Silent Synapses in the Adult Brain.

IF 13.2 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2025-07-01 Epub Date: 2025-02-25 DOI:10.1146/annurev-neuro-112723-032924
Dimitra Vardalaki, Courtney E Yaeger, Mark T Harnett
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引用次数: 0

Abstract

The formation of new synapses, the connections between neurons, is the critical step for neural circuit assembly. Newly formed glutamatergic synapses are initially silent and require activity-dependent plasticity to become fully functional connections. While these synapses have long been considered a vital part of the developmental program for neural networks, recent findings now indicate that silent synapses are a key source of neural circuit plasticity in the adult brain. Here, we review current evidence for silent synapses in the adult brain and explore the potential roles of these highly plastic structures. We argue that silent synapses may be instrumental in adult neural circuit remodeling and can serve as a latent reservoir of plasticity that enhances information processing and storage. This previously underappreciated aspect of adult plasticity underscores the need for innovative approaches and further investigation into the dynamic contribution of silent synapses to learning and memory in the adult brain.

成人大脑中的沉默突触。
新突触的形成,即神经元之间的连接,是神经回路组装的关键步骤。新形成的谷氨酸突触最初是沉默的,需要活动依赖的可塑性才能成为功能齐全的连接。虽然这些突触长期以来一直被认为是神经网络发育程序的重要组成部分,但最近的研究结果表明,沉默突触是成人大脑神经回路可塑性的关键来源。在这里,我们回顾了成人大脑中沉默突触的现有证据,并探讨了这些高度可塑性结构的潜在作用。我们认为沉默突触可能有助于成人神经回路的重塑,并可以作为一个潜在的可塑性库,增强信息处理和存储。这一以前未被重视的成人可塑性方面强调了创新方法的必要性,并进一步研究成人大脑中沉默突触对学习和记忆的动态贡献。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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