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Annual review of neuroscience最新文献

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Dense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish. 密集电路重构以理解神经元计算:以斑马鱼为例。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 Epub Date: 2021-03-17 DOI: 10.1146/annurev-neuro-110220-013050
Rainer W Friedrich, Adrian A Wanner
{"title":"Dense Circuit Reconstruction to Understand Neuronal Computation: Focus on Zebrafish.","authors":"Rainer W Friedrich, Adrian A Wanner","doi":"10.1146/annurev-neuro-110220-013050","DOIUrl":"https://doi.org/10.1146/annurev-neuro-110220-013050","url":null,"abstract":"The dense reconstruction of neuronal wiring diagrams from volumetric electron microscopy data has the potential to generate fundamentally new insights into mechanisms of information processing and storage in neuronal circuits. Zebrafish provide unique opportunities for dynamical connectomics approaches that combine reconstructions of wiring diagrams with measurements of neuronal population activity and behavior. Such approaches have the power to reveal higher-order structure in wiring diagrams that cannot be detected by sparse sampling of connectivity and that is essential for neuronal computations. In the brain stem, recurrently connected neuronal modules were identified that can account for slow, low-dimensional dynamics in an integrator circuit. In the spinal cord, connectivity specifies functional differences between premotor interneurons. In the olfactory bulb, tuning-dependent connectivity implements a whitening transformation that is based on the selective suppression of responses to overrepresented stimulus features. These findings illustrate the potential of dynamical connectomics in zebrafish to analyze the circuit mechanisms underlying higher-order neuronal computations. Expected final online publication date for the Annual Review of Neuroscience, Volume 44 is July 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"275-293"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25487119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Sources of Individual Differences in Pain. 个体疼痛差异的来源。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 DOI: 10.1146/annurev-neuro-092820-105941
Jeffrey S Mogil
{"title":"Sources of Individual Differences in Pain.","authors":"Jeffrey S Mogil","doi":"10.1146/annurev-neuro-092820-105941","DOIUrl":"https://doi.org/10.1146/annurev-neuro-092820-105941","url":null,"abstract":"<p><p>Pain is an immense clinical and societal challenge, and the key to understanding and treating it is variability. Robust interindividual differences are consistently observed in pain sensitivity, susceptibility to developing painful disorders, and response to analgesic manipulations. This review examines the causes of this variability, including both organismic and environmental sources. Chronic pain development is a textbook example of a gene-environment interaction, requiring both chance initiating events (e.g., trauma, infection) and more immutable risk factors. The focus is on genetic factors, since twin studies have determined that a plurality of the variance likely derives from inherited genetic variants, but sex, age, ethnicity, personality variables, and environmental factors are also considered.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"1-25"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39163847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Astrocytes and Behavior. 星形胶质细胞与行为。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 Epub Date: 2021-01-06 DOI: 10.1146/annurev-neuro-101920-112225
Paulo Kofuji, Alfonso Araque
{"title":"Astrocytes and Behavior.","authors":"Paulo Kofuji,&nbsp;Alfonso Araque","doi":"10.1146/annurev-neuro-101920-112225","DOIUrl":"https://doi.org/10.1146/annurev-neuro-101920-112225","url":null,"abstract":"<p><p>Animal behavior was classically considered to be determined exclusively by neuronal activity, whereas surrounding glial cells such as astrocytes played only supportive roles. However, astrocytes are as numerous as neurons in the mammalian brain, and current findings indicate a chemically based dialog between astrocytes and neurons. Activation of astrocytes by synaptically released neurotransmitters converges on regulating intracellular Ca<sup>2+</sup> in astrocytes, which then can regulate the efficacy of near and distant tripartite synapses at diverse timescales through gliotransmitter release. Here, we discuss recent evidence on how diverse behaviors are impacted by this dialog. These recent findings support a paradigm shift in neuroscience, in which animal behavior does not result exclusively from neuronal activity but from the coordinated activity of both astrocytes and neurons. Decoding how astrocytes and neurons interact with each other in various brain circuits will be fundamental to fully understanding how behaviors originate and become dysregulated in disease.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"49-67"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8257756/pdf/nihms-1667246.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39135458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 60
Parkinson's Disease Genetics and Pathophysiology. 帕金森病遗传学和病理生理学。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 DOI: 10.1146/annurev-neuro-100720-034518
Gabriel E Vázquez-Vélez, Huda Y Zoghbi
