Beyond Wrapping: Canonical and Noncanonical Functions of Schwann Cells.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Carla Taveggia, M Laura Feltri
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引用次数: 7

Abstract

Schwann cells in the peripheral nervous system (PNS) are essential for the support and myelination of axons, ensuring fast and accurate communication between the central nervous system and the periphery. Schwann cells and related glia accompany innervating axons in virtually all tissues in the body, where they exhibit remarkable plasticity and the ability to modulate pathology in extraordinary, and sometimes surprising, ways. Here, we provide a brief overview of the various glial cell types in the PNS and describe the cornerstone cellular and molecular processes that enable Schwann cells to perform their canonical functions. We then dive into discussing exciting noncanonical functions of Schwann cells and related PNS glia, which include their role in organizing the PNS, in regulating synaptic activity and pain, in modulating immunity, in providing a pool of stem cells for different organs, and, finally, in influencing cancer.

Abstract Image

Abstract Image

超越包装:雪旺细胞的规范和非规范功能。
外周神经系统(PNS)中的雪旺细胞对轴突的支持和髓鞘形成至关重要,确保了中枢神经系统和外周神经系统之间快速准确的通信。许旺细胞和相关胶质细胞伴随神经支配轴突存在于几乎所有的身体组织中,在这些组织中,它们表现出非凡的可塑性和以非凡的、有时令人惊讶的方式调节病理的能力。在这里,我们简要概述了PNS中各种胶质细胞类型,并描述了使雪旺细胞发挥其规范功能的基础细胞和分子过程。然后,我们深入讨论了雪旺细胞和相关PNS胶质的令人兴奋的非规范功能,包括它们在组织PNS,调节突触活动和疼痛,调节免疫,为不同器官提供干细胞库以及最终影响癌症方面的作用。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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