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Annual review of neuroscience最新文献

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A Motor Theory of Sleep-Wake Control: Arousal-Action Circuit. 睡眠-觉醒控制的运动理论:觉醒-动作回路。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-01-30 DOI: 10.1146/annurev-neuro-080317-061813
Danqian Liu, Yang Dan
{"title":"A Motor Theory of Sleep-Wake Control: Arousal-Action Circuit.","authors":"Danqian Liu,&nbsp;Yang Dan","doi":"10.1146/annurev-neuro-080317-061813","DOIUrl":"https://doi.org/10.1146/annurev-neuro-080317-061813","url":null,"abstract":"<p><p>Wakefulness, rapid eye movement (REM) sleep, and non-rapid eye movement (NREM) sleep are characterized by distinct electroencephalogram (EEG), electromyogram (EMG), and autonomic profiles. The circuit mechanism coordinating these changes during sleep-wake transitions remains poorly understood. The past few years have witnessed rapid progress in the identification of REM and NREM sleep neurons, which constitute highly distributed networks spanning the forebrain, midbrain, and hindbrain. Here we propose an arousal-action circuit for sleep-wake control in which wakefulness is supported by separate arousal and action neurons, while REM and NREM sleep neurons are part of the central somatic and autonomic motor circuits. This model is well supported by the currently known sleep and wake neurons. It can also account for the EEG, EMG, and autonomic profiles of wake, REM, and NREM states and several key features of their transitions. The intimate association between the sleep and autonomic/somatic motor control circuits suggests that a primary function of sleep is to suppress motor activity.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"27-46"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-080317-061813","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 99
Acoustic Pattern Recognition and Courtship Songs: Insights from Insects. 声学模式识别和求偶歌曲:来自昆虫的见解。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-02-20 DOI: 10.1146/annurev-neuro-080317-061839
Christa A Baker, Jan Clemens, Mala Murthy
{"title":"Acoustic Pattern Recognition and Courtship Songs: Insights from Insects.","authors":"Christa A Baker,&nbsp;Jan Clemens,&nbsp;Mala Murthy","doi":"10.1146/annurev-neuro-080317-061839","DOIUrl":"https://doi.org/10.1146/annurev-neuro-080317-061839","url":null,"abstract":"<p><p>Across the animal kingdom, social interactions rely on sound production and perception. From simple cricket chirps to more elaborate bird songs, animals go to great lengths to communicate information critical for reproduction and survival via acoustic signals. Insects produce a wide array of songs to attract a mate, and the intended receivers must differentiate these calls from competing sounds, analyze the quality of the sender from spectrotemporal signal properties, and then determine how to react. Insects use numerically simple nervous systems to analyze and respond to courtship songs, making them ideal model systems for uncovering the neural mechanisms underlying acoustic pattern recognition. We highlight here how the combination of behavioral studies and neural recordings in three groups of insects-crickets, grasshoppers, and fruit flies-reveals common strategies for extracting ethologically relevant information from acoustic patterns and how these findings might translate to other systems.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"129-147"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-080317-061839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36974425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Lessons from Worm Dendritic Patterning. 蠕虫树突模式的经验教训。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-04-02 DOI: 10.1146/annurev-neuro-072116-031437
Sharon Inberg, Anna Meledin, Veronika Kravtsov, Yael Iosilevskii, Meital Oren-Suissa, Benjamin Podbilewicz
{"title":"Lessons from Worm Dendritic Patterning.","authors":"Sharon Inberg,&nbsp;Anna Meledin,&nbsp;Veronika Kravtsov,&nbsp;Yael Iosilevskii,&nbsp;Meital Oren-Suissa,&nbsp;Benjamin Podbilewicz","doi":"10.1146/annurev-neuro-072116-031437","DOIUrl":"https://doi.org/10.1146/annurev-neuro-072116-031437","url":null,"abstract":"<p><p>The structural and functional properties of neurons have intrigued scientists since the pioneering work of Santiago Ramón y Cajal. Since then, emerging cutting-edge technologies, including light and electron microscopy, electrophysiology, biochemistry, optogenetics, and molecular biology, have dramatically increased our understanding of dendritic properties. This advancement was also facilitated by the establishment of different animal model organisms, from flies to mammals. Here we describe the emerging model system of a <i>Caenorhabditis elegans</i> polymodal neuron named PVD, whose dendritic tree follows a stereotypical structure characterized by repeating candelabra-like structural units. In the past decade, progress has been made in understanding PVD's functions, morphogenesis, regeneration, and aging, yet many questions still remain.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"365-383"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-072116-031437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37114846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Genes Involved in the Development and Physiology of Both the Peripheral and Central Auditory Systems. 参与外周和中枢听觉系统发育和生理的基因。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-01-30 DOI: 10.1146/annurev-neuro-070918-050428
Nicolas Michalski, Christine Petit
