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Annual review of neuroscience最新文献

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Brainstem Circuits Controlling Action Diversification. 控制动作多样化的脑干回路。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 DOI: 10.1146/annurev-neuro-070918-050201
Ludwig Ruder, Silvia Arber
{"title":"Brainstem Circuits Controlling Action Diversification.","authors":"Ludwig Ruder,&nbsp;Silvia Arber","doi":"10.1146/annurev-neuro-070918-050201","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050201","url":null,"abstract":"<p><p>Neuronal circuits that regulate movement are distributed throughout the nervous system. The brainstem is an important interface between upper motor centers involved in action planning and circuits in the spinal cord ultimately leading to execution of body movements. Here we focus on recent work using genetic and viral entry points to reveal the identity of functionally dedicated and frequently spatially intermingled brainstem populations essential for action diversification, a general principle conserved throughout evolution. Brainstem circuits with distinct organization and function control skilled forelimb behavior, orofacial movements, and locomotion. They convey regulatory parameters to motor output structures and collaborate in the construction of complex natural motor behaviors. Functionally tuned brainstem neurons for different actions serve as important integrators of synaptic inputs from upstream centers, including the basal ganglia and cortex, to regulate and modulate behavioral function in different contexts.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"485-504"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37407600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
The Emerging Nature of Astrocyte Diversity. 星形胶质细胞多样性的新兴性质。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 DOI: 10.1146/annurev-neuro-070918-050443
Baljit S Khakh, Benjamin Deneen
{"title":"The Emerging Nature of Astrocyte Diversity.","authors":"Baljit S Khakh,&nbsp;Benjamin Deneen","doi":"10.1146/annurev-neuro-070918-050443","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050443","url":null,"abstract":"<p><p>Astrocytes are morphologically complex, ubiquitous cells that are viewed as a homogeneous population tiling the entire central nervous system (CNS). However, this view has been challenged in the last few years with the availability of RNA sequencing, immunohistochemistry, electron microscopy, morphological reconstruction, and imaging data. These studies suggest that astrocytes represent a diverse population of cells and that they display brain area- and disease-specific properties and functions. In this review, we summarize these observations, emphasize areas where clear conclusions can be made, and discuss potential unifying themes. We also identify knowledge gaps that need to be addressed in order to exploit astrocyte diversity as a biological phenomenon of physiological relevance in the CNS. We thus provide a summary and a perspective on astrocyte diversity in the vertebrate CNS.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"187-207"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37407602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 276
What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation. 什么，如果和何时运动:基底神经节回路和自定节奏动作启动。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-04-24 DOI: 10.1146/annurev-neuro-072116-031033
Andreas Klaus, Joaquim Alves da Silva, Rui M Costa
{"title":"What, If, and When to Move: Basal Ganglia Circuits and Self-Paced Action Initiation.","authors":"Andreas Klaus,&nbsp;Joaquim Alves da Silva,&nbsp;Rui M Costa","doi":"10.1146/annurev-neuro-072116-031033","DOIUrl":"https://doi.org/10.1146/annurev-neuro-072116-031033","url":null,"abstract":"<p><p>Deciding what to do and when to move is vital to our survival. Clinical and fundamental studies have identified basal ganglia circuits as critical for this process. The main input nucleus of the basal ganglia, the striatum, receives inputs from frontal, sensory, and motor cortices and interconnected thalamic areas that provide information about potential goals, context, and actions and directly or indirectly modulates basal ganglia outputs. The striatum also receives dopaminergic inputs that can signal reward prediction errors and also behavioral transitions and movement initiation. Here we review studies and models of how direct and indirect pathways can modulate basal ganglia outputs to facilitate movement initiation, and we discuss the role of cortical and dopaminergic inputs to the striatum in determining what to do and if and when to do it. Complex but exciting scenarios emerge that shed new light on how basal ganglia circuits modulate self-paced movement initiation.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"459-483"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-072116-031033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 157
Early Binaural Hearing: The Comparison of Temporal Differences at the Two Ears. 早期双耳听力:双耳时间差异的比较。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-04-24 DOI: 10.1146/annurev-neuro-080317-061925
Philip X Joris, Marcel van der Heijden
