Neuroimmune Interactions in Peripheral Organs.

IF 12.1 1区医学 Q1 NEUROSCIENCES

Annual review of neuroscience Pub Date : 2022-04-01 DOI:10.1146/annurev-neuro-111020-105359

Roel G J Klein Wolterink, Glendon S. Wu, I. Chiu, H. Veiga-Fernandes

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引用次数: 24

Abstract

Interactions between the nervous and immune systems were recognized long ago, but recent studies show that this crosstalk occurs more frequently than was previously appreciated. Moreover, technological advances have enabled the identification of the molecular mediators and receptors that enable the interaction between these two complex systems and provide new insights on the role of neuroimmune crosstalk in organismal physiology. Most neuroimmune interaction occurs at discrete anatomical locations in which neurons and immune cells colocalize. Here, we describe the interactions of the different branches of the peripheral nervous system with immune cells in various organs, including the skin, intestine, lung, and adipose tissue. We highlight how neuroimmune crosstalk orchestrates physiological processes such as host defense, tissue repair, metabolism, and thermogenesis. Unraveling these intricate relationships is invaluable to explore the therapeutic potential of neuroimmune interaction. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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外周器官的神经免疫相互作用。

神经系统和免疫系统之间的相互作用早就被认识到了，但最近的研究表明，这种串扰的发生频率比以前更高。此外，技术进步使得能够识别分子介质和受体，从而实现这两个复杂系统之间的相互作用，并为神经免疫串扰在生物体生理学中的作用提供了新的见解。大多数神经免疫相互作用发生在神经元和免疫细胞共同定位的离散解剖位置。在这里，我们描述了外周神经系统的不同分支与各种器官中的免疫细胞的相互作用，包括皮肤、肠道、肺和脂肪组织。我们强调了神经免疫串扰如何协调宿主防御、组织修复、代谢和产热等生理过程。解开这些错综复杂的关系对于探索神经免疫相互作用的治疗潜力是非常宝贵的。《神经科学年度评论》第45卷预计最终在线出版日期为2022年7月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual review of neuroscience 医学-神经科学

CiteScore

25.30

自引率

0.70%

发文量

期刊介绍： The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.