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Annual review of neuroscience最新文献

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How the Hippocampal Cognitive Map Supports Flexible Navigation.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-04-08 DOI: 10.1146/annurev-neuro-112723-023341
John O'Keefe
{"title":"How the Hippocampal Cognitive Map Supports Flexible Navigation.","authors":"John O'Keefe","doi":"10.1146/annurev-neuro-112723-023341","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-023341","url":null,"abstract":"<p><p>During navigation to a goal, a portion of the hippocampal place cells exhibit directional preferences, firing more in some directions than in others. These directional preferences create vector fields oriented toward locations scattered around the environment called ConSinks. The population vector field averaged across all of the cells recorded in each animal flows toward an average ConSink located close to the goal, providing a means for navigation in unobstructed environments. Closer examination of the ConSink place cell directional firing reveals a fantail representation in which alternative paths to the goal are evaluated, providing the basis for flexible navigation. Additional assumptions about how obstructions might be represented suggest a solution for navigation in more complicated environments. Implications for the phenomena of directionality on linear tracks and splitter cells are discussed.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Deep Evolutionary Roots of the Nervous System.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-04-08 DOI: 10.1146/annurev-neuro-112723-040945
Maria Sachkova, Vengamanaidu Modepalli, Maike Kittelmann
{"title":"The Deep Evolutionary Roots of the Nervous System.","authors":"Maria Sachkova, Vengamanaidu Modepalli, Maike Kittelmann","doi":"10.1146/annurev-neuro-112723-040945","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-040945","url":null,"abstract":"<p><p>The evolutionary success of animals can, at least in part, be attributed to the presence of neurons that allow long-distance communication between tissues, coordination of movements, and the capacity for learning. However, the evolutionary origin and relationship of neurons to other cell types are fundamental questions that remain unsolved. The first neurons probably evolved shortly after the rise of the first animals over 600 million years ago. Studies on early-diverging animal lineages have provided key insights into the mechanisms underlying the origin of neurons. Recent discoveries in morphology, molecular signatures, and function of neurons in cnidarians and comb jellies, as well as neuron-like cells in nerveless placozoans, sponges, and other eukaryotes, may prompt a redefinition of what constitutes a neuron. Here we review the latest insights into the origin of neurons and nervous systems, while also highlighting exciting technological advancements that not only are accelerating our understanding of nervous system evolution, morphology, and function but also hold the potential to revolutionize the field.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prenatal Immune Stress: Its Impact on Brain Development and Neuropsychiatric Disorders.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-04-08 DOI: 10.1146/annurev-neuro-112723-024048
Navneet A Vasistha, Akira Sawa
{"title":"Prenatal Immune Stress: Its Impact on Brain Development and Neuropsychiatric Disorders.","authors":"Navneet A Vasistha, Akira Sawa","doi":"10.1146/annurev-neuro-112723-024048","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-024048","url":null,"abstract":"<p><p>Many epidemiological studies have indicated that prenatal immune stress, frequently elicited by maternal immune activation, underlies a major risk for neuropsychiatric disorders of neurodevelopmental origin, such as schizophrenia and autism spectrum disorders. Animal models have been utilized to understand the biological processes of how immune stress influences brain development and resultant behavioral changes. Through such studies, the impacts of orchestrated immune-inflammatory mechanisms led by interleukin-6 (IL-6) on several developing cells, such as neural progenitors, neurons, and microglia, have been deciphered. In addition to prenatal immune stress from adverse maternal environments, mechanisms regulated by intrinsic factors directly associated with the offspring also exist. This review also introduces human stem cell models for addressing this topic and refers to potential modifiers of prenatal immune stress that could influence the eventual behavioral outcomes. Altogether, a mechanistic understanding of the impact of prenatal immune stress on brain development provides a fundamental addition in translational and clinical neurology and psychiatry.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory Feedback and the Dynamic Control of Movement.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-04-08 DOI: 10.1146/annurev-neuro-112723-042229
Martyn Goulding, Tejapratap Bollu, Ansgar Büschges
