Annual review of neuroscience最新文献_第3页

Striosomes and Matrisomes: Scaffolds for Dynamic Coupling of Volition and Action. 纹状体和基质体：Volition和Action动态耦合的支架。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-04-17 DOI: 10.1146/annurev-neuro-121522-025740

Ann M Graybiel, Ayano Matsushima

{"title":"Striosomes and Matrisomes: Scaffolds for Dynamic Coupling of Volition and Action.","authors":"Ann M Graybiel, Ayano Matsushima","doi":"10.1146/annurev-neuro-121522-025740","DOIUrl":"10.1146/annurev-neuro-121522-025740","url":null,"abstract":"Striosomes form neurochemically specialized compartments of the striatum embedded in a large matrix made up of modules called matrisomes. Striosome-matrix architecture is multiplexed with the canonical direct-indirect organization of the striatum. Striosomal functions remain to be fully clarified, but key information is emerging. First, striosomes powerfully innervate nigral dopamine-containing neurons and can completely shut down their activity, with a following rebound excitation. Second, striosomes receive limbic and cognition-related corticostriatal afferents and are dynamically modulated in relation to value-based actions. Third, striosomes are spatially interspersed among matrisomes and interneurons and are influenced by local and global neuromodulatory and oscillatory activities. Fourth, striosomes tune engagement and the motivation to perform reinforcement learning, to manifest stereotypical behaviors, and to navigate valence conflicts and valence discriminations. We suggest that, at an algorithmic level, striosomes could serve as distributed scaffolds to provide formats of the striatal computations generated through development and refined through learning. We propose that striosomes affect subjective states. By transforming corticothalamic and other inputs to the functional formats of the striatum, they could implement state transitions in nigro-striato-nigral circuits to affect bodily and cognitive actions according to internal motives whose functions are compromised in neuropsychiatric conditions.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"359-380"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9790583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of PTB Inhibition Through Converting Glial Cells to Neurons in the Brain. 通过将脑胶质细胞转化为神经元抑制PTB的治疗潜力。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-083022-113120

Xiang-Dong Fu, William C Mobley

引用次数: 0

How Do You Build a Cognitive Map? The Development of Circuits and Computations for the Representation of Space in the Brain. 如何构建认知地图?大脑空间表征电路和计算的发展。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-090922-010618

Flavio Donato, Anja Xu Schwartzlose, Renan Augusto Viana Mendes

引用次数: 0

Cognition from the Body-Brain Partnership: Exaptation of Memory. 认知来自身体与大脑的合作：记忆的嬗变。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-14 DOI: 10.1146/annurev-neuro-101222-110632

György Buzsáki, David Tingley

{"title":"Cognition from the Body-Brain Partnership: Exaptation of Memory.","authors":"György Buzsáki, David Tingley","doi":"10.1146/annurev-neuro-101222-110632","DOIUrl":"10.1146/annurev-neuro-101222-110632","url":null,"abstract":"Examination of cognition has historically been approached from language and introspection. However, human language-dependent definitions ignore the evolutionary roots of brain mechanisms and constrain their study in experimental animals. We promote an alternative view, namely that cognition, including memory, can be explained by exaptation and expansion of the circuits and algorithms serving bodily functions. Regulation and protection of metabolic and energetic processes require time-evolving brain computations enabling the organism to prepare for altered future states. Exaptation of such circuits was likely exploited for exploration of the organism's niche. We illustrate that exploration gives rise to a cognitive map, and in turn, environment-disengaged computation allows for mental travel into the past (memory) and the future (planning). Such brain-body interactions not only occur during waking but also persist during sleep. These exaptation steps are illustrated by the dual, endocrine-homeostatic and memory, contributions of the hippocampal system, particularly during hippocampal sharp-wave ripples.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"191-210"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10793243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10146992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly. 昼夜节律与星形胶质细胞：好、坏、丑。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-28 DOI: 10.1146/annurev-neuro-100322-112249

