Annual review of neuroscience最新文献_第7页

Challenges of Organoid Research. 类器官研究的挑战。

IF 12.1 1区医学

Annual review of neuroscience Pub Date : 2022-07-08 Epub Date: 2022-01-05 DOI: 10.1146/annurev-neuro-111020-090812

Madeline G Andrews, Arnold R Kriegstein

引用次数: 0

Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It? 中囊多巴胺异质性：多巴胺的发射与释放有何关系？

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-07-08 Epub Date: 2022-02-28 DOI: 10.1146/annurev-neuro-110920-011929

Johannes W de Jong, Kurt M Fraser, Stephan Lammel

引用次数: 0

Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development. 清除你的头脑:神经发育过程中细胞死亡后碎片清除机制。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-07-08 DOI: 10.1146/annurev-neuro-110920-022431

Kendra E Liu, Michael H Raymond, Kodi S Ravichandran, Sarah Kucenas

{"title":"Clearing Your Mind: Mechanisms of Debris Clearance After Cell Death During Neural Development.","authors":"Kendra E Liu, Michael H Raymond, Kodi S Ravichandran, Sarah Kucenas","doi":"10.1146/annurev-neuro-110920-022431","DOIUrl":"https://doi.org/10.1146/annurev-neuro-110920-022431","url":null,"abstract":"Neurodevelopment and efferocytosis have fascinated scientists for decades. How an organism builds a nervous system that is precisely tuned for efficient behaviors and survival and how it simultaneously manages constant somatic cell turnover are complex questions that have resulted in distinct fields of study. Although neurodevelopment requires the overproduction of cells that are subsequently pruned back, very few studies marry these fields to elucidate the cellular and molecular mechanisms that drive nervous system development through the lens of cell clearance. In this review, we discuss these fields to highlight exciting areas of future synergy. We first review neurodevelopment from the perspective of overproduction and subsequent refinement and then discuss who clears this developmental debris and the mechanisms that control these events. We then end with how a more deliberate merger ofneurodevelopment and efferocytosis could reframe our understanding of homeostasis and disease and discuss areas of future study.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"45 ","pages":"177-198"},"PeriodicalIF":13.9,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10157384/pdf/nihms-1892295.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9764128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Microglia and Neurodevelopmental Disorders. 小胶质细胞和神经发育障碍。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-07-08 DOI: 10.1146/annurev-neuro-110920-023056

John R Lukens, Ukpong B Eyo

引用次数: 33

Synaptic Mechanisms Regulating Mood State Transitions in Depression. 调节抑郁情绪状态转换的突触机制。

IF 12.1 1区医学

Annual review of neuroscience Pub Date : 2022-07-08 Epub Date: 2022-05-04 DOI: 10.1146/annurev-neuro-110920-040422

Puja K Parekh, Shane B Johnson, Conor Liston

{"title":"Synaptic Mechanisms Regulating Mood State Transitions in Depression.","authors":"Puja K Parekh, Shane B Johnson, Conor Liston","doi":"10.1146/annurev-neuro-110920-040422","DOIUrl":"10.1146/annurev-neuro-110920-040422","url":null,"abstract":"Depression is an episodic form of mental illness characterized by mood state transitions with poorly understood neurobiological mechanisms. Antidepressants reverse the effects of stress and depression on synapse function, enhancing neurotransmission, increasing plasticity, and generating new synapses in stress-sensitive brain regions. These properties are shared to varying degrees by all known antidepressants, suggesting that synaptic remodeling could play a key role in depression pathophysiology and antidepressant function. Still, it is unclear whether and precisely how synaptogenesis contributes to mood state transitions. Here, we review evidence supporting an emerging model in which depression is defined by a distinct brain state distributed across multiple stress-sensitive circuits, with neurons assuming altered functional properties, synapse configurations, and, importantly, a reduced capacity for plasticity and adaptation. Antidepressants act initially by facilitating plasticity and enabling a functional reconfiguration of this brain state. Subsequently, synaptogenesis plays a specific role in sustaining these changes over time.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"1 1","pages":"581-601"},"PeriodicalIF":12.1,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11577286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43171529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adeno-Associated Virus Toolkit to Target Diverse Brain Cells. 针对不同脑细胞的腺相关病毒工具包。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-04-19 DOI: 10.1146/annurev-neuro-111020-100834

Rosemary C. Challis, Sripriya Ravindra Kumar, Xinhong Chen, David Goertsen, G. M. Coughlin, A. Hori, Miguel R. Chuapoco, T. Otis, T. F. Miles, V. Gradinaru