{"title":"Sensory Feedback and the Dynamic Control of Movement.","authors":"Martyn Goulding, Tejapratap Bollu, Ansgar Büschges","doi":"10.1146/annurev-neuro-112723-042229","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-042229","url":null,"abstract":"<p><p>Motor systems in animals are highly dependent on sensory information for optimal control and precision, with mechanosensory feedback from the somatosensory system playing a critical role. These mechanosensory pathways are woven into the descending feedforward pathways and local central pattern generator circuits that control and generate movement, respectively. Somatosensory feedback in mammals and insects, the two animal classes this review touches upon, is complex due to the increased demands that limbed locomotion, weight-bearing, and corrective movements place on sensorimotor control. In this review, we outline the salient features of the proprioceptive and exteroceptive sensory feedback pathways animals rely on for controlling movement and highlight some of the key principles of sensory feedback that are shared across the animal kingdom.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurobiology of Thirst and Hunger Drives.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-04-08 DOI: 10.1146/annurev-neuro-112723-032328
Lucas Encarnacion-Rivera, Karl Deisseroth, Liqun Luo
{"title":"Neurobiology of Thirst and Hunger Drives.","authors":"Lucas Encarnacion-Rivera, Karl Deisseroth, Liqun Luo","doi":"10.1146/annurev-neuro-112723-032328","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-032328","url":null,"abstract":"<p><p>Thirst and hunger drives are fundamental survival mechanisms that transform physiological need into motivated behavior. In the brain, discrete types of circumventricular and hypothalamic neurons serve as neural circuit elements underlying thirst and hunger drives. These neurons receive signals of dehydration and starvation arising from outside the brain and communicate these homeostatic needs to downstream neural circuit elements. Recent advances in neural circuit activity recording and control in behaving mammals have elucidated how direct and indirect targets of these cells encode goal-relevant, affective, autonomic, and behavioral components of the drives, resulting in a finely tuned, robust, and flexible set of survival-appropriate behaviors.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell Type-Specific Studies of Human Tissue for Investigation of the Molecular Cell Biology of Late-Onset Neurodegenerative Disease.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-03-18 DOI: 10.1146/annurev-neuro-112723-025516
Kert Mätlik, Christina Pressl, Nathaniel Heintz
{"title":"Cell Type-Specific Studies of Human Tissue for Investigation of the Molecular Cell Biology of Late-Onset Neurodegenerative Disease.","authors":"Kert Mätlik, Christina Pressl, Nathaniel Heintz","doi":"10.1146/annurev-neuro-112723-025516","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-025516","url":null,"abstract":"<p><p>Decades of research into human neurodegenerative diseases have revealed important similarities as well as dissimilarities between diseases. While investigations of specific mechanistic aspects of diseases have been aided by cell and animal models, true advances in the understanding of neurodegeneration require that we deal with the daunting complexities of the human brain. In this review, we discuss novel molecular profiling methods that have been applied to human postmortem brain tissue during the last decade and highlight insights into cell type-specific molecular characteristics and disease-associated changes in both vulnerable and resilient cell types in Huntington's disease, Parkinson's disease, and Alzheimer's disease. We also illustrate how these approaches can complement human genetic analyses and studies of animal models to advance our understanding of human neurodegeneration.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocytes as Key Regulators of Neural Signaling in Health and Disease.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-03-11 DOI: 10.1146/annurev-neuro-112723-035356
Woojin Won, Mridula Bhalla, Jae-Hun Lee, C Justin Lee
{"title":"Astrocytes as Key Regulators of Neural Signaling in Health and Disease.","authors":"Woojin Won, Mridula Bhalla, Jae-Hun Lee, C Justin Lee","doi":"10.1146/annurev-neuro-112723-035356","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-035356","url":null,"abstract":"<p><p>Astrocytes, traditionally viewed as supportive cells within the central nervous system (CNS), are now recognized as dynamic regulators of neural signaling and homeostasis. They actively engage in synaptic transmission and brain health by releasing gliotransmitters such as glutamate, GABA, ATP, adenosine, lactate, and d-serine. Astrocytes also play a critical role in ion homeostasis and immune response through cytokine modulation and reactive oxygen species regulation. In pathological states, astrocytes can become reactive, contributing to neurodegeneration through dysregulated gliotransmitter release and metabolic dysfunction. Recently developed molecular and pharmacological tools allow the exploration of astrocytic response to injury and its influence on neuronal function. This review explores the multifaceted roles of astrocytes in health and disease, emphasizing sensory and motor functions as well as various neurological and psychiatric disorders. Understanding astrocyte-neuron signaling in health and disease provides crucial insights into their dual roles, offering novel avenues for therapeutic interventions in CNS disorders.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-Image-Forming Functions of Intrinsically Photosensitive Retinal Ganglion Cells.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-03-07 DOI: 10.1146/annurev-neuro-112723-035532
