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Annual review of neuroscience最新文献

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Neuromodulation and Neurophysiology on the Timescale of Learning and Decision-Making. 学习和决策时间尺度上的神经调节和神经生理学。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2022-04-01 DOI: 10.1146/annurev-neuro-092021-125059
Cooper D. Grossman, Jeremiah Y. Cohen
{"title":"Neuromodulation and Neurophysiology on the Timescale of Learning and Decision-Making.","authors":"Cooper D. Grossman, Jeremiah Y. Cohen","doi":"10.1146/annurev-neuro-092021-125059","DOIUrl":"https://doi.org/10.1146/annurev-neuro-092021-125059","url":null,"abstract":"Nervous systems evolved to effectively navigate the dynamics of the environment to achieve their goals. One framework used to study this fundamental problem arose in the study of learning and decision-making. In this framework, the demands of effective behavior require slow dynamics-on the scale of seconds to minutes-of networks of neurons. Here, we review the phenomena and mechanisms involved. Using vignettes from a few species and areas of the nervous system, we view neuromodulators as key substrates for temporal scaling of neuronal dynamics. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48220260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Neuroimmune Interactions in Peripheral Organs. 外周器官的神经免疫相互作用。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2022-04-01 DOI: 10.1146/annurev-neuro-111020-105359
Roel G J Klein Wolterink, Glendon S. Wu, I. Chiu, H. Veiga-Fernandes
{"title":"Neuroimmune Interactions in Peripheral Organs.","authors":"Roel G J Klein Wolterink, Glendon S. Wu, I. Chiu, H. Veiga-Fernandes","doi":"10.1146/annurev-neuro-111020-105359","DOIUrl":"https://doi.org/10.1146/annurev-neuro-111020-105359","url":null,"abstract":"Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled the identification of the molecular mediators and receptors that enable the interaction between these two complex systems and provide new insights on the role of neuroimmune crosstalk in organismal physiology. Most neuroimmune interaction occurs at discrete anatomical locations in which neurons and immune cells colocalize. Here, we describe the interactions of the different branches of the peripheral nervous system with immune cells in various organs, including the skin, intestine, lung, and adipose tissue. We highlight how neuroimmune crosstalk orchestrates physiological processes such as host defense, tissue repair, metabolism, and thermogenesis. Unraveling these intricate relationships is invaluable to explore the therapeutic potential of neuroimmune interaction. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45858570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Melding Synthetic Molecules and Genetically Encoded Proteins to Forge New Tools for Neuroscience. 融合合成分子和基因编码蛋白质，打造神经科学新工具。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2022-02-28 DOI: 10.1146/annurev-neuro-110520-030031
Pratik Kumar, L. Lavis
{"title":"Melding Synthetic Molecules and Genetically Encoded Proteins to Forge New Tools for Neuroscience.","authors":"Pratik Kumar, L. Lavis","doi":"10.1146/annurev-neuro-110520-030031","DOIUrl":"https://doi.org/10.1146/annurev-neuro-110520-030031","url":null,"abstract":"Unraveling the complexity of the brain requires sophisticated methods to probe and perturb neurobiological processes with high spatiotemporal control. The field of chemical biology has produced general strategies to combine the molecular specificity of small-molecule tools with the cellular specificity of genetically encoded reagents. Here, we survey the application, refinement, and extension of these hybrid small-molecule:protein methods to problems in neuroscience, which yields powerful reagents to precisely measure and manipulate neural systems. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":" ","pages":""},"PeriodicalIF":13.9,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45689722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model. 皮层电路如何实现皮层计算？以小鼠视觉皮层为模型
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2021-07-08 Epub Date: 2021-04-29 DOI: 10.1146/annurev-neuro-102320-085825
Cristopher M Niell, Massimo Scanziani
{"title":"How Cortical Circuits Implement Cortical Computations: Mouse Visual Cortex as a Model.","authors":"Cristopher M Niell, Massimo Scanziani","doi":"10.1146/annurev-neuro-102320-085825","DOIUrl":"10.1146/annurev-neuro-102320-085825","url":null,"abstract":"<p><p>The mouse, as a model organism to study the brain, gives us unprecedented experimental access to the mammalian cerebral cortex. By determining the cortex's cellular composition, revealing the interaction between its different components, and systematically perturbing these components, we are obtaining mechanistic insight into some of the most basic properties of cortical function. In this review, we describe recent advances in our understanding of how circuits of cortical neurons implement computations, as revealed by the study of mouse primary visual cortex. Further, we discuss how studying the mouse has broadened our understanding of the range of computations performed by visual cortex. Finally, we address how future approaches will fulfill the promise of the mouse in elucidating fundamental operations of cortex.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"44 ","pages":"517-546"},"PeriodicalIF":13.9,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9925090/pdf/nihms-1849805.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10711078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating Through Time: A Spatial Navigation Perspective on How the Brain May Encode Time. 时间导航：从空间导航角度看大脑如何编码时间。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-01-21 DOI: 10.1146/annurev-neuro-101419-011117
