Endoplasmic Reticulum-Plasma Membrane Junctions as Sites of Depolarization-Induced Ca2+ Signaling in Excitable Cells.

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-10-06 DOI:10.1146/annurev-physiol-032122-104610
Rose E Dixon, James S Trimmer
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引用次数: 0

Abstract

Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM), or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles in organizing diverse forms of Ca2+ signaling as triggered by membrane depolarization. ER-PM junctions underlie crucial physiological processes such as excitation-contraction coupling, smooth muscle contraction and relaxation, and various forms of activity-dependent signaling and plasticity in neurons. In many cases the structure and molecular composition of ER-PM junctions in excitable cells comprise important regulatory feedback loops linking depolarization-induced Ca2+ signaling at these sites to the regulation of membrane potential. Here, we describe recent findings on physiological roles and molecular composition of native ER-PM junctions in excitable cells. We focus on recent studies that provide new insights into canonical forms of depolarization-induced Ca2+ signaling occurring at junctional triads and dyads of striated muscle, as well as the diversity of ER-PM junctions in these cells and in smooth muscle and neurons.

内质网-浆膜连接是可兴奋细胞中去极化诱导 Ca2+ 信号传导的场所
所有真核细胞中都存在内质网(ER)和质膜(PM)之间的膜接触点,即ER-PM连接点。在可兴奋细胞中,它们在组织由膜去极化引发的各种形式的 Ca2+ 信号传导方面发挥着独特的作用。ER-PM连接是关键生理过程的基础,如兴奋-收缩耦合、平滑肌收缩和松弛,以及神经元中各种形式的依赖活动的信号传递和可塑性。在许多情况下,可兴奋细胞中 ER-PM 连接的结构和分子组成构成了重要的调节反馈回路,将这些部位去极化诱导的 Ca2+ 信号传导与膜电位调节联系起来。在此,我们将介绍有关可兴奋细胞中原生 ER-PM 连接的生理作用和分子组成的最新发现。我们重点关注最近的研究,这些研究提供了对发生在横纹肌三联体和二联体交界处的去极化诱导 Ca2+ 信号的典型形式以及这些细胞、平滑肌和神经元中 ER-PM 连接多样性的新见解。
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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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