Michael H Hastings, Marco Brancaccio, Maria F Gonzalez-Aponte, Erik D Herzog

{"title":"Circadian Rhythms and Astrocytes: The Good, the Bad, and the Ugly.","authors":"Michael H Hastings, Marco Brancaccio, Maria F Gonzalez-Aponte, Erik D Herzog","doi":"10.1146/annurev-neuro-100322-112249","DOIUrl":"10.1146/annurev-neuro-100322-112249","url":null,"abstract":"This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous circadian clocks exert a particular role in controlling longer-term oscillations of brain function: the maintenance of sleep states and the circadian ordering of sleep and wakefulness. This is most evident in the central circadian pacemaker, the suprachiasmatic nucleus, where the molecular clock of astrocytes suffices to drive daily cycles of neuronal activity and behavior. In Alzheimer's disease, sleep impairments accompany cognitive decline. In mouse models of the disease, circadian disturbances accelerate astroglial activation and other brain pathologies, suggesting that daily functions in astrocytes protect neuronal homeostasis. In brain cancer, treatment in the morning has been associated with prolonged survival, and gliomas have daily rhythms in gene expression and drug sensitivity. Thus, circadian time is fast becoming critical to elucidating reciprocal astrocytic-neuronal interactions in health and disease.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"123-143"},"PeriodicalIF":13.9,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10381027/pdf/nihms-1918905.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10328146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural Circuits for Emotion. 情绪的神经回路。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-111020-103314

Meryl Malezieux, Alexandra S Klein, Nadine Gogolla

引用次数: 5

Specialized Networks for Social Cognition in the Primate Brain. 灵长类动物大脑中的社会认知特化网络

IF 12.1 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-102522-121410

Ben Deen, Caspar M Schwiedrzik, Julia Sliwa, Winrich A Freiwald

{"title":"Specialized Networks for Social Cognition in the Primate Brain.","authors":"Ben Deen, Caspar M Schwiedrzik, Julia Sliwa, Winrich A Freiwald","doi":"10.1146/annurev-neuro-102522-121410","DOIUrl":"10.1146/annurev-neuro-102522-121410","url":null,"abstract":"Primates have evolved diverse cognitive capabilities to navigate their complex social world. To understand how the brain implements critical social cognitive abilities, we describe functional specialization in the domains of face processing, social interaction understanding, and mental state attribution. Systems for face processing are specialized from the level of single cells to populations of neurons within brain regions to hierarchically organized networks that extract and represent abstract social information. Such functional specialization is not confined to the sensorimotor periphery but appears to be a pervasive theme of primate brain organization all the way to the apex regions of cortical hierarchies. Circuits processing social information are juxtaposed with parallel systems involved in processing nonsocial information, suggesting common computations applied to different domains. The emerging picture of the neural basis of social cognition is a set of distinct but interacting subnetworks involved in component processes such as face perception and social reasoning, traversing large parts of the primate brain.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"381-401"},"PeriodicalIF":12.1,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11115357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meningeal Mechanisms and the Migraine Connection. 脑膜机制与偏头痛的联系。

IF 12.1 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-03-13 DOI: 10.1146/annurev-neuro-080422-105509

Dan Levy, Michael A Moskowitz

引用次数: 0

Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion. PTBP1抑制的治疗潜力（如果有的话）不归因于神经胶质转化。

IF 12.1 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 Epub Date: 2023-02-07 DOI: 10.1146/annurev-neuro-092822-083410

Lei-Lei Wang, Chun-Li Zhang

{"title":"Therapeutic Potential of PTBP1 Inhibition, If Any, Is Not Attributed to Glia-to-Neuron Conversion.","authors":"Lei-Lei Wang, Chun-Li Zhang","doi":"10.1146/annurev-neuro-092822-083410","DOIUrl":"10.1146/annurev-neuro-092822-083410","url":null,"abstract":"A holy grail of regenerative medicine is to replenish the cells that are lost due to disease. The adult mammalian central nervous system (CNS) has, however, largely lost such a regenerative ability. An emerging strategy for the generation of new neurons is through glia-to-neuron (GtN) conversion in vivo, mainly accomplished by the regulation of fate-determining factors. When inhibited, PTBP1, a factor involved in RNA biology, was reported to induce rapid and efficient GtN conversion in multiple regions of the adult CNS. Remarkably, PTBP1 inhibition was also claimed to greatly improve behaviors of mice with neurological diseases or aging. These phenomenal claims, if confirmed, would constitute a significant advancement in regenerative medicine. Unfortunately, neither GtN conversion nor therapeutic potential via PTBP1 inhibition was validated by the results of multiple subsequent replication studies with stringent methods. Here we review these controversial studies and conclude with recommendations for examining GtN conversion in vivo and future investigations of PTBP1.","PeriodicalId":8008,"journal":{"name":"Annual review of neuroscience","volume":"46 ","pages":"1-15"},"PeriodicalIF":12.1,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10321067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integration of Feedforward and Feedback Information Streams in the Modular Architecture of Mouse Visual Cortex. 小鼠视觉皮层模块化结构中前馈和反馈信息流的集成。

IF 13.9 1区医学

Annual review of neuroscience Pub Date : 2023-07-10 DOI: 10.1146/annurev-neuro-083122-021241

Andreas Burkhalter, Rinaldo D D'Souza, Weiqing Ji, Andrew M Meier

引用次数: 1