John B Issa, Gilad Tocker, Michael E Hasselmo, James G Heys, Daniel A Dombeck
{"title":"Navigating Through Time: A Spatial Navigation Perspective on How the Brain May Encode Time.","authors":"John B Issa, Gilad Tocker, Michael E Hasselmo, James G Heys, Daniel A Dombeck","doi":"10.1146/annurev-neuro-101419-011117","DOIUrl":"10.1146/annurev-neuro-101419-011117","url":null,"abstract":"<p><p>Interval timing, which operates on timescales of seconds to minutes, is distributed across multiple brain regions and may use distinct circuit mechanisms as compared to millisecond timing and circadian rhythms. However, its study has proven difficult, as timing on this scale is deeply entangled with other behaviors. Several circuit and cellular mechanisms could generate sequential or ramping activity patterns that carry timing information. Here we propose that a productive approach is to draw parallels between interval timing and spatial navigation, where direct analogies can be made between the variables of interest and the mathematical operations necessitated. Along with designing experiments that isolate or disambiguate timing behavior from other variables, new techniques will facilitate studies that directly address the neural mechanisms that are responsible for interval timing.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"73-93"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351603/pdf/nihms-1583039.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37562949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interneuron Types as Attractors and Controllers. 作为吸引子和控制器的中间神经元类型。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2019-07-12 DOI: 10.1146/annurev-neuro-070918-050421
Gord Fishell, Adam Kepecs
{"title":"Interneuron Types as Attractors and Controllers.","authors":"Gord Fishell, Adam Kepecs","doi":"10.1146/annurev-neuro-070918-050421","DOIUrl":"10.1146/annurev-neuro-070918-050421","url":null,"abstract":"<p><p>Cortical interneurons display striking differences in shape, physiology, and other attributes, challenging us to appropriately classify them. We previously suggested that interneuron types should be defined by their role in cortical processing. Here, we revisit the question of how to codify their diversity based upon their division of labor and function as controllers of cortical information flow. We suggest that developmental trajectories provide a guide for appreciating interneuron diversity and argue that subtype identity is generated using a configurational (rather than combinatorial) code of transcription factors that produce attractor states in the underlying gene regulatory network. We present our updated three-stage model for interneuron specification: an initial cardinal step, allocating interneurons into a few major classes, followed by definitive refinement, creating subclasses upon settling within the cortex, and lastly, state determination, reflecting the incorporation of interneurons into functional circuit ensembles. We close by discussing findings indicating that major interneuron classes are both evolutionarily ancient and conserved. We propose that the complexity of cortical circuits is generated by phylogenetically old interneuron types, complemented by an evolutionary increase in principal neuron diversity. This suggests that a natural neurobiological definition of interneuron types might be derived from a match between their developmental origin and computational function.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"1-30"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37412619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 112
Neuromodulation of Brain State and Behavior. 脑状态和行为的神经调节。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-04-06 DOI: 10.1146/annurev-neuro-100219-105424
David A McCormick, Dennis B Nestvogel, Biyu J He
{"title":"Neuromodulation of Brain State and Behavior.","authors":"David A McCormick,&nbsp;Dennis B Nestvogel,&nbsp;Biyu J He","doi":"10.1146/annurev-neuro-100219-105424","DOIUrl":"https://doi.org/10.1146/annurev-neuro-100219-105424","url":null,"abstract":"<p><p>Neural activity and behavior are both notoriously variable, with responses differing widely between repeated presentation of identical stimuli or trials. Recent results in humans and animals reveal that these variations are not random in their nature, but may in fact be due in large part to rapid shifts in neural, cognitive, and behavioral states. Here we review recent advances in the understanding of rapid variations in the waking state, how variations are generated, and how they modulate neural and behavioral responses in both mice and humans. We propose that the brain has an identifiable set of states through which it wanders continuously in a nonrandom fashion, owing to the activity of both ascending modulatory and fast-acting corticocortical and subcortical-cortical neural pathways. These state variations provide the backdrop upon which the brain operates, and understanding them is critical to making progress in revealing the neural mechanisms underlying cognition and behavior.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"391-415"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-100219-105424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37805124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 133
