Heterogeneity of Astrocyte Reactivity.

IF 13.2 1区 医学 Q1 NEUROSCIENCES
Benjamin L L Clayton, Shane A Liddelow
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引用次数: 0

Abstract

Astrocytes, the bushy, star-shaped glial cells of the brain and spinal cord, support the proper development and function of many cells in the central nervous system. In response to disease or injury they transform, adopting varied morphologies, molecular signatures, and functions-this state of transformation is known as reactivity. For over a century, the reactivity of astrocytes has been recognized, but it is the recent surge in technological innovation that has shed light on the diverse nature of this reactivity. It is this developing understanding of the heterogeneity of reactive astrocytes across disease-specific contexts and a spatiotemporal gradient that now excites the astrocyte field. In this review, we discuss the current understanding of reactive astrocyte heterogeneity, highlight the biological implications of this heterogeneity, and propose future approaches to aid in fully understanding the heterogeneity of reactive astrocytes.

星形细胞反应性的异质性。
星形胶质细胞是大脑和脊髓中浓密的星形胶质细胞,支持中枢神经系统中许多细胞的正常发育和功能。在对疾病或损伤的反应中,它们会发生转化,采用不同的形态、分子特征和功能——这种转化状态被称为反应性。一个多世纪以来,星形胶质细胞的反应性已经得到了认可,但最近技术创新的激增才揭示了这种反应性的多样性。正是这种对反应性星形胶质细胞在疾病特异性背景下的异质性和时空梯度的不断发展的理解,现在激发了星形胶质细胞领域。在这篇综述中,我们讨论了目前对反应性星形胶质细胞异质性的理解,强调了这种异质性的生物学意义,并提出了未来的方法来帮助充分理解反应性星形胶质细胞的异质性。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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