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Annual review of neuroscience最新文献

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Cognition from the Body-Brain Partnership: Exaptation of Memory. 认知来自身体与大脑的合作：记忆的嬗变。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-14 DOI: 10.1146/annurev-neuro-101222-110632
György Buzsáki, David Tingley
{"title":"Cognition from the Body-Brain Partnership: Exaptation of Memory.","authors":"György Buzsáki, David Tingley","doi":"10.1146/annurev-neuro-101222-110632","DOIUrl":"10.1146/annurev-neuro-101222-110632","url":null,"abstract":"<p><p>Examination of cognition has historically been approached from language and introspection. However, human language-dependent definitions ignore the evolutionary roots of brain mechanisms and constrain their study in experimental animals. We promote an alternative view, namely that cognition, including memory, can be explained by exaptation and expansion of the circuits and algorithms serving bodily functions. Regulation and protection of metabolic and energetic processes require time-evolving brain computations enabling the organism to prepare for altered future states. Exaptation of such circuits was likely exploited for exploration of the organism's niche. We illustrate that exploration gives rise to a cognitive map, and in turn, environment-disengaged computation allows for mental travel into the past (memory) and the future (planning). Such brain-body interactions not only occur during waking but also persist during sleep. These exaptation steps are illustrated by the dual, endocrine-homeostatic and memory, contributions of the hippocampal system, particularly during hippocampal sharp-wave ripples.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"191-210"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly. 昼夜节律与星形胶质细胞：好、坏、丑。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-28 DOI: 10.1146/annurev-neuro-100322-112249
Michael H Hastings, Marco Brancaccio, Maria F Gonzalez-Aponte, Erik D Herzog
{"title":"Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.","authors":"Michael H Hastings, Marco Brancaccio, Maria F Gonzalez-Aponte, Erik D Herzog","doi":"10.1146/annurev-neuro-100322-112249","DOIUrl":"10.1146/annurev-neuro-100322-112249","url":null,"abstract":"<p><p>This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous circadian clocks exert a particular role in controlling longer-term oscillations of brain function: the maintenance of sleep states and the circadian ordering of sleep and wakefulness. This is most evident in the central circadian pacemaker, the suprachiasmatic nucleus, where the molecular clock of astrocytes suffices to drive daily cycles of neuronal activity and behavior. In Alzheimer's disease, sleep impairments accompany cognitive decline. In mouse models of the disease, circadian disturbances accelerate astroglial activation and other brain pathologies, suggesting that daily functions in astrocytes protect neuronal homeostasis. In brain cancer, treatment in the morning has been associated with prolonged survival, and gliomas have daily rhythms in gene expression and drug sensitivity. Thus, circadian time is fast becoming critical to elucidating reciprocal astrocytic-neuronal interactions in health and disease.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"123-143"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381027/pdf/nihms-1918905.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10328146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neural Circuits for Emotion. 情绪的神经回路。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-111020-103314
Meryl Malezieux, Alexandra S Klein, Nadine Gogolla
{"title":"Neural Circuits for Emotion.","authors":"Meryl Malezieux,&nbsp;Alexandra S Klein,&nbsp;Nadine Gogolla","doi":"10.1146/annurev-neuro-111020-103314","DOIUrl":"https://doi.org/10.1146/annurev-neuro-111020-103314","url":null,"abstract":"<p><p>Emotions are fundamental to our experience and behavior, affecting and motivating all aspects of our lives. Scientists of various disciplines have been fascinated by emotions for centuries, yet even today vigorous debates abound about how to define emotions and how to best study their neural underpinnings. Defining emotions from an evolutionary perspective and acknowledging their important functional roles in supporting survival allows the study of emotion states in diverse species. This approach enables taking advantage of modern tools in behavioral, systems, and circuit neurosciences, allowing the precise dissection of neural mechanisms and behavior underlying emotion processes in model organisms. Here we review findings about the neural circuit mechanisms underlying emotion processing across species and try to identify points of convergence as well as important next steps in the pursuit of understanding how emotions emerge from neural activity.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"211-231"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9844301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Specialized Networks for Social Cognition in the Primate Brain. 灵长类动物大脑中的社会认知特化网络
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-102522-121410
Ben Deen, Caspar M Schwiedrzik, Julia Sliwa, Winrich A Freiwald
