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Annual review of neuroscience最新文献

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Neural Mechanisms of Itch. 瘙痒的神经机制。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-02-19 DOI: 10.1146/annurev-neuro-083019-024537
Mark Lay, Xinzhong Dong
{"title":"Neural Mechanisms of Itch.","authors":"Mark Lay,&nbsp;Xinzhong Dong","doi":"10.1146/annurev-neuro-083019-024537","DOIUrl":"https://doi.org/10.1146/annurev-neuro-083019-024537","url":null,"abstract":"<p><p>Itch is a unique sensation that helps organisms scratch away external threats; scratching itself induces an immune response that can contribute to more itchiness. Itch is induced chemically in the peripheral nervous system via a wide array of receptors. Given the superficial localization of itch neuron terminals, cells that dwell close to the skin contribute significantly to itch. Certain mechanical stimuli mediated by recently discovered circuits also contribute to the itch sensation. Ultimately, in the spinal cord, and likely in the brain, circuits that mediate touch, pain, and itch engage in cross modulation. Much of itch perception is still a mystery, but we present in this review the known ligands and receptors associated with itch. We also describe experiments and findings from investigations into the spinal and supraspinal circuitry responsible for the sensation of itch.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"187-205"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-083019-024537","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37659064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
Reward Contributions to Serotonergic Functions. 奖励对血清素功能的贡献。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 DOI: 10.1146/annurev-neuro-093019-112252
Zhixiang Liu, Rui Lin, Minmin Luo
{"title":"Reward Contributions to Serotonergic Functions.","authors":"Zhixiang Liu,&nbsp;Rui Lin,&nbsp;Minmin Luo","doi":"10.1146/annurev-neuro-093019-112252","DOIUrl":"https://doi.org/10.1146/annurev-neuro-093019-112252","url":null,"abstract":"<p><p>The brain serotonin systems participate in numerous aspects of reward processing, although it remains elusive how exactly serotonin signals regulate neural computation and reward-related behavior. The application of optogenetics and imaging techniques during the last decade has provided many insights. Here, we review recent progress on the organization and physiology of the dorsal raphe serotonin neurons and the relationships between their activity and behavioral functions in the context of reward processing. We also discuss several interesting theories on serotonin's function and how these theories may be reconciled by the possibility that serotonin, acting in synergy with coreleased glutamate, tracks and calculates the so-called beneficialness of the current state to guide an animal's behavior in dynamic environments.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"141-162"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-093019-112252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Toward Community-Driven Big Open Brain Science: Open Big Data and Tools for Structure, Function, and Genetics. 面向社区驱动的大开放脑科学:结构、功能和遗传学的开放大数据和工具。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-04-13 DOI: 10.1146/annurev-neuro-100119-110036
Adam S Charles, Benjamin Falk, Nicholas Turner, Talmo D Pereira, Daniel Tward, Benjamin D Pedigo, Jaewon Chung, Randal Burns, Satrajit S Ghosh, Justus M Kebschull, William Silversmith, Joshua T Vogelstein
{"title":"Toward Community-Driven Big Open Brain Science: Open Big Data and Tools for Structure, Function, and Genetics.","authors":"Adam S Charles,&nbsp;Benjamin Falk,&nbsp;Nicholas Turner,&nbsp;Talmo D Pereira,&nbsp;Daniel Tward,&nbsp;Benjamin D Pedigo,&nbsp;Jaewon Chung,&nbsp;Randal Burns,&nbsp;Satrajit S Ghosh,&nbsp;Justus M Kebschull,&nbsp;William Silversmith,&nbsp;Joshua T Vogelstein","doi":"10.1146/annurev-neuro-100119-110036","DOIUrl":"https://doi.org/10.1146/annurev-neuro-100119-110036","url":null,"abstract":"<p><p>As acquiring bigger data becomes easier in experimental brain science, computational and statistical brain science must achieve similar advances to fully capitalize on these data. Tackling these problems will benefit from a more explicit and concerted effort to work together. Specifically, brain science can be further democratized by harnessing the power of community-driven tools, which both are built by and benefit from many different people with different backgrounds and expertise. This perspective can be applied across modalities and scales and enables collaborations across previously siloed communities.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"441-464"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-100119-110036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37829621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
The Glial Perspective on Sleep and Circadian Rhythms. 从神经胶质角度看睡眠和昼夜节律。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-02-19 DOI: 10.1146/annurev-neuro-091819-094557
Gregory Artiushin, Amita Sehgal