{"title":"Genes Involved in the Development and Physiology of Both the Peripheral and Central Auditory Systems.","authors":"Nicolas Michalski,&nbsp;Christine Petit","doi":"10.1146/annurev-neuro-070918-050428","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050428","url":null,"abstract":"<p><p>The genetic approach, based on the study of inherited forms of deafness, has proven to be particularly effective for deciphering the molecular mechanisms underlying the development of the peripheral auditory system, the cochlea and its afferent auditory neurons, and how this system extracts the physical parameters of sound. Although this genetic dissection has provided little information about the central auditory system, scattered data suggest that some genes may have a critical role in both the peripheral and central auditory systems. Here, we review the genes controlling the development and function of the peripheral and central auditory systems, focusing on those with demonstrated intrinsic roles in both systems and highlighting the current underappreciation of these genes. Their encoded products are diverse, from transcription factors to ion channels, as are their roles in the central auditory system, mostly evaluated in brainstem nuclei. We examine the ontogenetic and evolutionary mechanisms that may underlie their expression at different sites.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"67-86"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050428","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Glia-Neuron Interactions in Caenorhabditis elegans. 秀丽隐杆线虫的神经胶质细胞相互作用。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-03-18 DOI: 10.1146/annurev-neuro-070918-050314
Aakanksha Singhvi, Shai Shaham
{"title":"Glia-Neuron Interactions in <i>Caenorhabditis elegans</i>.","authors":"Aakanksha Singhvi,&nbsp;Shai Shaham","doi":"10.1146/annurev-neuro-070918-050314","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050314","url":null,"abstract":"<p><p>Glia are abundant components of animal nervous systems. Recognized 170 years ago, concerted attempts to understand these cells began only recently. From these investigations glia, once considered passive filler material in the brain, have emerged as active players in neuron development and activity. Glia are essential for nervous system function, and their disruption leads to disease. The nematode <i>Caenorhabditis elegans</i> possesses glial types similar to vertebrate glia, based on molecular, morphological, and functional criteria, and has become a powerful model in which to study glia and their neuronal interactions. Facile genetic and transgenic methods in this animal allow the discovery of genes required for glial functions, and effects of glia at single synapses can be monitored by tracking neuron shape, physiology, or animal behavior. Here, we review recent progress in understanding glia-neuron interactions in <i>C. elegans</i>. We highlight similarities with glia in other animals, and suggest conserved emerging principles of glial function.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"149-168"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37065360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
Repeat-Associated Non-ATG Translation: Molecular Mechanisms and Contribution to Neurological Disease. 重复相关的非atg翻译:神经系统疾病的分子机制和贡献。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-03-25 DOI: 10.1146/annurev-neuro-070918-050405
Lien Nguyen, John Douglas Cleary, Laura P W Ranum
{"title":"Repeat-Associated Non-ATG Translation: Molecular Mechanisms and Contribution to Neurological Disease.","authors":"Lien Nguyen,&nbsp;John Douglas Cleary,&nbsp;Laura P W Ranum","doi":"10.1146/annurev-neuro-070918-050405","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050405","url":null,"abstract":"<p><p>Microsatellite mutations involving the expansion of tri-, tetra-, penta-, or hexanucleotide repeats cause more than 40 different neurological disorders. Although, traditionally, the position of the repeat within or outside of an open reading frame has been used to focus research on disease mechanisms involving protein loss of function, protein gain of function, or RNA gain of function, the discoveries of bidirectional transcription and repeat-associated non-ATG (RAN) have blurred these distinctions. Here we review what is known about RAN proteins in disease, the mechanisms by which they are produced, and the novel therapeutic opportunities they provide.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"227-247"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37251263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 50
Magnetic Strategies for Nervous System Control. 神经系统控制的磁策略。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-04-02 DOI: 10.1146/annurev-neuro-070918-050241
Michael G Christiansen, Alexander W Senko, Polina Anikeeva
{"title":"Magnetic Strategies for Nervous System Control.","authors":"Michael G Christiansen,&nbsp;Alexander W Senko,&nbsp;Polina Anikeeva","doi":"10.1146/annurev-neuro-070918-050241","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050241","url":null,"abstract":"<p><p>Magnetic fields pass through tissue undiminished and without producing harmful effects, motivating their use as a wireless, minimally invasive means to control neural activity. Here, we review mechanisms and techniques coupling magnetic fields to changes in electrochemical potentials across neuronal membranes. Biological magnetoreception, although incompletely understood, is discussed as a potential source of inspiration. The emergence of magnetic properties in materials is reviewed to clarify the distinction between biomolecules containing transition metals and ferrite nanoparticles that exhibit significant net moments. We describe recent developments in the use of magnetic nanomaterials as transducers converting magnetic stimuli to forms readily perceived by neurons and discuss opportunities for multiplexed and bidirectional control as well as the challenges posed by delivery to the brain. The variety of magnetic field conditions and mechanisms by which they can be coupled to neuronal signaling cascades highlights the desirability of continued interchange between magnetism physics and neurobiology.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"271-293"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37114848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 37