{"title":"Early Binaural Hearing: The Comparison of Temporal Differences at the Two Ears.","authors":"Philip X Joris,&nbsp;Marcel van der Heijden","doi":"10.1146/annurev-neuro-080317-061925","DOIUrl":"https://doi.org/10.1146/annurev-neuro-080317-061925","url":null,"abstract":"<p><p>Many mammals, including humans, are exquisitely sensitive to tiny time differences between sounds at the two ears. These interaural time differences are an important source of information for sound detection, for sound localization in space, and for environmental awareness. Two brainstem circuits are involved in the initial temporal comparisons between the ears, centered on the medial and lateral superior olive. Cells in these nuclei, as well as their afferents, display a large number of striking physiological and anatomical specializations to enable submillisecond sensitivity. As such, they provide an important model system to study temporal processing in the central nervous system. We review the progress that has been made in characterizing these primary binaural circuits as well as the variety of mechanisms that have been proposed to underlie their function.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"433-457"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-080317-061925","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37180824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Peeling the Onion of Brain Representations. 剥开大脑表征的洋葱。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 DOI: 10.1146/annurev-neuro-080317-061906
Nikolaus Kriegeskorte, Jörn Diedrichsen
{"title":"Peeling the Onion of Brain Representations.","authors":"Nikolaus Kriegeskorte,&nbsp;Jörn Diedrichsen","doi":"10.1146/annurev-neuro-080317-061906","DOIUrl":"https://doi.org/10.1146/annurev-neuro-080317-061906","url":null,"abstract":"<p><p>The brain's function is to enable adaptive behavior in the world. To this end, the brain processes information about the world. The concept of representation links the information processed by the brain back to the world and enables us to understand what the brain does at a functional level. The appeal of making the connection between brain activity and what it represents has been irresistible to neuroscience, despite the fact that representational interpretations pose several challenges: We must define which aspects of brain activity matter, how the code works, and how it supports computations that contribute to adaptive behavior. It has been suggested that we might drop representational language altogether and seek to understand the brain, more simply, as a dynamical system. In this review, we argue that the concept of representation provides a useful link between dynamics and computational function and ask which aspects of brain activity should be analyzed to achieve a representational understanding. We peel the onion of brain representations in search of the layers (the aspects of brain activity) that matter to computation. The article provides an introduction to the motivation and mathematics of representational models, a critical discussion of their assumptions and limitations, and a preview of future directions in this area.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"407-432"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-080317-061906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37407598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 84
Neuronal Development of Hearing and Language: Cochlear Implants and Critical Periods. 听力和语言的神经元发育:人工耳蜗和关键期。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-01-30 DOI: 10.1146/annurev-neuro-080317-061513
Andrej Kral, Michael F Dorman, Blake S Wilson
{"title":"Neuronal Development of Hearing and Language: Cochlear Implants and Critical Periods.","authors":"Andrej Kral,&nbsp;Michael F Dorman,&nbsp;Blake S Wilson","doi":"10.1146/annurev-neuro-080317-061513","DOIUrl":"https://doi.org/10.1146/annurev-neuro-080317-061513","url":null,"abstract":"<p><p>The modern cochlear implant (CI) is the most successful neural prosthesis developed to date. CIs provide hearing to the profoundly hearing impaired and allow the acquisition of spoken language in children born deaf. Results from studies enabled by the CI have provided new insights into (<i>a</i>) minimal representations at the periphery for speech reception, (<i>b</i>) brain mechanisms for decoding speech presented in quiet and in acoustically adverse conditions, (<i>c</i>) the developmental neuroscience of language and hearing, and (<i>d</i>) the mechanisms and time courses of intramodal and cross-modal plasticity. Additionally, the results have underscored the interconnectedness of brain functions and the importance of top-down processes in perception and learning. The findings are described in this review with emphasis on the developing brain and the acquisition of hearing and spoken language.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"47-65"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-080317-061513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36912309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 93
Probing Computation in the Primate Visual System at Single-Cone Resolution. 灵长类视觉系统在单锥分辨率下的探测计算。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-03-11 DOI: 10.1146/annurev-neuro-070918-050233
A Kling, G D Field, D H Brainard, E J Chichilnisky
{"title":"Probing Computation in the Primate Visual System at Single-Cone Resolution.","authors":"A Kling,&nbsp;G D Field,&nbsp;D H Brainard,&nbsp;E J Chichilnisky","doi":"10.1146/annurev-neuro-070918-050233","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050233","url":null,"abstract":"<p><p>Daylight vision begins when light activates cone photoreceptors in the retina, creating spatial patterns of neural activity. These cone signals are then combined and processed in downstream neural circuits, ultimately producing visual perception. Recent technical advances have made it possible to deliver visual stimuli to the retina that probe this processing by the visual system at its elementary resolution of individual cones. Physiological recordings from nonhuman primate retinas reveal the spatial organization of cone signals in retinal ganglion cells, including how signals from cones of different types are combined to support both spatial and color vision. Psychophysical experiments with human subjects characterize the visual sensations evoked by stimulating a single cone, including the perception of color. Future combined physiological and psychophysical experiments focusing on probing the elementary visual inputs are likely to clarify how neural processing generates our perception of the visual world.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"169-186"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050233","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37043213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System. 寨卡病毒感染神经系统的病理生理学和机制。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 DOI: 10.1146/annurev-neuro-080317-062231
