融合合成分子和基因编码蛋白质，打造神经科学新工具。

IF 12.1 1区医学 Q1 NEUROSCIENCES

Annual review of neuroscience Pub Date : 2022-02-28 DOI:10.1146/annurev-neuro-110520-030031

Pratik Kumar, L. Lavis

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引用次数: 1

摘要

揭示大脑的复杂性需要复杂的方法来探测和干扰具有高度时空控制的神经生物学过程。化学生物学领域已经产生了将小分子工具的分子特异性与基因编码试剂的细胞特异性相结合的一般策略。在这里，我们调查了这些混合小分子:蛋白质方法的应用，改进和扩展，以解决神经科学问题，从而产生强大的试剂来精确测量和操纵神经系统。《神经科学年度评论》第45卷的最终在线出版日期预计为2022年7月。修订后的估计数请参阅http://www.annualreviews.org/page/journal/pubdates。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Melding Synthetic Molecules and Genetically Encoded Proteins to Forge New Tools for Neuroscience.

Unraveling the complexity of the brain requires sophisticated methods to probe and perturb neurobiological processes with high spatiotemporal control. The field of chemical biology has produced general strategies to combine the molecular specificity of small-molecule tools with the cellular specificity of genetically encoded reagents. Here, we survey the application, refinement, and extension of these hybrid small-molecule:protein methods to problems in neuroscience, which yields powerful reagents to precisely measure and manipulate neural systems. Expected final online publication date for the Annual Review of Neuroscience, Volume 45 is July 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual review of neuroscience 医学-神经科学

CiteScore

25.30

自引率

0.70%

发文量

期刊介绍： The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.