imaging and single-cell transcriptomics. Recent studies have highlighted important distinctions in mural cell morphology, gene expression, and contractile dynamics, which can explain observed differences in response to vasoactive mediators between arteriole, transitional, and capillary zones. Smooth muscle cells of arterioles and ensheathing pericytes of the arteriole-capillary transitional zone control large-scale, rapid changes in blood flow. In contrast, capillary pericytes downstream of the transitional zone act on slower and smaller scales and are involved in establishing resting capillary tone and flow heterogeneity. Many unresolved issues remain, including the vasoactive mediators that activate the different pericyte types in vivo, the role of pericyte-endothelial communication in conducting signals from capillaries to arterioles, and how neurological disease affects these mechanisms.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10480047/pdf/nihms-1928192.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

The Diverse Physiological Functions of Mechanically Activated Ion Channels in Mammals. 哺乳动物机械激活离子通道的多种生理功能。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-12 DOI: 10.1146/annurev-physiol-060721-100935

Kate Poole

引用次数: 12

β-Arrestins as Important Regulators of Glucose and Energy Homeostasis. β-抑制蛋白是葡萄糖和能量稳态的重要调节因子。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-27 DOI: 10.1146/annurev-physiol-060721-092948

Sai P Pydi, Luiz F Barella, Lu Zhu, Jaroslawna Meister, Mario Rossi, Jürgen Wess

{"title":"β-Arrestins as Important Regulators of Glucose and Energy Homeostasis.","authors":"Sai P Pydi, Luiz F Barella, Lu Zhu, Jaroslawna Meister, Mario Rossi, Jürgen Wess","doi":"10.1146/annurev-physiol-060721-092948","DOIUrl":"https://doi.org/10.1146/annurev-physiol-060721-092948","url":null,"abstract":"β-Arrestin-1 and -2 (also known as arrestin-2 and -3, respectively) are ubiquitously expressed cytoplasmic proteins that dampen signaling through G protein-coupled receptors. However, β-arrestins can also act as signaling molecules in their own right. To investigate the potential metabolic roles of the two β-arrestins in modulating glucose and energy homeostasis, recent studies analyzed mutant mice that lacked or overexpressed β-arrestin-1 and/or -2 in distinct, metabolically important cell types. Metabolic analysis of these mutant mice clearly demonstrated that both β-arrestins play key roles in regulating the function of most of these cell types, resulting in striking changes in whole-body glucose and/or energy homeostasis. These studies also revealed that β-arrestin-1 and -2, though structurally closely related, clearly differ in their metabolic roles under physiological and pathophysiological conditions. These new findings should guide the development of novel drugs for the treatment of various metabolic disorders, including type 2 diabetes and obesity.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39562754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Innate Bacteriostatic Mechanisms Defend the Urinary Tract. 先天抑菌机制保卫尿路

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-11-15 DOI: 10.1146/annurev-physiol-052521-121810

Jose A Munoz, Anne-Catrin Uhlemann, Jonathan Barasch

引用次数: 0

Extracellular Vesicles as Central Mediators of COPD Pathophysiology. 细胞外小泡是慢性阻塞性肺疾病病理生理学的核心介质。

IF 15.7 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-11-01 DOI: 10.1146/annurev-physiol-061121-035838

Derek W Russell, Kristopher R Genschmer, J Edwin Blalock

{"title":"Extracellular Vesicles as Central Mediators of COPD Pathophysiology.","authors":"Derek W Russell, Kristopher R Genschmer, J Edwin Blalock","doi":"10.1146/annurev-physiol-061121-035838","DOIUrl":"10.1146/annurev-physiol-061121-035838","url":null,"abstract":"Chronic obstructive pulmonary disease (COPD) is a complex, heterogeneous, smoking-related disease of significant global impact. The complex biology of COPD is ultimately driven by a few interrelated processes, including proteolytic tissue remodeling, innate immune inflammation, derangements of the host-pathogen response, aberrant cellular phenotype switching, and cellular senescence, among others. Each of these processes are engendered and perpetuated by cells modulating their environment or each other. Extracellular vesicles (EVs) are powerful effectors that allow cells to perform a diverse array of functions on both adjacent and distant tissues, and their pleiotropic nature is only beginning to be appreciated. As such, EVs are candidates to play major roles in these fundamental mechanisms of disease behind COPD. Furthermore, some such roles for EVs are already established, and EVs are implicated in significant aspects of COPD pathogenesis. Here, we discuss known and potential ways that EVs modulate the environment of their originating cells to contribute to the processes that underlie COPD.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":15.7,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831481/pdf/nihms-1769489.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9511220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders. 造血的炎症调节:将训练免疫和克隆造血与慢性疾病联系起来。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-06 DOI: 10.1146/annurev-physiol-052521-013627

Triantafyllos Chavakis, Ben Wielockx, George Hajishengallis

引用次数: 14

Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies. 在人类小血管疾病中检测到的脑血管功能障碍及其临床前研究的意义。

IF 18.2 1区医学

Annual review of physiology Pub Date : 2022-02-10 DOI: 10.1146/annurev-physiol-060821-014521

Joanna M Wardlaw, Helene Benveniste, Anna Williams

{"title":"Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies.","authors":"Joanna M Wardlaw, Helene Benveniste, Anna Williams","doi":"10.1146/annurev-physiol-060821-014521","DOIUrl":"https://doi.org/10.1146/annurev-physiol-060821-014521","url":null,"abstract":"Cerebral small vessel disease (SVD) is highly prevalent and a common cause of ischemic and hemorrhagic stroke and dementia, yet the pathophysiology is poorly understood. Its clinical expression is highly varied, and prognostic implications are frequently overlooked in clinics; thus, treatment is currently confined to vascular risk factor management. Traditionally, SVD is considered the small vessel equivalent of large artery stroke (occlusion, rupture), but data emerging from human neuroimaging and genetic studies refute this, instead showing microvessel endothelial dysfunction impacting on cell-cell interactions and leading to brain damage. These dysfunctions reflect defects that appear to be inherited and secondary to environmental exposures, including vascular risk factors. Interrogation in preclinical models shows consistent and converging molecular and cellular interactions across the endothelial-glial-neural unit that increasingly explain the human macroscopic observations and identify common patterns of pathology despite different triggers. Importantly, these insights may offer new targets for therapeutic intervention focused on restoring endothelial-glial physiology.","PeriodicalId":8196,"journal":{"name":"Annual review of physiology","volume":null,"pages":null},"PeriodicalIF":18.2,"publicationDate":"2022-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9311507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16