The Cerebellar Cortex.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Court Hull, Wade G Regehr
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引用次数: 10

Abstract

The cerebellar cortex is an important system for relating neural circuits and learning. Its promise reflects the longstanding idea that it contains simple, repeated circuit modules with only a few cell types and a single plasticity mechanism that mediates learning according to classical Marr-Albus models. However, emerging data have revealed surprising diversity in neuron types, synaptic connections, and plasticity mechanisms, both locally and regionally within the cerebellar cortex. In light of these findings, it is not surprising that attempts to generate a holistic model of cerebellar learning across different behaviors have not been successful. While the cerebellum remains an ideal system for linking neuronal function with behavior, it is necessary to update the cerebellar circuit framework to achieve its great promise. In this review, we highlight recent advances in our understanding of cerebellar-cortical cell types, synaptic connections, signaling mechanisms, and forms of plasticity that enrich cerebellar processing.

Abstract Image

Abstract Image

Abstract Image

小脑皮层。
小脑皮层是连接神经回路和学习的重要系统。它的前景反映了长期以来的想法,即它包含简单,重复的电路模块,只有少数细胞类型和单一的可塑性机制,根据经典的马尔-阿不思模型调节学习。然而,新出现的数据揭示了小脑皮层局部和区域内神经元类型、突触连接和可塑性机制的惊人多样性。鉴于这些发现,试图建立一个跨越不同行为的小脑学习的整体模型并没有成功就不足为奇了。虽然小脑仍然是连接神经元功能与行为的理想系统,但有必要更新小脑回路框架以实现其巨大的前景。在这篇综述中,我们重点介绍了我们对小脑皮层细胞类型、突触连接、信号机制和丰富小脑加工的可塑性形式的理解的最新进展。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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