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Annual review of neuroscience最新文献

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Estrogen Control of Social Behaviors. 雌激素对社会行为的控制。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-02-21 DOI: 10.1146/annurev-neuro-112723-041639
Oluwadamilola O Lawal, Dayu Lin, Julieta E Lischinsky
{"title":"Estrogen Control of Social Behaviors.","authors":"Oluwadamilola O Lawal, Dayu Lin, Julieta E Lischinsky","doi":"10.1146/annurev-neuro-112723-041639","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-041639","url":null,"abstract":"<p><p>Social behaviors, including parental care, mating, and fighting, all depend on the hormonal milieu of an organism. Decades of work highlighted estrogen as a key hormonal controller of social behaviors, exerting its influence primarily through binding to estrogen receptor alpha (Esr1). Recent technological advances in chemogenetics, optogenetics, gene editing, and transgenic model organisms have allowed for a detailed understanding of the neuronal subpopulations and circuits for estrogen action across Esr1-expressing interconnected brain regions. Focusing on rodent studies, in this review we examine classical and contemporary research demonstrating the multifaceted role of estrogen and Esr1 in regulating social behaviors in a sex-specific and context-dependent manner. We highlight gaps in knowledge, particularly a missing link in the molecular cascade that allows estrogen to exert such a diverse behavioral repertoire through the coordination of gene expression changes. Understanding the molecular and cellular basis of Esr1's action in social behaviors provides insights into the broader mechanisms of hormone-driven behavior modulation across the lifespan.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phase Separation-Mediated Compartmentalization Underlies Synapse Formation and Plasticity. 相分离介导的区隔化是突触形成和可塑性的基础。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-02-21 DOI: 10.1146/annurev-neuro-112723-040159
Xiandeng Wu, Zeyu Shen, Mingjie Zhang
{"title":"Phase Separation-Mediated Compartmentalization Underlies Synapse Formation and Plasticity.","authors":"Xiandeng Wu, Zeyu Shen, Mingjie Zhang","doi":"10.1146/annurev-neuro-112723-040159","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-040159","url":null,"abstract":"<p><p>The synapse is polarized and highly compartmentalized on both its pre- and postsynaptic sides. The compartmentalization of synaptic vesicles, as well as vesicle releasing and recycling machineries, allows neurotransmitters to be released with precisely controlled timing, speed, and amplitude. The compartmentalized and clustered organization of neurotransmitter receptors and their downstream signaling enzymes allows neuronal signals to be properly received and amplified. Synaptic adhesion molecules also form clustered assemblies to align pre- and postsynaptic subcompartments for synaptic formation, stability, and transmission. Recent studies indicate that such synaptic and subsynaptic compartmentalized organizations are formed via phase separation. This review discusses how such condensed subsynaptic compartments may form and function in the context of synapse formation and plasticity. We discuss how phase separation allows for the formation of multiple distinct condensates on both sides of a synapse and how such condensates communicate with each other. We also highlight how proteins display unique properties in condensed phases compared to the same proteins in dilute solutions.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anesthetics as Treatments for Depression: Clinical Insights and Underlying Mechanisms. 麻醉药治疗抑郁症：临床观察和潜在机制。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-02-19 DOI: 10.1146/annurev-neuro-112723-062031
Macauley Smith Breault, Sirma Orguc, Ohyoon Kwon, Gloria H Kang, Bryan Tseng, David R Schreier, Emery N Brown
{"title":"Anesthetics as Treatments for Depression: Clinical Insights and Underlying Mechanisms.","authors":"Macauley Smith Breault, Sirma Orguc, Ohyoon Kwon, Gloria H Kang, Bryan Tseng, David R Schreier, Emery N Brown","doi":"10.1146/annurev-neuro-112723-062031","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-062031","url":null,"abstract":"<p><p>Major depressive disorder and treatment-resistant depression are significant worldwide health problems that need new therapies. The success of the anesthetic ketamine as an antidepressant is well known. It is less widely known that several other anesthetic agents have also shown antidepressant effects. These include nitrous oxide, propofol, isoflurane, sevoflurane, dexmedetomidine, and xenon. We review clinical and basic science investigations that have studied the therapeutic value of these anesthetics for treating depression. We propose potential neurophysiological mechanisms underlying the antidepressant effects of anesthetics by combining our understanding of how anesthetics modulate brain dynamics to alter arousal states, current theories of depression pathophysiology, and findings from other depression treatment modalities.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Replay and Ripples in Humans. 人类的重播和涟漪。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-02-19 DOI: 10.1146/annurev-neuro-112723-024516