{"title":"Parkinson's Disease Genetics and Pathophysiology.","authors":"Gabriel E Vázquez-Vélez,&nbsp;Huda Y Zoghbi","doi":"10.1146/annurev-neuro-100720-034518","DOIUrl":"https://doi.org/10.1146/annurev-neuro-100720-034518","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a common neurodegenerative disorder characterized by degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in Lewy bodies. PD is caused by a combination of environmental factors and genetic variants. These variants range from highly penetrant Mendelian alleles to alleles that only modestly increase disease risk. Here, we review what is known about the genetics of PD. We also describe how PD genetics have solidified the role of endosomal, lysosomal, and mitochondrial dysfunction in PD pathophysiology. Finally, we highlight how all three pathways are affected by α-synuclein and how this knowledge may be harnessed for the development of disease-modifying therapeutics.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"87-108"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39163849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 67
The Cortical Motor Areas and the Emergence of Motor Skills: A Neuroanatomical Perspective. 皮层运动区和运动技能的出现:一个神经解剖学的观点。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 Epub Date: 2021-04-16 DOI: 10.1146/annurev-neuro-070918-050216
Peter L Strick, Richard P Dum, Jean-Alban Rathelot
{"title":"The Cortical Motor Areas and the Emergence of Motor Skills: A Neuroanatomical Perspective.","authors":"Peter L Strick,&nbsp;Richard P Dum,&nbsp;Jean-Alban Rathelot","doi":"10.1146/annurev-neuro-070918-050216","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050216","url":null,"abstract":"<p><p>What changes in neural architecture account for the emergence and expansion of dexterity in primates? Dexterity, or skill in performing motor tasks, depends on the ability to generate highly fractionated patterns of muscle activity. It also involves the spatiotemporal coordination of activity in proximal and distal muscles across multiple joints. Many motor skills require the generation of complex movement sequences that are only acquired and refined through extensive practice. Improvements in dexterity have enabled primates to manufacture and use tools and humans to engage in skilled motor behaviors such as typing, dance, musical performance, and sports. Our analysis leads to the following synthesis: The neural substrate that endows primates with their enhanced motor capabilities is due, in part, to (<i>a</i>) major organizational changes in the primary motor cortex and (<i>b</i>) the proliferation of output pathways from other areas of the cerebral cortex, especially from the motor areas on the medial wall of the hemisphere.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"425-447"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38801372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Oxytocin, Neural Plasticity, and Social Behavior. 催产素，神经可塑性和社会行为。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 Epub Date: 2021-04-06 DOI: 10.1146/annurev-neuro-102320-102847
Robert C Froemke, Larry J Young
{"title":"Oxytocin, Neural Plasticity, and Social Behavior.","authors":"Robert C Froemke,&nbsp;Larry J Young","doi":"10.1146/annurev-neuro-102320-102847","DOIUrl":"https://doi.org/10.1146/annurev-neuro-102320-102847","url":null,"abstract":"<p><p>Oxytocin regulates parturition, lactation, parental nurturing, and many other social behaviors in both sexes. The circuit mechanisms by which oxytocin modulates social behavior are receiving increasing attention. Here, we review recent studies on oxytocin modulation of neural circuit function and social behavior, largely enabled by new methods of monitoring and manipulating oxytocin or oxytocin receptor neurons in vivo. These studies indicate that oxytocin can enhance the salience of social stimuli and increase signal-to-noise ratios by modulating spiking and synaptic plasticity in the context of circuits and networks. We highlight oxytocin effects on social behavior in nontraditional organisms such as prairie voles and discuss opportunities to enhance the utility of these organisms for studying circuit-level modulation of social behaviors. We then discuss recent insights into oxytocin neuron activity during social interactions. We conclude by discussing some of the major questions and opportunities in the field ahead.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"359-381"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604207/pdf/nihms-1752167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25566623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 132
Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors. 社会情境的适应性预测:小脑对典型和非典型社会行为的贡献。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 DOI: 10.1146/annurev-neuro-100120-092143
Catherine J Stoodley, Peter T Tsai