{"title":"Adeno-Associated Virus Toolkit to Target Diverse Brain Cells.","authors":"Rosemary C. Challis, Sripriya Ravindra Kumar, Xinhong Chen, David Goertsen, G. M. Coughlin, A. Hori, Miguel R. Chuapoco, T. Otis, T. F. Miles, V. Gradinaru","doi":"10.1146/annurev-neuro-111020-100834","DOIUrl":"https://doi.org/10.1146/annurev-neuro-111020-100834","url":null,"abstract":"Recombinant adeno-associated viruses (AAVs) are commonly used gene delivery vehicles for neuroscience research. They have two engineerable features: the capsid (outer protein shell) and cargo (encapsulated genome). These features can be modified to enhance cell type or tissue tropism and control transgene expression, respectively. Several engineered AAV capsids with unique tropisms have been identified, including variants with enhanced central nervous system transduction, cell type specificity, and retrograde transport in neurons. Pairing these AAVs with modern gene regulatory elements and state-of-the-art reporter, sensor, and effector cargo enables highly specific transgene expression for anatomical and functional analyses of brain cells and circuits. Here, we discuss recent advances that provide a comprehensive (capsid and cargo) AAV toolkit for genetic access to molecularly defined brain cell types. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48597804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Considering Organismal Physiology in Laboratory Studies of Rodent Behavior. 在啮齿动物行为的实验室研究中考虑生物生理学。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-04-08 DOI: 10.1146/annurev-neuro-111020-085500

Patricia Rubio Arzola, R. Shansky

引用次数: 1

Subcortical Cognition: The Fruit Below the Rind. 皮层下认知：Rind下的果实。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-04-06 DOI: 10.1146/annurev-neuro-110920-013544

K. Janacsek, Tanya M. Evans, Mariann M. Kiss, Leela Shah, H. Blumenfeld, M. Ullman

{"title":"Subcortical Cognition: The Fruit Below the Rind.","authors":"K. Janacsek, Tanya M. Evans, Mariann M. Kiss, Leela Shah, H. Blumenfeld, M. Ullman","doi":"10.1146/annurev-neuro-110920-013544","DOIUrl":"https://doi.org/10.1146/annurev-neuro-110920-013544","url":null,"abstract":"Cognitive neuroscience has highlighted the cerebral cortex while often overlooking subcortical structures. This cortical proclivity is found in basic and translational research on many aspects of cognition, especially higher cognitive domains such as language, reading, music, and math. We suggest that, for both anatomical and evolutionary reasons, multiple subcortical structures play substantial roles across higher and lower cognition. We present a comprehensive review of existing evidence, which indeed reveals extensive subcortical contributions in multiple cognitive domains. We argue that the findings are overall both real and important. Next, we advance a theoretical framework to capture the nature of (sub)cortical contributions to cognition. Finally, we propose how new subcortical cognitive roles can be identified by leveraging anatomical and evolutionary principles, and we describe specific methods that can be used to reveal subcortical cognition. Altogether, this review aims to advance cognitive neuroscience by highlighting subcortical cognition and facilitating its future investigation. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43715681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Neuromodulation and Neurophysiology on the Timescale of Learning and Decision-Making. 学习和决策时间尺度上的神经调节和神经生理学。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-04-01 DOI: 10.1146/annurev-neuro-092021-125059

Cooper D. Grossman, Jeremiah Y. Cohen

引用次数: 8

Neuroimmune Interactions in Peripheral Organs. 外周器官的神经免疫相互作用。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2022-04-01 DOI: 10.1146/annurev-neuro-111020-105359

Roel G J Klein Wolterink, Glendon S. Wu, I. Chiu, H. Veiga-Fernandes

{"title":"Neuroimmune Interactions in Peripheral Organs.","authors":"Roel G J Klein Wolterink, Glendon S. Wu, I. Chiu, H. Veiga-Fernandes","doi":"10.1146/annurev-neuro-111020-105359","DOIUrl":"https://doi.org/10.1146/annurev-neuro-111020-105359","url":null,"abstract":"Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled the identification of the molecular mediators and receptors that enable the interaction between these two complex systems and provide new insights on the role of neuroimmune crosstalk in organismal physiology. Most neuroimmune interaction occurs at discrete anatomical locations in which neurons and immune cells colocalize. Here, we describe the interactions of the different branches of the peripheral nervous system with immune cells in various organs, including the skin, intestine, lung, and adipose tissue. We highlight how neuroimmune crosstalk orchestrates physiological processes such as host defense, tissue repair, metabolism, and thermogenesis. Unraveling these intricate relationships is invaluable to explore the therapeutic potential of neuroimmune interaction. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45858570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24