Annual review of neuroscience最新文献_第2页

Development of the Binocular Circuit 双目电路的发展

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2024-04-18 DOI: 10.1146/annurev-neuro-111020-093230

Eloísa Herrera, Alain Chédotal, Carol Mason

引用次数: 0

From Blur to Brilliance: The Ascendance of Advanced Microscopy in Neuronal Cell Biology 从模糊到辉煌：先进显微技术在神经元细胞生物学中的应用

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2024-04-12 DOI: 10.1146/annurev-neuro-111020-090208

Kirby R. Campbell, Liam P. Hallada, Yu-Shan Huang, David J. Solecki

{"title":"From Blur to Brilliance: The Ascendance of Advanced Microscopy in Neuronal Cell Biology","authors":"Kirby R. Campbell, Liam P. Hallada, Yu-Shan Huang, David J. Solecki","doi":"10.1146/annurev-neuro-111020-090208","DOIUrl":"https://doi.org/10.1146/annurev-neuro-111020-090208","url":null,"abstract":"The intricate network of the brain's neurons and synapses poses unparalleled challenges for research, distinct from other biological studies. This is particularly true when dissecting how neurons and their functional units work at a cell biological level. While traditional microscopy has been foundational, it was unable to reveal the deeper complexities of neural interactions. However, an imaging renaissance has transformed our capabilities. Advancements in light and electron microscopy, combined with correlative imaging, now achieve unprecedented resolutions, uncovering the most nuanced neural structures. Maximizing these tools requires more than just technical proficiency. It is crucial to align research aims, allocate resources wisely, and analyze data effectively. At the heart of this evolution is interdisciplinary collaboration, where various experts come together to translate detailed imagery into significant biological insights. This review navigates the latest developments in microscopy, underscoring both the promise of and prerequisites for bending this powerful tool set to understanding neuronal cell biology.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"18 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140560339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Budding Neuroscience of Ant Social Behavior 蚂蚁社会行为的萌芽神经科学

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2024-04-11 DOI: 10.1146/annurev-neuro-083023-102101

Dominic D. Frank, Daniel J.C. Kronauer

引用次数: 0

Toward Optogenetic Hearing Restoration 实现光遗传学听力恢复

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2024-04-10 DOI: 10.1146/annurev-neuro-070623-103247

Antoine Huet, Thomas Mager, Christian Gossler, Tobias Moser

引用次数: 0

Keeping Your Brain in Balance: Homeostatic Regulation of Network Function 保持大脑平衡：网络功能的平衡调节

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2024-02-21 DOI: 10.1146/annurev-neuro-092523-110001

Wei Wen, Gina G. Turrigiano

{"title":"Keeping Your Brain in Balance: Homeostatic Regulation of Network Function","authors":"Wei Wen, Gina G. Turrigiano","doi":"10.1146/annurev-neuro-092523-110001","DOIUrl":"https://doi.org/10.1146/annurev-neuro-092523-110001","url":null,"abstract":"To perform computations with the efficiency necessary for animal survival, neocortical microcircuits must be capable of reconfiguring in response to experience, while carefully regulating excitatory and inhibitory connectivity to maintain stable function. This dynamic fine-tuning is accomplished through a rich array of cellular homeostatic plasticity mechanisms that stabilize important cellular and network features such as firing rates, information flow, and sensory tuning properties. Further, these functional network properties can be stabilized by different forms of homeostatic plasticity, including mechanisms that target excitatory or inhibitory synapses, or that regulate intrinsic neuronal excitability. Here we discuss which aspects of neocortical circuit function are under homeostatic control, how this homeostasis is realized on the cellular and molecular levels, and the pathological consequences when circuit homeostasis is impaired. A remaining challenge is to elucidate how these diverse homeostatic mechanisms cooperate within complex circuits to enable them to be both flexible and stable.Expected final online publication date for the Annual Review of Neuroscience, Volume 47 is July 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"19 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2024-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139921874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Brain Stimulation for Obsessive-Compulsive Disorder and Depression. 深部脑刺激治疗强迫症和抑郁症。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-110122-110434

Sameer A Sheth, Helen S Mayberg

引用次数: 4

Neural Networks for Navigation: From Connections to Computations. 导航神经网络:从连接到计算。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-110920-032645

Rachel I Wilson

引用次数: 4

The Computational and Neural Bases of Context-Dependent Learning. 情境依赖学习的计算和神经基础》（The Computational and Neural Bases of Context-Dependent Learning）。