{"title":"The Glial Perspective on Sleep and Circadian Rhythms.","authors":"Gregory Artiushin, Amita Sehgal","doi":"10.1146/annurev-neuro-091819-094557","DOIUrl":"10.1146/annurev-neuro-091819-094557","url":null,"abstract":"<p><p>While neurons and circuits are almost unequivocally considered to be the computational units and actuators of behavior, a complete understanding of the nervous system must incorporate glial cells. Far beyond a copious but passive substrate, glial influence is inextricable from neuronal physiology, whether during developmental guidance and synaptic shaping or through the trophic support, neurotransmitter and ion homeostasis, cytokine signaling and immune function, and debris engulfment contributions that this class provides throughout an organism's life. With such essential functions, among a growing literature of nuanced roles, it follows that glia are consequential to behavior in adult animals, with novel genetic tools allowing for the investigation of these phenomena in living organisms. We discuss here the relevance of glia for maintaining circadian rhythms and also for serving functions of sleep.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"119-140"},"PeriodicalIF":12.1,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10826096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37658967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suckling, Feeding, and Swallowing: Behaviors, Circuits, and Targets for Neurodevelopmental Pathology. 哺乳、喂养和吞咽:神经发育病理学的行为、回路和目标。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-02-26 DOI: 10.1146/annurev-neuro-100419-100636
Thomas M Maynard, Irene E Zohn, Sally A Moody, Anthony-S LaMantia
{"title":"Suckling, Feeding, and Swallowing: Behaviors, Circuits, and Targets for Neurodevelopmental Pathology.","authors":"Thomas M Maynard,&nbsp;Irene E Zohn,&nbsp;Sally A Moody,&nbsp;Anthony-S LaMantia","doi":"10.1146/annurev-neuro-100419-100636","DOIUrl":"https://doi.org/10.1146/annurev-neuro-100419-100636","url":null,"abstract":"<p><p>All mammals must suckle and swallow at birth, and subsequently chew and swallow solid foods, for optimal growth and health. These initially innate behaviors depend critically upon coordinated development of the mouth, tongue, pharynx, and larynx as well as the cranial nerves that control these structures. Disrupted suckling, feeding, and swallowing from birth onward-perinatal dysphagia-is often associated with several neurodevelopmental disorders that subsequently alter complex behaviors. Apparently, a broad range of neurodevelopmental pathologic mechanisms also target oropharyngeal and cranial nerve differentiation. These aberrant mechanisms, including altered patterning, progenitor specification, and neurite growth, prefigure dysphagia and may then compromise circuits for additional behavioral capacities. Thus, perinatal dysphagia may be an early indicator of disrupted genetic and developmental programs that compromise neural circuits and yield a broad range of behavioral deficits in neurodevelopmental disorders.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"315-336"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-100419-100636","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37680187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
The Genetic Control of Stoichiometry Underlying Autism. 自闭症背后的化学计量学基因控制。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 DOI: 10.1146/annurev-neuro-100119-024851
Robert B Darnell
{"title":"The Genetic Control of Stoichiometry Underlying Autism.","authors":"Robert B Darnell","doi":"10.1146/annurev-neuro-100119-024851","DOIUrl":"https://doi.org/10.1146/annurev-neuro-100119-024851","url":null,"abstract":"<p><p>Autism is a common and complex neurologic disorder whose scientific underpinnings have begun to be established in the past decade. The essence of this breakthrough has been a focus on families, where genetic analyses are strongest, versus large-scale, case-control studies. Autism genetics has progressed in parallel with technology, from analyses of copy number variation to whole-exome sequencing (WES) and whole-genome sequencing (WGS). Gene mutations causing complete loss of function account for perhaps one-third of cases, largely detected through WES. This limitation has increased interest in understanding the regulatory variants of genes that contribute in more subtle ways to the disorder. Strategies combining biochemical analysis of gene regulation, WGS analysis of the noncoding genome, and machine learning have begun to succeed. The emerging picture is that careful control of the amounts of transcription, mRNA, and proteins made by key brain genes-stoichiometry-plays a critical role in defining the clinical features of autism.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"509-533"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-100119-024851","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Finding the Brain in the Nose. 在鼻子里发现大脑。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 DOI: 10.1146/annurev-neuro-102119-103452
David H Brann, Sandeep Robert Datta
{"title":"Finding the Brain in the Nose.","authors":"David H Brann,&nbsp;Sandeep Robert Datta","doi":"10.1146/annurev-neuro-102119-103452","DOIUrl":"https://doi.org/10.1146/annurev-neuro-102119-103452","url":null,"abstract":"<p><p>Olfaction is fundamentally distinct from other sensory modalities. Natural odor stimuli are complex mixtures of volatile chemicals that interact in the nose with a receptor array that, in rodents, is built from more than 1,000 unique receptors. These interactions dictate a peripheral olfactory code, which in the brain is transformed and reformatted as it is broadcast across a set of highly interconnected olfactory regions. Here we discuss the problems of characterizing peripheral population codes for olfactory stimuli, of inferring the specific functions of different higher olfactory areas given their extensive recurrence, and of ultimately understanding how odor representations are linked to perception and action. We argue that, despite the differences between olfaction and other sensory modalities, addressing these specific questions will reveal general principles underlying brain function.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"277-295"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-102119-103452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
