神经元和回路弹性中的离子通道简并、变异性和共变。

IF 2.9 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
ACS Chemical Health & Safety Pub Date : 2021-07-08 Epub Date: 2021-03-26 DOI:10.1146/annurev-neuro-092920-121538
Jean-Marc Goaillard, Eve Marder
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引用次数: 75

摘要

在所有神经系统中发现的大量离子通道提出了一个基本问题,即单个神经元的特征固有特性是如何由它们表达的特定通道子集决定的。所有神经元都显示出许多不同的离子通道,这些通道具有重叠的电压和时间依赖特性。我们推测这些重叠的特性促进了神经元功能的弹性。同一细胞类型的单个神经元在离子通道电导密度上表现出可变性,尽管它们可以产生可靠的和相似的行为。这使得对任何传导的简单功能分配变得复杂,并且与相同细胞类型的神经元对扰动、缺失和药理学操作的可变反应有关。离子通道基因通常表现出强烈的正相关表达,这可能是由于分子和发育规则决定了哪些离子通道在给定的细胞类型中表达。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ion Channel Degeneracy, Variability, and Covariation in Neuron and Circuit Resilience.

The large number of ion channels found in all nervous systems poses fundamental questions concerning how the characteristic intrinsic properties of single neurons are determined by the specific subsets of channels they express. All neurons display many different ion channels with overlapping voltage- and time-dependent properties. We speculate that these overlapping properties promote resilience in neuronal function. Individual neurons of the same cell type show variability in ion channel conductance densities even though they can generate reliable and similar behavior. This complicates a simple assignment of function to any conductance and is associated with variable responses of neurons of the same cell type to perturbations, deletions, and pharmacological manipulation. Ion channel genes often show strong positively correlated expression, which may result from the molecular and developmental rules that determine which ion channels are expressed in a given cell type.

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来源期刊
ACS Chemical Health & Safety
ACS Chemical Health & Safety PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
3.10
自引率
20.00%
发文量
63
期刊介绍: The Journal of Chemical Health and Safety focuses on news, information, and ideas relating to issues and advances in chemical health and safety. The Journal of Chemical Health and Safety covers up-to-the minute, in-depth views of safety issues ranging from OSHA and EPA regulations to the safe handling of hazardous waste, from the latest innovations in effective chemical hygiene practices to the courts'' most recent rulings on safety-related lawsuits. The Journal of Chemical Health and Safety presents real-world information that health, safety and environmental professionals and others responsible for the safety of their workplaces can put to use right away, identifying potential and developing safety concerns before they do real harm.
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