IF 12.1 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-27 DOI: 10.1146/annurev-neuro-092322-100402

James B Heald, Daniel M Wolpert, Máté Lengyel

{"title":"The Computational and Neural Bases of Context-Dependent Learning.","authors":"James B Heald, Daniel M Wolpert, Máté Lengyel","doi":"10.1146/annurev-neuro-092322-100402","DOIUrl":"10.1146/annurev-neuro-092322-100402","url":null,"abstract":"Flexible behavior requires the creation, updating, and expression of memories to depend on context. While the neural underpinnings of each of these processes have been intensively studied, recent advances in computational modeling revealed a key challenge in context-dependent learning that had been largely ignored previously: Under naturalistic conditions, context is typically uncertain, necessitating contextual inference. We review a theoretical approach to formalizing context-dependent learning in the face of contextual uncertainty and the core computations it requires. We show how this approach begins to organize a large body of disparate experimental observations, from multiple levels of brain organization (including circuits, systems, and behavior) and multiple brain regions (most prominently the prefrontal cortex, the hippocampus, and motor cortices), into a coherent framework. We argue that contextual inference may also be key to understanding continual learning in the brain. This theory-driven perspective places contextual inference as a core component of learning.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"233-258"},"PeriodicalIF":12.1,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9779931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception. 皮层整合导航、视觉处理和感知的前庭和视觉线索

IF 12.1 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-120722-100503

Sepiedeh Keshavarzi, Mateo Velez-Fort, Troy W Margrie

{"title":"Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception.","authors":"Sepiedeh Keshavarzi, Mateo Velez-Fort, Troy W Margrie","doi":"10.1146/annurev-neuro-120722-100503","DOIUrl":"10.1146/annurev-neuro-120722-100503","url":null,"abstract":"Despite increasing evidence of its involvement in several key functions of the cerebral cortex, the vestibular sense rarely enters our consciousness. Indeed, the extent to which these internal signals are incorporated within cortical sensory representation and how they might be relied upon for sensory-driven decision-making, during, for example, spatial navigation, is yet to be understood. Recent novel experimental approaches in rodents have probed both the physiological and behavioral significance of vestibular signals and indicate that their widespread integration with vision improves both the cortical representation and perceptual accuracy of self-motion and orientation. Here, we summarize these recent findings with a focus on cortical circuits involved in visual perception and spatial navigation and highlight the major remaining knowledge gaps. We suggest that vestibulo-visual integration reflects a process of constant updating regarding the status of self-motion, and access to such information by the cortex is used for sensory perception and predictions that may be implemented for rapid, navigation-related decision-making.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"301-320"},"PeriodicalIF":12.1,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7616138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9813082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Striosomes and Matrisomes: Scaffolds for Dynamic Coupling of Volition and Action. 纹状体和基质体：Volition和Action动态耦合的支架。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-04-17 DOI: 10.1146/annurev-neuro-121522-025740

Ann M Graybiel, Ayano Matsushima

{"title":"Striosomes and Matrisomes: Scaffolds for Dynamic Coupling of Volition and Action.","authors":"Ann M Graybiel, Ayano Matsushima","doi":"10.1146/annurev-neuro-121522-025740","DOIUrl":"10.1146/annurev-neuro-121522-025740","url":null,"abstract":"Striosomes form neurochemically specialized compartments of the striatum embedded in a large matrix made up of modules called matrisomes. Striosome-matrix architecture is multiplexed with the canonical direct-indirect organization of the striatum. Striosomal functions remain to be fully clarified, but key information is emerging. First, striosomes powerfully innervate nigral dopamine-containing neurons and can completely shut down their activity, with a following rebound excitation. Second, striosomes receive limbic and cognition-related corticostriatal afferents and are dynamically modulated in relation to value-based actions. Third, striosomes are spatially interspersed among matrisomes and interneurons and are influenced by local and global neuromodulatory and oscillatory activities. Fourth, striosomes tune engagement and the motivation to perform reinforcement learning, to manifest stereotypical behaviors, and to navigate valence conflicts and valence discriminations. We suggest that, at an algorithmic level, striosomes could serve as distributed scaffolds to provide formats of the striatal computations generated through development and refined through learning. We propose that striosomes affect subjective states. By transforming corticothalamic and other inputs to the functional formats of the striatum, they could implement state transitions in nigro-striato-nigral circuits to affect bodily and cognitive actions according to internal motives whose functions are compromised in neuropsychiatric conditions.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"359-380"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0