特定回路的深部脑刺激为运动控制提供洞察力

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI:10.1146/annurev-neuro-092823-104810
Aryn H Gittis, Roy V Sillitoe
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引用次数: 0

摘要

深部脑刺激(DBS)是一种向大脑特定区域施加电刺激的方法,是控制多种神经和神经精神疾病症状的有效治疗方法。通过 DBS 对神经回路进行临床访问,为研究神经回路与行为之间的功能联系提供了机会。本综述讨论了 DBS 在帕金森病和肌张力障碍中的应用如何让人们深入了解运动控制的大脑网络和生理机制。与此同时,关于电刺激模式如何影响神经回路内的可塑性和交流的基础科学见解正在将 DBS 从治疗症状的疗法转变为治疗回路的疗法,目的是训练大脑摆脱病态。神经科学年刊》(Annual Review of Neuroscience)第 47 卷的最终在线出版日期预计为 2024 年 7 月。修订后的预计日期请参见 http://www.annualreviews.org/page/journal/pubdates。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Circuit-Specific Deep Brain Stimulation Provides Insights into Movement Control.

Deep brain stimulation (DBS), a method in which electrical stimulation is delivered to specific areas of the brain, is an effective treatment for managing symptoms of a number of neurological and neuropsychiatric disorders. Clinical access to neural circuits during DBS provides an opportunity to study the functional link between neural circuits and behavior. This review discusses how the use of DBS in Parkinson's disease and dystonia has provided insights into the brain networks and physiological mechanisms that underlie motor control. In parallel, insights from basic science about how patterns of electrical stimulation impact plasticity and communication within neural circuits are transforming DBS from a therapy for treating symptoms to a therapy for treating circuits, with the goal of training the brain out of its diseased state.

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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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