Kimberly M Christian, Hongjun Song, Guo-Li Ming
{"title":"Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System.","authors":"Kimberly M Christian, Hongjun Song, Guo-Li Ming","doi":"10.1146/annurev-neuro-080317-062231","DOIUrl":"10.1146/annurev-neuro-080317-062231","url":null,"abstract":"<p><p>In 2015, public awareness of Zika virus (ZIKV) rose in response to alarming statistics of infants with microcephaly being born to women who were infected with the virus during pregnancy, triggering global concern over these potentially devastating consequences. Although we have discovered a great deal about the genome and pathogenesis of this reemergent flavivirus since this recent outbreak, we still have much more to learn, including the nature of the virus-host interactions and mechanisms that determine its tropism and pathogenicity in the nervous system, which are in turn shaped by the continual evolution of the virus. Inevitably, we will find out more about the potential long-term effects of ZIKV exposure on the nervous system from ongoing longitudinal studies. Integrating clinical and epidemiological data with a wider range of animal and human cell culture models will be critical to understanding the pathogenetic mechanisms and developing more specific antiviral compounds and vaccines.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"249-269"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7523638/pdf/nihms-1553016.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37407605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons. 下丘脑神经元分子、网络和内分泌特征的统一分类。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 Epub Date: 2019-02-08 DOI: 10.1146/annurev-neuro-070918-050414
Roman A Romanov, Alán Alpár, Tomas Hökfelt, Tibor Harkany
{"title":"Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons.","authors":"Roman A Romanov,&nbsp;Alán Alpár,&nbsp;Tomas Hökfelt,&nbsp;Tibor Harkany","doi":"10.1146/annurev-neuro-070918-050414","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050414","url":null,"abstract":"<p><p>Peripheral endocrine output relies on either direct or feed-forward multi-order command from the hypothalamus. Efficient coding of endocrine responses is made possible by the many neuronal cell types that coexist in intercalated hypothalamic nuclei and communicate through extensive synaptic connectivity. Although general anatomical and neurochemical features of hypothalamic neurons were described during the past decades, they have yet to be reconciled with recently discovered molecular classifiers and neurogenetic function determination. By interrogating magnocellular as well as parvocellular dopamine, GABA, glutamate, and phenotypically mixed neurons, we integrate available information at the molecular, cellular, network, and endocrine output levels to propose a framework for the comprehensive classification of hypothalamic neurons. Simultaneously, we single out putative neuronal subclasses for which future research can fill in existing gaps of knowledge to rationalize cellular diversity through function-determinant molecular marks in the hypothalamus.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"1-26"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050414","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36941526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Light-Sheet Microscopy in Neuroscience. 神经科学中的光片显微镜。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 DOI: 10.1146/annurev-neuro-070918-050357
Elizabeth M C Hillman, Venkatakaushik Voleti, Wenze Li, Hang Yu
{"title":"Light-Sheet Microscopy in Neuroscience.","authors":"Elizabeth M C Hillman, Venkatakaushik Voleti, Wenze Li, Hang Yu","doi":"10.1146/annurev-neuro-070918-050357","DOIUrl":"10.1146/annurev-neuro-070918-050357","url":null,"abstract":"<p><p>Light-sheet microscopy is an imaging approach that offers unique advantages for a diverse range of neuroscience applications. Unlike point-scanning techniques such as confocal and two-photon microscopy, light-sheet microscopes illuminate an entire plane of tissue, while imaging this plane onto a camera. Although early implementations of light sheet were optimized for longitudinal imaging of embryonic development in small specimens, emerging implementations are capable of capturing light-sheet images in freely moving, unconstrained specimens and even the intact in vivo mammalian brain. Meanwhile, the unique photobleaching and signal-to-noise benefits afforded by light-sheet microscopy's parallelized detection deliver the ability to perform volumetric imaging at much higher speeds than can be achieved using point scanning. This review describes the basic principles and evolution of light-sheet microscopy, followed by perspectives on emerging applications and opportunities for both imaging large, cleared, and expanded neural tissues and high-speed, functional imaging in vivo.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"295-313"},"PeriodicalIF":12.1,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800245/pdf/nihms-1052828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37407599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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