Jinbo Zhang, Jianxin Ou, Yunzhe Liu
{"title":"Replay and Ripples in Humans.","authors":"Jinbo Zhang, Jianxin Ou, Yunzhe Liu","doi":"10.1146/annurev-neuro-112723-024516","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-024516","url":null,"abstract":"<p><p>During rest and sleep, the brain processes information through replay, reactivating neural patterns linked to past events and facilitating the exploration of potential future scenarios. This review summarizes recent advances in understanding human replay and its biomarker, sharp-wave ripples (SPW-Rs). We explore detection methods and connect insights from rodent studies. The review highlights unique aspects of human replay in internal cognition such as prioritizing past experiences for offline learning, generating hypothesized solutions to current problems, and factorizing structural representations for future generalization. We also examine the characteristics of SPW-Rs in humans, including their distribution along the hippocampal longitudinal axis, their widespread brain activations, and their influence on internal cognitive processes. Finally, we emphasize the need for improved methodologies and technologies to advance our understanding of cognitive processes during rest and sleep.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental Origins and Oncogenesis in Medulloblastoma. 髓母细胞瘤的发育起源和肿瘤发生。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-02-14 DOI: 10.1146/annurev-neuro-112723-061540
Karrie M Kiang, Yogesh K H Wong, Soma Sengupta, Martine F Roussel, Q Richard Lu
{"title":"Developmental Origins and Oncogenesis in Medulloblastoma.","authors":"Karrie M Kiang, Yogesh K H Wong, Soma Sengupta, Martine F Roussel, Q Richard Lu","doi":"10.1146/annurev-neuro-112723-061540","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-061540","url":null,"abstract":"<p><p>Medulloblastoma is the most common pediatric brain cancer and is broadly categorized into four molecular subgroups. Understanding the cell origins of medulloblastoma is crucial for preventing tumor formation and relapse. Recent single-cell transcriptomics studies have identified the potential cell lineage vulnerabilities and mechanisms underpinning malignant transformation in medulloblastoma. Emerging evidence suggests that genetic-epigenetic alterations specific to each subgroup lead to a lineage-specific stall in the neural developmental program and subsequent tumorigenesis. We discuss the putative cells of origin, plasticity, and heterogeneity within medulloblastoma subgroups and delve into the genetic and epigenetic changes that predispose cells to transformation. Additionally, we review the current insights into how cerebellar stem/progenitor cells and lineage plasticity impact medulloblastoma pathogenesis and highlight recent therapeutic advances targeting specific oncogenic vulnerabilities in this malignancy.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control Principles of Neural Dynamics Revealed by the Neurobiology of Timing. 时序神经生物学揭示的神经动力学控制原理。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-01-29 DOI: 10.1146/annurev-neuro-091724-015512
Gabriel M Stine, Mehrdad Jazayeri
{"title":"Control Principles of Neural Dynamics Revealed by the Neurobiology of Timing.","authors":"Gabriel M Stine, Mehrdad Jazayeri","doi":"10.1146/annurev-neuro-091724-015512","DOIUrl":"10.1146/annurev-neuro-091724-015512","url":null,"abstract":"<p><p>Cognition unfolds dynamically over flexible timescales. A major goal of the field is to understand the computational and neurobiological principles that enable this flexibility. Here, we argue that the neurobiology of timing provides a platform for tackling these questions. We begin with an overview of proposed coding schemes for the representation of elapsed time, highlighting their computational properties. We then leverage the one-dimensional and unidirectional nature of time to highlight common principles across these coding schemes. These principles facilitate a precise formulation of questions related to the flexible control, variability, and calibration of neural dynamics. We review recent work that demonstrates how dynamical systems analysis of thalamocortical population activity in timing tasks has provided fundamental insights into how the brain calibrates and flexibly controls neural dynamics. We conclude with speculations about the architectural biases and neural substrates that support the control and calibration of neural dynamics more generally.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circuit Modules for Flexible Locomotion. 柔性运动电路模块。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-01-23 DOI: 10.1146/annurev-neuro-112723-061241
Laurence Picton, Irene Pallucchi, Pierre Fontanel, Maria Bertuzzi, Jianren Song, Abdeljabbar El Manira