CA2: A Highly Connected Intrahippocampal Relay. CA2:一个高度连接的海马内中继。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2019-12-24 DOI: 10.1146/annurev-neuro-080719-100343
Steven J Middleton, Thomas J McHugh
{"title":"CA2: A Highly Connected Intrahippocampal Relay.","authors":"Steven J Middleton,&nbsp;Thomas J McHugh","doi":"10.1146/annurev-neuro-080719-100343","DOIUrl":"https://doi.org/10.1146/annurev-neuro-080719-100343","url":null,"abstract":"<p><p>Although Lorente de No' recognized the anatomical distinction of the hippocampal Cornu Ammonis (CA) 2 region, it had, until recently, been assigned no unique function. Its location between the key players of the circuit, CA3 and CA1, which along with the entorhinal cortex and dentate gyrus compose the classic trisynaptic circuit, further distracted research interest. However, the connectivity of CA2 pyramidal cells, together with unique patterns of gene expression, hints at a much larger contribution to hippocampal information processing than has been ascribed. Here we review recent advances that have identified new roles for CA2 in hippocampal centric processing, together with specialized functions in social memory and, potentially, as a broadcaster of novelty. These new data, together with CA2's role in disease, justify a closer look at how this small region exerts its influence and how it might best be exploited to understand and treat disease-related circuit dysfunctions.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"55-72"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-080719-100343","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37488101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Multiscale Patterning from Competing Interactions and Length Scales. 来自竞争相互作用和长度尺度的多尺度模式。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-04-17 DOI: 10.1146/annurev-matsci-081519-050045
Alan Bishop
{"title":"Multiscale Patterning from Competing Interactions and Length Scales.","authors":"Alan Bishop","doi":"10.1146/annurev-matsci-081519-050045","DOIUrl":"https://doi.org/10.1146/annurev-matsci-081519-050045","url":null,"abstract":"We live in a research era marked by impressive new tools powering the scientific method to accelerate the discovery, prediction, and control of increasingly complex systems. In common with many disciplines and societal challenges and opportunities, materials and condensed matter sciences are beneficiaries. The volume and fidelity of experimental, computational, and visualization data available, and tools to rapidly interpret them, are remarkable. Conceptual frameworks, including multiscale, multiphysics modeling of this complexity, are fueled by the data and, in turn, guide directions for future experimental and computational strategies. In this spirit, I discuss the importance of competing interactions, length scales, and constraints as pervasive sources of spatiotemporal complexity. I use representative examples drawn from materials and condensed matter, including the important role of elasticity in some technologically important quantum materials. Expected final online publication date for the Annual Review of Materials Research, Volume 50 is July 1, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"1 1","pages":""},"PeriodicalIF":13.9,"publicationDate":"2020-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-matsci-081519-050045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42432754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neuron-Glia Signaling in Synapse Elimination. 突触消除中的神经元-胶质信号传导。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2019-07-08 DOI: 10.1146/annurev-neuro-070918-050306
Daniel K Wilton, Lasse Dissing-Olesen, Beth Stevens
{"title":"Neuron-Glia Signaling in Synapse Elimination.","authors":"Daniel K Wilton,&nbsp;Lasse Dissing-Olesen,&nbsp;Beth Stevens","doi":"10.1146/annurev-neuro-070918-050306","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050306","url":null,"abstract":"<p><p>Maturation of neuronal circuits requires selective elimination of synaptic connections. Although neuron-intrinsic mechanisms are important in this process, it is increasingly recognized that glial cells also play a critical role. Without proper functioning of these cells, the number, morphology, and function of synaptic contacts are profoundly altered, resulting in abnormal connectivity and behavioral abnormalities. In addition to their role in synaptic refinement, glial cells have also been implicated in pathological synapse loss and dysfunction following injury or nervous system degeneration in adults. Although mechanisms regulating glia-mediated synaptic elimination are still being uncovered, it is clear this complex process involves many cues that promote and inhibit the removal of specific synaptic connections. Gaining a greater understanding of these signals and the contribution of different cell types will not only provide insight into this critical biological event but also be instrumental in advancing knowledge of brain development and neural disease.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"42 ","pages":"107-127"},"PeriodicalIF":13.9,"publicationDate":"2019-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37407603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 192
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