Adipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation.

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-06-11 DOI:10.1146/annurev-physiol-042222-021346
Murray D Polkinghorne, Henry W West, Charalambos Antoniades
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引用次数: 0

Abstract

The perception of adipose tissue as a metabolically quiescent tissue, primarily responsible for lipid storage and energy balance (with some endocrine, thermogenic, and insulation functions), has changed. It is now accepted that adipose tissue is a crucial regulator of metabolic health, maintaining bidirectional communication with other organs including the cardiovascular system. Additionally, adipose tissue depots are functionally and morphologically heterogeneous, acting not only as sources of bioactive molecules that regulate the physiological functioning of the vasculature and myocardium but also as biosensors of the paracrine and endocrine signals arising from these tissues. In this way, adipose tissue undergoes phenotypic switching in response to vascular and/or myocardial signals (proinflammatory, profibrotic, prolipolytic), a process that novel imaging technologies are able to visualize and quantify with implications for clinical prognosis. Furthermore, a range of therapeutic modalities have emerged targeting adipose tissue metabolism and altering its secretome, potentially benefiting those at risk of cardiovascular disease.

心血管疾病中的脂肪组织:从基础科学到临床翻译。
将脂肪组织视为代谢静止组织,主要负责脂质储存和能量平衡(具有一些内分泌、产热和绝缘功能),这种看法已经改变。现在人们普遍认为,脂肪组织是代谢健康的关键调节因子,与包括心血管系统在内的其他器官保持双向沟通。此外,脂肪组织库在功能和形态上是异质的,不仅作为调节血管系统和心肌生理功能的生物活性分子的来源,而且作为这些组织产生的旁分泌和内分泌信号的生物传感器。通过这种方式,脂肪组织对血管和/或心肌信号(促炎、促纤维化、促脂蛋白溶解)进行表型转换,新的成像技术能够对这一过程进行可视化和量化,并对临床预后产生影响。此外,已经出现了一系列针对脂肪组织代谢和改变其分泌组的治疗模式,这可能有利于那些有心血管疾病风险的人。《生理学年度评论》第86卷预计最终在线出版日期为2024年2月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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