Jianjun Meng, Xiaodan Huang, Chaoran Ren, Tian Xue
{"title":"Non-Image-Forming Functions of Intrinsically Photosensitive Retinal Ganglion Cells.","authors":"Jianjun Meng, Xiaodan Huang, Chaoran Ren, Tian Xue","doi":"10.1146/annurev-neuro-112723-035532","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-035532","url":null,"abstract":"<p><p>Life on this planet is heavily influenced by light, the most critical external environmental factor. Mammals perceive environmental light mainly through three types of photoreceptors in the retina-rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). The latest discovered ipRGCs are particularly sensitive to short-wavelength light and have a unique phototransduction mechanism, compared with rods and cones. Piles of evidence suggest that ipRGCs mediate a series of light-regulated physiological functions such as circadian rhythms, sleep, metabolic homeostasis, mood, development, and higher cognitions, collectively known as non-image-forming vision. Recent advances in systems neuroscience, driven by modern neural circuit tools, have illuminated the structure and function of the neural pathways connecting the retina to subcortical regions, highlighting their involvement in an array of non-image-forming functions. Here we review key discoveries and recent progress regarding the neural circuit mechanisms employed by ipRGCs to regulate diverse biological functions and provide insights into unresolved scientific questions in this area.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Circuits Underlying Sexually Dimorphic Innate Behaviors. 性双态先天行为的神经回路
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-03-03 DOI: 10.1146/annurev-neuro-112723-034621
Meital Oren-Suissa, Troy R Shirangi
{"title":"Neural Circuits Underlying Sexually Dimorphic Innate Behaviors.","authors":"Meital Oren-Suissa, Troy R Shirangi","doi":"10.1146/annurev-neuro-112723-034621","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-034621","url":null,"abstract":"<p><p>Sexually dimorphic instinctual behaviors that set females and males apart are found across animal clades. Recent studies in a variety of animal systems have provided deep insights into the neural circuits that guide sexually dimorphic behaviors, such as mating practices and social responses, and how sex differences in these circuits develop. Here, we discuss the neural circuits of several sexually dimorphic instinctual behaviors in rodents, flies, and worms-from mate attraction and aggression to pain perception and empathy. We highlight several salient similarities and differences between these circuits and reveal general principles that underlie the function and development of neural circuits for dimorphic behaviors.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Silent Synapses in the Adult Brain.
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2025-02-25 DOI: 10.1146/annurev-neuro-112723-032924
Dimitra Vardalaki, Courtney E Yaeger, Mark T Harnett
{"title":"Silent Synapses in the Adult Brain.","authors":"Dimitra Vardalaki, Courtney E Yaeger, Mark T Harnett","doi":"10.1146/annurev-neuro-112723-032924","DOIUrl":"https://doi.org/10.1146/annurev-neuro-112723-032924","url":null,"abstract":"<p><p>The formation of new synapses, the connections between neurons, is the critical step for neural circuit assembly. Newly formed glutamatergic synapses are initially silent and require activity-dependent plasticity to become fully functional connections. While these synapses have long been considered a vital part of the developmental program for neural networks, recent findings now indicate that silent synapses are a key source of neural circuit plasticity in the adult brain. Here, we review current evidence for silent synapses in the adult brain and explore the potential roles of these highly plastic structures. We argue that silent synapses may be instrumental in adult neural circuit remodeling and can serve as a latent reservoir of plasticity that enhances information processing and storage. This previously underappreciated aspect of adult plasticity underscores the need for innovative approaches and further investigation into the dynamic contribution of silent synapses to learning and memory in the adult brain.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":12.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143498027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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