{"title":"Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors.","authors":"Catherine J Stoodley,&nbsp;Peter T Tsai","doi":"10.1146/annurev-neuro-100120-092143","DOIUrl":"https://doi.org/10.1146/annurev-neuro-100120-092143","url":null,"abstract":"<p><p>Social interactions involve processes ranging from face recognition to understanding others' intentions. To guide appropriate behavior in a given context, social interactions rely on accurately predicting the outcomes of one's actions and the thoughts of others. Because social interactions are inherently dynamic, these predictions must be continuously adapted. The neural correlates of social processing have largely focused on emotion, mentalizing, and reward networks, without integration of systems involved in prediction. The cerebellum forms predictive models to calibrate movements and adapt them to changing situations, and cerebellar predictive modeling is thought to extend to nonmotor behaviors. Primary cerebellar dysfunction can produce social deficits, and atypical cerebellar structure and function are reported in autism, which is characterized by social communication challenges and atypical predictive processing. We examine the evidence that cerebellar-mediated predictions and adaptation play important roles in social processes and argue that disruptions in these processes contribute to autism.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"475-493"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9037460/pdf/nihms-1739755.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39163850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Physiology and Pathophysiology of Mechanically Activated PIEZO Channels. 机械激活压电通道的生理学和病理生理学。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 DOI: 10.1146/annurev-neuro-093020-120939
Ruhma Syeda
{"title":"Physiology and Pathophysiology of Mechanically Activated PIEZO Channels.","authors":"Ruhma Syeda","doi":"10.1146/annurev-neuro-093020-120939","DOIUrl":"https://doi.org/10.1146/annurev-neuro-093020-120939","url":null,"abstract":"<p><p>Nearly all structures in our body experience mechanical forces. At a molecular scale, these forces are detected by ion channels that function as mechanotransducers converting physical forces into electrochemical responses. Here we focus on PIEZOs, a family of mechanically activated ion channels comprising PIEZO1 and PIEZO2. The significance of these channels is highlighted by their roles in touch and pain sensation as well as in cardiovascular and respiratory physiology, among others. Moreover, mutations in PIEZOs cause somatosensory, proprioceptive, and blood disorders. The goal here is to present the diverse physiology and pathophysiology of these unique channels, discuss ongoing research and critical gaps in the field, and explore the pharmaceutical interest in targeting PIEZOs for therapeutic development.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"383-402"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39163846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
The Role of the Medial Prefrontal Cortex in Moderating Neural Representations of Self and Other in Primates. 内侧前额叶皮层在调节灵长类动物自我和他者神经表征中的作用。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 Epub Date: 2021-03-22 DOI: 10.1146/annurev-neuro-101420-011820
Masaki Isoda
{"title":"The Role of the Medial Prefrontal Cortex in Moderating Neural Representations of Self and Other in Primates.","authors":"Masaki Isoda","doi":"10.1146/annurev-neuro-101420-011820","DOIUrl":"https://doi.org/10.1146/annurev-neuro-101420-011820","url":null,"abstract":"<p><p>As a frontal node in the primate social brain, the medial prefrontal cortex (MPFC) plays a critical role in coordinating one's own behavior with respect to that of others. Current literature demonstrates that single neurons in the MPFC encode behavior-related variables such as intentions, actions, and rewards, specifically for self and other, and that the MPFC comes into play when reflecting upon oneself and others. The social moderator account of MPFC function can explain maladaptive social cognition in people with autism spectrum disorder, which tips the balance in favor of self-centered perspectives rather than taking into consideration the perspective of others. Several strands of evidence suggest a hypothesis that the MPFC represents different other mental models, depending on the context at hand, to better predict others' emotions and behaviors. This hypothesis also accounts for aberrant MPFC activity in autistic individuals while they are mentalizing others.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"295-313"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25505396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
A Common Space Approach to Comparative Neuroscience. 比较神经科学的共同空间方法。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 Epub Date: 2021-02-03 DOI: 10.1146/annurev-neuro-100220-025942
Rogier B Mars, Saad Jbabdi, Matthew F S Rushworth
{"title":"A Common Space Approach to Comparative Neuroscience.","authors":"Rogier B Mars, Saad Jbabdi, Matthew F S Rushworth","doi":"10.1146/annurev-neuro-100220-025942","DOIUrl":"10.1146/annurev-neuro-100220-025942","url":null,"abstract":"<p><p>Comparative neuroscience is entering the era of big data. New high-throughput methods and data-sharing initiatives have resulted in the availability of large, digital data sets containing many types of data from ever more species. Here, we present a framework for exploiting the new possibilities offered. The multimodality of the data allows vertical translations, which are comparisons of different aspects of brain organization within a single species and across scales. Horizontal translations compare particular aspects of brain organization across species, often by building abstract feature spaces. Combining vertical and horizontal translations allows for more sophisticated comparisons, including relating principles of brain organization across species by contrasting horizontal translations, and for making formal predictions of unobtainable data based on observed results in a model species.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":"69-86"},"PeriodicalIF":12.1,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25327844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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