Dexterous Hand Movements and Their Recovery After Central Nervous System Injury. 中枢神经系统损伤后灵巧手运动及其恢复。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-04-02 DOI: 10.1146/annurev-neuro-070918-050436
Tadashi Isa
{"title":"Dexterous Hand Movements and Their Recovery After Central Nervous System Injury.","authors":"Tadashi Isa","doi":"10.1146/annurev-neuro-070918-050436","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050436","url":null,"abstract":"<p><p>Hand dexterity has uniquely developed in higher primates and is thought to rely on the direct corticomotoneuronal (CM) pathway. Recent studies have shown that rodents and carnivores lack the direct CM pathway but can control certain levels of dexterous hand movements through various indirect CM pathways. Some homologous pathways also exist in higher primates, and among them, propriospinal (PrS) neurons in the mid-cervical segments (C3-C4) are significantly involved in hand dexterity. When the direct CM pathway was lesioned caudal to the PrS and transmission of cortical commands to hand motoneurons via the PrS neurons remained intact, dexterous hand movements could be significantly recovered. This recovery model was intensively studied, and it was found that, in addition to the compensation by the PrS neurons, a large-scale reorganization in the bilateral cortical motor-related areas and mesolimbic structures contributed to recovery. Future therapeutic strategies should target these multihierarchical areas.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"315-335"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37114849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Antisense Oligonucleotide Therapies for Neurodegenerative Diseases. 反义寡核苷酸治疗神经退行性疾病。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 DOI: 10.1146/annurev-neuro-070918-050501
C Frank Bennett, Adrian R Krainer, Don W Cleveland
{"title":"Antisense Oligonucleotide Therapies for Neurodegenerative Diseases.","authors":"C Frank Bennett,&nbsp;Adrian R Krainer,&nbsp;Don W Cleveland","doi":"10.1146/annurev-neuro-070918-050501","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050501","url":null,"abstract":"<p><p>Antisense oligonucleotides represent a novel therapeutic platform for the discovery of medicines that have the potential to treat most neurodegenerative diseases. Antisense drugs are currently in development for the treatment of amyotrophic lateral sclerosis, Huntington's disease, and Alzheimer's disease, and multiple research programs are underway for additional neurodegenerative diseases. One antisense drug, nusinersen, has been approved for the treatment of spinal muscular atrophy. Importantly, nusinersen improves disease symptoms when administered to symptomatic patients rather than just slowing the progression of the disease. In addition to the benefit to spinal muscular atrophy patients, there are discoveries from nusinersen that can be applied to other neurological diseases, including method of delivery, doses, tolerability of intrathecally delivered antisense drugs, and the biodistribution of intrathecal dosed antisense drugs. Based in part on the early success of nusinersen, antisense drugs hold great promise as a therapeutic platform for the treatment of neurological diseases.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"385-406"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37407601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 184
Neurite Development and Repair in Worms and Flies. 蠕虫和苍蝇的神经突发育和修复。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-03-18 DOI: 10.1146/annurev-neuro-070918-050208
Claire E Richardson, Kang Shen
{"title":"Neurite Development and Repair in Worms and Flies.","authors":"Claire E Richardson,&nbsp;Kang Shen","doi":"10.1146/annurev-neuro-070918-050208","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050208","url":null,"abstract":"<p><p>How the nervous system is wired has been a central question of neuroscience since the inception of the field, and many of the foundational discoveries and conceptual advances have been made through the study of invertebrate experimental organisms, including <i>Caenorhabditis elegans</i> and <i>Drosophila melanogaster</i>. Although many guidance molecules and receptors have been identified, recent experiments have shed light on the many modes of action for these pathways. Here, we summarize the recent progress in determining how the physical and temporal constraints of the surrounding environment provide instructive regulations in nervous system wiring. We use Netrin and its receptors as an example to analyze the complexity of how they guide neurite outgrowth. In neurite repair, conserved injury detection and response-signaling pathways regulate gene expression and cytoskeletal dynamics. We also describe recent developments in the research on molecular mechanisms of neurite regeneration in worms and flies.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"209-226"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37065361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
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