{"title":"Specialized Networks for Social Cognition in the Primate Brain.","authors":"Ben Deen, Caspar M Schwiedrzik, Julia Sliwa, Winrich A Freiwald","doi":"10.1146/annurev-neuro-102522-121410","DOIUrl":"10.1146/annurev-neuro-102522-121410","url":null,"abstract":"<p><p>Primates have evolved diverse cognitive capabilities to navigate their complex social world. To understand how the brain implements critical social cognitive abilities, we describe functional specialization in the domains of face processing, social interaction understanding, and mental state attribution. Systems for face processing are specialized from the level of single cells to populations of neurons within brain regions to hierarchically organized networks that extract and represent abstract social information. Such functional specialization is not confined to the sensorimotor periphery but appears to be a pervasive theme of primate brain organization all the way to the apex regions of cortical hierarchies. Circuits processing social information are juxtaposed with parallel systems involved in processing nonsocial information, suggesting common computations applied to different domains. The emerging picture of the neural basis of social cognition is a set of distinct but interacting subnetworks involved in component processes such as face perception and social reasoning, traversing large parts of the primate brain.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"381-401"},"PeriodicalIF":12.1,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meningeal Mechanisms and the Migraine Connection. 脑膜机制与偏头痛的联系。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-13 DOI: 10.1146/annurev-neuro-080422-105509
Dan Levy, Michael A Moskowitz
{"title":"Meningeal Mechanisms and the Migraine Connection.","authors":"Dan Levy, Michael A Moskowitz","doi":"10.1146/annurev-neuro-080422-105509","DOIUrl":"10.1146/annurev-neuro-080422-105509","url":null,"abstract":"<p><p>Migraine is a complex neurovascular pain disorder linked to the meninges, a border tissue innervated by neuropeptide-containing primary afferent fibers chiefly from the trigeminal nerve. Electrical or mechanical stimulation of this nerve surrounding large blood vessels evokes headache patterns as in migraine, and the brain, blood, and meninges are likely sources of headache triggers. Cerebrospinal fluid may play a significant role in migraine by transferring signals released from the brain to overlying pain-sensitive meningeal tissues, including dura mater. Interactions between trigeminal afferents, neuropeptides, and adjacent meningeal cells and tissues cause neurogenic inflammation, a critical target for current prophylactic and abortive migraine therapies. Here we review the importance of the cranial meninges to migraine headaches, explore the properties of trigeminal meningeal afferents, and briefly review emerging concepts, such as meningeal neuroimmune interactions, that may one day prove therapeutically relevant.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"39-58"},"PeriodicalIF":12.1,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11412714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocyte Endfeet in Brain Function and Pathology: Open Questions. 星形胶质细胞末梢在脑功能和病理学中的作用：悬而未决的问题。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-02-28 DOI: 10.1146/annurev-neuro-091922-031205
Blanca Díaz-Castro, Stefanie Robel, Anusha Mishra
{"title":"Astrocyte Endfeet in Brain Function and Pathology: Open Questions.","authors":"Blanca Díaz-Castro, Stefanie Robel, Anusha Mishra","doi":"10.1146/annurev-neuro-091922-031205","DOIUrl":"10.1146/annurev-neuro-091922-031205","url":null,"abstract":"<p><p>Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood flow, nutrient uptake, and waste clearance. Accordingly, astrocyte endfeet contain specialized organelles and proteins, including local protein translation machinery and highly organized scaffold proteins, which anchor channels, transporters, receptors, and enzymes critical for astrocyte-vascular interactions. Many neurological diseases are characterized by the loss of polarization of specific endfoot proteins, vascular dysregulation, BBB disruption, altered waste clearance, or, in extreme cases, loss of endfoot coverage. A role for astrocyte endfeet has been demonstrated or postulated in many of these conditions. This review provides an overview of the development, composition, function, and pathological changes of astrocyte endfeet and highlights the gaps in our knowledge that future research should address.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"101-121"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10164141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion. PTBP1抑制的治疗潜力（如果有的话）不归因于神经胶质转化。
IF 12.1 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-02-07 DOI: 10.1146/annurev-neuro-092822-083410
Lei-Lei Wang, Chun-Li Zhang
