Neural Signaling in Cancer.

IF 12.1 1区医学 Q1 NEUROSCIENCES

Annual review of neuroscience Pub Date : 2022-07-08 DOI:10.1146/annurev-neuro-111020-092702

Michael B Keough, Michelle Monje

引用次数: 6

Abstract

Nervous system activity regulates development, homeostasis, and plasticity of the brain as well as other organs in the body. These mechanisms are subverted in cancer to propel malignant growth. In turn, cancers modulate neural structure and function to augment growth-promoting neural signaling in the tumor microenvironment. Approaching cancer biology from a neuroscience perspective will elucidate new therapeutic strategies for presently lethal forms of cancer. In this review, we highlight the neural signaling mechanisms recapitulated in primary brain tumors, brain metastases, and solid tumors throughout the body that regulate cancer progression.

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癌症中的神经信号传导。

神经系统活动调节大脑和身体其他器官的发育、体内平衡和可塑性。这些机制在癌症中被破坏以促进恶性生长。反过来，癌症调节神经结构和功能，以增强肿瘤微环境中促进生长的神经信号。从神经科学的角度来看癌症生物学将阐明目前致命形式癌症的新治疗策略。在这篇综述中，我们重点介绍了原发性脑肿瘤、脑转移瘤和全身实体瘤中调节癌症进展的神经信号机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of neuroscience 医学-神经科学

CiteScore

25.30

自引率

0.70%

发文量

期刊介绍： The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.