{"title":"Circuit Modules for Flexible Locomotion.","authors":"Laurence Picton, Irene Pallucchi, Pierre Fontanel, Maria Bertuzzi, Jianren Song, Abdeljabbar El Manira","doi":"10.1146/annurev-neuro-112723-061241","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-061241","url":null,"abstract":"<p><p>Locomotion, like all behaviors, possesses an inherent flexibility that allows for the scaling of movement kinematic features, such as speed and vigor, in response to an ever-changing external world and internal drives. This flexibility is embedded in the organization of the spinal locomotor circuits, which encode and decode commands from the brainstem and proprioceptive feedback. This review highlights our current understanding of the modular organization of these locomotor circuits and how this modularity endows them with intrinsic mechanisms to adjust speed and vigor, thereby contributing to the flexibility of locomotor movements.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptive Cost-Benefit Control Fueled by Striatal Dopamine. 纹状体多巴胺驱动的适应性成本-收益控制。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-01-15 DOI: 10.1146/annurev-neuro-112723-025228
Michael J Frank
{"title":"Adaptive Cost-Benefit Control Fueled by Striatal Dopamine.","authors":"Michael J Frank","doi":"10.1146/annurev-neuro-112723-025228","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-025228","url":null,"abstract":"<p><p>The twenty-first century has brought forth a deluge of theories and data shedding light on the neural mechanisms of motivated behavior. Much of this progress has focused on dopaminergic dynamics, including their signaling properties (how do they vary with expectations and outcomes?) and their downstream impacts in target regions (how do they affect learning and behavior?). In parallel, the basal ganglia have been elevated from their original implication in motoric function to a canonical circuit facilitating the initiation, invigoration, and selection of actions across levels of abstraction, from motor to cognitive operations. This review considers how striatal D1 and D2 opponency allows animals to perform cost-benefit calculations across multiple scales: locally, whether to select a given action, and globally, whether to engage a particular corticostriatal circuit for guiding behavior. An emerging understanding of such functions reconciles seemingly conflicting data and has implications for neuroscience, psychology, behavioral economics, and artificial intelligence.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control. 特定回路的深部脑刺激为运动控制提供洞察力
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1146/annurev-neuro-092823-104810
Aryn H Gittis, Roy V Sillitoe
{"title":"Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control.","authors":"Aryn H Gittis, Roy V Sillitoe","doi":"10.1146/annurev-neuro-092823-104810","DOIUrl":"10.1146/annurev-neuro-092823-104810","url":null,"abstract":"<p><p>Deep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie motor control. In parallel, insights from basic science about how patterns of electrical stimulation impact plasticity and communication within neural circuits are transforming DBS from a therapy for treating symptoms to a therapy for treating circuits, with the goal of training the brain out of its diseased state.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"63-83"},"PeriodicalIF":12.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139995341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain. 听觉分子乐团的和谐：从耳朵到大脑的发育机制
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1146/annurev-neuro-081423-093942
Sonja J Pyott, Gabriela Pavlinkova, Ebenezer N Yamoah, Bernd Fritzsch
{"title":"Harmony in the Molecular Orchestra of Hearing: Developmental Mechanisms from the Ear to the Brain.","authors":"Sonja J Pyott, Gabriela Pavlinkova, Ebenezer N Yamoah, Bernd Fritzsch","doi":"10.1146/annurev-neuro-081423-093942","DOIUrl":"10.1146/annurev-neuro-081423-093942","url":null,"abstract":"<p><p>Auditory processing in mammals begins in the peripheral inner ear and extends to the auditory cortex. Sound is transduced from mechanical stimuli into electrochemical signals of hair cells, which relay auditory information via the primary auditory neurons to cochlear nuclei. Information is subsequently processed in the superior olivary complex, lateral lemniscus, and inferior colliculus and projects to the auditory cortex via the medial geniculate body in the thalamus. Recent advances have provided valuable insights into the development and functioning of auditory structures, complementing our understanding of the physiological mechanisms underlying auditory processing. This comprehensive review explores the genetic mechanisms required for auditory system development from the peripheral cochlea to the auditory cortex. We highlight transcription factors and other genes with key recurring and interacting roles in guiding auditory system development and organization. Understanding these gene regulatory networks holds promise for developing novel therapeutic strategies for hearing disorders, benefiting millions globally.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"1-20"},"PeriodicalIF":12.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139740214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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