{"title":"Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion.","authors":"Lei-Lei Wang, Chun-Li Zhang","doi":"10.1146/annurev-neuro-092822-083410","DOIUrl":"10.1146/annurev-neuro-092822-083410","url":null,"abstract":"<p><p>A holy grail of regenerative medicine is to replenish the cells that are lost due to disease. The adult mammalian central nervous system (CNS) has, however, largely lost such a regenerative ability. An emerging strategy for the generation of new neurons is through glia-to-neuron (GtN) conversion in vivo, mainly accomplished by the regulation of fate-determining factors. When inhibited, PTBP1, a factor involved in RNA biology, was reported to induce rapid and efficient GtN conversion in multiple regions of the adult CNS. Remarkably, PTBP1 inhibition was also claimed to greatly improve behaviors of mice with neurological diseases or aging. These phenomenal claims, if confirmed, would constitute a significant advancement in regenerative medicine. Unfortunately, neither GtN conversion nor therapeutic potential via PTBP1 inhibition was validated by the results of multiple subsequent replication studies with stringent methods. Here we review these controversial studies and conclude with recommendations for examining GtN conversion in vivo and future investigations of PTBP1.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"1-15"},"PeriodicalIF":12.1,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10321067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of Feedforward and Feedback Information Streams in the Modular Architecture of Mouse Visual Cortex. 小鼠视觉皮层模块化结构中前馈和反馈信息流的集成。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-083122-021241
Andreas Burkhalter, Rinaldo D D'Souza, Weiqing Ji, Andrew M Meier
{"title":"Integration of Feedforward and Feedback Information Streams in the Modular Architecture of Mouse Visual Cortex.","authors":"Andreas Burkhalter,&nbsp;Rinaldo D D'Souza,&nbsp;Weiqing Ji,&nbsp;Andrew M Meier","doi":"10.1146/annurev-neuro-083122-021241","DOIUrl":"https://doi.org/10.1146/annurev-neuro-083122-021241","url":null,"abstract":"<p><p>Radial cell columns are a hallmark feature of cortical architecture in many mammalian species. It has long been held, based on the lack of orientation columns, that such functional units are absent in rodent primary visual cortex (V1). These observations led to the view that rodent visual cortex has a fundamentally different network architecture than that of carnivores and primates. While columns may be lacking in rodent V1, we describe in this review that modular clusters of inputs to layer 1 and projection neurons in the layers below are prominent features of the mouse visual cortex. We propose that modules organize thalamocortical inputs, intracortical processing streams, and transthalamic communications that underlie distinct sensory and sensorimotor functions.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"259-280"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9786565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neural Control of Sexually Dimorphic Social Behavior: Connecting Development to Adulthood. 两性两性社会行为的神经控制:将发育与成年联系起来。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-121522-110856
Margaret M McCarthy
{"title":"Neural Control of Sexually Dimorphic Social Behavior: Connecting Development to Adulthood.","authors":"Margaret M McCarthy","doi":"10.1146/annurev-neuro-121522-110856","DOIUrl":"https://doi.org/10.1146/annurev-neuro-121522-110856","url":null,"abstract":"<p><p>Rapid advances in the neural control of social behavior highlight the role of interconnected nodes engaged in differential information processing to generate behavior. Many innate social behaviors are essential to reproductive fitness and therefore fundamentally different in males and females. Programming these differences occurs early in development in mammals, following gonadal differentiation and copious androgen production by the fetal testis during a critical period. Early-life programming of social behavior and its adult manifestation are separate but yoked processes, yet how they are linked is unknown. This review seeks to highlight that gap by identifying four core mechanisms (epigenetics, cell death, circuit formation, and adult hormonal modulation) that could connect developmental changes to the adult behaviors of mating and aggression. We further propose that a unique social behavior, adolescent play, bridges the preweaning to the postpubertal brain by engaging the same neural networks underpinning adult reproductive and aggressive behaviors.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"321-339"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
How Flies See Motion. 苍蝇是如何看到运动的。
IF 13.9 1区 医学
Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-080422-111929
Alexander Borst, Lukas N Groschner
{"title":"How Flies See Motion.","authors":"Alexander Borst,&nbsp;Lukas N Groschner","doi":"10.1146/annurev-neuro-080422-111929","DOIUrl":"https://doi.org/10.1146/annurev-neuro-080422-111929","url":null,"abstract":"<p><p>How neurons detect the direction of motion is a prime example of neural computation: Motion vision is found in the visual systems of virtually all sighted animals, it is important for survival, and it requires interesting computations with well-defined linear and nonlinear processing steps-yet the whole process is of moderate complexity. The genetic methods available in the fruit fly <i>Drosophila</i> and the charting of a connectome of its visual system have led to rapid progress and unprecedented detail in our understanding of how neurons compute the direction of motion in this organism. The picture that emerged incorporates not only the identity, morphology, and synaptic connectivity of each neuron involved but also its neurotransmitters, its receptors, and their subcellular localization. Together with the neurons' membrane potential responses to visual stimulation, this information provides the basis for a biophysically realistic model of the circuit that computes the direction of visual motion.</p>","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"17-37"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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