咳嗽的感染和炎症途径

IF 15.7 1区医学 Q1 PHYSIOLOGY

Annual review of physiology Pub Date : 2023-02-10 Epub Date: 2022-09-28 DOI:10.1146/annurev-physiol-031422-092315

Kubra F Naqvi, Stuart B Mazzone, Michael U Shiloh

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引用次数: 0

摘要

咳嗽是一个动态的生理过程，是由支配呼吸道的迷走神经感觉输入和感觉到的呼吸道刺激引起的。虽然咳嗽有保护和清理呼吸道的作用，但也可能被呼吸道病原体利用来促进疾病传播。微生物成分或感染引起的炎症介质可直接与感觉神经受体相互作用，诱发咳嗽反应。对咳嗽产生的气溶胶的分析和传播研究进一步证明了传染病是如何通过咳嗽传播的。本综述概述了咳嗽的神经生理学、呼吸道病原体和炎症诱导的咳嗽以及咳嗽介导的疾病传播。

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Infectious and Inflammatory Pathways to Cough.

Coughing is a dynamic physiological process resulting from input of vagal sensory neurons innervating the airways and perceived airway irritation. Although cough serves to protect and clear the airways, it can also be exploited by respiratory pathogens to facilitate disease transmission. Microbial components or infection-induced inflammatory mediators can directly interact with sensory nerve receptors to induce a cough response. Analysis of cough-generated aerosols and transmission studies have further demonstrated how infectious disease is spread through coughing. This review summarizes the neurophysiology of cough, cough induction by respiratory pathogens and inflammation, and cough-mediated disease transmission.

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来源期刊

Annual review of physiology 医学-生理学

CiteScore

35.60

自引率

0.00%

发文量

期刊介绍： Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.