Basal Ganglia Circuits for Action Specification. 动作规范的基底神经节回路。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-04-17 DOI: 10.1146/annurev-neuro-070918-050452
Junchol Park, Luke T Coddington, Joshua T Dudman
{"title":"Basal Ganglia Circuits for Action Specification.","authors":"Junchol Park,&nbsp;Luke T Coddington,&nbsp;Joshua T Dudman","doi":"10.1146/annurev-neuro-070918-050452","DOIUrl":"https://doi.org/10.1146/annurev-neuro-070918-050452","url":null,"abstract":"<p><p>Behavior is readily classified into patterns of movements with inferred common goals-actions. Goals may be discrete; movements are continuous. Through the careful study of isolated movements in laboratory settings, or via introspection, it has become clear that animals can exhibit exquisite graded specification to their movements. Moreover, graded control can be as fundamental to success as the selection of which action to perform under many naturalistic scenarios: a predator adjusting its speed to intercept moving prey, or a tool-user exerting the perfect amount of force to complete a delicate task. The basal ganglia are a collection of nuclei in vertebrates that extend from the forebrain (telencephalon) to the midbrain (mesencephalon), constituting a major descending extrapyramidal pathway for control over midbrain and brainstem premotor structures. Here we discuss how this pathway contributes to the continuous specification of movements that endows our voluntary actions with vigor and grace.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"485-507"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-070918-050452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37846273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 43
Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction. 神经节细胞：肠-脑感觉传导的新兴生物学。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-02-26 DOI: 10.1146/annurev-neuro-091619-022657
Melanie Maya Kaelberer, Laura E Rupprecht, Winston W Liu, Peter Weng, Diego V Bohórquez
{"title":"Neuropod Cells: The Emerging Biology of Gut-Brain Sensory Transduction.","authors":"Melanie Maya Kaelberer, Laura E Rupprecht, Winston W Liu, Peter Weng, Diego V Bohórquez","doi":"10.1146/annurev-neuro-091619-022657","DOIUrl":"10.1146/annurev-neuro-091619-022657","url":null,"abstract":"<p><p>Guided by sight, scent, texture, and taste, animals ingest food. Once ingested, it is up to the gut to make sense of the food's nutritional value. Classic sensory systems rely on neuroepithelial circuits to convert stimuli into signals that guide behavior. However, sensation of the gut milieu was thought to be mediated only by the passive release of hormones until the discovery of synapses in enteroendocrine cells. These are gut sensory epithelial cells, and those that form synapses are referred to as neuropod cells. Neuropod cells provide the foundation for the gut to transduce sensory signals from the intestinal milieu to the brain through fast neurotransmission onto neurons, including those of the vagus nerve. These findings have sparked a new field of exploration in sensory neurobiology-that of gut-brain sensory transduction.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"337-353"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573801/pdf/nihms-1635794.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37680185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computation Through Neural Population Dynamics. 基于神经种群动力学的计算。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2020-07-08 DOI: 10.1146/annurev-neuro-092619-094115
Saurabh Vyas, Matthew D Golub, David Sussillo, Krishna V Shenoy
{"title":"Computation Through Neural Population Dynamics.","authors":"Saurabh Vyas,&nbsp;Matthew D Golub,&nbsp;David Sussillo,&nbsp;Krishna V Shenoy","doi":"10.1146/annurev-neuro-092619-094115","DOIUrl":"https://doi.org/10.1146/annurev-neuro-092619-094115","url":null,"abstract":"<p><p>Significant experimental, computational, and theoretical work has identified rich structure within the coordinated activity of interconnected neural populations. An emerging challenge now is to uncover the nature of the associated computations, how they are implemented, and what role they play in driving behavior. We term this computation through neural population dynamics. If successful, this framework will reveal general motifs of neural population activity and quantitatively describe how neural population dynamics implement computations necessary for driving goal-directed behavior. Here, we start with a mathematical primer on dynamical systems theory and analytical tools necessary to apply this perspective to experimental data. Next, we highlight some recent discoveries resulting from successful application of dynamical systems. We focus on studies spanning motor control, timing, decision-making, and working memory. Finally, we briefly discuss promising recent lines of investigation and future directions for the computation through neural population dynamics framework.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"43 ","pages":"249-275"},"PeriodicalIF":13.9,"publicationDate":"2020-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-neuro-092619-094115","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 291
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