代谢重组和通讯:肾近端小管功能的综合观点。

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-27 DOI:10.1146/annurev-physiol-042222-024724
Maria Chrysopoulou, Markus M Rinschen
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引用次数: 0

摘要

肾近端小管是人体代谢的重要器官。肾脏对压力的反应是代谢产物转化的改变和代谢途径的紊乱,这是肾脏疾病的最终原因。在这里,我们通过运输、代谢和功能的综合观点来回顾近端小管的代谢功能,并将其纳入代谢组数据驱动研究的背景下。功能(过滤、运输、分泌和重吸收)、代谢物转化和代谢物信号决定疾病中肾脏代谢重新布线。能量代谢和关键代谢途径的底物由代谢物传感器协调。鉴于肾脏功能对体内环境的重要性,我们也回顾了与其他器官的代谢通讯途径。存在令人兴奋的研究机会,以了解肾脏和近端小管功能的代谢扰动,例如高血压相关肾脏疾病。我们认为,基于这里概述的综合观点,没有遗传原因的肾脏疾病应该作为代谢性疾病进行科学处理。《生理学年度评论》第86卷的最终在线出版日期预计为2024年2月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function.

The kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic function through an integrative view of transport, metabolism, and function, and embed it in the context of metabolome-wide data-driven research. Function (filtration, transport, secretion, and reabsorption), metabolite transformation, and metabolite signaling determine kidney metabolic rewiring in disease. Energy metabolism and substrates for key metabolic pathways are orchestrated by metabolite sensors. Given the importance of renal function for the inner milieu, we also review metabolic communication routes with other organs. Exciting research opportunities exist to understand metabolic perturbation of kidney and proximal tubule function, for example, in hypertension-associated kidney disease. We argue that, based on the integrative view outlined here, kidney diseases without genetic cause should be approached scientifically as metabolic diseases.

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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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